chlorpromazine has been researched along with Leukoma in 31 studies
Chlorpromazine: The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking DOPAMINE RECEPTORS. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the treatment of intractable hiccup.
chlorpromazine : A substituted phenothiazine in which the ring nitrogen at position 10 is attached to C-3 of an N,N-dimethylpropanamine moiety.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Chlorpromazine is known to cause abnormal oculocutaneous pigmentation in sun-exposed areas." | 1.40 | Chlorpromazine-induced skin pigmentation with corneal and lens opacities. ( Dunnick, CA; Huff, LS; Lucas, LM; Pederson, JF; Prado, R, 2014) |
| " Chlorpromazine therapy in a cumulative dosage exceeding 1,100 g resulted in dramatic skin discoloration and multiple crystalline deposits in both corneas." | 1.31 | Corneal deposition after high-dose chlorpromazine hydrochloride therapy. ( Domniz, Y; Lawless, MA; Rogers, CM; Sutton, GL; Webber, SK, 2001) |
| " We analyzed the prevalence of ocular side effects of chlorpromazine and found that the most prevalent side effect was anterior lens capsule dusting followed by corneal stromal pigment dusting." | 1.27 | The prevalence of the ocular side effects of chlorpromazine in the Tuscaloosa Veterans Administration patient population. ( Alexander, LJ; Bowerman, L; Thompson, LR, 1985) |
| " The risk of using chlorpromazine in moderate dosage is slight." | 1.26 | Deposits in the lens and cornea of the eye during long-term chlorpromazine medication. ( Faurbye, A; Kirk, L; Rasmussen, K, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 26 (83.87) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (6.45) | 29.6817 |
| 2010's | 2 (6.45) | 24.3611 |
| 2020's | 1 (3.23) | 2.80 |
| Authors | Studies |
|---|---|
| Sahyoun, JY | 1 |
| Sabeti, S | 1 |
| Robert, MC | 1 |
| Huff, LS | 1 |
| Prado, R | 1 |
| Pederson, JF | 1 |
| Dunnick, CA | 1 |
| Lucas, LM | 1 |
| Molina-Ruiz, AM | 1 |
| Pulpillo, Á | 1 |
| Molina-Ruiz, RM | 1 |
| Sagrario, T | 1 |
| Requena, L | 1 |
| GREINER, AC | 1 |
| BERRY, K | 1 |
| FELDMAN, PE | 1 |
| FRIERSON, BD | 1 |
| MASSEY, LW | 1 |
| BARSA, JA | 2 |
| NEWTON, JC | 2 |
| SAUNDERS, JC | 2 |
| Toshida, H | 1 |
| Uesugi, Y | 1 |
| Ebihara, N | 1 |
| Murakami, A | 1 |
| Johnson, AW | 3 |
| Buffaloe, WJ | 3 |
| Gombos, GM | 1 |
| Yarden, PE | 1 |
| McDonald, CJ | 1 |
| Snell, RS | 1 |
| Lerner, AB | 1 |
| Geiger, LA | 1 |
| Lesser, LL | 1 |
| Gualtieri, CT | 1 |
| Lefler, WH | 1 |
| Guimond, M | 1 |
| Staye, JI | 1 |
| Deluise, VP | 1 |
| Flynn, JT | 1 |
| Webber, SK | 1 |
| Domniz, Y | 1 |
| Sutton, GL | 1 |
| Rogers, CM | 1 |
| Lawless, MA | 1 |
| Rasmussen, K | 1 |
| Kirk, L | 1 |
| Faurbye, A | 1 |
| Alexander, LJ | 1 |
| Bowerman, L | 1 |
| Thompson, LR | 1 |
| Adams, HR | 1 |
| Manian, AA | 1 |
| Steenberg, ML | 1 |
| Buckley, JP | 1 |
| Appleton, WS | 1 |
| Shader, RI | 1 |
| DiMascio, A | 1 |
| Gol'dovskaia, IL | 1 |
| Sandifer, MG | 1 |
| Nouri, A | 1 |
| Cuendet, JF | 1 |
| Barron, CN | 2 |
| Rubin, LF | 2 |
| Steelman, RL | 1 |
| Murchison, TE | 1 |
| Rubin, ML | 1 |
| Herron, W | 1 |
| Muscarella, M | 1 |
| Birkhead, H | 1 |
| Boet, DJ | 1 |
| Dencker, SJ | 1 |
| Enoksson, P | 1 |
| Edler, K | 1 |
| Gunby, B | 1 |
| Sandvig, K | 1 |
| Steenfeldt-Foss, OW | 1 |
3 reviews available for chlorpromazine and Leukoma
| Article | Year |
|---|---|
Drug-induced corneal deposits: an up-to-date review.
Topics: Chlorpromazine; Corneal Dystrophies, Hereditary; Corneal Opacity; Humans; Rifabutin; Vision Disorder | 2022 |
Ocular (pigmentary) effects of psychotropic drugs.
Topics: Cataract; Chlorpromazine; Corneal Opacity; Humans; Phenothiazines; Pigmentation Disorders; Tranquili | 1970 |
[Complications on the part of the eyes during employment of psychotropic drugs (review of the foreign literature)].
Topics: Chlorpromazine; Corneal Opacity; Eye Diseases; Female; Humans; Lens, Crystalline; Male; Methotrimepr | 1969 |
1 trial available for chlorpromazine and Leukoma
| Article | Year |
|---|---|
[False-positive ocular pigmentation during administration of neuroleptics].
Topics: Chlorpromazine; Clinical Trials as Topic; Corneal Opacity; Diagnostic Errors; Humans; Pigmentation D | 1971 |
27 other studies available for chlorpromazine and Leukoma
| Article | Year |
|---|---|
Chlorpromazine-induced skin pigmentation with corneal and lens opacities.
Topics: Antipsychotic Agents; Chlorpromazine; Cornea; Corneal Opacity; Female; Humans; Pigmentation Disorder | 2014 |
Chlorpromazine-induced severe skin pigmentation and corneal opacities in a patient with schizophrenia.
Topics: Biopsy, Needle; Chlorpromazine; Corneal Opacity; Female; Follow-Up Studies; Humans; Hyperpigmentatio | 2016 |
SKIN PIGMENTATION AND CORNEAL AND LENS OPACITIES WITH PROLONGED CHLORPROMAZINE THERAPY.
Topics: Cataract; Chlorpromazine; Cornea; Corneal Opacity; Female; Humans; Lens, Crystalline; Melanins; Opht | 1964 |
DERMATOLOGICAL AND OPHTHALMOLOGICAL CHANGES ASSOCIATED WITH PROLONGED CHLORPROMAZINE THERAPY.
Topics: Chlorpromazine; Corneal Opacity; Female; Humans; Menstruation Disturbances; Pigmentation Disorders; | 1964 |
SKIN PIGMENTATION, CORNEAL AND LENS OPACITIES WITH PROLONGED CHLORPROMAZINE TREATMENT.
Topics: Biopsy; Cataract; Chlorpromazine; Cornea; Corneal Opacity; Drug Therapy; Electrocardiography; Eye Di | 1965 |
LENTICULAR AND CORNEAL OPACITIES DURING PHENOTHIAZINE THERAPY.
Topics: Cataract; Chlorpromazine; Corneal Opacity; Drug Therapy; Lens, Crystalline; Mental Disorders; Phenot | 1965 |
LENS AND CORENEA CHANGES DURING PHENOTHIAZINE THERAPY: A PRELIMINARY REPORT.
Topics: Chlorpromazine; Corneal Opacity; Drug Therapy; Eye Diseases; Fluphenazine; Lens, Crystalline; Mental | 1965 |
In vivo observations of a case of chlorpromazine deposits in the cornea using an HRT II Rostock corneal module.
Topics: Adult; Chlorpromazine; Cornea; Corneal Opacity; Dopamine Antagonists; Female; Humans; Microscopy, Co | 2007 |
Chlorpromazine epithelial keratopathy.
Topics: Chlorpromazine; Corneal Opacity; Epithelium; Humans; Schizophrenia | 1966 |
Ocular and cutaneous side effects after prolonged chlorpromazine treatment.
Topics: Chlorpromazine; Corneal Opacity; Eye Diseases; Humans; Israel; Lens, Crystalline; Male; Schizophreni | 1967 |
The effect of chlorpromazine on oculocutaneous pigmentation in the guinea pig.
Topics: Animals; Chlorpromazine; Corneal Opacity; Eye; Guinea Pigs; Pigmentation; Radiation Injuries, Experi | 1967 |
Ocular side effects of chlorpromazine in a child.
Topics: Adolescent; Child; Chlorpromazine; Corneal Opacity; Humans; Mental Disorders | 1967 |
Corneal and lenticular opacities in mentally retarded young adults treated with thioridazine and chlorpromazine.
Topics: Adolescent; Adult; Cataract; Child; Chlorpromazine; Corneal Opacity; Female; Humans; Institutionaliz | 1982 |
Asymmetric anterior segment changes induced by chlorpromazine.
Topics: Blepharoptosis; Cataract; Chlorpromazine; Conjunctival Diseases; Corneal Opacity; Eye Diseases; Huma | 1981 |
Corneal deposition after high-dose chlorpromazine hydrochloride therapy.
Topics: Antipsychotic Agents; Chlorpromazine; Cornea; Corneal Opacity; Humans; Male; Middle Aged; Pigmentati | 2001 |
Deposits in the lens and cornea of the eye during long-term chlorpromazine medication.
Topics: Adult; Aged; Cataract; Chlorpromazine; Corneal Opacity; Female; Humans; Middle Aged; Schizophrenia; | 1976 |
The prevalence of the ocular side effects of chlorpromazine in the Tuscaloosa Veterans Administration patient population.
Topics: Adult; Aged; Cataract; Chlorpromazine; Cornea; Corneal Opacity; Corneal Stroma; Eye; Humans; Lens Ca | 1985 |
Effects of promazine and chlorpromazine metabolites on the cornea.
Topics: Adaptation, Ocular; Animals; Chlorpromazine; Cornea; Corneal Opacity; Dark Adaptation; Female; Hydro | 1974 |
Total dosage of chlorpromazine and ocular opacities.
Topics: Cataract; Chlorpromazine; Corneal Opacity; Dose-Response Relationship, Drug; Humans; Schizophrenia | 1967 |
[Ocular involvement during prolonged treatment with neuroleptics].
Topics: Adult; Aged; Chlorpromazine; Corneal Opacity; Eye Diseases; Female; Fundus Oculi; Humans; Lens, Crys | 1968 |
Chlorpromazine and the eye of the dog. 3. Natural daylight versus artificial light.
Topics: Animals; Chlorpromazine; Cornea; Corneal Opacity; Cytoplasmic Granules; Dogs; Female; Light; Lightin | 1972 |
Chlorpromazine and the eye of the dog. VI. A comparison of phenothiazine tranquilizers.
Topics: Administration, Oral; Animals; Chlorpromazine; Cornea; Corneal Opacity; Cytoplasmic Granules; Depres | 1972 |
Toxic effects of phenothiazines on the eye.
Topics: Adult; Arsenic; Cataract; Chemical Phenomena; Chemistry; Chlorpromazine; Color Vision Defects; Conju | 1970 |
Chlorpromazine corneal toxicity.
Topics: Chlorpromazine; Corneal Opacity; Humans; Schizophrenia | 1968 |
Ocular changes produced by chlorpromazine.
Topics: Adult; Aged; Cataract; Chlorpromazine; Corneal Opacity; Female; Humans; Male; Middle Aged; Ophthalmo | 1966 |
Ocular changes associated with chlorpromazine therapy. A preliminary report.
Topics: Adult; Aged; Cataract; Chlorpromazine; Corneal Opacity; Female; Glaucoma; Humans; Male; Middle Aged; | 1966 |
Late oculocutaneous complications in phenothiazine therapy.
Topics: Adult; Chlorpromazine; Corneal Opacity; Female; Humans; Lens, Crystalline; Male; Middle Aged; Phenot | 1966 |