chlorpromazine has been researched along with Huntington Disease in 25 studies
Chlorpromazine: The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking DOPAMINE RECEPTORS. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the treatment of intractable hiccup.
chlorpromazine : A substituted phenothiazine in which the ring nitrogen at position 10 is attached to C-3 of an N,N-dimethylpropanamine moiety.
Huntington Disease: A familial disorder inherited as an autosomal dominant trait and characterized by the onset of progressive CHOREA and DEMENTIA in the fourth or fifth decade of life. Common initial manifestations include paranoia; poor impulse control; DEPRESSION; HALLUCINATIONS; and DELUSIONS. Eventually intellectual impairment; loss of fine motor control; ATHETOSIS; and diffuse chorea involving axial and limb musculature develops, leading to a vegetative state within 10-15 years of disease onset. The juvenile variant has a more fulminant course including SEIZURES; ATAXIA; dementia; and chorea. (From Adams et al., Principles of Neurology, 6th ed, pp1060-4)
| Excerpt | Relevance | Reference |
|---|---|---|
| "However, the performances of Huntington's disease subjects appeared to be different when compared to the other two groups." | 2.69 | Kinematic analysis of the reach to grasp movement in Parkinson's and Huntington's disease subjects. ( Bonfiglioli, C; Castiello, U; De Berti, G; Nichelli, P; Nicoletti, R, 1998) |
| "Tetrabenazine alone, was restarted after 48 hours to control her Huntington's Chorea and there was no recurrence of parkinsonism." | 1.27 | Iatrogenic parkinsonism in Huntington's chorea. ( Moss, JH; Stewart, DE, 1986) |
| "Eight individuals with Huntington's chorea had low basal and impaired human prolactin responses to both chlorpromazine and thyrotrophin-releasing hormone." | 1.26 | Impaired prolactin release in Huntington's chorea. Evidence for dopaminergic excess. ( Beighton, P; Hayden, MR; Paul, M; Vinik, AI, 1977) |
| "Huntington's disease (Huntington's chorea), a degenerative disorder of the central nervous system, is inherited in an autosomal dominant pattern." | 1.26 | Huntington's disease: current concepts of therapy. ( Goetz, CG; Weiner, WJ, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 20 (80.00) | 18.7374 |
| 1990's | 4 (16.00) | 18.2507 |
| 2000's | 1 (4.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| WALTHER-BUEL, H | 2 |
| PAOLOZZI, C | 1 |
| NAYRAC, P | 1 |
| ARNOTT, G | 1 |
| MILBLED, G | 1 |
| LASCELLES, CF | 1 |
| RISER, M | 1 |
| GAYRAL, L | 1 |
| STERN, H | 1 |
| TURNIN, J | 1 |
| MILLET, L | 1 |
| Schilling, G | 1 |
| Savonenko, AV | 1 |
| Coonfield, ML | 1 |
| Morton, JL | 1 |
| Vorovich, E | 1 |
| Gale, A | 1 |
| Neslon, C | 1 |
| Chan, N | 1 |
| Eaton, M | 1 |
| Fromholt, D | 1 |
| Ross, CA | 1 |
| Borchelt, DR | 1 |
| Gale, K | 1 |
| Casu, M | 1 |
| Barbosa, ER | 1 |
| Marchiori, PE | 1 |
| Scaff, M | 1 |
| de Assis, JL | 1 |
| Folstein, S | 1 |
| Folstein, M | 1 |
| Bonfiglioli, C | 1 |
| De Berti, G | 1 |
| Nichelli, P | 1 |
| Nicoletti, R | 1 |
| Castiello, U | 1 |
| Hayden, MR | 1 |
| Vinik, AI | 1 |
| Paul, M | 1 |
| Beighton, P | 1 |
| Müller, EE | 1 |
| Cocchi, D | 1 |
| Mantegazza, P | 1 |
| Parati, EA | 1 |
| Caraceni, T | 1 |
| Bailey, E | 1 |
| Bond, PA | 1 |
| Brooks, BA | 1 |
| Dimitrakoudi, M | 1 |
| Jenner, FA | 1 |
| Judd, A | 1 |
| Lee, CR | 1 |
| Lenton, EA | 1 |
| McNeil, S | 1 |
| Pollitt, RJ | 1 |
| Sampson, GA | 1 |
| Thompson, EA | 1 |
| Glaeser, BS | 1 |
| Vogel, WH | 1 |
| Oleweiler, DB | 1 |
| Hare, TA | 1 |
| Caine, E | 1 |
| Kartzinel, R | 1 |
| Ebert, M | 1 |
| Carter, AC | 1 |
| Goetz, CG | 1 |
| Weiner, WJ | 2 |
| Levy, CL | 1 |
| Carlson, HE | 1 |
| Sowers, JR | 1 |
| Goodlett, RE | 1 |
| Tourtellotte, WW | 1 |
| Hershman, JM | 1 |
| Oke, AF | 1 |
| Putz, C | 1 |
| Adams, RN | 1 |
| Bird, ED | 1 |
| Waldman, AJ | 1 |
| Stewart, JT | 1 |
| Feinberg, TE | 1 |
| Cianci, CD | 1 |
| Morrow, JS | 1 |
| Pehta, JC | 1 |
| Redman, CM | 1 |
| Huima, T | 1 |
| Koroshetz, WJ | 1 |
| Moss, JH | 1 |
| Stewart, DE | 1 |
| Tan, BK | 1 |
| Leijnse-Ybema, HJ | 1 |
| v d Brand, HJ | 1 |
| Klawans, HL | 1 |
| Mattsson, B | 1 |
| Persson, SA | 1 |
| Schergna, E | 1 |
1 review available for chlorpromazine and Huntington Disease
| Article | Year |
|---|---|
Dynamic utilization of GABA in substantia nigra: regulation by dopamine and GABA in the striatum, and its clinical and behavioral implications.
Topics: 4-Aminobutyrate Transaminase; Afferent Pathways; Aminocaproates; Animals; Basal Ganglia; Behavior, A | 1981 |
2 trials available for chlorpromazine and Huntington Disease
| Article | Year |
|---|---|
Kinematic analysis of the reach to grasp movement in Parkinson's and Huntington's disease subjects.
Topics: Adult; Age of Onset; Aged; Analysis of Variance; Antiparkinson Agents; Basal Ganglia; Chlorpromazine | 1998 |
Neuroendocrine function in Huntington's disease: dopaminergic regulation of prolactin release.
Topics: Adult; Bromocriptine; Carbidopa; Chlorpromazine; Dopamine; Female; Humans; Huntington Disease; Levod | 1978 |
22 other studies available for chlorpromazine and Huntington Disease
| Article | Year |
|---|---|
The action of neuroleptic drugs in Huntington's disease.
Topics: Chlorpromazine; Humans; Huntington Disease; Reserpine | 1956 |
The action of neuroleptic drugs in Huntington's disease.
Topics: Chlorpromazine; Humans; Huntington Disease; Reserpine | 1956 |
The action of neuroleptic drugs in Huntington's disease.
Topics: Chlorpromazine; Humans; Huntington Disease; Reserpine | 1956 |
The action of neuroleptic drugs in Huntington's disease.
Topics: Chlorpromazine; Humans; Huntington Disease; Reserpine | 1956 |
[A case of death caused by acute gastric atonia during phenothiazine therapy].
Topics: Chlorpromazine; Gastrointestinal Tract; Gastroparesis; Humans; Huntington Disease; Paralysis; Phenot | 1957 |
[HUNTINGTON'S CHOREA, HUMOR DISORDERS WITH MANIC MANIFESTATIONS, BENEFICIAL EFFECTS OF HALOPERIDOL (FLUOROPHENYLPIPERIDINOBUTYROPHENONE). ABSENCE OF THE THERAPEUTIC AKINETO-HYPERTONIC SYNDROME].
Topics: Bipolar Disorder; Chlorpromazine; Chorea; Electroencephalography; Electromyography; Haloperidol; Hum | 1964 |
HUNTINGTON'S CHOREA.
Topics: Barbiturates; Cerebral Cortex; Chlorpromazine; Chorea; Drug Therapy; Huntington Disease; Pathology; | 1964 |
[Treatment of Huntington's chorea with chlorpromazine (largactil) and thioridazine (melleril)].
Topics: Chlorpromazine; Chorea; Huntington Disease; Thioridazine; Tranquilizing Agents | 1959 |
Environmental, pharmacological, and genetic modulation of the HD phenotype in transgenic mice.
Topics: Acetamides; Animals; Celecoxib; Chlorpromazine; Coenzymes; Cyclooxygenase Inhibitors; Disease Models | 2004 |
[Huntington chorea: report of 16 cases].
Topics: Adult; Aged; Brain Diseases; Chlorpromazine; Dementia; Diagnosis, Differential; Female; gamma-Aminob | 1983 |
Diagnosis and treatment of Huntington's disease.
Topics: Affective Symptoms; Amitriptyline; Chlorpromazine; Cognition Disorders; Counseling; Deglutition Diso | 1981 |
Impaired prolactin release in Huntington's chorea. Evidence for dopaminergic excess.
Topics: Adolescent; Adult; Aged; Chlorpromazine; Dopamine; Female; Humans; Huntington Disease; Hypothalamus; | 1977 |
Prolactin control in Huntington's chorea.
Topics: Adult; Chlorpromazine; Humans; Huntington Disease; Hypothalamus; Middle Aged; Pituitary Gland, Anter | 1977 |
The medicinal chemistry of lithium.
Topics: Adenylyl Cyclases; Adrenal Cortex; Affective Symptoms; Animals; Antidepressive Agents; Bipolar Disor | 1975 |
GABA levels in cerebrospinal fluid of patients with Huntington's chorea: a preliminary report.
Topics: Adult; Aged; Aminobutyrates; Amitriptyline; Chlorpromazine; Diazepam; Female; gamma-Aminobutyric Aci | 1975 |
Huntington's disease: current concepts of therapy.
Topics: Acetylcholine; Adolescent; Adult; Butyrophenones; Child; Chlorpromazine; Dopamine Antagonists; gamma | 1979 |
Growth hormone and prolactin secretion in Huntington's disease.
Topics: Adult; Aged; Apomorphine; Chlorpromazine; Female; Growth Hormone; Humans; Huntington Disease; Levodo | 1979 |
Neuroleptic treatment is an unlikely cause of elevated dopamine in thalamus of schizophrenic subjects.
Topics: Adult; Aged; Antipsychotic Agents; Chlorpromazine; Dopamine; Haloperidol; Humans; Huntington Disease | 1992 |
Chlorpromazine & appetite.
Topics: Anorexia; Chlorpromazine; Humans; Huntington Disease; Male; Middle Aged | 1991 |
Diagnostic tests for choreoacanthocytosis.
Topics: Acanthocytes; Atrophy; Blood Cells; Brain; Chlorpromazine; Chorea; Corpus Striatum; Edetic Acid; Fem | 1991 |
Iatrogenic parkinsonism in Huntington's chorea.
Topics: Chlorpromazine; Drug Interactions; Female; Humans; Huntington Disease; Middle Aged; Parkinson Diseas | 1986 |
Levodopa in Huntington's chorea.
Topics: Chlorpromazine; Dihydroxyphenylalanine; Female; Humans; Huntington Disease; Mental Disorders; Middle | 1972 |
Lingual-facial-buccal movements in the elderly. I. Pathophysiology and treatment.
Topics: Aged; Amphetamine; Chemoreceptor Cells; Chlorpromazine; Corpus Striatum; Dopamine Antagonists; Facia | 1973 |
Cerebrospinal homovanillic acid and 5-hydroxyindoleacetic acid in huntington's chorea.
Topics: Adult; Chlormethiazole; Chlorpromazine; Female; Fluphenazine; Haloperidol; Homovanillic Acid; Humans | 1974 |
[Recent therapeutic conquests in extrapyramidal syndromes].
Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Amantadine; Athetosis; Brain Diseases; Central | 1970 |