Compounds > chlorpromazine
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chlorpromazine and Dementia

chlorpromazine has been researched along with Dementia in 40 studies

Chlorpromazine: The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking DOPAMINE RECEPTORS. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the treatment of intractable hiccup.
chlorpromazine : A substituted phenothiazine in which the ring nitrogen at position 10 is attached to C-3 of an N,N-dimethylpropanamine moiety.

Dementia: An acquired organic mental disorder with loss of intellectual abilities of sufficient severity to interfere with social or occupational functioning. The dysfunction is multifaceted and involves memory, behavior, personality, judgment, attention, spatial relations, language, abstract thought, and other executive functions. The intellectual decline is usually progressive, and initially spares the level of consciousness.

Research

Studies (40)

TimeframeStudies, this research(%)All Research%
pre-199033 (82.50)18.7374
1990's1 (2.50)18.2507
2000's2 (5.00)29.6817
2010's3 (7.50)24.3611
2020's1 (2.50)2.80

Authors

AuthorsStudies
Kołaczkowski, M3
Marcinkowska, M3
Bucki, A3
Pawłowski, M3
Mitka, K1
Jaśkowska, J1
Kowalski, P1
Kazek, G2
Siwek, A3
Wasik, A2
Wesołowska, A3
Mierzejewski, P3
Bienkowski, P2
Śniecikowska, J2
Jastrzębska-Więsek, M2
Partyka, A2
Zagórska, A1
Jamrozik, M1
Głuch-Lutwin, M1
Jakubczyk, M1
Pytka, K1
Abengaña, J1
Chong, MS1
Tay, L1
TERMAN, LA1
UGELSTAD, E1
TENNENT, JJ1
ABSE, DW1
DAHLSTROM, WG1
BOREL, J1
LAUZEL, JP1
HANUS, M1
ISRAEL, P1
KRONBERGEROVA, J1
DERZSI, S1
FENYVESI, T1
BUIS, C1
FLOHIL, JM1
HEIJBEL, J1
PERSSON, I1
ROBINSON, DB1
MARKOVICH, VI1
Hollis, J1
Grayson, D1
Forrester, L1
Brodaty, H1
Touyz, S1
Cumming, R1
Singh, D1
Forlano, R1
Athey, R1
Herbert, ME1
Jacobson, S1
Barbosa, ER1
Marchiori, PE1
Scaff, M1
de Assis, JL1
Schorah, CJ1
Morgan, DB1
Hullin, RP1
Devanand, DP1
Gallien, M1
Schnetzler, JP1
Morin, J1
Dall, JL1
Kamen, S1
Naku, AG1
Mikhlin, VM1
Markianos, M1
Tripodianakis, J1
Gottfries, CG1
Gottfries, I1
Dascalov, D1
Asnes, DP1
Altman, H1
Mehta, D1
Evenson, RC1
Sletten, IW1
Tewfik, GI1
Jain, VK1
Harcup, M1
Magowan, S1
Birkett, DP1
Boltuch, B1
Ermolina, LA1
Goldschmidt, L1
Barton, R1
Hurst, L1
Kramp, JL1
Radzuweit, H1
Knorr, W1
Morozova, TV1
Felger, HL1

Trials

5 trials available for chlorpromazine and Dementia

ArticleYear
Behavioral effects of drug therapy on psychogeriatric inpatients. I. Chlorpromazine and thioridazine.
    Journal of the American Geriatrics Society, 1973, Volume: 21, Issue:6

    Topics: Administration, Oral; Aged; Behavior; Chlorpromazine; Clinical Trials as Topic; Dementia; Evaluation

1973
Effectiveness of various tranquilisers in the management of senile restlessness.
    Gerontologia clinica, 1970, Volume: 12, Issue:6

    Topics: Aged; Carbamates; Chlorpromazine; Clinical Trials as Topic; Dementia; Female; Haloperidol; Humans; H

1970
Chlorpromazine in geriatric psychiatry.
    Journal of the American Geriatrics Society, 1972, Volume: 20, Issue:8

    Topics: Aged; Chloral Hydrate; Chlorpromazine; Constipation; Dementia; Drug Synergism; Humans; Intracranial

1972
Studies on the effect of clinical dosages of chlorpromazine and other neurotropics on primaquine-sensitive Negro mental patients.
    The Journal of nervous and mental disease, 1966, Volume: 143, Issue:1

    Topics: Adult; Anemia, Hemolytic; Black or African American; Chlorpromazine; Clinical Trials as Topic; Demen

1966
Unnecessary use of tranquilizers in elderly patients.
    The British journal of psychiatry : the journal of mental science, 1966, Volume: 112, Issue:491

    Topics: Aged; Chlorpromazine; Clinical Trials as Topic; Dementia; Female; Humans; Middle Aged; Placebos; Sch

1966

Other Studies

35 other studies available for chlorpromazine and Dementia

ArticleYear
Novel arylsulfonamide derivatives with 5-HT₆/5-HT₇ receptor antagonism targeting behavioral and psychological symptoms of dementia.
    Journal of medicinal chemistry, 2014, Jun-12, Volume: 57, Issue:11

    Topics: Animals; Antidepressive Agents; Antipsychotic Agents; Avoidance Learning; Benzoxazoles; Catalepsy; C

2014
Novel 5-HT6 receptor antagonists/D2 receptor partial agonists targeting behavioral and psychological symptoms of dementia.
    European journal of medicinal chemistry, 2015, Mar-06, Volume: 92

    Topics: Animals; Benzamides; Dementia; Dose-Response Relationship, Drug; Drug Partial Agonism; Humans; Indol

2015
Multifunctional 6-fluoro-3-[3-(pyrrolidin-1-yl)propyl]-1,2-benzoxazoles targeting behavioral and psychological symptoms of dementia (BPSD).
    European journal of medicinal chemistry, 2020, Apr-01, Volume: 191

    Topics: Animals; Antipsychotic Agents; Behavior, Animal; Benzoxazoles; Dementia; Dizocilpine Maleate; Dose-R

2020
Delirium superimposed on dementia: phenomenological differences between patients with and without behavioral and psychological symptoms of dementia in a specialized delirium unit.
    International psychogeriatrics, 2017, Volume: 29, Issue:3

    Topics: Aged; Aged, 80 and over; Chlorpromazine; Delirium; Dementia; Female; Humans; Length of Stay; Linear

2017
Treatment of senile agitation with chlorpromazine.
    Geriatrics, 1955, Volume: 10, Issue:11

    Topics: Chlorpromazine; Dementia; Mental Disorders; Psychomotor Agitation; Psychotic Disorders

1955
Chlorpromazine treatment in senile psychoses.
    Acta psychiatrica et neurologica Scandinavica. Supplementum, 1956, Volume: 106

    Topics: Chlorpromazine; Dementia; Mental Disorders; Psychotic Disorders

1956
Experiences with chlorpromazine in aged psychotics in a state institution.
    New York state journal of medicine, 1957, Aug-01, Volume: 57, Issue:15

    Topics: Chlorpromazine; Dementia; Health Facilities; Mental Disorders; Psychotic Disorders

1957
The value of chemotherapy in senile mental distrubances. Controlled comparison of chlorpromazine, reserpine-pipradrol, and opium.
    JAMA, 1960, Dec-17, Volume: 174

    Topics: Chlorpromazine; Dementia; Humans; Mental Disorders; Opium; Piperidines; Psychopharmacology; Psychoti

1960
[Apropos of a paranoid dementia cured by neuroleptic therapy for 15 months].
    Annales medico-psychologiques, 1963, Volume: 2

    Topics: Antipsychotic Agents; Chlorpromazine; Dementia; Muscle Relaxants, Central; Psychiatric Somatic Thera

1963
[CHANGES IN THE CLINICAL PICTURE OF ARTERIOSCLEROTIC AND SENILE DISEASES].
    Ceskoslovenska psychiatrie, 1963, Volume: 59

    Topics: Antihypertensive Agents; Chlorpromazine; Dementia; Electroconvulsive Therapy; Geriatrics; Intracrani

1963
HIREPINE IN PSYCHIATRY.
    Therapia Hungarica (English edition), 1964, Volume: 12

    Topics: Catatonia; Chlorpromazine; Convulsive Therapy; Dementia; Depression; Electroconvulsive Therapy; Huma

1964
[CLINICAL EXPERIENCES WITH HALOPERIDOL (SERENASE)].
    Nederlands tijdschrift voor geneeskunde, 1964, Apr-18, Volume: 108

    Topics: Bipolar Disorder; Chlorpromazine; Chorea; Dementia; Depressive Disorder, Major; Epilepsy; Haloperido

1964
[DEMENTIA PRAECOCISSIMA].
    Nordisk medicin, 1964, Jun-04, Volume: 71

    Topics: Autistic Disorder; Brain; Brain Damage, Chronic; Catatonia; Child; Chlorpromazine; Clopenthixol; Dem

1964
[Chlorpromazine in therapy of arteriosclerotic psychosis and senile dementia].
    Nordisk medicin, 1955, Feb-10, Volume: 53, Issue:6

    Topics: Alzheimer Disease; Arteriosclerosis; Chlorpromazine; Dementia; Mental Disorders; Psychotic Disorders

1955
Evaluation of certain drugs in geriatric patients: effects of chlorpromazine, reserpine, pentylenetetrazol U. S. P., and placebo on eighty-four female geriatric patients in a state hospital.
    A.M.A. archives of general psychiatry, 1959, Volume: 1

    Topics: Chlorpromazine; Dementia; Female; Hospitals, State; Mental Disorders; Pentylenetetrazole; Psychotic

1959
[On the problem of protracted amential states and their treatment with neuroleptics].
    Voprosy psikhiatrii i nevropatologii; sbornik trudov, 1961, Volume: 7

    Topics: Antipsychotic Agents; Chlorpromazine; Dementia; Electroconvulsive Therapy; Mental Disorders; Psychot

1961
Antipsychotic medication dispensing and risk of death in veterans and war widows 65 years and older.
    The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 2007, Volume: 15, Issue:11

    Topics: Age Factors; Aged; Aged, 80 and over; Anticonvulsants; Antipsychotic Agents; Australia; Benzodiazepi

2007
Neuroleptic malignant syndrome and catatonia in a patient with dementia.
    The Australian and New Zealand journal of psychiatry, 2008, Volume: 42, Issue:6

    Topics: Aged; Anti-Anxiety Agents; Antipsychotic Agents; Benzodiazepines; Catatonia; Chlorpromazine; Choline

2008
Late paraphrenia.
    The British journal of psychiatry : the journal of mental science, 1967, Volume: 113, Issue:498

    Topics: Aged; Chlorpromazine; Dementia; Diagnosis, Differential; Electroconvulsive Therapy; Female; Hearing

1967
[Huntington chorea: report of 16 cases].
    Arquivos de neuro-psiquiatria, 1983, Volume: 41, Issue:2

    Topics: Adult; Aged; Brain Diseases; Chlorpromazine; Dementia; Diagnosis, Differential; Female; gamma-Aminob

1983
Plasma vitamin C concentrations in patients in a psychiatric hospital.
    Human nutrition. Clinical nutrition, 1983, Volume: 37, Issue:6

    Topics: Affective Disorders, Psychotic; Age Factors; Aged; Ascorbic Acid; Chlorpromazine; Dementia; Female;

1983
Antipsychotic treatment in outpatients with dementia.
    International psychogeriatrics, 1996, Volume: 8 Suppl 3

    Topics: Aged; Alzheimer Disease; Ambulatory Care; Antipsychotic Agents; Chlorpromazine; Dementia; Dose-Respo

1996
[Antinuclear antibodies and lupus due to phenothiazines in 600 hospitalized patients].
    Annales medico-psychologiques, 1975, Volume: 1, Issue:2

    Topics: Adult; Aged; Antibodies, Antinuclear; Antipsychotic Agents; Chlorpromazine; Dementia; Female; Fluphe

1975
Chlormethiazole and electro-encephalogram changes.
    Age and ageing, 1979, Volume: 8, Issue:4

    Topics: Aged; Brain; Chlormethiazole; Chlorpromazine; Dementia; Electroencephalography; Humans

1979
Tardive dyskinesia. A significant syndrome for geriatric dentistry.
    Oral surgery, oral medicine, and oral pathology, 1975, Volume: 39, Issue:1

    Topics: Aged; Arteriosclerosis; Bruxism; Chlorpromazine; Dementia; Denture, Complete; Depression; Depressive

1975
[Differentiation of amentive from catatonic syndromes].
    Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1975, Volume: 75, Issue:6

    Topics: Acoustic Stimulation; Catatonia; Chlorpromazine; Dementia; Electroencephalography; Humans; Parasympa

1975
Low plasma dopamine-beta-hydroxylase in demented schizophrenics.
    Biological psychiatry, 1985, Volume: 20, Issue:1

    Topics: Chlorpromazine; Chronic Disease; Dementia; Dopamine beta-Hydroxylase; Dose-Response Relationship, Dr

1985
Antinuclear factors in relation to age, sex, mental disease and treatment with phenothiazines.
    Acta psychiatrica Scandinavica. Supplementum, 1974, Volume: 255

    Topics: Age Factors; Aged; Antibodies, Antinuclear; Antipsychotic Agents; Chlorpromazine; Dementia; Female;

1974
EEG findings in Alzheimer's disease.
    Electroencephalography and clinical neurophysiology, 1969, Volume: 27, Issue:4

    Topics: Chlorpromazine; Dementia; Electroencephalography; Epilepsy; Female; Humans; Male

1969
Psychopharmacology in the aged. Use of major psychotropic medications in treatment of the elderly: case examples.
    Journal of geriatric psychiatry, 1974, Volume: 7, Issue:2

    Topics: Adjustment Disorders; Aged; Alzheimer Disease; Amitriptyline; Benztropine; Bipolar Disorder; Cataton

1974
[Febrile states in schizophrenia following a paroxysmal course].
    Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1971, Volume: 71, Issue:5

    Topics: Adolescent; Adult; Catatonia; Chlorpromazine; Dementia; Female; Fever; Humans; Hyperkinesis; Male; M

1971
[Treatment of senile dementia with methylperidol (Luvatren)].
    Nordisk psykiatrisk tidsskrift. Nordic journal of psychiatry, 1969, Volume: 23, Issue:1

    Topics: Aged; Barbiturates; Butyrophenones; Chlorpromazine; Dementia; Female; Humans; Time Factors

1969
[Influencing of biological and immunologic pregnancy reactions by psychotropic drugs].
    Endokrinologie, 1969, Volume: 54, Issue:1

    Topics: Adolescent; Adult; Aged; Butyrophenones; Chlorpromazine; Dementia; Depressive Disorder, Major; Dysau

1969
[Spatial synchronization of alpha-activity in the cerebral cortex in patients with psychoses in advanced age].
    Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1967, Volume: 67, Issue:4

    Topics: Aged; Cerebral Cortex; Cerebrovascular Disorders; Chlorpromazine; Delirium; Dementia; Electroencepha

1967
Thioridazine (mellaril) in the geriatric patient.
    Diseases of the nervous system, 1966, Volume: 27, Issue:8

    Topics: Aged; Chlorpromazine; Dementia; Humans; Orientation; Thioridazine

1966