chlorpromazine has been researched along with Coronary Disease in 29 studies
Chlorpromazine: The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking DOPAMINE RECEPTORS. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the treatment of intractable hiccup.
chlorpromazine : A substituted phenothiazine in which the ring nitrogen at position 10 is attached to C-3 of an N,N-dimethylpropanamine moiety.
Coronary Disease: An imbalance between myocardial functional requirements and the capacity of the CORONARY VESSELS to supply sufficient blood flow. It is a form of MYOCARDIAL ISCHEMIA (insufficient blood supply to the heart muscle) caused by a decreased capacity of the coronary vessels.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Chlorpromazine pretreatment (15 mg X kg-1 intravenously) reduced the increase in nonsedimentable cathepsin D activity slightly, but no appreciable protective effect on the anatomical redistribution of the enzyme or the development of ultrastructural signs of necrosis could be detected." | 1.27 | Influence of chlorpromazine on lysosomal alterations during myocardial ischaemia. ( Chien, KR; Crie, JS; Decker, RS; Wildenthal, K, 1983) |
| "Treatment with chlorpromazine before and subsequent to surgery prevented the appearance of ischemic cell death in the main portion of the free-wall myocardium for at least 24 hours without affecting the reaction of the subepicardial and subendocardial cells." | 1.26 | Ischemic myocardial cell injury. Prevention by chlorpromazine of an accelerated phospholipid degradation and associated membrane dysfunction. ( Chien, KR; Farber, JL; Peau, RG, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 28 (96.55) | 18.7374 |
| 1990's | 1 (3.45) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| SZABO, G | 1 |
| SOLTI, F | 1 |
| REV, J | 1 |
| REFI, Z | 1 |
| MEGYESI, K | 1 |
| Takahashi, K | 2 |
| Kako, KJ | 2 |
| Tribulová, N | 4 |
| Slezák, J | 7 |
| Gabauer, I | 6 |
| Holec, V | 4 |
| Epstein, LH | 1 |
| THomas, GE | 1 |
| Levitsky, S | 1 |
| Feinberg, H | 1 |
| Styk, J | 2 |
| Okolicány, J | 2 |
| Holec, VI | 1 |
| Chien, KR | 3 |
| Crie, JS | 1 |
| Decker, RS | 1 |
| Wildenthal, K | 1 |
| Born, GV | 2 |
| Wehmeier, A | 1 |
| Farber, JL | 2 |
| Mittnacht, S | 1 |
| Burton, KP | 1 |
| Hagler, HK | 1 |
| Willerson, JT | 1 |
| Buja, LM | 1 |
| Schneider, JM | 1 |
| Roger, DJ | 1 |
| Uhl, RL | 1 |
| Peau, RG | 1 |
| Hanson, EL | 1 |
| Kane, PB | 1 |
| Askanazi, J | 1 |
| Neville, JF | 1 |
| Webb, WR | 1 |
| Katsuoka, M | 1 |
| Ohnishi, ST | 1 |
| Afanas'ev, SA | 1 |
| Laptev, BI | 1 |
| Prokop'eva, VD | 1 |
| Larionov, NP | 1 |
| Ziegelhöffer, A | 1 |
| Chatelain, P | 1 |
| Gremel, M | 1 |
| Brotelle, R | 1 |
| Cutler, SJ | 1 |
| Greenhouse, SW | 1 |
| Cornfield, J | 1 |
| Schneiderman, MA | 1 |
| Haragus, S | 1 |
| Uza, G | 1 |
| Crisnic, I | 1 |
| Missits, P | 1 |
| Askrog, VF | 1 |
| Dam, WH | 2 |
| Hagelsten, JO | 2 |
| Kositskiĭ, GI | 1 |
| El'gort, PE | 1 |
| Tiul'mankov, VN | 1 |
| Lugovskiĭ, BK | 1 |
| Askrog, V | 1 |
| Poblinkova, EI | 1 |
2 reviews available for chlorpromazine and Coronary Disease
| Article | Year |
|---|---|
The direct effects of compliance on health outcome.
Topics: Alcoholism; Chlorpromazine; Chorionic Gonadotropin; Clofibrate; Coronary Disease; Disulfiram; Drug T | 1984 |
Myocardial ischemia: the pathogenesis of irreversible cell injury in ischemia.
Topics: Animals; Calcium; Cell Membrane; Cell Survival; Chlorpromazine; Coronary Disease; Dogs; Liver Diseas | 1981 |
2 trials available for chlorpromazine and Coronary Disease
| Article | Year |
|---|---|
The direct effects of compliance on health outcome.
Topics: Alcoholism; Chlorpromazine; Chorionic Gonadotropin; Clofibrate; Coronary Disease; Disulfiram; Drug T | 1984 |
The role of hypothesis testing in clinical trials. Biometrics seminar.
Topics: Biometry; Cardiovascular Diseases; Chlorpromazine; Clinical Trials as Topic; Coronary Disease; Estro | 1966 |
26 other studies available for chlorpromazine and Coronary Disease
| Article | Year |
|---|---|
[Effect of chlorpromazine on hypoxia of myocardium].
Topics: Anti-Arrhythmia Agents; Chlorpromazine; Coronary Disease; Electrocardiography; Humans; Myocardium | 1957 |
Ischemia-induced changes in sarcolemmal (Na+, K+)-ATPase, K+-pNPPase, sialic acid, and phospholipid in the dog and effects of the nisoldipine and chlorpromazine treatment.
Topics: 4-Nitrophenylphosphatase; Animals; Chlorpromazine; Coronary Disease; Dogs; Electrocardiography; Fema | 1984 |
[Protective effect of Chlorpromazine and Trasylol on the ischemic heart muscle of the dog].
Topics: Animals; Aprotinin; Chlorpromazine; Coronary Disease; Dogs; Histocytochemistry; Myocardium; Protease | 1983 |
Chlorpromazine inhibits loss of contractile function, compliance and ATP in ischemic rabbit heart.
Topics: Adenosine Triphosphate; Animals; Blood Pressure; Chlorpromazine; Compliance; Coronary Circulation; C | 1983 |
[The effect of chlorpromazine and intra-aortic balloon counterpulsation on the contractility and performance of the heart after coronary occlusion and reperfusion].
Topics: Animals; Assisted Circulation; Chlorpromazine; Coronary Circulation; Coronary Disease; Dogs; Heart; | 1984 |
Effect of chlorpromazine on the extent of ischemic changes of the myocardium. A histochemical study.
Topics: Animals; Chlorpromazine; Coronary Disease; Dogs; Histocytochemistry | 1984 |
Influence of chlorpromazine on lysosomal alterations during myocardial ischaemia.
Topics: Animals; Cathepsin D; Cathepsins; Chlorpromazine; Coronary Disease; Disease Models, Animal; Lysosome | 1983 |
Possible approaches to the pharmacological prevention of myocardial ischaemia.
Topics: Arteriosclerosis; Blood Platelets; Blood Vessels; Chlorpromazine; Coronary Disease; Hemolysis; Human | 1980 |
[Influencing ischemic changes in the myocardium after reperfusion with chlorpromazine].
Topics: Animals; Chlorpromazine; Coronary Circulation; Coronary Disease; Dogs; Myocardium; Perfusion | 1982 |
Abnormal lanthanum accumulation due to ischemia in isolated myocardium: effect of chlorpromazine.
Topics: Animals; Chlorpromazine; Coronary Disease; Heart; Kinetics; Lanthanum; Microscopy, Electron; Myocard | 1981 |
Bilateral forearm compartment syndromes resulting from neuroleptic malignant syndrome.
Topics: Angioplasty, Balloon, Coronary; Antipsychotic Agents; Chlorpromazine; Compartment Syndromes; Coronar | 1996 |
Possible role for chlorpromazine in protection against myocardial infarction.
Topics: Anticoagulants; Chlorpromazine; Coronary Disease; Hemolysis; Humans; Myocardial Infarction; Platelet | 1979 |
Ischemic myocardial cell injury. Prevention by chlorpromazine of an accelerated phospholipid degradation and associated membrane dysfunction.
Topics: Animals; Calcium; Chlorpromazine; Coronary Disease; Female; Heart; Myocardium; Permeability; Phospho | 1979 |
Comparison of patients with coronary artery or valve disease: intraoperative differences in blood volume and observations of vasomotor response.
Topics: Blood Pressure; Blood Transfusion; Blood Volume; Chlorpromazine; Coronary Disease; Depression, Chemi | 1976 |
Pharmacologic protection of perfused rat heart against global ischemia.
Topics: Animals; Chlorpromazine; Coronary Disease; Egtazic Acid; Free Radicals; Heart; In Vitro Techniques; | 1989 |
[Protective effect of aminazine in ischemia and re-perfusion of an isolated heart].
Topics: Animals; Biological Transport; Blood Pressure; Calcium; Calcium-Transporting ATPases; Chlorpromazine | 1986 |
Diminution of injury in reperfused ischemic myocardium by phenothiazines. A quantitative morphological study.
Topics: Animals; Calmodulin; Chlorpromazine; Coronary Circulation; Coronary Disease; Dogs; Female; Male; Myo | 1987 |
Prevention by amiodarone of phospholipid depletion in isoproterenol-induced ischemia in rats.
Topics: Amiodarone; Animals; Chlorpromazine; Cholesterol; Coronary Disease; Creatine Kinase; Isoproterenol; | 1987 |
The effects of myocardial ischemia and nisoldipine pretreatment on the asymmetric distribution of phosphatidylethanolamine in a canine heart sarcolemmal preparation.
Topics: Animals; Calcium Channel Blockers; Cell Fractionation; Chlorpromazine; Coronary Disease; Dogs; Femal | 1986 |
[The effect of phenothiazines on reperfusion of the ischemic myocardium].
Topics: Animals; Chlorpromazine; Coronary Circulation; Coronary Disease; Dogs; Myocardial Contraction; Trifl | 1985 |
The effect of chlorpromazine on platelet adhesiveness and extraction of oxygen in the tissues.
Topics: Arteriosclerosis; Blood Pressure Determination; Chlorpromazine; Coronary Disease; Humans; Myocardial | 1971 |
Treatment of patients with pulmonary oedema in an intensive therapy department.
Topics: Aged; Chlorpromazine; Coronary Disease; Digitalis Glycosides; Diuretics; Electrocardiography; Female | 1967 |
[Reactions of the blood system during short-term disturbances of the coronary circulation].
Topics: Adrenalectomy; Animals; Blood Cell Count; Blood Sedimentation; Chlorpromazine; Constriction; Coronar | 1967 |
[Vascular complications during aminazin therapy of mental patients].
Topics: Aged; Arteriosclerosis; Blood Coagulation; Blood Pressure; Cerebral Hemorrhage; Chlorpromazine; Coro | 1968 |
[Centralized treatment of patients with pulmonary edema].
Topics: Chlorpromazine; Coronary Disease; Denmark; Humans; Intensive Care Units; Mortality; Pulmonary Edema; | 1966 |
[The electroencephalogram in patients with coronary atherosclerosis during therapy with aminazine].
Topics: Aged; Brain; Chlorpromazine; Coronary Disease; Electroencephalography; Female; Humans; Male; Middle | 1966 |