chlorpromazine has been researched along with Epilepsy, Tonic-Clonic in 21 studies
Chlorpromazine: The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking DOPAMINE RECEPTORS. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the treatment of intractable hiccup.
chlorpromazine : A substituted phenothiazine in which the ring nitrogen at position 10 is attached to C-3 of an N,N-dimethylpropanamine moiety.
Epilepsy, Tonic-Clonic: A generalized seizure disorder characterized by recurrent major motor seizures. The initial brief tonic phase is marked by trunk flexion followed by diffuse extension of the trunk and extremities. The clonic phase features rhythmic flexor contractions of the trunk and limbs, pupillary dilation, elevations of blood pressure and pulse, urinary incontinence, and tongue biting. This is followed by a profound state of depressed consciousness (post-ictal state) which gradually improves over minutes to hours. The disorder may be cryptogenic, familial, or symptomatic (caused by an identified disease process). (From Adams et al., Principles of Neurology, 6th ed, p329)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Epileptiform EEG changes, myoclonus, and seizures are reported in some patients treated with clozapine." | 7.69 | Clozapine and seizures. ( Denney, D; Stevens, JR, 1995) |
| "Epileptiform EEG changes, myoclonus, and seizures are reported in some patients treated with clozapine." | 3.69 | Clozapine and seizures. ( Denney, D; Stevens, JR, 1995) |
| "An adult female with developmental disability was prescribed chlorpromazine for the target behaviors of aggression and self-injurious behavior (SIB), and she was prescribed phenobarbital for seizures." | 3.68 | A case of phenobarbital exacerbation of a preexisting maladaptive behavior partially suppressed by chlorpromazine and misinterpreted as chlorpromazine efficacy. ( Hanzel, TE; Harder, SR; Kalachnik, JE, 1992) |
| "The authors describe a woman with chronic schizophrenia who experienced delirium, grand mal seizure, and photosensitivity after the addition of propranolol to her neuroleptic regimen." | 3.66 | Adverse effects of combined propranolol and chlorpromazine therapy. ( Miller, FA; Rampling, D, 1982) |
| "The seizure was brief and subsided spontaneously." | 1.29 | Convulsions after enflurane in a schizophrenic patient receiving neuroleptics. ( Vohra, SB, 1994) |
| "Patients with Down syndrome are at high risk for early Alzheimer's disease." | 1.29 | Dementia and Down syndrome. ( Shank, JC; Tyler, CV, 1996) |
| "Maprotiline has been reported to be less likely to cause epileptic seizures than the tricyclic antidepressants." | 1.26 | Maprotiline and seizures. ( Hoffman, BF; Wachsmuth, R, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 17 (80.95) | 18.7374 |
| 1990's | 4 (19.05) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| AYCRIGG, JB | 1 |
| LORGE, M | 1 |
| GREINER, AC | 1 |
| NICOLSON, GA | 1 |
| BARTEN, HH | 1 |
| Menes, C | 1 |
| Burra, P | 1 |
| Hoaken, PC | 1 |
| Hoffman, BF | 1 |
| Wachsmuth, R | 1 |
| Miller, FA | 1 |
| Rampling, D | 1 |
| Denney, D | 1 |
| Stevens, JR | 1 |
| Vohra, SB | 1 |
| Tyler, CV | 1 |
| Shank, JC | 1 |
| Vol'f, MSh | 1 |
| Hindmarsh, T | 1 |
| Grepe, A | 1 |
| Widén, L | 1 |
| Wässer, S | 1 |
| Bergmann, L | 1 |
| Hanzel, TE | 1 |
| Kalachnik, JE | 1 |
| Harder, SR | 1 |
| Afifi, AK | 1 |
| Van Allen, MW | 1 |
| Simpson, GM | 1 |
| Varga, E | 1 |
| Reiss, M | 1 |
| Cooper, TB | 1 |
| Bergner, PE | 1 |
| Lee, JH | 1 |
| Richardson, HL | 1 |
| Graupner, KI | 1 |
| Richardson, ME | 1 |
| Hambert, O | 1 |
| Petersén, I | 1 |
| Chiu, E | 1 |
| Wolpowitz, E | 1 |
| Viukari, NM | 1 |
2 trials available for chlorpromazine and Epilepsy, Tonic-Clonic
| Article | Year |
|---|---|
Bioequivalency of generic and brand-named chlorpromazine.
Topics: Adult; Analysis of Variance; Basal Ganglia Diseases; Body Weight; Carbon Radioisotopes; Chlorpromazi | 1974 |
Diphenylhydantoin as an anticonvulsant: evaluation of treatment in forty mentally subnormal epileptics.
Topics: Adolescent; Adult; Chlorpromazine; Clinical Trials as Topic; Electroencephalography; Epilepsies, Par | 1969 |
19 other studies available for chlorpromazine and Epilepsy, Tonic-Clonic
| Article | Year |
|---|---|
TWO CASES OF WITHDRAWAL FROM ETHCHLORVYNOL.
Topics: Chlorpromazine; Delirium; Epilepsy, Tonic-Clonic; Ethchlorvynol; Hallucinations; Hypnotics and Sedat | 1964 |
[THE PROSTRATION SYNDROME. SERIOUS DANGER OF DRUG THERAPY IN EPILEPSY].
Topics: Adolescent; Anticonvulsants; Chlorpromazine; Down Syndrome; Drug Therapy; Electroencephalography; Ep | 1964 |
PIGMENT DEPOSITION IN VISCERA ASSOCIATED WITH PROLONGED CHLORPROMAZINE THERAPY.
Topics: Adolescent; Autonomic Nervous System; Cerebral Cortex; Chlorpromazine; Cornea; Endocrine Glands; Epi | 1964 |
TOXIC PSYCHOSIS WITH TRANSIENT DYSMNESTIC SYNDROME FOLLOWING WITHDRAWAL FROM VALIUM.
Topics: Chlorpromazine; Diazepam; Epilepsy; Epilepsy, Tonic-Clonic; Hallucinations; Humans; Memory; Psychose | 1965 |
Untoward effects following combined neuroleptic-lithium therapy. Cardiac arrhythmias and seizure.
Topics: Adult; Arrhythmias, Cardiac; Bipolar Disorder; Chlorpromazine; Drug Therapy, Combination; Epilepsy, | 1980 |
Maprotiline and seizures.
Topics: Adult; Anthracenes; Chlorpromazine; Depressive Disorder; Drug Therapy, Combination; Epilepsy, Tonic- | 1982 |
Adverse effects of combined propranolol and chlorpromazine therapy.
Topics: Adult; Chlorpromazine; Delirium; Drug Therapy, Combination; Epilepsy, Tonic-Clonic; Female; Humans; | 1982 |
Clozapine and seizures.
Topics: Amygdala; Animals; Brain; Brain Mapping; Chlorpromazine; Clozapine; Dose-Response Relationship, Drug | 1995 |
Convulsions after enflurane in a schizophrenic patient receiving neuroleptics.
Topics: Adult; Anesthesia, Inhalation; Chlorpromazine; Drug Synergism; Enflurane; Epilepsy, Tonic-Clonic; Fl | 1994 |
Dementia and Down syndrome.
Topics: Adult; Alzheimer Disease; Antipsychotic Agents; Chlorpromazine; Disease Progression; Down Syndrome; | 1996 |
[Psychotropic drugs in the clinical picture of epilepsy (review of the literature)].
Topics: Amitriptyline; Animals; Anti-Anxiety Agents; Anticonvulsants; Antipsychotic Agents; Carbamazepine; C | 1975 |
Metrizamide-phenothiazine interaction. Report of a case with seizures following myelography.
Topics: Adult; Chlorpromazine; Drug Interactions; Epilepsy, Tonic-Clonic; Humans; Iodobenzoates; Male; Metri | 1975 |
[Short time EEG examinations during sleep in epileptic children].
Topics: Adolescent; Child; Child, Preschool; Chlorpromazine; Electroencephalography; Epilepsy; Epilepsy, Ton | 1976 |
A case of phenobarbital exacerbation of a preexisting maladaptive behavior partially suppressed by chlorpromazine and misinterpreted as chlorpromazine efficacy.
Topics: Adult; Aggression; Chlorpromazine; Diagnosis, Differential; Dose-Response Relationship, Drug; Epilep | 1992 |
Cerebellar atrophy in epilepsy. Pneumographic and histological documentation of a case with psychosis.
Topics: Adult; Brain; Cerebellar Ataxia; Cerebral Ventriculography; Chlorpromazine; Diplopia; Electroconvuls | 1968 |
Intramyocardial lesions in patients dying suddenly and unexpectedly.
Topics: Adult; Aged; Bipolar Disorder; Brain Damage, Chronic; Chlorpromazine; Death, Sudden; Epilepsy, Tonic | 1966 |
Clinical, electroencephalographical and neuropharmacological studies in syndromes of progressive myoclonus epilepsy.
Topics: Administration, Oral; Adrenocorticotropic Hormone; Adult; Amobarbital; Benzazepines; Chloral Hydrate | 1970 |
Psychiatric aspects of disseminated lupus erythematosus in Hong Kong Chinese--report of three cases.
Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Adult; Amitriptyline; Chlorpromazine; Epilepsy | 1971 |
The use of thioridazine (Melleril) in cases of epileptic psychosis.
Topics: Adult; Chlorpromazine; Epilepsy, Tonic-Clonic; Female; Humans; Middle Aged; Psychotic Disorders; Thi | 1966 |