chlorpromazine has been researched along with Hypergonadotropic Hypogonadism in 12 studies
Chlorpromazine: The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking DOPAMINE RECEPTORS. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the treatment of intractable hiccup.
chlorpromazine : A substituted phenothiazine in which the ring nitrogen at position 10 is attached to C-3 of an N,N-dimethylpropanamine moiety.
| Excerpt | Relevance | Reference |
|---|---|---|
| "33 mg/kg chlorpromazine and changes in plasma levels of LH and FSH after the injection of 100 micrograms iv GnRH, in 16 patients with delayed puberty, 10 patients with hypogonadotrophic hypogonadism and 6 healthy controls." | 7.69 | [Delayed puberty and hypogonadotrophic hypogonadism: differential diagnosis with prolactin stimulation probe with chlorpromazine]. ( Beas L, F; Torrealba, IM, 1995) |
| "The prolactin response to metoclopramide (MCP) was studied in 23 sexually immature males, 14 with isolated hypogonadotrophic hypogonadism (IHH) and nine with constitutional delayed puberty." | 7.67 | Prolactin response to metoclopramide does not distinguish patients with hypogonadotrophic hypogonadism from delayed puberty. ( Cassorla, F; Cristiano, AM; el Sabbagh, H; Munabi, A; Sherins, RJ, 1988) |
| "The effect of chlorpromazine (CPZ) on prolactin (PRL) secretion was studied in fourteen sexually immature males; nine with idiopathic hypogonadotrophic hypogonadism and five who proved to be normal early pubertal boys." | 7.66 | The response of prolactin to chlorpromazine stimulation in men with hypogonadotrophic hypogonadism and early pubertal boys: relationship to sex steroid exposure. ( Johnsonbaugh, RE; Sherins, RJ; Winters, SJ, 1982) |
| "33 mg/kg chlorpromazine and changes in plasma levels of LH and FSH after the injection of 100 micrograms iv GnRH, in 16 patients with delayed puberty, 10 patients with hypogonadotrophic hypogonadism and 6 healthy controls." | 3.69 | [Delayed puberty and hypogonadotrophic hypogonadism: differential diagnosis with prolactin stimulation probe with chlorpromazine]. ( Beas L, F; Torrealba, IM, 1995) |
| "The prolactin response to metoclopramide (MCP) was studied in 23 sexually immature males, 14 with isolated hypogonadotrophic hypogonadism (IHH) and nine with constitutional delayed puberty." | 3.67 | Prolactin response to metoclopramide does not distinguish patients with hypogonadotrophic hypogonadism from delayed puberty. ( Cassorla, F; Cristiano, AM; el Sabbagh, H; Munabi, A; Sherins, RJ, 1988) |
| "The effect of chlorpromazine (CPZ) on prolactin (PRL) secretion was studied in fourteen sexually immature males; nine with idiopathic hypogonadotrophic hypogonadism and five who proved to be normal early pubertal boys." | 3.66 | The response of prolactin to chlorpromazine stimulation in men with hypogonadotrophic hypogonadism and early pubertal boys: relationship to sex steroid exposure. ( Johnsonbaugh, RE; Sherins, RJ; Winters, SJ, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (91.67) | 18.7374 |
| 1990's | 1 (8.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Patwardhan, MH | 1 |
| Chander, S | 1 |
| Dash, RJ | 1 |
| Winters, SJ | 2 |
| Sherins, RJ | 3 |
| Johnsonbaugh, RE | 2 |
| García-Peris, P | 1 |
| Jara Albarrán, A | 1 |
| Eusebio Ocumares, R | 1 |
| Haj-Ali, MF | 1 |
| Toledano Marín, E | 1 |
| Salmerón de Diego, J | 1 |
| Cabellero Asensi, A | 1 |
| Palacios Mateos, JM | 1 |
| Holtz, G | 1 |
| Williamson, HO | 1 |
| Torrealba, IM | 1 |
| Beas L, F | 1 |
| Turksoy, RN | 1 |
| Lufkin, EG | 1 |
| Baldus, WP | 1 |
| Bergstralh, EJ | 1 |
| Kao, PC | 1 |
| Cristiano, AM | 1 |
| Munabi, A | 1 |
| el Sabbagh, H | 1 |
| Cassorla, F | 1 |
| Antaki, A | 1 |
| Somma, M | 1 |
| Wyman, H | 1 |
| Van Campenhout, J | 1 |
| Proctor, P | 1 |
| McGinness, J | 1 |
| Corry, P | 1 |
| Santen, RJ | 1 |
| Bardin, CW | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Reproductive Hormonal Alterations in Obesity, AIMS #1 & #2[NCT01457703] | 62 participants (Actual) | Interventional | 2010-06-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Follicle-stimulating hormone was measured hourly during the 12 hour study visit, and was compared between the obese and normal weight groups. (NCT01457703)
Timeframe: Measured hourly and averaged over the 12 hour study visit
| Intervention | IU/L (Mean) |
|---|---|
| BMI ≥30 kg/m2 | 3.8 |
| BMI 18-25 kg/m2 | 3.3 |
Follicle-stimulating hormone was measured hourly during the 12 hour study visit, and was compared between the obese and normal weight groups. (NCT01457703)
Timeframe: Measured hourly and averaged over the 12 hour study visit
| Intervention | IU/L (Mean) |
|---|---|
| BMI ≥30 kg/m2 | 5.31 |
| BMI 18-25 kg/m2 | 6.18 |
Luteinizing Hormone (LH) Pulse Amplitude was measured hourly during the 12 hour study visit, and was compared between the obese and normal weight groups. (NCT01457703)
Timeframe: Measured hourly and averaged over the 12 hour study visit
| Intervention | IU/L (Mean) |
|---|---|
| BMI ≥30 kg/m2 | 4.1 |
| BMI 18-25 kg/m2 | 3.6 |
Luteinizing Hormone (LH) Pulse Amplitude was measured hourly during the 12 hour study visit, and was compared between the obese and normal weight groups. (NCT01457703)
Timeframe: Measured hourly and averaged over the 12 hour study visit
| Intervention | IU/L (Mean) |
|---|---|
| BMI ≥30 kg/m2 | 2.21 |
| BMI 18-25 kg/m2 | 4.44 |
Pregnanediol glucuronide (PdG) was collected daily over the course of one menstrual cycle and averaged. (NCT01457703)
Timeframe: Averaged over the length of menstrual cycle
| Intervention | ug/cycle (Mean) |
|---|---|
| BMI ≥30 kg/m2 | 54.1 |
| BMI 18-25 kg/m2 | 88.7 |
12 other studies available for chlorpromazine and Hypergonadotropic Hypogonadism
| Article | Year |
|---|---|
Prolactin response to chlorpromazine in hypogonadism.
Topics: Adolescent; Adult; Chlorpromazine; Cryptorchidism; Gonadotropins, Pituitary; Humans; Hypogonadism; M | 1984 |
The response of prolactin to chlorpromazine: use in the differential diagnosis of hypogonadotropic hypogonadism and delayed puberty.
Topics: Adolescent; Child; Chlorpromazine; Diagnosis, Differential; Humans; Hypogonadism; Male; Prolactin; P | 1984 |
[Response of prolactin to thyrotrophin-RH(TRH) and chlorpromazine stimulation in the syndrome of hypogonadism and anosmia (author's transl)].
Topics: Adolescent; Adult; Chlorpromazine; Female; Follicle Stimulating Hormone; Humans; Hypogonadism; Lutei | 1980 |
The response of prolactin to chlorpromazine stimulation in men with hypogonadotrophic hypogonadism and early pubertal boys: relationship to sex steroid exposure.
Topics: Adolescent; Adult; Child; Chlorpromazine; Chorionic Gonadotropin; Follicle Stimulating Hormone; Huma | 1982 |
Dynamic hormonal testing in Kallman's syndrome.
Topics: Adolescent; Chlorpromazine; Female; Gonadotropins, Pituitary; Humans; Hypogonadism; Olfactory Bulb; | 1980 |
[Delayed puberty and hypogonadotrophic hypogonadism: differential diagnosis with prolactin stimulation probe with chlorpromazine].
Topics: Adolescent; Adult; Chlorpromazine; Diagnosis, Differential; Follicle Stimulating Hormone; Gonadotrop | 1995 |
Dissociation of prolactin responsiveness to thyrotropin-releasing hormone and chlorpromazine in a female with Kallmann's syndrome.
Topics: Adolescent; Chlorpromazine; Female; Gonadotropin-Releasing Hormone; Humans; Hypogonadism; Luteinizin | 1979 |
Influence of phlebotomy treatment on abnormal hypothalamic-pituitary function in genetic hemochromatosis.
Topics: Adult; Aged; Bloodletting; Chlorpromazine; Gonadotropin-Releasing Hormone; Hemochromatosis; Hormones | 1987 |
Prolactin response to metoclopramide does not distinguish patients with hypogonadotrophic hypogonadism from delayed puberty.
Topics: Adolescent; Adult; Chlorpromazine; Chorionic Gonadotropin; Diagnosis, Differential; Humans; Hypogona | 1988 |
Hypothalamic-pituitary function in the olfacto-genital syndrome.
Topics: Adolescent; Adrenocorticotropic Hormone; Adult; Chlorpromazine; Color Vision Defects; Eunuchism; Fem | 1974 |
A hypothesis on the preferential destruction of melanized tissues.
Topics: Cell Survival; Chlorpromazine; DNA; Dwarfism; Ear, Inner; Energy Transfer; Humans; Hypogonadism; Mel | 1974 |
Episodic luteinizing hormone secretion in man. Pulse analysis, clinical interpretation, physiologic mechanisms.
Topics: Adult; Amenorrhea; Anorexia Nervosa; Chlorpromazine; Female; Follicle Stimulating Hormone; Half-Life | 1973 |