chlorpromazine has been researched along with Inflammation in 39 studies
Chlorpromazine: The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking DOPAMINE RECEPTORS. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the treatment of intractable hiccup.
chlorpromazine : A substituted phenothiazine in which the ring nitrogen at position 10 is attached to C-3 of an N,N-dimethylpropanamine moiety.
Inflammation: A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The present work aimed to question as to whether inflammation is a determinant factor in hepatic lesions induced by chlorpromazine (CPZ) using the human HepaRG cell line." | 7.80 | Impact of inflammation on chlorpromazine-induced cytotoxicity and cholestatic features in HepaRG cells. ( Abdel-Razzak, Z; Al-Attrache, H; Antherieu, S; Bachour-El Azzi, P; Guguen-Guillouzo, C; Guillouzo, A; Labbe, G; Lepage, S; Morel, I; Savary, CC; Sharanek, A, 2014) |
| "Inflammation is a major component of idiosyncratic adverse drug reactions (IADRs)." | 5.39 | Chlorpromazine-induced hepatotoxicity during inflammation is mediated by TIRAP-dependent signaling pathway in mice. ( Gandhi, A; Ghose, R; Guo, T; Moorthy, B; Shah, P, 2013) |
| "Chlorpromazine (CPZ) is a neuroleptic drug and prototype compound used to study intrahepatic cholestasis." | 3.91 | Chlorpromazine toxicity is associated with disruption of cell membrane integrity and initiation of a pro-inflammatory response in the HepaRG hepatic cell line. ( Bagnaninchi, P; Brzeszczynska, J; Brzeszczyński, F; Gamal, W; Hayes, P; Kozlowska, A; Martucci, N; Morgan, K; Nelson, L; Plevris, J; Samuel, K; Treskes, P, 2019) |
| " The present work aimed to question as to whether inflammation is a determinant factor in hepatic lesions induced by chlorpromazine (CPZ) using the human HepaRG cell line." | 3.80 | Impact of inflammation on chlorpromazine-induced cytotoxicity and cholestatic features in HepaRG cells. ( Abdel-Razzak, Z; Al-Attrache, H; Antherieu, S; Bachour-El Azzi, P; Guguen-Guillouzo, C; Guillouzo, A; Labbe, G; Lepage, S; Morel, I; Savary, CC; Sharanek, A, 2014) |
| "To confirm the inflammatory activity of polymeric photoproducts (CPZ-polymers) of chlorpromazine (CPZ), which were obtained by gel filtration of a UV-pre-irradiated CPZ aqueous solution, the histamine release from rat peritoneal exudate cells was studied and the paw-inflammation in mice induced by these CPZ-polymers was examined." | 3.68 | Inflammatory activity of polymeric photoproducts of chlorpromazine. ( Isobe, A; Kakegawa, H; Matsumoto, H; Miyataka, H; Satoh, T; Shigehara, N, 1993) |
| "In order to investigate the influence of antioxidative/anti-inflammatory combination therapy (AACT) with dimethyl sulfoxide (DMSO), chlorpromazine (CPZ) and vitamin E upon the activity of the inflammation, plasma lipid peroxide was measured as thiobarbituric acid reactive substance (TBARS) 12 hrs postoperatively in the modified cecal ligation sepsis model in the mouse." | 3.67 | Plasma lipid peroxides in murine sepsis--sex differences and effect of antioxidative/anti-inflammatory therapy. ( Marinkovic, D; Zuyderhoudt, FM, 1988) |
| "Cholestasis is one of the major causes of drug-induced liver injury (DILI), which can result in withdrawal of approved drugs from the market." | 1.46 | Mechanism-based risk assessment strategy for drug-induced cholestasis using the transcriptional benchmark dose derived by toxicogenomics. ( Honda, H; Ito, Y; Kawamoto, T; Morita, O, 2017) |
| "Systemic lupus erythematosus is characterized by dysregulated activation of T and B cells and autoantibodies to nuclear antigens and, in some cases, lipid antigens." | 1.42 | Nonbilayer Phospholipid Arrangements Are Toll-Like Receptor-2/6 and TLR-4 Agonists and Trigger Inflammation in a Mouse Model Resembling Human Lupus. ( Astudillo, H; Baeza, I; España, L; Estrada-García, I; Estrada-Parra, S; Flores-Romo, L; Landa, C; Reséndiz, A; Serafín-López, J; Tescucano, A; Wong, C; Wong-Baeza, C, 2015) |
| "Inflammation is a major component of idiosyncratic adverse drug reactions (IADRs)." | 1.39 | Chlorpromazine-induced hepatotoxicity during inflammation is mediated by TIRAP-dependent signaling pathway in mice. ( Gandhi, A; Ghose, R; Guo, T; Moorthy, B; Shah, P, 2013) |
| "Chlorpromazine (CPZ) is a phenothiazine, antipsychotic drug that has caused several idiosyncratic responses during its therapeutic use." | 1.31 | Underlying endotoxemia augments toxic responses to chlorpromazine: is there a relationship to drug idiosyncrasy? ( Buchweitz, JP; Bursian, SJ; Ganey, PE; Roth, RA, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 19 (48.72) | 18.7374 |
| 1990's | 2 (5.13) | 18.2507 |
| 2000's | 2 (5.13) | 29.6817 |
| 2010's | 14 (35.90) | 24.3611 |
| 2020's | 2 (5.13) | 2.80 |
| Authors | Studies |
|---|---|
| Wang, Z | 1 |
| Wang, Y | 1 |
| Wang, B | 1 |
| Li, W | 1 |
| Huang, L | 1 |
| Li, X | 1 |
| Vivier, D | 1 |
| Bennis, K | 1 |
| Lesage, F | 1 |
| Ducki, S | 1 |
| Blaess, M | 1 |
| Bibak, N | 1 |
| Claus, RA | 1 |
| Kohl, M | 1 |
| Bonaterra, GA | 1 |
| Kinscherf, R | 1 |
| Laufer, S | 1 |
| Deigner, HP | 1 |
| Lübow, C | 1 |
| Bockstiegel, J | 1 |
| Weindl, G | 1 |
| Morishita, M | 1 |
| Horita, M | 1 |
| Higuchi, A | 1 |
| Marui, M | 1 |
| Katsumi, H | 1 |
| Yamamoto, A | 1 |
| Obuchowicz, E | 1 |
| Bielecka-Wajdman, AM | 1 |
| Paul-Samojedny, M | 1 |
| Nowacka, M | 1 |
| Kawamoto, T | 1 |
| Ito, Y | 1 |
| Morita, O | 1 |
| Honda, H | 1 |
| Zárate-Neira, LÁ | 1 |
| Sánchez-Barbosa, S | 1 |
| Pedroza-Torres, A | 1 |
| Reséndiz-Mora, A | 1 |
| Wong, C | 2 |
| Baeza, I | 2 |
| Pérez-Plasencia, C | 1 |
| Wong-Baeza, C | 2 |
| Masuda, K | 1 |
| Kishimoto, T | 1 |
| Morgan, K | 1 |
| Martucci, N | 1 |
| Kozlowska, A | 1 |
| Gamal, W | 1 |
| Brzeszczyński, F | 1 |
| Treskes, P | 1 |
| Samuel, K | 1 |
| Hayes, P | 1 |
| Nelson, L | 1 |
| Bagnaninchi, P | 1 |
| Brzeszczynska, J | 1 |
| Plevris, J | 1 |
| Parmentier, C | 1 |
| Truisi, GL | 1 |
| Moenks, K | 1 |
| Stanzel, S | 1 |
| Lukas, A | 1 |
| Kopp-Schneider, A | 1 |
| Alexandre, E | 1 |
| Hewitt, PG | 1 |
| Mueller, SO | 1 |
| Richert, L | 1 |
| Bachour-El Azzi, P | 1 |
| Sharanek, A | 1 |
| Abdel-Razzak, Z | 1 |
| Antherieu, S | 1 |
| Al-Attrache, H | 1 |
| Savary, CC | 1 |
| Lepage, S | 1 |
| Morel, I | 1 |
| Labbe, G | 1 |
| Guguen-Guillouzo, C | 1 |
| Guillouzo, A | 1 |
| Neumann, K | 1 |
| Erben, U | 1 |
| Kruse, N | 1 |
| Wechsung, K | 1 |
| Schumann, M | 1 |
| Klugewitz, K | 1 |
| Scheffold, A | 1 |
| Kühl, AA | 1 |
| Tescucano, A | 1 |
| Astudillo, H | 1 |
| Reséndiz, A | 1 |
| Landa, C | 1 |
| España, L | 1 |
| Serafín-López, J | 1 |
| Estrada-García, I | 1 |
| Estrada-Parra, S | 1 |
| Flores-Romo, L | 1 |
| Villarreal, CF | 1 |
| Funez, MI | 1 |
| Cunha, Fde Q | 1 |
| Parada, CA | 1 |
| Ferreira, SH | 1 |
| Gandhi, A | 1 |
| Guo, T | 1 |
| Shah, P | 1 |
| Moorthy, B | 1 |
| Ghose, R | 1 |
| THIEBLOT, L | 1 |
| BERTHELAY, J | 1 |
| WOLF, S | 1 |
| JASMIN, G | 1 |
| BREVDO, GV | 1 |
| MEDVEDEV, IuA | 1 |
| LENFELD, J | 1 |
| SLADKOVA, O | 1 |
| GRUNDMAN, M | 1 |
| ARRIGONIMARTELLI, E | 1 |
| CONTI, I | 1 |
| LASKIN, DM | 1 |
| KOLODNY, SC | 1 |
| Tukov, FF | 1 |
| Maddox, JF | 1 |
| Amacher, DE | 1 |
| Bobrowski, WF | 1 |
| Roth, RA | 2 |
| Ganey, PE | 2 |
| Burnett, S | 1 |
| Davy, CW | 1 |
| Jackson, MR | 1 |
| Gryglewski, RJ | 1 |
| Shigehara, N | 1 |
| Kakegawa, H | 1 |
| Miyataka, H | 1 |
| Matsumoto, H | 1 |
| Isobe, A | 1 |
| Satoh, T | 1 |
| Buchweitz, JP | 1 |
| Bursian, SJ | 1 |
| Hirschelmann, R | 1 |
| Bekemeier, H | 1 |
| Metzner, J | 1 |
| Giessler, AJ | 1 |
| Stelzner, A | 1 |
| Hopkin, DA | 1 |
| Laplane, R | 1 |
| Bertini, R | 1 |
| Mengozzi, M | 1 |
| Bianchi, M | 1 |
| Sipe, JD | 1 |
| Ghezzi, P | 1 |
| Marinkovic, D | 1 |
| Zuyderhoudt, FM | 1 |
| Somogyi, A | 1 |
| Selye, H | 1 |
| Perper, RJ | 1 |
| Sanda, M | 1 |
| Chinea, G | 1 |
| Oronsky, AL | 1 |
| Geschickter, CF | 1 |
| Aronson, RS | 1 |
| Geschickter, EH | 1 |
| De Cato, L | 1 |
| Brown, JK | 1 |
| Malone, MH | 1 |
| Komendantova, MV | 1 |
| Kravtsova, GN | 1 |
| Sergeev, PV | 1 |
| Bree, MM | 1 |
| Cohen, BJ | 1 |
| Abrams, GD | 1 |
| Jaques, R | 1 |
| Riesterer, L | 1 |
| Ryan, GB | 1 |
| Hurley, JV | 1 |
3 reviews available for chlorpromazine and Inflammation
| Article | Year |
|---|---|
Perspectives on the Two-Pore Domain Potassium Channel TREK-1 (TWIK-Related K(+) Channel 1). A Novel Therapeutic Target?
Topics: Arrhythmias, Cardiac; Depression; Epilepsy; Humans; Inflammation; Models, Molecular; Molecular Struc | 2016 |
A Potential Therapeutic Target RNA-binding Protein, Arid5a for the Treatment of Inflammatory Disease Associated with Aberrant Cytokine Expression.
Topics: Animals; Anti-Bacterial Agents; Autoimmune Diseases; Chlorpromazine; Cytokines; DNA-Binding Proteins | 2018 |
Evolution of ideas on the role of prostaglandins in inflammation.
Topics: Acetaminophen; Animals; Arachidonic Acids; Biological Evolution; Butylated Hydroxytoluene; Chlorprom | 1980 |
36 other studies available for chlorpromazine and Inflammation
| Article | Year |
|---|---|
Design, Synthesis, and Evaluation of Orally Available Clioquinol-Moracin M Hybrids as Multitarget-Directed Ligands for Cognitive Improvement in a Rat Model of Neurodegeneration in Alzheimer's Disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Benzofurans; Clioquinol; Cognition; | 2015 |
NB 06: From a simple lysosomotropic aSMase inhibitor to tools for elucidating the role of lysosomes in signaling apoptosis and LPS-induced inflammation.
Topics: Apoptosis; Cell Line; Cells, Cultured; Ceramides; Enzyme Inhibitors; Humans; Inflammation; Lipopolys | 2018 |
Lysosomotropic drugs enhance pro-inflammatory responses to IL-1β in macrophages by inhibiting internalization of the IL-1 receptor.
Topics: Autophagy; Cell Culture Techniques; Cell Survival; Chloroquine; Chlorpromazine; Endocytosis; Fluoxet | 2020 |
Characterizing Different Probiotic-Derived Extracellular Vesicles as a Novel Adjuvant for Immunotherapy.
Topics: Adjuvants, Immunologic; Animals; beta-Cyclodextrins; Cells, Cultured; Chlorpromazine; Cytochalasin B | 2021 |
Different influence of antipsychotics on the balance between pro- and anti-inflammatory cytokines depends on glia activation: An in vitro study.
Topics: Animals; Antipsychotic Agents; Cell Differentiation; Cell Survival; Cells, Cultured; Chlorpromazine; | 2017 |
Mechanism-based risk assessment strategy for drug-induced cholestasis using the transcriptional benchmark dose derived by toxicogenomics.
Topics: Administration, Oral; Animals; Chlorpromazine; Cholestasis; Cholesterol; Cyclosporine; Diclofenac; D | 2017 |
Dysregulation of miR-155-5p and miR-200-3p and the Anti-Non-Bilayer Phospholipid Arrangement Antibodies Favor the Development of Lupus in Three Novel Murine Lupus Models.
Topics: Adaptor Proteins, Vesicular Transport; Animals; Antibody Formation; Chlorpromazine; Disease Models, | 2017 |
Chlorpromazine toxicity is associated with disruption of cell membrane integrity and initiation of a pro-inflammatory response in the HepaRG hepatic cell line.
Topics: Cell Line; Cell Membrane; Cell Survival; Chlorpromazine; Cholestasis; Cytochrome P-450 Enzyme System | 2019 |
Transcriptomic hepatotoxicity signature of chlorpromazine after short- and long-term exposure in primary human sandwich cultures.
Topics: Aged; Cells, Cultured; Chemical and Drug Induced Liver Injury; Chlorpromazine; Female; Hepatocytes; | 2013 |
Impact of inflammation on chlorpromazine-induced cytotoxicity and cholestatic features in HepaRG cells.
Topics: Actins; Bile Acids and Salts; C-Reactive Protein; Cell Line; Chlorpromazine; Cholestasis; Cytochrome | 2014 |
Chemokine Transfer by Liver Sinusoidal Endothelial Cells Contributes to the Recruitment of CD4+ T Cells into the Murine Liver.
Topics: Animals; Caveolae; CD4-Positive T-Lymphocytes; Chemokine CXCL10; Chemokine CXCL12; Chemokine CXCL9; | 2015 |
Nonbilayer Phospholipid Arrangements Are Toll-Like Receptor-2/6 and TLR-4 Agonists and Trigger Inflammation in a Mouse Model Resembling Human Lupus.
Topics: Animals; Autoantibodies; Chlorpromazine; Cytokines; Diglycerides; Disease Models, Animal; Female; Fl | 2015 |
The long-lasting sensitization of primary afferent nociceptors induced by inflammation involves prostanoid and dopaminergic systems in mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biphenyl Compounds; Carrageenan; Central Nervous S | 2013 |
Chlorpromazine-induced hepatotoxicity during inflammation is mediated by TIRAP-dependent signaling pathway in mice.
Topics: Alanine Transaminase; Animals; Chlorpromazine; Histocytochemistry; Immunoblotting; Inflammation; JNK | 2013 |
[Description of a test for measuring inflammation; study of so-called neuroplegic drugs].
Topics: Anti-Allergic Agents; Chlorpromazine; Cortisone; Histamine H1 Antagonists; Inflammation; Urethane | 1957 |
[Anti-inflammatory properties of chlorpromazine].
Topics: Anti-Inflammatory Agents; Chlorpromazine; Humans; Inflammation | 1957 |
[On the problem of pathogenesis and pathogenetic method of prevention and therapy of inflammatory infiltrates forming at the site of intramuscular injections of Aminazine solution].
Topics: Chlorpromazine; Humans; Inflammation; Injections; Injections, Intramuscular; Pharmaceutical Solution | 1962 |
[ON THE MECHANISM OF INHIBITION OF INFLAMMATORY EDEMA WITH CAFFEINE, WITH REFERENCE TO SEROTONIN].
Topics: Caffeine; Chlorpromazine; Dextrans; Edema; Epinephrine; Formaldehyde; Inflammation; Rats; Research; | 1963 |
[RESEARCH ON A NEW METHOD OF EXPERIMENTAL INFLAMMATION: SUBPLANTAR EDEMA CAUSED BY CARRAGEENIN].
Topics: Adrenalectomy; Analgesics; Analgesics, Non-Narcotic; Antipyretics; Carrageenan; Chlorpheniramine; Ch | 1964 |
INHIBITION OF EXUDATE PRODUCTION BY ANTI-INFLAMMATORY DRUGS.
Topics: Anti-Inflammatory Agents; Chlorpheniramine; Chlorpromazine; Deoxyribonuclease I; Exudates and Transu | 1965 |
Modeling inflammation-drug interactions in vitro: a rat Kupffer cell-hepatocyte coculture system.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Antipsychotic Agents; Carcinogens; Cell Separation | 2006 |
Assessment of local irritancy of drugs in rats after intramuscular injection.
Topics: Animals; Chlorpromazine; Drug Evaluation, Preclinical; Inflammation; Injections, Intramuscular; Musc | 1981 |
Inflammatory activity of polymeric photoproducts of chlorpromazine.
Topics: Animals; Chlorpromazine; Edema; Histamine Release; In Vitro Techniques; Inflammation; L-Lactate Dehy | 1993 |
Underlying endotoxemia augments toxic responses to chlorpromazine: is there a relationship to drug idiosyncrasy?
Topics: Animals; Antipsychotic Agents; Chemical and Drug Induced Liver Injury; Chlorpromazine; Cholestasis; | 2002 |
[Modification of the adjuvans arthritis by carrageenin, compound 48/80, histamine- and serotonin antagonists, non-steroid antiphlogistics as well as protease inhibitors and their possible relations to inflammation mediators].
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Carrageenan; Chlorpromazine; Cyproheptadin | 1975 |
James Reilly and the autonomic nervous system. A prophet unheeded?
Topics: Animals; Autonomic Nervous System; Capillary Permeability; Chlorpromazine; Gastrointestinal Hemorrha | 1978 |
Chlorpromazine protection against interleukin-1 and tumor necrosis factor-mediated activities in vivo.
Topics: Animals; Chlorpromazine; Corticosterone; Eating; Fibrinogen; Inflammation; Interleukin-1; Male; Mice | 1991 |
Plasma lipid peroxides in murine sepsis--sex differences and effect of antioxidative/anti-inflammatory therapy.
Topics: Animals; Bacterial Infections; Cecal Diseases; Chlorpromazine; Dimethyl Sulfoxide; Drug Therapy, Com | 1988 |
Tourniquet poditis--an experimental pedal inflammation in the rat.
Topics: Animals; Anti-Bacterial Agents; Chlorpromazine; Cyproheptadine; Depression, Chemical; Dextrans; Dibe | 1969 |
Leukocyte chemotaxis in vivo. II. Analysis of the selective inhibition of neutrophil or mononuclear cell accumulation.
Topics: Animals; Bucladesine; Carrageenan; Chemotaxis; Chloroquine; Chlorpromazine; Chromium Radioisotopes; | 1974 |
Inhibition of the inflammatory response in the microcirculation by tourniquet shock and release of adrenal hormones. In vivo and electronmicroscopic observations.
Topics: Adrenal Glands; Adrenalectomy; Animals; Capillaries; Chlorpromazine; Cortisone; Edema; Egg White; Ep | 1969 |
Effects of benzoquinolizine homologues on proliferative and exudative inflammation.
Topics: Adrenal Glands; Animals; Anti-Inflammatory Agents; Body Weight; Carrageenan; Catecholamines; Chlorpr | 1974 |
[Effect of aminazin and trizercin on the permeability of the blood-brain barrier in normal conditions and in experimental inflammation].
Topics: Animals; Blood-Brain Barrier; Chlorpromazine; Inflammation; Iodine Isotopes; Male; Phenothiazines; R | 1972 |
Injection lesions following intramuscular administration of chlorpromazine in rabbits.
Topics: Animals; Chlorpromazine; Inflammation; Injections, Intramuscular; Male; Muscular Diseases; Necrosis; | 1971 |
The influence of psychopharmacologically active substances on various models of an inflammatory reaction.
Topics: Animals; Anthracenes; Arthritis; Carrageenan; Chlorpromazine; Diazepam; Edema; Foot; Hindlimb; Infla | 1971 |
The drug inhibition of increased vascular permeability.
Topics: Animals; Blood Vessels; Burns; Capillary Permeability; Chlorpromazine; Digoxin; Diphenhydramine; Ind | 1968 |