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chlorpromazine and Hyperprolactinemia

chlorpromazine has been researched along with Hyperprolactinemia in 7 studies

Chlorpromazine: The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking DOPAMINE RECEPTORS. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the treatment of intractable hiccup.
chlorpromazine : A substituted phenothiazine in which the ring nitrogen at position 10 is attached to C-3 of an N,N-dimethylpropanamine moiety.

Hyperprolactinemia: Increased levels of PROLACTIN in the BLOOD, which may be associated with AMENORRHEA and GALACTORRHEA. Relatively common etiologies include PROLACTINOMA, medication effect, KIDNEY FAILURE, granulomatous diseases of the PITUITARY GLAND, and disorders which interfere with the hypothalamic inhibition of prolactin release. Ectopic (non-pituitary) production of prolactin may also occur. (From Joynt, Clinical Neurology, 1992, Ch36, pp77-8)

Research Excerpts

ExcerptRelevanceReference
"Hyperprolactinemia is a common side effect of antipsychotic drugs that requires further investigation."5.42Chlorpromazine-Induced Hyperprolactinemia on Rat's Uterus. ( Ahmadi, A; Movahed, E; Sadrkhanlou, R; Zamani, Z; Zare, S, 2015)
"Hyperprolactinemia is a common side effect of antipsychotic drugs that requires further investigation."1.42Chlorpromazine-Induced Hyperprolactinemia on Rat's Uterus. ( Ahmadi, A; Movahed, E; Sadrkhanlou, R; Zamani, Z; Zare, S, 2015)
"The 39% recurrence rate of hyperprolactinemia and persistent abnormalities in pituitary-hypothalamic regulation of PRL secretion after transsphenoidal surgery raise important questions about the choice of primary therapy for patients with PRL-secreting tumors."1.27Long term follow-up of women with surgically treated prolactin-secreting pituitary tumors. ( Chapler, FK; Schlechte, JA; Sherman, BM; VanGilder, J, 1986)

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19901 (14.29)18.7374
1990's1 (14.29)18.2507
2000's2 (28.57)29.6817
2010's2 (28.57)24.3611
2020's1 (14.29)2.80

Authors

AuthorsStudies
Lange, JH1
Reinders, JH1
Tolboom, JT1
Glennon, JC1
Coolen, HK1
Kruse, CG1
Yakubu, MT1
Fayemo, HT1
Zamani, Z1
Zare, S1
Sadrkhanlou, R1
Ahmadi, A1
Movahed, E1
Kunimatsu, T1
Kimura, J1
Funabashi, H1
Inoue, T1
Seki, T1
Meaney, AM1
Smith, S1
Howes, OD1
O'Brien, M1
Murray, RM1
O'Keane, V1
Azuma, K1
Irahara, M1
Aono, T1
Schlechte, JA1
Sherman, BM1
Chapler, FK1
VanGilder, J1

Reviews

1 review available for chlorpromazine and Hyperprolactinemia

ArticleYear
[Metoclopramide, sulpiride, and chlorpromazine loading test].
    Nihon rinsho. Japanese journal of clinical medicine, 1997, Volume: 55 Suppl 2

    Topics: Chlorpromazine; Humans; Hyperprolactinemia; Metoclopramide; Pituitary Function Tests; Pituitary Glan

1997

Other Studies

6 other studies available for chlorpromazine and Hyperprolactinemia

ArticleYear
Principal component analysis differentiates the receptor binding profiles of three antipsychotic drug candidates from current antipsychotic drugs.
    Journal of medicinal chemistry, 2007, Oct-18, Volume: 50, Issue:21

    Topics: Antipsychotic Agents; Basal Ganglia Diseases; Benzoxazines; Biogenic Monoamines; Humans; Hyperprolac

2007
Anti-hyperprolactinemic activities of aqueous extract of Uvaria chamae (P. Beauv) roots and associated biochemical changes in chlorpromazine-induced hyperprolactinemic female Wistar rats.
    Journal of ethnopharmacology, 2021, May-10, Volume: 271

    Topics: Animals; Chlorpromazine; Estradiol; Female; Follicle Stimulating Hormone; Humans; Hyperprolactinemia

2021
Chlorpromazine-Induced Hyperprolactinemia on Rat's Uterus.
    Iranian biomedical journal, 2015, Volume: 19, Issue:4

    Topics: Animals; Antipsychotic Agents; Chlorpromazine; Estradiol; Female; Follicle Stimulating Hormone; Gala

2015
The antipsychotics haloperidol and chlorpromazine increase bone metabolism and induce osteopenia in female rats.
    Regulatory toxicology and pharmacology : RTP, 2010, Volume: 58, Issue:3

    Topics: Amino Acids; Animals; Antipsychotic Agents; Bone and Bones; Bone Density; Bone Diseases, Metabolic;

2010
Effects of long-term prolactin-raising antipsychotic medication on bone mineral density in patients with schizophrenia.
    The British journal of psychiatry : the journal of mental science, 2004, Volume: 184

    Topics: Adult; Age Factors; Antipsychotic Agents; Bone Density; Chlorpromazine; Dopamine Antagonists; Female

2004
Long term follow-up of women with surgically treated prolactin-secreting pituitary tumors.
    The Journal of clinical endocrinology and metabolism, 1986, Volume: 62, Issue:6

    Topics: Adenoma; Adolescent; Adult; Chlorpromazine; Female; Follow-Up Studies; Humans; Hyperprolactinemia; I

1986