chlorpromazine has been researched along with Leukoencephalopathy, Progressive Multifocal in 3 studies
Chlorpromazine: The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking DOPAMINE RECEPTORS. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the treatment of intractable hiccup.
chlorpromazine : A substituted phenothiazine in which the ring nitrogen at position 10 is attached to C-3 of an N,N-dimethylpropanamine moiety.
Leukoencephalopathy, Progressive Multifocal: An opportunistic viral infection of the central nervous system associated with conditions that impair cell-mediated immunity (e.g., ACQUIRED IMMUNODEFICIENCY SYNDROME and other IMMUNOLOGIC DEFICIENCY SYNDROMES; HEMATOLOGIC NEOPLASMS; IMMUNOSUPPRESSION; and COLLAGEN DISEASES). The causative organism is JC Polyomavirus (JC VIRUS) which primarily affects oligodendrocytes, resulting in multiple areas of demyelination. Clinical manifestations include DEMENTIA; ATAXIA; visual disturbances; and other focal neurologic deficits, generally progressing to a vegetative state within 6 months. (From Joynt, Clinical Neurology, 1996, Ch26, pp36-7)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Progressive multifocal leukoencephalopathy was diagnosed by magnetic resonance imaging (MRI) of the brain and detection of JC virus genome in the cerebrospinal fluid." | 1.34 | Chlorpromazine combined with cidofovir for treatment of a patient suffering from progressive multifocal leukoencephalopathy. ( Bandt, D; Ehninger, G; Hochauf, K; Jacobs, E; Pöhlmann, C; Rohayem, J; Röllig, C; Schetelig, J; Wunderlich, O, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Baum, S | 1 |
| Ashok, A | 1 |
| Gee, G | 1 |
| Dimitrova, S | 1 |
| Querbes, W | 1 |
| Jordan, J | 1 |
| Atwood, WJ | 2 |
| Pöhlmann, C | 1 |
| Hochauf, K | 1 |
| Röllig, C | 1 |
| Schetelig, J | 1 |
| Wunderlich, O | 1 |
| Bandt, D | 1 |
| Ehninger, G | 1 |
| Jacobs, E | 1 |
| Rohayem, J | 1 |
3 other studies available for chlorpromazine and Leukoencephalopathy, Progressive Multifocal
| Article | Year |
|---|---|
Early events in the life cycle of JC virus as potential therapeutic targets for the treatment of progressive multifocal leukoencephalopathy.
Topics: Antipsychotic Agents; Antiviral Agents; Cell Line; Chlorpromazine; Clozapine; Drug Synergism; Drug T | 2003 |
Chlorpromazine combined with cidofovir for treatment of a patient suffering from progressive multifocal leukoencephalopathy.
Topics: AIDS-Related Opportunistic Infections; Antiviral Agents; Brain; Chlorpromazine; Cidofovir; Cytosine; | 2007 |
A combination of low-dose chlorpromazine and neutralizing antibodies inhibits the spread of JC virus (JCV) in a tissue culture model: implications for prophylactic and therapeutic treatment of progressive multifocal leukencephalopathy.
Topics: Antibodies, Viral; Antipsychotic Agents; Cell Line; Chlorpromazine; Dose-Response Relationship, Drug | 2001 |