chlorpromazine has been researched along with Hypogonadism in 12 studies
Chlorpromazine: The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking DOPAMINE RECEPTORS. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the treatment of intractable hiccup.
chlorpromazine : A substituted phenothiazine in which the ring nitrogen at position 10 is attached to C-3 of an N,N-dimethylpropanamine moiety.
Hypogonadism: Condition resulting from deficient gonadal functions, such as GAMETOGENESIS and the production of GONADAL STEROID HORMONES. It is characterized by delay in GROWTH, germ cell maturation, and development of secondary sex characteristics. Hypogonadism can be due to a deficiency of GONADOTROPINS (hypogonadotropic hypogonadism) or due to primary gonadal failure (hypergonadotropic hypogonadism).
| Excerpt | Relevance | Reference |
|---|---|---|
| "33 mg/kg chlorpromazine and changes in plasma levels of LH and FSH after the injection of 100 micrograms iv GnRH, in 16 patients with delayed puberty, 10 patients with hypogonadotrophic hypogonadism and 6 healthy controls." | 7.69 | [Delayed puberty and hypogonadotrophic hypogonadism: differential diagnosis with prolactin stimulation probe with chlorpromazine]. ( Beas L, F; Torrealba, IM, 1995) |
| "The prolactin response to metoclopramide (MCP) was studied in 23 sexually immature males, 14 with isolated hypogonadotrophic hypogonadism (IHH) and nine with constitutional delayed puberty." | 7.67 | Prolactin response to metoclopramide does not distinguish patients with hypogonadotrophic hypogonadism from delayed puberty. ( Cassorla, F; Cristiano, AM; el Sabbagh, H; Munabi, A; Sherins, RJ, 1988) |
| "The effect of chlorpromazine (CPZ) on prolactin (PRL) secretion was studied in fourteen sexually immature males; nine with idiopathic hypogonadotrophic hypogonadism and five who proved to be normal early pubertal boys." | 7.66 | The response of prolactin to chlorpromazine stimulation in men with hypogonadotrophic hypogonadism and early pubertal boys: relationship to sex steroid exposure. ( Johnsonbaugh, RE; Sherins, RJ; Winters, SJ, 1982) |
| "33 mg/kg chlorpromazine and changes in plasma levels of LH and FSH after the injection of 100 micrograms iv GnRH, in 16 patients with delayed puberty, 10 patients with hypogonadotrophic hypogonadism and 6 healthy controls." | 3.69 | [Delayed puberty and hypogonadotrophic hypogonadism: differential diagnosis with prolactin stimulation probe with chlorpromazine]. ( Beas L, F; Torrealba, IM, 1995) |
| "The prolactin response to metoclopramide (MCP) was studied in 23 sexually immature males, 14 with isolated hypogonadotrophic hypogonadism (IHH) and nine with constitutional delayed puberty." | 3.67 | Prolactin response to metoclopramide does not distinguish patients with hypogonadotrophic hypogonadism from delayed puberty. ( Cassorla, F; Cristiano, AM; el Sabbagh, H; Munabi, A; Sherins, RJ, 1988) |
| "The effect of chlorpromazine (CPZ) on prolactin (PRL) secretion was studied in fourteen sexually immature males; nine with idiopathic hypogonadotrophic hypogonadism and five who proved to be normal early pubertal boys." | 3.66 | The response of prolactin to chlorpromazine stimulation in men with hypogonadotrophic hypogonadism and early pubertal boys: relationship to sex steroid exposure. ( Johnsonbaugh, RE; Sherins, RJ; Winters, SJ, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (91.67) | 18.7374 |
| 1990's | 1 (8.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Patwardhan, MH | 1 |
| Chander, S | 1 |
| Dash, RJ | 1 |
| Winters, SJ | 2 |
| Sherins, RJ | 3 |
| Johnsonbaugh, RE | 2 |
| García-Peris, P | 1 |
| Jara Albarrán, A | 1 |
| Eusebio Ocumares, R | 1 |
| Haj-Ali, MF | 1 |
| Toledano Marín, E | 1 |
| Salmerón de Diego, J | 1 |
| Cabellero Asensi, A | 1 |
| Palacios Mateos, JM | 1 |
| Holtz, G | 1 |
| Williamson, HO | 1 |
| Torrealba, IM | 1 |
| Beas L, F | 1 |
| Turksoy, RN | 1 |
| Lufkin, EG | 1 |
| Baldus, WP | 1 |
| Bergstralh, EJ | 1 |
| Kao, PC | 1 |
| Cristiano, AM | 1 |
| Munabi, A | 1 |
| el Sabbagh, H | 1 |
| Cassorla, F | 1 |
| Antaki, A | 1 |
| Somma, M | 1 |
| Wyman, H | 1 |
| Van Campenhout, J | 1 |
| Proctor, P | 1 |
| McGinness, J | 1 |
| Corry, P | 1 |
| Santen, RJ | 1 |
| Bardin, CW | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Reproductive Hormonal Alterations in Obesity, AIMS #1 & #2[NCT01457703] | 62 participants (Actual) | Interventional | 2010-06-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Follicle-stimulating hormone was measured hourly during the 12 hour study visit, and was compared between the obese and normal weight groups. (NCT01457703)
Timeframe: Measured hourly and averaged over the 12 hour study visit
| Intervention | IU/L (Mean) |
|---|---|
| BMI ≥30 kg/m2 | 3.8 |
| BMI 18-25 kg/m2 | 3.3 |
Follicle-stimulating hormone was measured hourly during the 12 hour study visit, and was compared between the obese and normal weight groups. (NCT01457703)
Timeframe: Measured hourly and averaged over the 12 hour study visit
| Intervention | IU/L (Mean) |
|---|---|
| BMI ≥30 kg/m2 | 5.31 |
| BMI 18-25 kg/m2 | 6.18 |
Luteinizing Hormone (LH) Pulse Amplitude was measured hourly during the 12 hour study visit, and was compared between the obese and normal weight groups. (NCT01457703)
Timeframe: Measured hourly and averaged over the 12 hour study visit
| Intervention | IU/L (Mean) |
|---|---|
| BMI ≥30 kg/m2 | 4.1 |
| BMI 18-25 kg/m2 | 3.6 |
Luteinizing Hormone (LH) Pulse Amplitude was measured hourly during the 12 hour study visit, and was compared between the obese and normal weight groups. (NCT01457703)
Timeframe: Measured hourly and averaged over the 12 hour study visit
| Intervention | IU/L (Mean) |
|---|---|
| BMI ≥30 kg/m2 | 2.21 |
| BMI 18-25 kg/m2 | 4.44 |
Pregnanediol glucuronide (PdG) was collected daily over the course of one menstrual cycle and averaged. (NCT01457703)
Timeframe: Averaged over the length of menstrual cycle
| Intervention | ug/cycle (Mean) |
|---|---|
| BMI ≥30 kg/m2 | 54.1 |
| BMI 18-25 kg/m2 | 88.7 |
12 other studies available for chlorpromazine and Hypogonadism
| Article | Year |
|---|---|
Prolactin response to chlorpromazine in hypogonadism.
Topics: Adolescent; Adult; Chlorpromazine; Cryptorchidism; Gonadotropins, Pituitary; Humans; Hypogonadism; M | 1984 |
The response of prolactin to chlorpromazine: use in the differential diagnosis of hypogonadotropic hypogonadism and delayed puberty.
Topics: Adolescent; Child; Chlorpromazine; Diagnosis, Differential; Humans; Hypogonadism; Male; Prolactin; P | 1984 |
[Response of prolactin to thyrotrophin-RH(TRH) and chlorpromazine stimulation in the syndrome of hypogonadism and anosmia (author's transl)].
Topics: Adolescent; Adult; Chlorpromazine; Female; Follicle Stimulating Hormone; Humans; Hypogonadism; Lutei | 1980 |
The response of prolactin to chlorpromazine stimulation in men with hypogonadotrophic hypogonadism and early pubertal boys: relationship to sex steroid exposure.
Topics: Adolescent; Adult; Child; Chlorpromazine; Chorionic Gonadotropin; Follicle Stimulating Hormone; Huma | 1982 |
Dynamic hormonal testing in Kallman's syndrome.
Topics: Adolescent; Chlorpromazine; Female; Gonadotropins, Pituitary; Humans; Hypogonadism; Olfactory Bulb; | 1980 |
[Delayed puberty and hypogonadotrophic hypogonadism: differential diagnosis with prolactin stimulation probe with chlorpromazine].
Topics: Adolescent; Adult; Chlorpromazine; Diagnosis, Differential; Follicle Stimulating Hormone; Gonadotrop | 1995 |
Dissociation of prolactin responsiveness to thyrotropin-releasing hormone and chlorpromazine in a female with Kallmann's syndrome.
Topics: Adolescent; Chlorpromazine; Female; Gonadotropin-Releasing Hormone; Humans; Hypogonadism; Luteinizin | 1979 |
Influence of phlebotomy treatment on abnormal hypothalamic-pituitary function in genetic hemochromatosis.
Topics: Adult; Aged; Bloodletting; Chlorpromazine; Gonadotropin-Releasing Hormone; Hemochromatosis; Hormones | 1987 |
Prolactin response to metoclopramide does not distinguish patients with hypogonadotrophic hypogonadism from delayed puberty.
Topics: Adolescent; Adult; Chlorpromazine; Chorionic Gonadotropin; Diagnosis, Differential; Humans; Hypogona | 1988 |
Hypothalamic-pituitary function in the olfacto-genital syndrome.
Topics: Adolescent; Adrenocorticotropic Hormone; Adult; Chlorpromazine; Color Vision Defects; Eunuchism; Fem | 1974 |
A hypothesis on the preferential destruction of melanized tissues.
Topics: Cell Survival; Chlorpromazine; DNA; Dwarfism; Ear, Inner; Energy Transfer; Humans; Hypogonadism; Mel | 1974 |
Episodic luteinizing hormone secretion in man. Pulse analysis, clinical interpretation, physiologic mechanisms.
Topics: Adult; Amenorrhea; Anorexia Nervosa; Chlorpromazine; Female; Follicle Stimulating Hormone; Half-Life | 1973 |