chlorpromazine has been researched along with Libman-Sacks Disease in 34 studies
Chlorpromazine: The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking DOPAMINE RECEPTORS. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the treatment of intractable hiccup.
chlorpromazine : A substituted phenothiazine in which the ring nitrogen at position 10 is attached to C-3 of an N,N-dimethylpropanamine moiety.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We report here two LA-positive cases (a 29-year-old male taking chlorpromazine for schizophrenia, and a 44-year-old female diagnosed as systemic lupus erythematosus) who underwent surgical procedures without complications." | 3.68 | Surgical experience on patients with serum lupus anticoagulants. A report of two cases. ( Ichikawa, Y; Minezaki, T, 1993) |
| "Further study of drug-induced systemic lupus erythematosus is necessary in order to resolve these problems regarding pathogenesis." | 2.36 | Drug-induced systemic lupus erythematosus. ( Weinstein, A, 1980) |
| "Extensive serologic changes occur in systemic lupus erythematosus (SLE) which are probably secondary to unknow primary cause(s)." | 2.35 | Serologic abnormalities in spontaneous and drug-induced systemic lupus erythematosus. ( Dubois, EL, 1975) |
| "Systemic lupus erythematosus is characterized by dysregulated activation of T and B cells and autoantibodies to nuclear antigens and, in some cases, lipid antigens." | 1.42 | Nonbilayer Phospholipid Arrangements Are Toll-Like Receptor-2/6 and TLR-4 Agonists and Trigger Inflammation in a Mouse Model Resembling Human Lupus. ( Astudillo, H; Baeza, I; España, L; Estrada-García, I; Estrada-Parra, S; Flores-Romo, L; Landa, C; Reséndiz, A; Serafín-López, J; Tescucano, A; Wong, C; Wong-Baeza, C, 2015) |
| "Psychiatric manifestations of systemic lupus erythematosus (SLE) are well recognized but usually occur in the later stages of the illness, with organic syndromes being the most common." | 1.31 | Systemic lupus erythematosus presenting as mania. ( Haddad, P; Khan, S; Montague, L; Summerton, C, 2000) |
| "Chlorpromazine did not cause apoptosis by inhibition of cytokine binding or blockade of early intracellular signaling." | 1.31 | Chlorpromazine induces apoptosis in activated human lymphoblasts: a mechanism supporting the induction of drug-induced lupus erythematosus? ( Blank, N; Capraru, D; Geiler, T; Grötsch, P; Grünke, M; Hieronymus, T; Kalden, JR; Lorenz, HM; Winkler, S, 2000) |
| "Neurologic complications of systemic lupus erythematosus (SLE) are common, but chorea is rare." | 1.25 | Clinical features of chorea associated with systemic lupus erythematosus. ( Lusins, JO; Szilagyi, PA, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 24 (70.59) | 18.7374 |
| 1990's | 4 (11.76) | 18.2507 |
| 2000's | 3 (8.82) | 29.6817 |
| 2010's | 3 (8.82) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zárate-Neira, LÁ | 1 |
| Sánchez-Barbosa, S | 1 |
| Pedroza-Torres, A | 1 |
| Reséndiz-Mora, A | 1 |
| Wong, C | 3 |
| Baeza, I | 3 |
| Pérez-Plasencia, C | 1 |
| Wong-Baeza, C | 3 |
| Tescucano, A | 2 |
| Astudillo, H | 1 |
| Reséndiz, A | 2 |
| Landa, C | 1 |
| España, L | 1 |
| Serafín-López, J | 1 |
| Estrada-García, I | 1 |
| Estrada-Parra, S | 1 |
| Flores-Romo, L | 1 |
| Akahoshi, T | 1 |
| Wada, T | 1 |
| Takemoto, T | 1 |
| Hernández-Pando, R | 1 |
| Bustos, I | 1 |
| Ibáñez, M | 1 |
| METCALF, RG | 1 |
| KUNA, A | 1 |
| MACCARRON, D | 1 |
| Harmon, CE | 1 |
| Portanova, JP | 1 |
| Alberti-Flor, JJ | 1 |
| Weinstein, A | 2 |
| Hess, EV | 1 |
| Goldman, LS | 1 |
| Hudson, JI | 1 |
| Weddington, WW | 1 |
| Yung, RL | 1 |
| Richardson, BC | 1 |
| Minezaki, T | 1 |
| Ichikawa, Y | 1 |
| Jiang, X | 1 |
| Khursigara, G | 1 |
| Rubin, RL | 1 |
| Khan, S | 1 |
| Haddad, P | 1 |
| Montague, L | 1 |
| Summerton, C | 1 |
| Hieronymus, T | 1 |
| Grötsch, P | 1 |
| Blank, N | 1 |
| Grünke, M | 1 |
| Capraru, D | 1 |
| Geiler, T | 1 |
| Winkler, S | 1 |
| Kalden, JR | 1 |
| Lorenz, HM | 1 |
| Gallien, M | 1 |
| Schnetzler, JP | 1 |
| Morin, J | 1 |
| Dubois, EL | 2 |
| Schwarz, JA | 1 |
| Schubothe, H | 1 |
| Maas, D | 1 |
| Alarcon-Segovia, D | 2 |
| Fishbein, E | 2 |
| Lusins, JO | 1 |
| Szilagyi, PA | 1 |
| Roche-Bayard, P | 1 |
| Rossi, R | 1 |
| Mann, JM | 1 |
| Cordier, JF | 1 |
| Delahaye, JP | 1 |
| Fields, TR | 1 |
| Zarrabi, MH | 1 |
| Gerardi, EN | 1 |
| Bennett, RS | 1 |
| Zucker, S | 1 |
| Hamburger, MI | 1 |
| Cush, JJ | 1 |
| Goldings, EA | 1 |
| Fabius, AJ | 1 |
| Gaulhofer, WK | 1 |
| Tallman, E | 1 |
| Wonka, RA | 1 |
| Cetina, JA | 1 |
| Raya, RJ | 1 |
| Barrera, E | 1 |
| Blumenkrantz, N | 1 |
| Asboe-Hansen, G | 1 |
| Harpey, JP | 1 |
| Chiu, E | 1 |
| Ananth, JV | 1 |
| Minn, K | 1 |
| Andreasen, PB | 1 |
| Heshe, J | 1 |
7 reviews available for chlorpromazine and Libman-Sacks Disease
| Article | Year |
|---|---|
[Fever induced by various drugs].
Topics: Amphetamine; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Body Temperature Regulation; | 2009 |
Drug-induced lupus: clinical and serological studies.
Topics: Acetyltransferases; Adult; Antibodies, Antinuclear; Anticonvulsants; Arthritis; Chlorpromazine; Cros | 1982 |
Drug-induced systemic lupus erythematosus.
Topics: Antibodies, Antinuclear; Anticonvulsants; Chlorpromazine; Humans; Hydralazine; Isoniazid; Lupus Eryt | 1980 |
Drug-induced lupus.
Topics: Anticonvulsants; Chlorpromazine; Complement System Proteins; DNA; HLA Antigens; Humans; Interferons; | 1994 |
Serologic abnormalities in spontaneous and drug-induced systemic lupus erythematosus.
Topics: Animals; Anti-Bacterial Agents; Antibodies, Anti-Idiotypic; Antibodies, Antinuclear; Anticonvulsants | 1975 |
Drug-induced lupus: clinical spectrum and pathogenesis.
Topics: Acetylation; Adult; Aged; Antibodies, Antinuclear; Antibody Specificity; Autoimmune Diseases; Black | 1985 |
Lupus-like syndromes induced by drugs.
Topics: Antibodies, Antinuclear; Antibody Formation; Arthritis, Rheumatoid; Chlorpromazine; DNA, Single-Stra | 1974 |
27 other studies available for chlorpromazine and Libman-Sacks Disease
| Article | Year |
|---|---|
Dysregulation of miR-155-5p and miR-200-3p and the Anti-Non-Bilayer Phospholipid Arrangement Antibodies Favor the Development of Lupus in Three Novel Murine Lupus Models.
Topics: Adaptor Proteins, Vesicular Transport; Animals; Antibody Formation; Chlorpromazine; Disease Models, | 2017 |
Nonbilayer Phospholipid Arrangements Are Toll-Like Receptor-2/6 and TLR-4 Agonists and Trigger Inflammation in a Mouse Model Resembling Human Lupus.
Topics: Animals; Autoantibodies; Chlorpromazine; Cytokines; Diglycerides; Disease Models, Animal; Female; Fl | 2015 |
Molecular organization of the non-bilayer phospholipid arrangements that induce an autoimmune disease resembling human lupus in mice.
Topics: Animals; Antibodies; Antibodies, Monoclonal; Cardiolipins; Cattle; Chlorpromazine; Kidney Glomerulus | 2012 |
Disseminated lupus erythematosus versus drug reaction; report of a case receiving chlorpromazine.
Topics: Chlorpromazine; Edema; Humans; Lupus Erythematosus, Systemic; Purpura; Purpura, Thrombocytopenic; Th | 1959 |
Chlorpromazine-induced lupus-like illness.
Topics: Adult; Chlorpromazine; Humans; Lupus Erythematosus, Systemic; Male | 1983 |
Introduction to drug-related lupus.
Topics: Acetylation; Acetyltransferases; Animals; Anticonvulsants; Autoimmune Diseases; Child; Chlorpromazin | 1981 |
Lupus-like illness associated with chlorpromazine.
Topics: Adult; Chlorpromazine; Humans; Lupus Erythematosus, Systemic; Male; Schizophrenia, Paranoid | 1980 |
Surgical experience on patients with serum lupus anticoagulants. A report of two cases.
Topics: Adult; Arthrodesis; Chlorpromazine; Female; Femur Head Necrosis; Hip Prosthesis; Humans; Lupus Coagu | 1993 |
Transformation of lupus-inducing drugs to cytotoxic products by activated neutrophils.
Topics: Animals; Biological Assay; Biotransformation; Cell Death; Chlorpromazine; Humans; Hydralazine; Hydro | 1994 |
Systemic lupus erythematosus presenting as mania.
Topics: Adult; Anti-Inflammatory Agents; Antibodies, Antinuclear; Antipsychotic Agents; Bipolar Disorder; Ch | 2000 |
Chlorpromazine induces apoptosis in activated human lymphoblasts: a mechanism supporting the induction of drug-induced lupus erythematosus?
Topics: Apoptosis; Chlorpromazine; Coloring Agents; Dose-Response Relationship, Drug; Humans; Lupus Erythema | 2000 |
[Antinuclear antibodies and lupus due to phenothiazines in 600 hospitalized patients].
Topics: Adult; Aged; Antibodies, Antinuclear; Antipsychotic Agents; Chlorpromazine; Dementia; Female; Fluphe | 1975 |
[Drug-induced disorders of lupus erythematosus type (author's transl)].
Topics: Animals; Antibody Formation; Anticonvulsants; Chlorpromazine; Drug-Related Side Effects and Adverse | 1977 |
[Drug-induced systemic lupus erythematosus (author's transl)].
Topics: Adolescent; Aged; Anti-Bacterial Agents; Antibody Formation; Autoantibodies; Child; Chlorpromazine; | 1977 |
Patterns of antinuclear antibodies and lupus-activating drugs.
Topics: Antibodies, Antinuclear; Anticonvulsants; Antigens; Chlorpromazine; Female; Humans; Hydralazine; Iso | 1975 |
Clinical features of chorea associated with systemic lupus erythematosus.
Topics: Adult; Azathioprine; Blood Sedimentation; Chlorpromazine; Chorea; Female; Haloperidol; Humans; Lupus | 1975 |
Left pulmonary artery thrombosis in chlorpromazine-induced lupus.
Topics: Adult; Chlorpromazine; Female; Humans; Lupus Erythematosus, Systemic; Magnetic Resonance Imaging; Pu | 1990 |
Reticuloendothelial system Fc receptor function in the drug induced lupus erythematosus syndrome.
Topics: Adult; Aged; Antigen-Antibody Complex; Autoantibodies; Chlorpromazine; DNA; Erythrocytes; Female; Hu | 1986 |
Systemic lupus erythematosus induced by psychotropic drugs.
Topics: Adult; Blood Cell Count; Chlorpromazine; Chlorprothixene; Female; Humans; Lupus Erythematosus, Syste | 1971 |
Chlorpromazine-induced systemic lupus erythematosus: case report and review of the literature.
Topics: Adult; Antibodies, Antinuclear; Arthritis; Chlorpromazine; Humans; Leukopenia; Lupus Erythematosus, | 1972 |
Antigenic specificity of chlorpromazine-induced antinuclear antibodies.
Topics: Adolescent; Adult; Aged; Antibodies, Antinuclear; Antibody Specificity; Anticonvulsants; Antigen-Ant | 1973 |
Connective-tissue effects of drugs causing lupoid syndrome.
Topics: Animals; Carbon Radioisotopes; Chick Embryo; Chlorpromazine; Collagen; Depression, Chemical; Glucosa | 1974 |
Drug-induced extrapyramidal symptoms. A cooperative study.
Topics: Antidepressive Agents; Antipsychotic Agents; Basal Ganglia Diseases; Butyrophenones; Chlorpromazine; | 1973 |
Psychiatric aspects of disseminated lupus erythematosus in Hong Kong Chinese--report of three cases.
Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Adult; Amitriptyline; Chlorpromazine; Epilepsy | 1971 |
Chlorpromazine-induced systemic lupus erythematosus.
Topics: Chlorpromazine; Female; Humans; Lupus Erythematosus, Systemic; Middle Aged; Psychotic Disorders | 1973 |
Chlorpromazine-induced SLE.
Topics: Chlorpromazine; Female; Humans; Lupus Erythematosus, Systemic; Mental Disorders | 1973 |
[Neuropsychiatric manifestations of systemic lupus erythematosus].
Topics: Adult; Chlorpromazine; Chlorprothixene; Female; Humans; Lupus Erythematosus, Systemic; Neurologic Ma | 1969 |