chlorpromazine has been researched along with Crohn Disease in 2 studies
Chlorpromazine: The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking DOPAMINE RECEPTORS. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the treatment of intractable hiccup.
chlorpromazine : A substituted phenothiazine in which the ring nitrogen at position 10 is attached to C-3 of an N,N-dimethylpropanamine moiety.
Crohn Disease: A chronic transmural inflammation that may involve any part of the DIGESTIVE TRACT from MOUTH to ANUS, mostly found in the ILEUM, the CECUM, and the COLON. In Crohn disease, the inflammation, extending through the intestinal wall from the MUCOSA to the serosa, is characteristically asymmetric and segmental. Epithelioid GRANULOMAS may be seen in some patients.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To assess the importance of disease-induced increases in plasma concentrations of alpha1 acid glycoprotein (an acute-phase plasma protein that binds cationic drugs), we determined binding of propranolol in plasma from 53 patients and 25 healthy volunteers." | 7.66 | Increased plasma protein binding of propranolol and chlorpromazine mediated by disease-induced elevations of plasma alpha1 acid glycoprotein. ( Borgá, O; Johansson, C; Odar-Cederlöf, I; Piafsky, KM; Sjöqvist, F, 1978) |
| "To assess the importance of disease-induced increases in plasma concentrations of alpha1 acid glycoprotein (an acute-phase plasma protein that binds cationic drugs), we determined binding of propranolol in plasma from 53 patients and 25 healthy volunteers." | 3.66 | Increased plasma protein binding of propranolol and chlorpromazine mediated by disease-induced elevations of plasma alpha1 acid glycoprotein. ( Borgá, O; Johansson, C; Odar-Cederlöf, I; Piafsky, KM; Sjöqvist, F, 1978) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (50.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Schwerd, T | 1 |
| Pandey, S | 1 |
| Yang, HT | 1 |
| Bagola, K | 1 |
| Jameson, E | 1 |
| Jung, J | 1 |
| Lachmann, RH | 1 |
| Shah, N | 1 |
| Patel, SY | 1 |
| Booth, C | 1 |
| Runz, H | 1 |
| Düker, G | 1 |
| Bettels, R | 1 |
| Rohrbach, M | 1 |
| Kugathasan, S | 1 |
| Chapel, H | 1 |
| Keshav, S | 1 |
| Elkadri, A | 1 |
| Platt, N | 1 |
| Muise, AM | 1 |
| Koletzko, S | 1 |
| Xavier, RJ | 1 |
| Marquardt, T | 1 |
| Powrie, F | 1 |
| Wraith, JE | 1 |
| Gyrd-Hansen, M | 1 |
| Platt, FM | 1 |
| Uhlig, HH | 1 |
| Piafsky, KM | 1 |
| Borgá, O | 1 |
| Odar-Cederlöf, I | 1 |
| Johansson, C | 1 |
| Sjöqvist, F | 1 |
2 other studies available for chlorpromazine and Crohn Disease
| Article | Year |
|---|---|
Impaired antibacterial autophagy links granulomatous intestinal inflammation in Niemann-Pick disease type C1 and XIAP deficiency with NOD2 variants in Crohn's disease.
Topics: Acetylmuramyl-Alanyl-Isoglutamine; Adolescent; Adult; Anti-Bacterial Agents; Autophagy; Bacteria; Ce | 2017 |
Increased plasma protein binding of propranolol and chlorpromazine mediated by disease-induced elevations of plasma alpha1 acid glycoprotein.
Topics: Adult; Aged; alpha-Macroglobulins; Arthritis; Chlorpromazine; Crohn Disease; Disease; Female; Humans | 1978 |