chlorpromazine has been researched along with Dystonia in 24 studies
Chlorpromazine: The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking DOPAMINE RECEPTORS. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the treatment of intractable hiccup.
chlorpromazine : A substituted phenothiazine in which the ring nitrogen at position 10 is attached to C-3 of an N,N-dimethylpropanamine moiety.
Dystonia: An attitude or posture due to the co-contraction of agonists and antagonist muscles in one region of the body. It most often affects the large axial muscles of the trunk and limb girdles. Conditions which feature persistent or recurrent episodes of dystonia as a primary manifestation of disease are referred to as DYSTONIC DISORDERS. (Adams et al., Principles of Neurology, 6th ed, p77)
| Excerpt | Relevance | Reference |
|---|---|---|
| "We have observed two cases of chlorpromazine-induced neuroleptic malignant syndrome (NMS); both were transiently responsive to intravenous diazepam challenge, but not to blind placebo or amyobarbitol." | 9.05 | Chlorpromazine-induced neuroleptic malignant syndrome and its response to diazepam. ( Lew, TY; Tollefson, G, 1983) |
| "A case of myxoedema coma is reported where the administration of chlorpromazine resulted in a prolonged dystonic reaction." | 7.66 | Prolonged dystonic reaction to chlorpromazine in myxoedema coma. ( Waters, AK; Wood, GM, 1980) |
| "We have observed two cases of chlorpromazine-induced neuroleptic malignant syndrome (NMS); both were transiently responsive to intravenous diazepam challenge, but not to blind placebo or amyobarbitol." | 5.05 | Chlorpromazine-induced neuroleptic malignant syndrome and its response to diazepam. ( Lew, TY; Tollefson, G, 1983) |
| "Our results did not lend strong support to the view that the genetic variation of the DRD2 gene plays a major role in the individually variable adverse effect induced by chlorpromazine, at least in Chinese patients with schizophrenia." | 3.73 | Association of DRD2 polymorphisms and chlorpromazine-induced extrapyramidal syndrome in Chinese schizophrenic patients. ( Feng, GY; Gao, R; Gu, NF; He, L; Li, HF; Shen, YF; Wu, SN; Xing, QH, 2006) |
| "It has been reported that intraventricular injection of chlorpromazine methiodide (CPZMI), a quaternary ammonium derivative of chlorpromazine, in rats induces abnormal, twisting postures which may serve as an experimental model of the human movement disorder dystonia." | 3.66 | Electroencephalographic studies of chlorpromazine methiodide and somatostatin-induced barrel rotation in rats. ( Burke, RE; Fahn, S, 1983) |
| "A case of myxoedema coma is reported where the administration of chlorpromazine resulted in a prolonged dystonic reaction." | 3.66 | Prolonged dystonic reaction to chlorpromazine in myxoedema coma. ( Waters, AK; Wood, GM, 1980) |
| "Acute dystonia can also be reliably induced in many primate species by neuroleptic treatment with comparable time course, symptomatology and pharmacological characteristics to those observed in man." | 2.37 | Acute dystonia induced by neuroleptic drugs. ( Jenner, P; Marsden, CD; Rupniak, NM, 1986) |
| "Most cases of acute dystonia are mild and easy to manage; nevertheless, some of them can be fatal because of the involvement of certain muscle groups such as the laryngeal muscles, thus requiring urgent intervention." | 1.39 | Is acute dystonia an emergency? Sometimes, it really is! ( Cizmeci, MN; Derinoz, O; Havali, C; Kanburoglu, MK, 2013) |
| " Data were analyzed to determine the effect of anticholinergic prophylaxis, age, sex, and type and dosage of neuroleptic on the incidence of dystonic reactions." | 1.27 | Anticholinergic agents for prophylaxis of neuroleptic-induced dystonic reactions: a prospective study. ( Heiser, JF; Morrison, RL; Simpson, GM; Sramek, JJ, 1986) |
| "Torsion dystonia in 13-year-old girl progressed to severe opisthotonus and dystonic posturing of the limbs, accompanied by severe psychic changes, cachexia and calcification around joints." | 1.26 | Torsion dystonia: a case with delayed remission following thalamotomy and phenothiazine therapy. ( Michaeli, Y; Rosin, AJ; Sahar, A, 1978) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 16 (66.67) | 18.7374 |
| 1990's | 5 (20.83) | 18.2507 |
| 2000's | 1 (4.17) | 29.6817 |
| 2010's | 2 (8.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kanburoglu, MK | 1 |
| Derinoz, O | 1 |
| Cizmeci, MN | 1 |
| Havali, C | 1 |
| Yagmur, F | 1 |
| Ulusoy, HB | 1 |
| Buyukoglan, H | 1 |
| Kaya, MG | 1 |
| GUIRAL, RJ | 2 |
| LASSALLE, P | 1 |
| GARRIGUES, A | 1 |
| PLAS, R | 1 |
| MAURY-LASCOUX, J | 1 |
| BERTUZZI, F | 1 |
| Wu, SN | 1 |
| Gao, R | 1 |
| Xing, QH | 1 |
| Li, HF | 1 |
| Shen, YF | 1 |
| Gu, NF | 1 |
| Feng, GY | 1 |
| He, L | 1 |
| Burke, RE | 2 |
| Fahn, S | 2 |
| Lew, TY | 1 |
| Tollefson, G | 1 |
| Cohen, GH | 1 |
| Casta, A | 1 |
| Sapire, DW | 1 |
| Talabi, A | 1 |
| Rotrosen, J | 1 |
| Stanley, M | 1 |
| Kuhn, C | 1 |
| Wazer, D | 1 |
| Gershon, S | 1 |
| O'Connor, M | 1 |
| Johnson, GH | 1 |
| James, DI | 1 |
| Wood, GM | 1 |
| Waters, AK | 1 |
| Auchus, AP | 1 |
| Freeman, A | 1 |
| Green, RC | 1 |
| Murray, V | 1 |
| Shulman, LM | 1 |
| Singer, C | 1 |
| Weiner, WJ | 1 |
| Bhopale, S | 1 |
| Seidel, JS | 1 |
| Gannon, MA | 1 |
| O'Sullivan, P | 1 |
| Rosin, AJ | 1 |
| Sahar, A | 1 |
| Michaeli, Y | 1 |
| Rupniak, NM | 1 |
| Jenner, P | 1 |
| Marsden, CD | 1 |
| Sramek, JJ | 1 |
| Simpson, GM | 1 |
| Morrison, RL | 1 |
| Heiser, JF | 1 |
| Addonizio, G | 1 |
| Alexopoulos, GS | 1 |
| Schou, H | 1 |
| Kongstad, LL | 1 |
| Yassa, R | 1 |
1 review available for chlorpromazine and Dystonia
| Article | Year |
|---|---|
Acute dystonia induced by neuroleptic drugs.
Topics: Acute Disease; alpha-Methyltyrosine; Animals; Antipsychotic Agents; Brain; Chlorpromazine; Disease M | 1986 |
1 trial available for chlorpromazine and Dystonia
| Article | Year |
|---|---|
Chlorpromazine-induced neuroleptic malignant syndrome and its response to diazepam.
Topics: Brain; Chlorpromazine; Diazepam; Dopamine; Dyskinesia, Drug-Induced; Dystonia; Female; Fever; gamma- | 1983 |
22 other studies available for chlorpromazine and Dystonia
| Article | Year |
|---|---|
Is acute dystonia an emergency? Sometimes, it really is!
Topics: Acute Disease; Adolescent; Antipsychotic Agents; Biperiden; Chlorpromazine; Diagnosis, Differential; | 2013 |
Acute respiratory distress due to antipsychotic drugs.
Topics: Adult; Antiparkinson Agents; Antipsychotic Agents; Benzodiazepines; Chlorpromazine; Drug Therapy, Co | 2010 |
[Use of chlorpromazine in the psychosomatic type of autonomic dystonias].
Topics: Autonomic Nervous System; Autonomic Nervous System Diseases; Chlorpromazine; Disease; Dystonia; Huma | 1956 |
[Use of chlorpromazine in the psychosomatic type of autonomic dystonias].
Topics: Autonomic Nervous System; Autonomic Nervous System Diseases; Chlorpromazine; Disease; Dystonia; Huma | 1956 |
[Use of chlorpromazine in the psychosomatic type of autonomic dystonias].
Topics: Autonomic Nervous System; Autonomic Nervous System Diseases; Chlorpromazine; Disease; Dystonia; Huma | 1956 |
[Use of chlorpromazine in the psychosomatic type of autonomic dystonias].
Topics: Autonomic Nervous System; Autonomic Nervous System Diseases; Chlorpromazine; Disease; Dystonia; Huma | 1956 |
[Postural dystonia in chlorpromazine-treated patients].
Topics: Chlorpromazine; Dystonia; Humans; Posture | 1957 |
[Considerations on a type of therapy in vegetative dystonia].
Topics: Chlorpromazine; Dystonia; Dystonic Disorders; Sympatholytics | 1959 |
Association of DRD2 polymorphisms and chlorpromazine-induced extrapyramidal syndrome in Chinese schizophrenic patients.
Topics: Adult; Akathisia, Drug-Induced; Alleles; Antipsychotic Agents; Asian People; Chlorpromazine; Dystoni | 2006 |
Electroencephalographic studies of chlorpromazine methiodide and somatostatin-induced barrel rotation in rats.
Topics: Animals; Behavior, Animal; Chlorpromazine; Disease Models, Animal; Dystonia; Electroencephalography; | 1983 |
Decorticate posture following 'cardiac cocktail': a transient complication of sedation for catheterization.
Topics: Cardiac Catheterization; Child, Preschool; Chlorpromazine; Diphenhydramine; Drug Combinations; Dysto | 1982 |
Experimental dystonia induced by quaternary-chlorpromazine.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Behavior, Animal; Chlorpromazine; Corpus Striatum; Disease | 1980 |
Intrauterine effect of phenothiazines.
Topics: Adult; Chlorpromazine; Dystonia; Female; Fluphenazine; Humans; Infant; Infant, Newborn; Infant, Newb | 1981 |
Prolonged dystonic reaction to chlorpromazine in myxoedema coma.
Topics: Aged; Chlorpromazine; Coma; Dystonia; Female; Humans; Myxedema | 1980 |
Agitated behavior relieved following treatment of cervical dystonia in dementia.
Topics: Alzheimer Disease; Botulinum Toxins; Chlorpromazine; Dystonia; Female; Humans; Isoxazoles; Middle Ag | 1995 |
Laryngeal dystonia.
Topics: Adolescent; Antipsychotic Agents; Chlorpromazine; Drug Overdose; Drug Synergism; Dystonia; Ethanol; | 1995 |
Improvement of both tardive dystonia and akathisia after botulinum toxin injection.
Topics: Akathisia, Drug-Induced; Botulinum Toxins; Chlorpromazine; Dystonia; Female; Humans; Injections, Int | 1996 |
Dystonic reaction to a phenothiazine presenting as Bell's palsy.
Topics: Antiemetics; Child; Chlorpromazine; Diagnosis, Differential; Dystonia; Facial Paralysis; Humans; Mal | 1997 |
Medical management of disturbed behaviour.
Topics: Antidepressive Agents; Benzodiazepines; Bipolar Disorder; Chlorpromazine; Depressive Disorder; Dysto | 1998 |
Torsion dystonia: a case with delayed remission following thalamotomy and phenothiazine therapy.
Topics: Adolescent; Calcinosis; Chlorpromazine; Dystonia; Female; Humans; Posture; Radiography; Remission, S | 1978 |
Anticholinergic agents for prophylaxis of neuroleptic-induced dystonic reactions: a prospective study.
Topics: Adolescent; Adult; Antiparkinson Agents; Antipsychotic Agents; Basal Ganglia Diseases; Child; Chlorp | 1986 |
Drug-induced dystonia in young and elderly patients.
Topics: Adult; Age Factors; Aged; Antipsychotic Agents; Chlorpromazine; Dystonia; Female; Fluphenazine; Halo | 1988 |
An evaluation of sustained postural abnormalities in rats induced by intracerebro-ventricular injection of chlorpromazine methiodide or somatostatin as models of dystonia.
Topics: Animals; Cerebral Ventricles; Chemical Phenomena; Chemistry; Chlorpromazine; Disease Models, Animal; | 1988 |
[Acute dystonia with fatal outcome. A possible adverse drug reaction in the simultaneous administration of chlorpromazine (Prozil) and metoclopramide (Primperan)].
Topics: Acute Disease; Aged; Cerebral Hemorrhage; Chlorpromazine; Drug Therapy, Combination; Dystonia; Femal | 1986 |
The Pisa syndrome: a report of two cases.
Topics: Adult; Chlorpromazine; Dyskinesia, Drug-Induced; Dystonia; Gait; Humans; Male; Middle Aged; Paranoid | 1985 |