chlorpromazine has been researched along with Diarrhea in 35 studies
Chlorpromazine: The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking DOPAMINE RECEPTORS. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the treatment of intractable hiccup.
chlorpromazine : A substituted phenothiazine in which the ring nitrogen at position 10 is attached to C-3 of an N,N-dimethylpropanamine moiety.
Diarrhea: An increased liquidity or decreased consistency of FECES, such as running stool. Fecal consistency is related to the ratio of water-holding capacity of insoluble solids to total water, rather than the amount of water present. Diarrhea is not hyperdefecation or increased fecal weight.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A randomised controlled trial was conducted to investigate the ability of chlorpromazine to reduce intestinal secretion in cholera." | 9.05 | Controlled trial of chlorpromazine as antisecretory agent in patients with cholera hydrated intravenously. ( Greenough, WB; Holmgren, J; Kirkwood, B; Rabbani, GH, 1982) |
| "Four hundred and ten patients with severe watery diarrhea; including 316 patients with cholera, were studied in a double-blind, randomized, placebo controlled trial to determine if chlorpromazine (1 mg/kg) would be useful in the management of such patients." | 9.05 | The use of chlorpromazine in the treatment of cholera and other severe acute watery diarrheal diseases. ( Bardhan, PK; Holmgren, J; Islam, MR; Rabbani, GH; Sack, DA, 1982) |
| "Because chlorpromazine inhibited cholera-toxin-stimulated intestinal adenylate cyclase and fluid secretion in laboratory animals its ability to reduce fluid-loss in human cholera was investigated." | 9.04 | Chlorpromazine reduces fluid-loss in cholera. ( Greenough, WB; Holmgren, J; Lönnroth, I; Rabbani, GH, 1979) |
| "The effect of chlorpromazine (CPZ) on diarrhea caused by enterotoxigenic Escherichia coli was tested in piglets since CPZ has been shown to be a potent antagonist to enterotoxins in vitro in a cell system and in vivo in a mouse model." | 7.66 | Chlorpromazine reverses diarrhea in piglets caused by enterotoxigenic Escherichia coli. ( Andrén, B; Holmgren, J; Lange, S; Lönnroth, I; Martinsson, K, 1979) |
| "A randomised controlled trial was conducted to investigate the ability of chlorpromazine to reduce intestinal secretion in cholera." | 5.05 | Controlled trial of chlorpromazine as antisecretory agent in patients with cholera hydrated intravenously. ( Greenough, WB; Holmgren, J; Kirkwood, B; Rabbani, GH, 1982) |
| "Four hundred and ten patients with severe watery diarrhea; including 316 patients with cholera, were studied in a double-blind, randomized, placebo controlled trial to determine if chlorpromazine (1 mg/kg) would be useful in the management of such patients." | 5.05 | The use of chlorpromazine in the treatment of cholera and other severe acute watery diarrheal diseases. ( Bardhan, PK; Holmgren, J; Islam, MR; Rabbani, GH; Sack, DA, 1982) |
| "Because chlorpromazine inhibited cholera-toxin-stimulated intestinal adenylate cyclase and fluid secretion in laboratory animals its ability to reduce fluid-loss in human cholera was investigated." | 5.04 | Chlorpromazine reduces fluid-loss in cholera. ( Greenough, WB; Holmgren, J; Lönnroth, I; Rabbani, GH, 1979) |
| "Effects of chlorpromazine and propranolol were tested in infant mice model of Enterotoxigenic Escherichia coli diarrhea." | 3.66 | Chlorpromazine and propranolol extend survival of infant mice inoculated with enterotoxigenic Escherichia coli. ( Bertin, A, 1981) |
| "The effect of chlorpromazine (CPZ) on diarrhea caused by enterotoxigenic Escherichia coli was tested in piglets since CPZ has been shown to be a potent antagonist to enterotoxins in vitro in a cell system and in vivo in a mouse model." | 3.66 | Chlorpromazine reverses diarrhea in piglets caused by enterotoxigenic Escherichia coli. ( Andrén, B; Holmgren, J; Lange, S; Lönnroth, I; Martinsson, K, 1979) |
| "Thus, diarrhea is not observed consistently and reliably in this species to allow valid evaluation of potential antidiarrheal agents." | 1.28 | Cecectomized rat. A model of experimental secretory diarrhea in conscious animals. ( Burnham, DB; Fondacaro, JD; Kolpak, DC; McCafferty, GP, 1990) |
| " Chlorpromazine, administered intramuscularly on 3 successive days following the dual infection in 8 K88ac susceptible pigs, in a dosage of 2 and 1." | 1.28 | Effect of chlorpromazine on experimental diarrhoea in just-weaned piglets. ( Cools, V; Cox, E; Houvenaghel, A, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 33 (94.29) | 18.7374 |
| 1990's | 1 (2.86) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (2.86) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Trepanier, L | 1 |
| GARCIA HERRERA, E | 1 |
| CORONADO, G | 1 |
| GARCIA HERRERA, A | 1 |
| FUNATSU, I | 1 |
| KAUDER, E | 1 |
| BAYLESS, TM | 1 |
| SCHELL, HW | 1 |
| CORDEIROFERREIRA, M | 1 |
| SABIDO, F | 1 |
| CORDEIROFERREIRA, N | 1 |
| SACRAMENTOMONTEIRO, ME | 1 |
| Robins-Browne, RM | 1 |
| Levine, MM | 1 |
| Raychaudhury, A | 1 |
| Agarwal, RK | 1 |
| Sanyal, SC | 1 |
| Burke, V | 1 |
| Gracey, M | 1 |
| Olsvik, O | 1 |
| Bergan, T | 1 |
| Oye, I | 1 |
| Hughes, S | 1 |
| Gyr, K | 1 |
| Ruppin, H | 1 |
| Catania, A | 1 |
| Caimi, G | 1 |
| Lönnroth, I | 3 |
| Lange, S | 2 |
| Rabbani, GH | 3 |
| Greenough, WB | 2 |
| Holmgren, J | 4 |
| Kirkwood, B | 1 |
| Islam, MR | 1 |
| Sack, DA | 1 |
| Bardhan, PK | 1 |
| Black, RE | 1 |
| Bertin, A | 1 |
| Ng, AS | 1 |
| Johan, A | 1 |
| Chia, BL | 1 |
| Nadarajah, K | 1 |
| Gullikson, GW | 1 |
| Dajani, EZ | 1 |
| Bianchi, RG | 1 |
| Andrén, B | 1 |
| Martinsson, K | 1 |
| Lippes, J | 1 |
| Hurd, M | 1 |
| Fondacaro, JD | 1 |
| Kolpak, DC | 1 |
| Burnham, DB | 1 |
| McCafferty, GP | 1 |
| Cox, E | 2 |
| Cools, V | 2 |
| Houvenaghel, A | 2 |
| Weikel, CS | 1 |
| Guerrant, RL | 1 |
| Willard, MD | 1 |
| Ballard, CA | 1 |
| Qilligan, EJ | 1 |
| Meyer, W | 2 |
| Stalport, J | 1 |
| Dardenne, A | 1 |
| Letawe, P | 1 |
| Boddaert, J | 1 |
| Lapin, IP | 1 |
| Osipova, SV | 1 |
| Uskova, NV | 1 |
| Stabrovski, EM | 1 |
| Göschke, H | 1 |
5 reviews available for chlorpromazine and Diarrhea
| Article | Year |
|---|---|
Acute vomiting in cats: rational treatment selection.
Topics: Acute Disease; Animals; Antiemetics; Cat Diseases; Cats; Chlorpromazine; Diarrhea; Famotidine; Indol | 2010 |
Toxin receptors and their pathogenetic significance.
Topics: Adenylyl Cyclases; Animals; Chlorpromazine; Cholera; Cholera Toxin; Cholera Vaccines; Combined Modal | 1984 |
The prophylaxis and therapy of secretory diarrhea.
Topics: Anti-Infective Agents, Urinary; Antidiarrheals; Chloramphenicol; Chlorpromazine; Cholera; Diarrhea; | 1982 |
[Cliniccal aspects, pathogenesis and therapy of shock due to sepsis caused by gram-negative organisms].
Topics: Adult; Animals; Blood; Chlorpromazine; Diarrhea; Dogs; Electrocardiography; Endotoxins; Escherichia | 1966 |
[Clinical aspects, pathogenesis and therapy of shock due to sepsis caused by gram-negative organisms].
Topics: Adult; Aldosterone; Animals; Blood; Chlorpromazine; Diarrhea; Dogs; Electrocardiography; Endotoxins; | 1966 |
3 trials available for chlorpromazine and Diarrhea
| Article | Year |
|---|---|
Controlled trial of chlorpromazine as antisecretory agent in patients with cholera hydrated intravenously.
Topics: Adult; Chlorpromazine; Cholera; Clinical Trials as Topic; Diarrhea; Fluid Therapy; Humans; Intestina | 1982 |
The use of chlorpromazine in the treatment of cholera and other severe acute watery diarrheal diseases.
Topics: Acute Disease; Adult; Child; Child, Preschool; Chlorpromazine; Cholera; Clinical Trials as Topic; Di | 1982 |
Chlorpromazine reduces fluid-loss in cholera.
Topics: Administration, Oral; Adult; Chlorpromazine; Cholera; Dehydration; Diarrhea; Drug Evaluation; Humans | 1979 |
27 other studies available for chlorpromazine and Diarrhea
| Article | Year |
|---|---|
[Evaluation of chloro-3-(dimethylamino-3-propyl)-10-phenothiazine hydrochloride in pediatrics].
Topics: Bronchitis; Child; Chlorpromazine; Colic; Diarrhea; Humans; Pediatrics; Phenothiazines; Vomiting; Wh | 1963 |
THE PATHOGENESIS OF SO-CALLED EKIRI-LIKE SYNDROME AND CONSIDERATION OF TREATMENT OF THE BACILLARY DYSENTERY.
Topics: Anti-Bacterial Agents; Antibiotics, Antitubercular; Bacillus; Blood Cell Count; Blood Chemical Analy | 1962 |
PERORAL INTESTINAL BIOPSY IN CHILDREN: A TECHNIQUE.
Topics: Biopsy; Celiac Disease; Child; Chlorpromazine; Diarrhea; Diarrhea, Infantile; Duodenum; Humans; Infa | 1964 |
CURRENT STATUS OF 5-FLUOROURACIL THERAPY IN FAR-ADVANCED NEOPLASTIC DISEASE.
Topics: Alopecia; Chlorpromazine; Diarrhea; Erythema; Fluorouracil; Leukopenia; Nausea; Neoplasms; Thrombocy | 1964 |
[NON-SPECIFIC TREATMENT OF GRAVE ENTERITIS IN INFANTS].
Topics: Adrenal Cortex Hormones; Amino Acids; Calcium; Chlorpromazine; Dehydration; Diarrhea; Diarrhea, Infa | 1964 |
Effect of chlorpromazine on intestinal secretion mediated by Escherichia coli heat-stable enterotoxin and 8-Br-cyclic GMP in infant mice.
Topics: Animals; Chlorpromazine; Cholera Toxin; Cyclic GMP; Diarrhea; Enterotoxins; Escherichia coli; Guanyl | 1981 |
Enteropathogenicity of Klebsiella pneumoniae strains isolated from stools of diarrhoeal patients and other clinical specimens: an experimental study.
Topics: Animals; Bacteriological Techniques; Child; Chlorpromazine; Diarrhea; Dibenz(b,f)(1,4)oxazepine-10(1 | 1984 |
Studies with enterotoxigenic microorganisms: effects of candidate antidiarrhoeals in experimental animals in vivo.
Topics: Aluminum Hydroxide; Animals; Antidiarrheals; Aspirin; Bacterial Infections; Charcoal; Chlorpromazine | 1984 |
Chlorpromazine inhibition of enterotoxin-induced fluid secretion and cAMP production in rat ileum.
Topics: Animals; Body Water; Chlorpromazine; Cyclic AMP; Diarrhea; Enterotoxins; Ileum; Male; Microscopy, El | 1982 |
Acute secretory diarrheas. Current concepts in pathogenesis and treatment.
Topics: Acute Disease; Anti-Bacterial Agents; Chlorpromazine; Cholera; Cholera Toxin; Diarrhea; Escherichia | 1983 |
[Motility inhibitors and secretion inhibitors].
Topics: Chlorpromazine; Codeine; Diarrhea; Gastrointestinal Motility; Humans; Intestinal Absorption; Intesti | 1984 |
[Acute intermittent porphyria].
Topics: Acute Disease; Chlorpromazine; Diarrhea; Heme; Hemin; Humans; Intestinal Obstruction; Mitochondria, | 1983 |
Toxin A of Clostridium difficile: production, purification and effect in mouse intestine.
Topics: Adenylyl Cyclases; Animals; Bacterial Proteins; Bacterial Toxins; Bile; Chlorpromazine; Cholera Toxi | 1983 |
Chlorpromazine and propranolol extend survival of infant mice inoculated with enterotoxigenic Escherichia coli.
Topics: Administration, Oral; Animals; Chlorpromazine; Diarrhea; Escherichia coli Infections; Injections, Su | 1981 |
Chlorpromazine induced T wave and QT alternans - a case report and review.
Topics: Chlorpromazine; Diarrhea; Electrocardiography; Female; Humans; Middle Aged; Tachycardia | 1982 |
Inhibition of intestinal secretion in the dog: a new approach for the management of diarrheal states.
Topics: Animals; Antidiarrheals; Body Water; Chlorpromazine; Deoxycholic Acid; Diarrhea; Dogs; Electrolytes; | 1981 |
Chlorpromazine reverses diarrhea in piglets caused by enterotoxigenic Escherichia coli.
Topics: Adenylyl Cyclases; Animals; Chlorpromazine; Diarrhea; Enterotoxins; Escherichia coli Infections; Int | 1979 |
The use of chlorpromazine and lomotil to prevent and/or reduce the side effects of prostaglandin E2 used for abortion.
Topics: Abortion, Induced; Atropine; Chlorpromazine; Diarrhea; Diphenoxylate; Drug Combinations; Female; Fev | 1975 |
Cecectomized rat. A model of experimental secretory diarrhea in conscious animals.
Topics: Animals; Antidiarrheals; Carbachol; Cecum; Chlorpromazine; Cholera Toxin; Clonidine; Colon; Diarrhea | 1990 |
Effect of chlorpromazine on experimental diarrhoea in just-weaned piglets.
Topics: Animals; Chlorpromazine; Diarrhea; Disease Models, Animal; Escherichia coli Infections; Female; Gast | 1989 |
Effect of antisecretory drugs on experimentally induced weanling diarrhoea in piglets.
Topics: Animals; Animals, Newborn; Chlorpromazine; Clonidine; Diarrhea; Disease Models, Animal; Escherichia | 1989 |
STb enterotoxin of Escherichia coli: cyclic nucleotide-independent secretion.
Topics: Animals; Bacterial Toxins; Calcium; Chlorides; Chlorpromazine; Cyclic AMP; Diarrhea; Electrolytes; E | 1985 |
Newer concepts in treatment of secretory diarrheas.
Topics: Animals; Antidiarrheals; Chlorpromazine; Diarrhea; Enterotoxins; Escherichia coli Infections; Fluid | 1985 |
Midtrimester abortion with intramuscular injection of 15-methyl-prostaglandin E2.
Topics: Abortifacient Agents; Abortion, Induced; Adult; Chlorpromazine; Diarrhea; Drug Evaluation; Esters; F | 1974 |
[Carcinoid tumor of the small intestine].
Topics: Aged; Anemia; Bromine; Carcinoid Tumor; Cecum; Chlorpromazine; Diarrhea; Glucocorticoids; Heart Dise | 1971 |
Pharmacological effects of imipramine and desmethylimipramine in developing rats.
Topics: Age Factors; Animals; Animals, Newborn; Blepharoptosis; Brain Chemistry; Chlorpromazine; Desipramine | 1969 |
[Drug therapy of the carcinoid syndrome].
Topics: Asthma; Carcinoid Tumor; Chlorpromazine; Cyclophosphamide; Cyproheptadine; Diarrhea; Humans; Methyse | 1968 |