chlorpromazine has been researched along with Leukemia in 8 studies
Chlorpromazine: The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking DOPAMINE RECEPTORS. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the treatment of intractable hiccup.
chlorpromazine : A substituted phenothiazine in which the ring nitrogen at position 10 is attached to C-3 of an N,N-dimethylpropanamine moiety.
Leukemia: A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)
| Excerpt | Relevance | Reference |
|---|---|---|
| "2-Chlorpromazine was shown previously [Syed SK, Christopherson RI and Roufogalis BD (1996) Biochem Mol Biol Int 39: 687-696] to be actively transported into vesicles from multidrug-resistant cells." | 1.30 | Reversal of vinblastine transport by chlorpromazine in membrane vesicles from multidrug-resistant human CCRF-CEM leukaemia cells. ( Christopherson, RI; Roufogalis, BD; Syed, SK, 1998) |
| "Chlorpromazine (CPZ) has been previously shown to protect against endotoxin [lipopolysaccharide (LPS)] lethality and inhibit the release of tumour necrosis factor in vivo." | 1.29 | Chlorpromazine inhibits tumour necrosis factor synthesis and cytotoxicity in vitro. ( Alzani, R; Cozzi, E; Demitri, MT; Fantuzzi, G; Fratelli, M; Galli, G; Ghezzi, P; Minto, M; Zinetti, M, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (62.50) | 18.7374 |
| 1990's | 2 (25.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (12.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tamura, M | 1 |
| Kawano, M | 1 |
| Sato, M | 1 |
| Nashimoto, M | 1 |
| WIEK, K | 1 |
| DOAN, CA | 1 |
| DUHAMEL, M | 1 |
| Zinetti, M | 1 |
| Galli, G | 1 |
| Demitri, MT | 1 |
| Fantuzzi, G | 1 |
| Minto, M | 1 |
| Ghezzi, P | 1 |
| Alzani, R | 1 |
| Cozzi, E | 1 |
| Fratelli, M | 1 |
| Syed, SK | 1 |
| Christopherson, RI | 1 |
| Roufogalis, BD | 1 |
| Weisenthal, LM | 1 |
| Su, YZ | 1 |
| Duarte, TE | 1 |
| Dill, PL | 1 |
| Nagourney, RA | 1 |
| Ter-Grigorova, EN | 1 |
| Afanas'eva, VM | 1 |
| Ivanovskaia, TE | 1 |
8 other studies available for chlorpromazine and Leukemia
| Article | Year |
|---|---|
Involvement of an intracellular vesicular transport process in naked-sgRNA-mediated TRUE gene silencing.
Topics: Apoptosis; bcl-2-Associated X Protein; beta-Cyclodextrins; Cell Line, Tumor; Chlorpromazine; Endocyt | 2015 |
[ON THE CLINICAL ASPECTS OF AGRANULOCYTOSIS].
Topics: Agranulocytosis; Aminopyrine; Analgesics; Analgesics, Non-Narcotic; Antipyretics; Chlorpromazine; Dr | 1964 |
APLASTIC VERSUS HYPERPLASTIC BLOOD DYSCRASIAS.
Topics: Anemia; Anemia, Aplastic; Anti-Bacterial Agents; Benzene; Bone Marrow Diseases; Chlorpromazine; Coba | 1964 |
[AGRANULOCYTOSIS AND NEUTROPENIA].
Topics: Adrenal Cortex Hormones; Agranulocytosis; Aminopyrine; Analgesics; Analgesics, Non-Narcotic; Antipyr | 1964 |
Chlorpromazine inhibits tumour necrosis factor synthesis and cytotoxicity in vitro.
Topics: Apoptosis; Cell Line; Chlorpromazine; Cytotoxicity Tests, Immunologic; Depression, Chemical; Humans; | 1995 |
Reversal of vinblastine transport by chlorpromazine in membrane vesicles from multidrug-resistant human CCRF-CEM leukaemia cells.
Topics: Biological Transport; Calcium; Cell Membrane; Chlorpromazine; Colchicine; Drug Resistance, Multiple; | 1998 |
Perturbation of in vitro drug resistance in human lymphatic neoplasms by combinations of putative inhibitors of protein kinase C.
Topics: Cell Survival; Chlorpromazine; Drug Resistance; Drug Synergism; Haloperidol; Humans; Imipramine; In | 1987 |
[Pathology of therapy and pathomorphosis of some diseases in children].
Topics: Adrenal Cortex Hormones; Adrenal Insufficiency; Anti-Bacterial Agents; Antimetabolites; Bone and Bon | 1967 |