chlorpromazine has been researched along with Lipidoses in 11 studies
Chlorpromazine: The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking DOPAMINE RECEPTORS. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the treatment of intractable hiccup.
chlorpromazine : A substituted phenothiazine in which the ring nitrogen at position 10 is attached to C-3 of an N,N-dimethylpropanamine moiety.
Lipidoses: Conditions characterized by abnormal lipid deposition due to disturbance in lipid metabolism, such as hereditary diseases involving lysosomal enzymes required for lipid breakdown. They are classified either by the enzyme defect or by the type of lipid involved.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Phospholipidosis (PLD) is a lysosomal storage disorder induced by compounds, notably cationic amphiphilic drugs, which although reversible interferes with cellular phospholipids." | 1.38 | In silico assay for assessing phospholipidosis potential of small druglike molecules: training, validation, and refinement using several data sets. ( Atzpodien, EA; Csato, M; Doessegger, L; Fischer, H; Lenz, B; Schmitt, G; Singer, T, 2012) |
| "Phospholipidosis is an adverse effect caused by numerous cationic amphiphilic drugs and can affect many cell types." | 1.36 | Predicting phospholipidosis using machine learning. ( Glen, RC; Lowe, R; Mitchell, JB, 2010) |
| "to drug-induced lipidosis." | 1.25 | Intraalveolar foam cells associated with lipidosis-like alterations in lung and liver of rats treated with tricyclic psychotropic drugs. ( Lüllmann-Rauch, R; Scheid, D, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (72.73) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (27.27) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lowe, R | 1 |
| Glen, RC | 1 |
| Mitchell, JB | 1 |
| Fischer, H | 1 |
| Atzpodien, EA | 1 |
| Csato, M | 1 |
| Doessegger, L | 1 |
| Lenz, B | 1 |
| Schmitt, G | 1 |
| Singer, T | 1 |
| Tomida, T | 1 |
| Ishimura, M | 1 |
| Iwaki, M | 1 |
| MYERS, JD | 1 |
| OLSON, RE | 1 |
| LEWIS, JH | 1 |
| MORAN, TJ | 1 |
| KOHN, NN | 1 |
| MYERSON, RM | 1 |
| Hostetler, KY | 1 |
| Matsuzawa, Y | 1 |
| Lüllmann-Rauch, R | 3 |
| Scheid, D | 1 |
| Drenckhahn, D | 1 |
| Kleine, L | 1 |
| Joshi, UM | 1 |
| Kodavanti, PR | 1 |
| Coudert, B | 1 |
| Dwyer, TM | 1 |
| Mehendale, HM | 1 |
| Duckett, S | 1 |
| Cracco, J | 1 |
| Lublin, F | 1 |
| Scott, T | 1 |
11 other studies available for chlorpromazine and Lipidoses
| Article | Year |
|---|---|
Predicting phospholipidosis using machine learning.
Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Bio | 2010 |
In silico assay for assessing phospholipidosis potential of small druglike molecules: training, validation, and refinement using several data sets.
Topics: Animals; Cattle; Cells, Cultured; Computer Simulation; Cornea; Drug-Related Side Effects and Adverse | 2012 |
A cell-based assay using HepaRG cells for predicting drug-induced phospholipidosis.
Topics: Amikacin; Amiodarone; Amitriptyline; Biological Assay; Chlorpromazine; Female; Hep G2 Cells; Humans; | 2017 |
Xanthomatous biliary cirrhosis following chlorpromazine, with observations indicating overproduction of cholesterol, hyperprothrombinemia, and the development of portal hypertension.
Topics: Chlorpromazine; Cholesterol; Humans; Hypertension; Hypertension, Portal; Lipidoses; Liver Cirrhosis; | 1957 |
Xanthomatous biliary cirrhosis following chlorpromazine.
Topics: Chlorpromazine; Lipidoses; Liver Cirrhosis; Liver Cirrhosis, Biliary; Splenomegaly | 1961 |
Studies on the mechanism of drug-induced lipidosis. Cationic amphiphilic drug inhibition of lysosomal phospholipases A and C.
Topics: Amantadine; Aniline Compounds; Animals; Chlorphentermine; Chlorpromazine; Heptanes; Imipramine; Lipi | 1981 |
Intraalveolar foam cells associated with lipidosis-like alterations in lung and liver of rats treated with tricyclic psychotropic drugs.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Chlorpromazine; Clomipramine; Dibenzocyclo | 1975 |
Lysosomal alterations in cultured macrophages exposed to anorexigenic and psychotropic drugs.
Topics: Acid Phosphatase; Animals; Antidepressive Agents, Tricyclic; Appetite Depressants; Chlorphentermine; | 1976 |
Types of interaction of amphiphilic drugs with phospholipid vesicles.
Topics: Amiodarone; Anilino Naphthalenesulfonates; Binding Sites; Chloramphenicol; Chloroquine; Chlorpromazi | 1988 |
Electron microscopical diagnosis of lipidosis with the use of rectal biopsy.
Topics: Adolescent; Aggression; Biopsy; Chlorpromazine; Epilepsy; Gait; Humans; Inclusion Bodies; Intellectu | 1974 |
Lipidosis-like ultrastructural alterations in rat lymph nodes after treatment with tricyclic antidepressants or neuroleptics.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Chlorpromazine; Clomipramine; Dibenzocyclo | 1974 |