chlorpromazine has been researched along with Colorectal Neoplasms in 2 studies
Chlorpromazine: The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking DOPAMINE RECEPTORS. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the treatment of intractable hiccup.
chlorpromazine : A substituted phenothiazine in which the ring nitrogen at position 10 is attached to C-3 of an N,N-dimethylpropanamine moiety.
Colorectal Neoplasms: Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Here, we investigated the effect and molecular mechanism of the antipsychotic drug chlorpromazine (CPZ) and identified its potential for treating colorectal cancer (CRC)." | 7.81 | Repositioning antipsychotic chlorpromazine for treating colorectal cancer by inhibiting sirtuin 1. ( Chen, KC; Cheng, CH; Cheng, HW; Chou, CM; Chung, CH; Ho, MN; Lee, WT; Lee, WY; Lin, CW; Sun, MS, 2015) |
| " Here, we investigated the effect and molecular mechanism of the antipsychotic drug chlorpromazine (CPZ) and identified its potential for treating colorectal cancer (CRC)." | 3.81 | Repositioning antipsychotic chlorpromazine for treating colorectal cancer by inhibiting sirtuin 1. ( Chen, KC; Cheng, CH; Cheng, HW; Chou, CM; Chung, CH; Ho, MN; Lee, WT; Lee, WY; Lin, CW; Sun, MS, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 1 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Xu, F | 1 |
| Xi, H | 1 |
| Liao, M | 1 |
| Zhang, Y | 2 |
| Ma, H | 1 |
| Wu, M | 1 |
| Xue, Q | 1 |
| Sun, H | 1 |
| Xia, Y | 1 |
| Lee, WY | 1 |
| Lee, WT | 1 |
| Cheng, CH | 1 |
| Chen, KC | 1 |
| Chou, CM | 1 |
| Chung, CH | 1 |
| Sun, MS | 1 |
| Cheng, HW | 1 |
| Ho, MN | 1 |
| Lin, CW | 1 |
2 other studies available for chlorpromazine and Colorectal Neoplasms
| Article | Year |
|---|---|
Repurposed antipsychotic chlorpromazine inhibits colorectal cancer and pulmonary metastasis by inducing G2/M cell cycle arrest, apoptosis, and autophagy.
Topics: Animals; Antineoplastic Agents; Antipsychotic Agents; Apoptosis; Autophagy; Cell Cycle; Cell Cycle C | 2022 |
Repositioning antipsychotic chlorpromazine for treating colorectal cancer by inhibiting sirtuin 1.
Topics: Animals; Antineoplastic Agents; Antipsychotic Agents; Apoptosis; Cell Line, Tumor; Cell Survival; Ch | 2015 |