chlorpromazine has been researched along with Delayed Effects, Prenatal Exposure in 14 studies
Chlorpromazine: The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking DOPAMINE RECEPTORS. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the treatment of intractable hiccup.
chlorpromazine : A substituted phenothiazine in which the ring nitrogen at position 10 is attached to C-3 of an N,N-dimethylpropanamine moiety.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A case is reported of a prolactin-secreting pituitary adenoma in a young woman who had been referred for evaluation of amenorrhea with a history of in utero exposure to diethylstilbestrol." | 7.66 | Prolactin-secreting pituitary adenoma: occurrence following prenatal exposure to diethylstilbestrol. ( Cunningham, JR; Duchesneau, PM; Gidwani, GP; Gupta, MS; Schumacher, OP, 1982) |
| " Maternal exposure to imipramine in a dose equivalent to the therapeutic dose per unit body weight induced hyperthermic response to chlorpromazine in the male offspring, while normal control rats showed a marked hypothermia." | 3.69 | Transgenerational effects of maternal exposure to chemicals on the functional development of the brain in the offspring. ( Fujii, T, 1997) |
| "Long-term behavioral effects of a low dose of diazepam (1 mg/kg body weight) or chlorpromazine (2." | 3.68 | Impact of prenatal low-dose diazepam or chlorpromazine on reflex and motor development and inhibitory-learning. ( Hassmannová, J; Josífko, M; Myslivecek, J, 1991) |
| "A case is reported of a prolactin-secreting pituitary adenoma in a young woman who had been referred for evaluation of amenorrhea with a history of in utero exposure to diethylstilbestrol." | 3.66 | Prolactin-secreting pituitary adenoma: occurrence following prenatal exposure to diethylstilbestrol. ( Cunningham, JR; Duchesneau, PM; Gidwani, GP; Gupta, MS; Schumacher, OP, 1982) |
| " 2) The body weight of rats in the F0 and F1 generations decreased depending on the dosage of CPZ, but the body weight of the F2 generation increased." | 1.28 | Inhibitory effect of chlorpromazine on rat reproduction: a two week administration test before mating. ( Yokoya, H, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (42.86) | 18.7374 |
| 1990's | 6 (42.86) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (14.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Basta-Kaim, A | 1 |
| Szczęsny, E | 1 |
| Leśkiewicz, M | 1 |
| Głombik, K | 1 |
| Slusarczyk, J | 1 |
| Budziszewska, B | 1 |
| Regulska, M | 1 |
| Kubera, M | 1 |
| Nowak, W | 1 |
| Wędzony, K | 1 |
| Lasoń, W | 1 |
| Zmarowski, A | 1 |
| Beekhuijzen, M | 1 |
| Lensen, J | 1 |
| Emmen, H | 1 |
| Feigenbaum, JJ | 1 |
| Yanai, J | 1 |
| Cunningham, JR | 1 |
| Gidwani, GP | 1 |
| Gupta, MS | 1 |
| Duchesneau, PM | 1 |
| Schumacher, OP | 1 |
| Smith, GN | 1 |
| Honer, WG | 1 |
| Kopala, L | 1 |
| MacEwan, GW | 1 |
| Altman, S | 1 |
| Smith, A | 1 |
| Lam, SK | 1 |
| To, WK | 1 |
| Rhodes, PG | 1 |
| Hu, ZY | 1 |
| Sun, GY | 1 |
| Fujii, T | 3 |
| Myslivecek, J | 1 |
| Hassmannová, J | 1 |
| Josífko, M | 1 |
| Yokoya, H | 1 |
| Szkilnik, R | 1 |
| Brus, R | 1 |
| Felińska, W | 1 |
| Juraszczyk, Z | 1 |
| Pyka, U | 1 |
| Piechocka, J | 1 |
| Kamiński, M | 1 |
| Konecki, J | 1 |
| Ohtaki, Y | 2 |
| Nakanishi, H | 1 |
| Morimoto, S | 1 |
| Hayashi, K | 1 |
| Yamamoto, N | 1 |
| Watanabe, T | 1 |
| Matsuhashi, K | 1 |
| Takayama, S | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Randomized Controlled Trial of Adjunctive Siltuximab in Schizophrenia[NCT02796859] | Phase 1/Phase 2 | 30 participants (Anticipated) | Interventional | 2016-05-31 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for chlorpromazine and Delayed Effects, Prenatal Exposure
| Article | Year |
|---|---|
Evidence for the involvement of central dopaminergic receptors in the acute and chronic effects induced by barbiturates.
Topics: Adenylyl Cyclases; Animals; Barbiturates; Brain; Chlorpromazine; Dopamine; Drug Interactions; Drug T | 1983 |
13 other studies available for chlorpromazine and Delayed Effects, Prenatal Exposure
| Article | Year |
|---|---|
Maternal immune activation leads to age-related behavioral and immunological changes in male rat offspring - the effect of antipsychotic drugs.
Topics: Age Factors; Aging; Animals; Antipsychotic Agents; Behavior, Animal; Cell Proliferation; Cells, Cult | 2012 |
Differential performance of Wistar Han and Sprague Dawley rats in behavioral tests: differences in baseline behavior and reactivity to positive control agents.
Topics: Animals; Behavior, Animal; Brain; Chlorpromazine; Control Groups; Dizocilpine Maleate; Female; Learn | 2012 |
Prolactin-secreting pituitary adenoma: occurrence following prenatal exposure to diethylstilbestrol.
Topics: Adenoma; Adolescent; Bromocriptine; Chlorpromazine; Diethylstilbestrol; Female; Humans; Levodopa; Pi | 1982 |
Obstetric complications and severity of illness in schizophrenia.
Topics: Activities of Daily Living; Chlorpromazine; Clozapine; Female; Follow-Up Studies; Humans; Obstetric | 1995 |
Neonatal narcotic withdrawal in Hong Kong Chinese.
Topics: Asian People; Case-Control Studies; Chlorpromazine; Female; Hong Kong; Humans; Infant, Newborn; Narc | 1994 |
Effects of chlorpromazine on phosphatidylserine biosynthesis in rat pup brain exposed to ethanol in utero.
Topics: Animals; Animals, Newborn; Brain; Cell Membrane; Chlorpromazine; Ethanol; Female; Kinetics; Microsom | 1993 |
Transgenerational effects of maternal exposure to chemicals on the functional development of the brain in the offspring.
Topics: Aggression; Aminobutyrates; Animals; Anticonvulsants; Antidepressive Agents, Tricyclic; Antineoplast | 1997 |
Impact of prenatal low-dose diazepam or chlorpromazine on reflex and motor development and inhibitory-learning.
Topics: Animals; Animals, Newborn; Avoidance Learning; Behavior, Animal; Body Weight; Chlorpromazine; Condit | 1991 |
Inhibitory effect of chlorpromazine on rat reproduction: a two week administration test before mating.
Topics: Animals; Body Weight; Chlorpromazine; Estrus; Female; Fetus; Insemination; Male; Organ Size; Pregnan | 1990 |
Effect of chlorpromazine administered to pregnant and lactating rat females on the behaviour of their offspring and its brain content of bioamines.
Topics: Animals; Animals, Suckling; Biogenic Amines; Brain Chemistry; Chlorpromazine; Female; Lactation; Mal | 1987 |
Alterations in the thermic response to chlorpromazine in rats exposed prenatally to central nervous system depressants.
Topics: Animals; Body Temperature; Central Nervous System Depressants; Chlorpromazine; Drug Interactions; Et | 1986 |
[Study on the postnatal neuro-behavioral development in rats treated prenatally with drugs acting on the autonomic nervous systems].
Topics: Animals; Atropine; Autonomic Agents; Central Nervous System Diseases; Chlorpromazine; Epinephrine; F | 1985 |
Sex-related hyperthermic response to chlorpromazine in the offspring of rats treated with imipramine.
Topics: Animals; Body Temperature; Chlorpromazine; Female; Growth; Imipramine; Male; Pregnancy; Prenatal Exp | 1985 |