chlorpromazine has been researched along with Endotoxin Shock in 48 studies
Chlorpromazine: The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking DOPAMINE RECEPTORS. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the treatment of intractable hiccup.
chlorpromazine : A substituted phenothiazine in which the ring nitrogen at position 10 is attached to C-3 of an N,N-dimethylpropanamine moiety.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The inhibitory effect of chlorpromazine (CPZ), pentoxifylline (PTX) and dexamethasone (DEX) was investigated in a model of endotoxin shock in Holstein calves following an intravenous administration of Esherichia coli endotoxin (LPS)." | 3.69 | Inhibitory effect on LPS-induced tumor necrosis factor in calves treated with chlorpromazine or pentoxifylline. ( Higuchi, T; Matsuzawa, H; Ohtsuka, H; Sato, H; Takahashi, J; Takahashi, K; Yoshino, TO, 1997) |
| "Chlorpromazine (CPZ) has potent immunomodulatory effects in vivo; it induces humoral autoimmunity in up to 50% of patients, inhibits delayed-type hypersensitivity reactions, and suppresses lethal immune hyperactivation in animal models of septic shock." | 1.29 | Chlorpromazine amplifies macrophage-dependent IL-10 production in vivo. ( Frechin, N; González-García, A; Gonzalo, JA; Kroemer, G; Marchetti, P; Martínez, C; Ruiz-Gayo, M; Tarazona, R; van Rooijen, N; Zamzami, N, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 37 (77.08) | 18.7374 |
| 1990's | 10 (20.83) | 18.2507 |
| 2000's | 1 (2.08) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Can, C | 1 |
| Demirci, B | 1 |
| Uysal, A | 1 |
| Akçay, YD | 1 |
| Koşay, S | 1 |
| LUND-JOHANSEN, P | 1 |
| AFANASEV, IN | 1 |
| CSABA, B | 1 |
| SZILAGYI, T | 1 |
| DAMJANOVICH, S | 1 |
| KOEVER, A | 1 |
| HASHIMOTO, Y | 1 |
| YUGE, K | 1 |
| COLLINS, VJ | 1 |
| JAFFE, RJ | 1 |
| ZAHONY, I | 1 |
| GERBER, EL | 1 |
| HART, PG | 1 |
| HOLSHUIJSEN, N | 1 |
| SAMBHI, MP | 1 |
| WEIL, MH | 1 |
| UDHOJI, VN | 1 |
| ROSOFF, L | 1 |
| WOROBEC, T | 1 |
| Dietzman, RH | 2 |
| Manax, WG | 1 |
| Lillehei, RC | 2 |
| Loeb, HS | 1 |
| Cruz, A | 1 |
| Teng, CY | 1 |
| Boswell, J | 1 |
| Pietras, RJ | 1 |
| Tobin, JR | 1 |
| Gunnar, RM | 1 |
| Kambara, N | 1 |
| Takagi, K | 1 |
| Satake, T | 1 |
| Sugiyama, S | 1 |
| Ozawa, T | 1 |
| Palacios, M | 1 |
| Padron, J | 1 |
| Glaria, L | 1 |
| Rojas, A | 1 |
| Delgado, R | 1 |
| Knowles, R | 1 |
| Moncada, S | 1 |
| Tarazona, R | 1 |
| González-García, A | 1 |
| Zamzami, N | 1 |
| Marchetti, P | 1 |
| Frechin, N | 1 |
| Gonzalo, JA | 1 |
| Ruiz-Gayo, M | 1 |
| van Rooijen, N | 1 |
| Martínez, C | 1 |
| Kroemer, G | 1 |
| Netea, MG | 1 |
| Blok, WL | 1 |
| Kullberg, BJ | 1 |
| Bemelmans, M | 1 |
| Vogels, MT | 1 |
| Buurman, WA | 1 |
| van der Meer, JW | 1 |
| Lindahl, M | 1 |
| Tagesson, C | 1 |
| Ohtsuka, H | 1 |
| Higuchi, T | 1 |
| Matsuzawa, H | 1 |
| Sato, H | 1 |
| Takahashi, K | 1 |
| Takahashi, J | 1 |
| Yoshino, TO | 1 |
| Song, SM | 1 |
| Lu, SM | 1 |
| Wang, ZG | 1 |
| Liu, JC | 1 |
| Guo, SQ | 1 |
| Li, Z | 1 |
| Hopkin, DA | 2 |
| Bertini, R | 2 |
| Mengozzi, M | 2 |
| Bianchi, M | 1 |
| Sipe, JD | 1 |
| Ghezzi, P | 2 |
| Gadina, M | 1 |
| Zandalasini, M | 1 |
| Mantovani, A | 1 |
| Parant, M | 2 |
| Kortelainen, ML | 1 |
| Särkioja, T | 1 |
| Cavanagh, D | 1 |
| Dahm, CH | 1 |
| Clauss, RH | 1 |
| Ray, JF | 1 |
| Lish, PM | 1 |
| Robbins, SI | 1 |
| Peters, EL | 1 |
| Martin, L | 1 |
| Anton, AH | 1 |
| Niklasson, PM | 1 |
| Blombäck, M | 1 |
| Lundbergh, P | 1 |
| Strandell, T | 1 |
| Simionescu, S | 1 |
| Daniel, B | 1 |
| Stancu, C | 1 |
| Lambotte, L | 1 |
| Rocmans, P | 1 |
| Meyer, W | 2 |
| Fonkalsrud, EW | 1 |
| Motsay, GJ | 1 |
| Pinkus, NB | 1 |
| Darrieulat, F | 1 |
| Zielińska, W | 2 |
| Tarján, G | 1 |
| Czeizel, E | 1 |
| Görgényi, F | 1 |
| Székesi, J | 1 |
| Bailey, GL | 1 |
| Strub, RL | 1 |
| Shoemaker, WC | 1 |
| Brown, RS | 1 |
| Torsti, P | 1 |
| Lascaro, M | 1 |
| Padula, A | 1 |
| Solazzo, G | 1 |
| Johnson, DG | 1 |
| Stengert, K | 1 |
| Brodzińska, K | 1 |
| Gehrung, E | 1 |
| Reyes, H | 1 |
| Gazmuri, R | 1 |
4 reviews available for chlorpromazine and Endotoxin Shock
| Article | Year |
|---|---|
Possible mediators in endotoxin-induced abortion.
Topics: Abortion, Spontaneous; Animals; Biological Factors; Chlorpromazine; Cytokines; Endotoxins; Female; G | 1990 |
Pharmacologic assistance to the failing circulation.
Topics: Adenosine Triphosphatases; Aminophylline; Angiotensin II; Blood Gas Analysis; Blood Pressure; Cardia | 1968 |
[Cliniccal aspects, pathogenesis and therapy of shock due to sepsis caused by gram-negative organisms].
Topics: Adult; Animals; Blood; Chlorpromazine; Diarrhea; Dogs; Electrocardiography; Endotoxins; Escherichia | 1966 |
[Clinical aspects, pathogenesis and therapy of shock due to sepsis caused by gram-negative organisms].
Topics: Adult; Aldosterone; Animals; Blood; Chlorpromazine; Diarrhea; Dogs; Electrocardiography; Endotoxins; | 1966 |
44 other studies available for chlorpromazine and Endotoxin Shock
| Article | Year |
|---|---|
Contradictory effects of chlorpromazine on endothelial cells in a rat model of endotoxic shock in association with its actions on serum TNF-alpha levels and antioxidant enzyme activities.
Topics: Analysis of Variance; Animals; Antioxidants; Aorta; Catalase; Chlorpromazine; Disease Models, Animal | 2003 |
Shock after administration of phenothiazines in patients with pheochromocytoma.
Topics: Antipsychotic Agents; Chlorpromazine; Chlorprothixene; Phenothiazines; Pheochromocytoma; Shock; Shoc | 1962 |
[PREVENTION OF HYPOTENSION AND COLLAPSE IN AMINAZINE THERAPY].
Topics: Chlorpromazine; Hypotension; Schizophrenia; Shock; Shock, Septic; Toxicology | 1963 |
[EFFECTS OF HYPOTHERMIA ON ANAPHYLACTIC AND PEPTONE SHOCK IN THE DOG].
Topics: Anaphylaxis; Chlorpromazine; Dogs; Histamine Release; Hypothermia; Hypothermia, Induced; Peptones; R | 1963 |
[CASES OF SHOCK-LIKE CONDITIONS. (1)].
Topics: Bronchoscopy; Chlorpromazine; Cocaine; Ganglionic Blockers; Nasal Septum; Otolaryngology; Physiology | 1963 |
NEWER ATTITUDES IN MANAGEMENT OF HEMORRHAGIC SHOCK. THE USE OF CHLORPROMAZINE AS AN ADJUNCT.
Topics: Animals; Attitude; Blood Transfusion; Chlorpromazine; Dogs; Gastrointestinal Hemorrhage; Oxygen Inha | 1964 |
[A CASE OF NECROTIC NEPHROSIS IN AMINAZIN THERAPY].
Topics: Chlorpromazine; Geriatrics; Hypertension; Necrosis; Nephrosis; Obesity; Pathology; Shock; Shock, Sep | 1963 |
[BACTERIAL SHOCK IN THE PLACENTAL PERIOD 3 DAYS AFTER THE RUPTURE OF THE MEMBRANES].
Topics: Blood Chemical Analysis; Blood Transfusion; Chlorpromazine; Cortisone; Female; Humans; Norepinephrin | 1963 |
EFFECT OF PRESSOR AMINES ON CARDIAC OUTPUT IN PATIENTS WITH ACUTE HYPOTENSION.
Topics: Amines; Barbiturates; Blood Pressure; Cardiac Output; Chlorpromazine; Dehydration; Drug Therapy; Dye | 1964 |
BLOOD DYSCRASIAS ASSOCIATED WITH ANTITUBERCULOSIS AND/OR TRANQUILIZING CHEMOTHERAPY. A LONG-TERM CLINICAL OBSERVATION.
Topics: Aminosalicylic Acid; Aminosalicylic Acids; Antitubercular Agents; Chemical and Drug Induced Liver In | 1965 |
Shock: mechanisms and therapy.
Topics: Animals; Chlorpromazine; Digitalis Glycosides; Dogs; Endotoxins; Epinephrine; Equipment and Supplies | 1967 |
Haemodynamic studies in shock associated with infection.
Topics: Aged; Blood Pressure; Blood Volume; Cardiac Output; Chlorpromazine; Dextrans; Digitalis Glycosides; | 1967 |
Mechanism responsible for endotoxin-induced lung microsomal dysfunction in rats.
Topics: Animals; Chlorpromazine; Coenzymes; Fatty Acids, Nonesterified; Female; Lung; Microsomes; Phospholip | 1983 |
Chlorpromazine inhibits both the constitutive nitric oxide synthase and the induction of nitric oxide synthase after LPS challenge.
Topics: Amino Acid Oxidoreductases; Animals; Arginase; Brain; Chlorpromazine; Citrulline; Cytosol; Enzyme In | 1993 |
Chlorpromazine amplifies macrophage-dependent IL-10 production in vivo.
Topics: Animals; Base Sequence; Chlorpromazine; Cytokines; Enterotoxins; In Situ Hybridization; Interleukin- | 1995 |
Pharmacologic inhibitors of tumor necrosis factor production exert differential effects in lethal endotoxemia and in infection with live microorganisms in mice.
Topics: Animals; Candidiasis; Chlorpromazine; Female; Interleukin-1; Kidney; Klebsiella Infections; Klebsiel | 1995 |
Selective inhibition of group II phospholipase A2 by quercetin.
Topics: Animals; Aristolochic Acids; Chlorpromazine; Humans; Indomethacin; Pancreas; Phenanthrenes; Phosphol | 1993 |
Inhibitory effect on LPS-induced tumor necrosis factor in calves treated with chlorpromazine or pentoxifylline.
Topics: Animals; Cattle; Chlorpromazine; Dexamethasone; Endotoxins; Escherichia coli Infections; Female; Lip | 1997 |
Subcellular membrane impairment and application of phospholipase A2 inhibitors in endotoxic shock.
Topics: Animals; Chloroquine; Chlorpromazine; Enzyme Inhibitors; Intracellular Membranes; Membrane Fluidity; | 1999 |
Frapper fort ou frapper doucement: a gram-negative dilemma.
Topics: Animals; Antitoxins; Bacterial Toxins; Chloramphenicol; Chlorpromazine; Cortisone; Endotoxins; Guine | 1978 |
Chlorpromazine protection against interleukin-1 and tumor necrosis factor-mediated activities in vivo.
Topics: Animals; Chlorpromazine; Corticosterone; Eating; Fibrinogen; Inflammation; Interleukin-1; Male; Mice | 1991 |
Protective effect of chlorpromazine on endotoxin toxicity and TNF production in glucocorticoid-sensitive and glucocorticoid-resistant models of endotoxic shock.
Topics: Adrenalectomy; Animals; Chlorpromazine; Dexamethasone; Dose-Response Relationship, Drug; Endotoxins; | 1991 |
Fatal complications of intramuscular and intra-articular injections.
Topics: Adult; Aged; Aged, 80 and over; Arthritis, Infectious; Brain Damage, Chronic; Cause of Death; Chlorp | 1990 |
Endotoxic shock.
Topics: Abortion, Septic; Animals; Anti-Bacterial Agents; Bacterial Infections; Blood Coagulation; Catechola | 1972 |
Specificity of antihistamine drugs and involvement of the adrenergic system in histamine deaths in the guinea pig.
Topics: Adrenal Medulla; Aerosols; Amitriptyline; Animals; Chlorpheniramine; Chlorpromazine; Diphenhydramine | 1966 |
Toxicity of acids and bases after intraperitoneal injection.
Topics: Acetates; Acids; Alkalies; Analgesics; Anesthetics, Local; Animals; Anti-Bacterial Agents; Body Temp | 1970 |
Thrombocytopenia and bleeding complications in severe cases of meningococcal infection treated with heparin, dextran 70 and chlorpromazine.
Topics: Adolescent; Adult; Aspirin; Blood Platelet Disorders; Cephalothin; Chlorpromazine; Dexamethasone; De | 1972 |
[Non-specific pharmacodynamic properties of chlorpromazine (CPZ) in relationship to the characteristic specific action of the drug].
Topics: Animals; Central Nervous System; Chlorpromazine; Chromaffin System; Dogs; Dose-Response Relationship | 1973 |
Letter: Antibiotics and endotoxic shock.
Topics: Anti-Bacterial Agents; Chlorpromazine; Cortisone; Humans; Shock, Septic | 1973 |
[Toxi-infectious shock].
Topics: Animals; Anti-Bacterial Agents; Bacterial Infections; Blood Transfusion; Chlorpromazine; Digitalis G | 1973 |
Common mechanisms of hypotension in irreversible shock and liver transplantation.
Topics: Animals; Chlorpromazine; Dogs; Hydrocortisone; Hypotension; Liver; Liver Transplantation; Phenoxyben | 1969 |
[Drugs in shock treatment].
Topics: Adrenal Cortex Hormones; Cardiac Output; Chlorpromazine; Digitalis Glycosides; Humans; Isoproterenol | 1971 |
Skin eruptions in drug-induced coma.
Topics: Adult; Barbiturates; Chlorpromazine; Coma; Humans; Middle Aged; Shock, Septic; Skin Diseases; Skin M | 1971 |
[Action of a serotonin antagonist, methysergide, on the abortive or lethal effect of bacterial endotoxins in mice].
Topics: Abortion, Spontaneous; Adrenalectomy; Animals; Blood Cell Count; Blood Platelet Disorders; Blood Pla | 1971 |
[Clinical symptoms of infectious shock].
Topics: Bicarbonates; Chlorpromazine; Digitalis Glycosides; Disseminated Intravascular Coagulation; Humans; | 1971 |
[Medicamentous prevention of endotoxin-induced mortality of pregnant animals].
Topics: Aminocaproates; Animals; Aprotinin; Chlorpromazine; Female; Fetal Death; Liver Diseases; Maternal Mo | 1967 |
Gram-negative septic shock: the new approach.
Topics: Adolescent; Adult; Anti-Bacterial Agents; Bicarbonates; Blood Pressure Determination; Chlorpromazine | 1966 |
The dilemma of vasopressors and vasodilators in the therapy of shock.
Topics: Blood Pressure; Cardiac Output; Central Venous Pressure; Chlorpromazine; Heart Rate; Hemodynamics; H | 1971 |
[The use of sympathomimetics and sympatholytics in shock].
Topics: Chlorpromazine; Dopamine; Humans; Isoproterenol; Metaraminol; Norepinephrine; Phenoxybenzamine; Phen | 1971 |
[11O cases of shock in the course of various infectious diseases according to the Clinic of Infectious Diseases, Medical Academy in Gdańsk in 1961-1966].
Topics: Adolescent; Adrenal Cortex Hormones; Adult; Aged; Child; Child, Preschool; Chlorpromazine; Dysentery | 1968 |
[A case of endotoxic shock treated with adrenolytics].
Topics: Adolescent; Chlorpromazine; Humans; Male; Shock, Septic; Sympatholytics; Typhoid Fever | 1969 |
Shock and its management.
Topics: Anti-Bacterial Agents; Anticoagulants; Blood Cell Count; Blood Pressure; Blood Transfusion; Body Wei | 1969 |
[Management in endotoxin shock].
Topics: Adult; Blood Pressure Determination; Chlorpromazine; Endotoxins; Female; Humans; Hydrocortisone; Mal | 1966 |
[Septic shock treated with a vasodilator drug (chlorpromazine)].
Topics: Adult; Chlorpromazine; Humans; Male; Middle Aged; Shock, Septic | 1966 |