chlorpromazine has been researched along with Glioblastoma in 4 studies
Chlorpromazine: The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking DOPAMINE RECEPTORS. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the treatment of intractable hiccup.
chlorpromazine : A substituted phenothiazine in which the ring nitrogen at position 10 is attached to C-3 of an N,N-dimethylpropanamine moiety.
Glioblastoma: A malignant form of astrocytoma histologically characterized by pleomorphism of cells, nuclear atypia, microhemorrhage, and necrosis. They may arise in any region of the central nervous system, with a predilection for the cerebral hemispheres, basal ganglia, and commissural pathways. Clinical presentation most frequently occurs in the fifth or sixth decade of life with focal neurologic signs or seizures.
| Excerpt | Relevance | Reference |
|---|---|---|
| "On these bases, and assisted by the information on the well-established chlorpromazine toxicity and dosage in humans, we designed a Phase II clinical trial involving the combination of chlorpromazine with the standard treatment, temozolomide, in the adjuvant phase of the therapeutic protocol." | 5.56 | Repurposing chlorpromazine in the treatment of glioblastoma multiforme: analysis of literature and forthcoming steps. ( Abbruzzese, C; Matteoni, S; Paggi, MG; Persico, M; Villani, V, 2020) |
| "On these bases, and assisted by the information on the well-established chlorpromazine toxicity and dosage in humans, we designed a Phase II clinical trial involving the combination of chlorpromazine with the standard treatment, temozolomide, in the adjuvant phase of the therapeutic protocol." | 1.56 | Repurposing chlorpromazine in the treatment of glioblastoma multiforme: analysis of literature and forthcoming steps. ( Abbruzzese, C; Matteoni, S; Paggi, MG; Persico, M; Villani, V, 2020) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 3 (75.00) | 2.80 |
| Authors | Studies |
|---|---|
| Matteoni, S | 2 |
| Matarrese, P | 1 |
| Ascione, B | 1 |
| Ricci-Vitiani, L | 1 |
| Pallini, R | 1 |
| Villani, V | 2 |
| Pace, A | 1 |
| Paggi, MG | 2 |
| Abbruzzese, C | 2 |
| Persico, M | 1 |
| Jeng, F | 1 |
| Reynolds, A | 1 |
| Aas, AT | 1 |
| Brun, A | 1 |
| Pero, RW | 1 |
| Salford, LG | 1 |
4 other studies available for chlorpromazine and Glioblastoma
| Article | Year |
|---|---|
Chlorpromazine induces cytotoxic autophagy in glioblastoma cells via endoplasmic reticulum stress and unfolded protein response.
Topics: Autophagy; Chlorpromazine; Dopamine Antagonists; Endoplasmic Reticulum Stress; Glioblastoma; Humans; | 2021 |
Repurposing chlorpromazine in the treatment of glioblastoma multiforme: analysis of literature and forthcoming steps.
Topics: Brain Neoplasms; Chlorpromazine; Drug Repositioning; Female; Glioblastoma; Humans; Male | 2020 |
Retrobulbar chlorpromazine injection in a child with gliosarcoma invasion into the orbits.
Topics: Antipsychotic Agents; Blindness; Brain Neoplasms; Chemoradiotherapy; Child; Chlorpromazine; Eye Pain | 2020 |
Chlorpromazine in combination with nitrosourea inhibits experimental glioma growth.
Topics: Animals; Body Weight; Brain Neoplasms; Calmodulin; Carmustine; Cell Division; Chlorpromazine; Drug S | 1994 |