chlorpromazine has been researched along with Glioma in 9 studies
Chlorpromazine: The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking DOPAMINE RECEPTORS. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the treatment of intractable hiccup.
chlorpromazine : A substituted phenothiazine in which the ring nitrogen at position 10 is attached to C-3 of an N,N-dimethylpropanamine moiety.
Glioma: Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Chlorpromazine, a cationic amphiphilic drug known to affect phospholipid metabolism, greatly increases the generation of inositol phosphates in C6 glioma cells." | 7.67 | Accumulation of inositol phosphates induced by chlorpromazine in C6 glioma cells. ( Ananth, U; Hauser, G; Leli, U, 1989) |
| "The effects of chlorpromazine (CPZ), desmethylimipramine (DMI) and propranolol (PRO) on phospholipid metabolism in C6 glioma cells were studied by following the incorporation of 32Pi, [U-14C]glycerol, [2-3H]glycerol and [1-14C]oleate into lipids." | 7.67 | Modifications of phospholipid metabolism induced by chlorpromazine, desmethylimipramine and propranolol in C6 glioma cells. ( Hauser, G; Leli, U, 1987) |
| "Chlorpromazine is a United States Food and Drug Administration-approved phenothiazine widely used as a psychotropic in clinical practice." | 5.46 | Repositioning chlorpromazine for treating chemoresistant glioma through the inhibition of cytochrome c oxidase bearing the COX4-1 regulatory subunit. ( Griguer, CE; Langford, C; Oliva, CR; Suto, MJ; Zhang, W, 2017) |
| "Treatment with chlorpromazine (CPZ) results in cell-cycle arrest at the G2/M phase in rat C6 glioma cells." | 5.36 | Chlorpromazine activates p21Waf1/Cip1 gene transcription via early growth response-1 (Egr-1) in C6 glioma cells. ( Kim, CG; Kim, SH; Kim, YS; Lee, YH; Lim, Y; Shin, SY, 2010) |
| "Previous studies have demonstrated that chronic treatment of C6 glioma cells with the antidepressants desipramine and fluoxetine increases the Triton X-100 solubility of the G protein Gsalpha (Toki et al." | 3.71 | Chronic treatment of C6 glioma cells with antidepressant drugs results in a redistribution of Gsalpha. ( Donati, RJ; Rasenick, MM; Thukral, C, 2001) |
| "Chlorpromazine, a cationic amphiphilic drug known to affect phospholipid metabolism, greatly increases the generation of inositol phosphates in C6 glioma cells." | 3.67 | Accumulation of inositol phosphates induced by chlorpromazine in C6 glioma cells. ( Ananth, U; Hauser, G; Leli, U, 1989) |
| "The effects of chlorpromazine (CPZ), desmethylimipramine (DMI) and propranolol (PRO) on phospholipid metabolism in C6 glioma cells were studied by following the incorporation of 32Pi, [U-14C]glycerol, [2-3H]glycerol and [1-14C]oleate into lipids." | 3.67 | Modifications of phospholipid metabolism induced by chlorpromazine, desmethylimipramine and propranolol in C6 glioma cells. ( Hauser, G; Leli, U, 1987) |
| "Chlorpromazine is a United States Food and Drug Administration-approved phenothiazine widely used as a psychotropic in clinical practice." | 1.46 | Repositioning chlorpromazine for treating chemoresistant glioma through the inhibition of cytochrome c oxidase bearing the COX4-1 regulatory subunit. ( Griguer, CE; Langford, C; Oliva, CR; Suto, MJ; Zhang, W, 2017) |
| "Treatment with chlorpromazine (CPZ) results in cell-cycle arrest at the G2/M phase in rat C6 glioma cells." | 1.36 | Chlorpromazine activates p21Waf1/Cip1 gene transcription via early growth response-1 (Egr-1) in C6 glioma cells. ( Kim, CG; Kim, SH; Kim, YS; Lee, YH; Lim, Y; Shin, SY, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (55.56) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (11.11) | 29.6817 |
| 2010's | 3 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Oliva, CR | 1 |
| Zhang, W | 1 |
| Langford, C | 1 |
| Suto, MJ | 1 |
| Griguer, CE | 1 |
| Shin, SY | 2 |
| Lee, KS | 1 |
| Choi, YK | 1 |
| Lim, HJ | 1 |
| Lee, HG | 1 |
| Lim, Y | 2 |
| Lee, YH | 2 |
| Kim, CG | 1 |
| Kim, SH | 1 |
| Kim, YS | 1 |
| Donati, RJ | 1 |
| Thukral, C | 1 |
| Rasenick, MM | 1 |
| Friedman, SJ | 1 |
| Skehan, P | 1 |
| Leli, U | 3 |
| Ananth, U | 1 |
| Hauser, G | 3 |
| Albouz, S | 1 |
| Le Saux, F | 1 |
| Wenger, D | 1 |
| Hauw, JJ | 1 |
| Baumann, N | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Repurposing the Antipsychotic Drug Chlorpromazine as a Therapeutic Agent in the Combined Treatment of Newly Diagnosed Glioblastoma Multiforme[NCT04224441] | Phase 2 | 41 participants (Anticipated) | Interventional | 2019-12-15 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
9 other studies available for chlorpromazine and Glioma
| Article | Year |
|---|---|
Repositioning chlorpromazine for treating chemoresistant glioma through the inhibition of cytochrome c oxidase bearing the COX4-1 regulatory subunit.
Topics: Animals; Antineoplastic Agents, Alkylating; Antipsychotic Agents; Brain Neoplasms; Cattle; Cell Line | 2017 |
The antipsychotic agent chlorpromazine induces autophagic cell death by inhibiting the Akt/mTOR pathway in human U-87MG glioma cells.
Topics: Animals; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Cell Line, Tumor; Cell Proliferation; C | 2013 |
Chlorpromazine activates p21Waf1/Cip1 gene transcription via early growth response-1 (Egr-1) in C6 glioma cells.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Chlorpromazine; Cyclin-Depende | 2010 |
Chronic treatment of C6 glioma cells with antidepressant drugs results in a redistribution of Gsalpha.
Topics: Animals; Antidepressive Agents; Chlorpromazine; Desipramine; Fluoxetine; Glioma; GTP-Binding Protein | 2001 |
The inhibition of sterol synthesis by anesthetics.
Topics: Acetates; Anesthetics, Local; Animals; Cell Line; Chlorpromazine; Diphenylacetic Acids; Glioma; Halo | 1979 |
Accumulation of inositol phosphates induced by chlorpromazine in C6 glioma cells.
Topics: Animals; Cell Line; Cell Survival; Chlorpromazine; Glioma; Inositol Phosphates; Kinetics; Magnesium; | 1989 |
Chlorpromazine induces accumulation of inositol phosphates in C6 glioma cells.
Topics: Animals; Cell Line; Chlorpromazine; Desipramine; Glioma; Inositol; Inositol Phosphates; Lysophosphol | 1986 |
Modifications of phospholipid metabolism induced by chlorpromazine, desmethylimipramine and propranolol in C6 glioma cells.
Topics: Animals; Cell Line; Chlorpromazine; Desipramine; Diglycerides; Dose-Response Relationship, Drug; Gli | 1987 |
Modifications of sphingomyelin and phosphatidylcholine metabolism by tricyclic antidepressants and phenothiazines.
Topics: Animals; Antidepressive Agents, Tricyclic; Cell Line; Chlorpromazine; Desipramine; Dose-Response Rel | 1986 |