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chlorpromazine and Cognition Disorders

chlorpromazine has been researched along with Cognition Disorders in 37 studies

Chlorpromazine: The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking DOPAMINE RECEPTORS. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the treatment of intractable hiccup.
chlorpromazine : A substituted phenothiazine in which the ring nitrogen at position 10 is attached to C-3 of an N,N-dimethylpropanamine moiety.

Cognition Disorders: Disorders characterized by disturbances in mental processes related to learning, thinking, reasoning, and judgment.

Research Excerpts

ExcerptRelevanceReference
"Olanzapine may be of benefit in anorexia nervosa by causing a reduction in anorexic rumination."9.11Randomized controlled trial of olanzapine in the treatment of cognitions in anorexia nervosa. ( Beumont, P; Birmingham, CL; Chapman, L; Mondraty, N; Sundakov, V; Touyz, S, 2005)
"Olanzapine may be of benefit in anorexia nervosa by causing a reduction in anorexic rumination."5.11Randomized controlled trial of olanzapine in the treatment of cognitions in anorexia nervosa. ( Beumont, P; Birmingham, CL; Chapman, L; Mondraty, N; Sundakov, V; Touyz, S, 2005)
" The long-term administration of neuroleptics in severe cases of SDAT caused a significant increase of SLI (p < 0."1.30Molecular forms of somatostatin-like immunoreactivity in the cerebrospinal fluid of patients with senile dementia of the Alzheimer type. ( Cramer, H; Hamann, G; Reuner, C; Schimrigk, K; Strittmatter, M; Strubel, D, 1997)

Research

Studies (37)

TimeframeStudies, this research(%)All Research%
pre-199012 (32.43)18.7374
1990's5 (13.51)18.2507
2000's15 (40.54)29.6817
2010's5 (13.51)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Naeem, S1
Ikram, R1
Khan, SS1
Rao, SS1
Wobrock, T1
Falkai, P1
Schneider-Axmann, T1
Hasan, A1
Galderisi, S1
Davidson, M1
Kahn, RS1
Derks, EM1
Boter, H1
Rybakowski, JK1
Libiger, J1
Dollfus, S1
López-Ibor, JJ1
Peuskens, J1
Hranov, LG1
Gaebel, W1
Fleischhacker, WW1
Rodewald, K1
Holt, DV1
Rentrop, M1
Roesch-Ely, D1
Liebrenz, M1
Funke, J1
Weisbrod, M1
Kaiser, S1
Chang, WC1
Chan, TC1
Chiu, SS1
Hui, CL1
Chan, SK1
Lee, EH1
Chen, EY1
Forbes, NF1
Carrick, LA1
McIntosh, AM1
Lawrie, SM1
Nemoto, T1
Yamazawa, R1
Kobayashi, H1
Fujita, N1
Chino, B1
Fujii, C1
Kashima, H1
Rassovsky, Y1
Green, MF1
Mizuno, M1
Iakimova, G1
Passerieux, C1
Denhière, G1
Laurent, JP1
Vistoli, D1
Vilain, J1
Hardy-Baylé, MC1
Shean, G1
Burnett, T1
Eckman, FS1
Youn, T1
Park, HJ1
Kim, JJ1
Kim, MS1
Kwon, JS1
Perlstein, WM1
Dixit, NK1
Carter, CS1
Noll, DC1
Cohen, JD1
Hagh-Shenas, H1
Toobai, S1
Makaremi, A1
Martínez-Arán, A1
Vieta, E1
Colom, F1
Torrent, C1
Sánchez-Moreno, J1
Reinares, M1
Benabarre, A1
Goikolea, JM1
Brugué, E1
Daban, C1
Salamero, M1
Peer, JE1
Rothmann, TL1
Penrod, RD1
Penn, DL1
Spaulding, WD2
Mondraty, N1
Birmingham, CL1
Touyz, S1
Sundakov, V1
Chapman, L1
Beumont, P1
Schuepbach, D1
Hill, SK1
Sanders, RD1
Hell, D1
Keshavan, MS1
Sweeney, JA1
Silverstein, SM1
Menditto, AA1
Savitz, A1
Liberman, RP1
Berten, S1
Starobin, H1
Watzke, S1
Brieger, P1
Kuss, O1
Schoettke, H1
Wiedl, KH1
Singh, D1
Forlano, R1
Athey, R1
Folstein, S1
Folstein, M1
King, DJ1
Delahunty, A1
Morice, R1
Frost, B1
Strittmatter, M1
Cramer, H1
Reuner, C1
Strubel, D1
Hamann, G1
Schimrigk, K1
Ikebuchi, E1
Nakagome, K1
Takahashi, N1
Evans, JD1
Negron, AE1
Palmer, BW1
Paulsen, JS1
Heaton, RK1
Jeste, DV1
Oades, RD1
Rao, ML1
Bender, S1
Sartory, G1
Müller, BW1
Darvesh, S1
MacKnight, C1
Rockwood, K1
Kay, SR1
Singh, MM1
Kolakowska, T1
Williams, AO1
Ardern, M1
Reveley, MA1
Jambor, K1
Gelder, MG1
Mandelbrote, BM1
Van Sweden, B1
Franzén, G1
Raskin, A1
Minde, K1
Weiss, G1
Mendelson, N1
Zolotnitskii, RI1
Kutsenok, BM1
Gastev, MD1
Cramond, WA1
Zlotlow, M1
Abenson, MH1
DeVito, RA1
Sykes, DE1
McDonald, EK1
Larson, JL1
Smith, JA1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Changes in Serum miRNA and BDNF Levels in Bipolar II Depression Treated by Theta-burst Stimulation: A Randomized Sham-controlled Exploratory Study[NCT04998097]60 participants (Anticipated)Interventional2022-05-23Recruiting
Effectiveness Trial of Attention Shaping for Schizophrenia[NCT00391677]120 participants (Actual)Interventional2007-01-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

2 reviews available for chlorpromazine and Cognition Disorders

ArticleYear
Working memory in schizophrenia: a meta-analysis.
    Psychological medicine, 2009, Volume: 39, Issue:6

    Topics: Antipsychotic Agents; Chlorpromazine; Cognition Disorders; Humans; Memory; Memory Disorders; Psychol

2009
Psychomotor impairment and cognitive disturbances induced by neuroleptics.
    Acta psychiatrica Scandinavica. Supplementum, 1994, Volume: 380

    Topics: Antipsychotic Agents; Attention; Chlorpromazine; Cognition Disorders; Eye Movements; Humans; Neurolo

1994

Trials

5 trials available for chlorpromazine and Cognition Disorders

ArticleYear
Comorbid substance abuse in first-episode schizophrenia: effects on cognition and psychopathology in the EUFEST study.
    Schizophrenia research, 2013, Volume: 147, Issue:1

    Topics: Adult; Analysis of Variance; Antipsychotic Agents; Antisocial Personality Disorder; Chlorpromazine;

2013
Predictors for improvement of problem-solving during cognitive remediation for patients with Schizophrenia.
    Journal of the International Neuropsychological Society : JINS, 2014, Volume: 20, Issue:4

    Topics: Adult; Antipsychotic Agents; Chlorpromazine; Cognition Disorders; Cognitive Behavioral Therapy; Fema

2014
Cognitive training for divergent thinking in schizophrenia: a pilot study.
    Progress in neuro-psychopharmacology & biological psychiatry, 2009, Nov-13, Volume: 33, Issue:8

    Topics: Adult; Antipsychotic Agents; Chlorpromazine; Cognition Disorders; Cognitive Behavioral Therapy; Fema

2009
Randomized controlled trial of olanzapine in the treatment of cognitions in anorexia nervosa.
    Australasian psychiatry : bulletin of Royal Australian and New Zealand College of Psychiatrists, 2005, Volume: 13, Issue:1

    Topics: Adult; Anorexia Nervosa; Antipsychotic Agents; Benzodiazepines; Chlorpromazine; Cognition Disorders;

2005
Attention shaping: a reward-based learning method to enhance skills training outcomes in schizophrenia.
    Schizophrenia bulletin, 2009, Volume: 35, Issue:1

    Topics: Adult; Antipsychotic Agents; Attention; Chlorpromazine; Cognition Disorders; Cognitive Behavioral Th

2009

Other Studies

30 other studies available for chlorpromazine and Cognition Disorders

ArticleYear
NSAIDs ameliorate cognitive and motor impairment in a model of parkinsonism induced by chlorpromazine.
    Pakistan journal of pharmaceutical sciences, 2017, Volume: 30, Issue:3

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antipsychotic Agents; Behavior, Animal; Chlorproma

2017
Self-perceived cognitive functioning and its relationship with objective performance in first-episode schizophrenia: the Subjective Cognitive Impairment Scale.
    Comprehensive psychiatry, 2015, Volume: 56

    Topics: Adolescent; Adult; Antipsychotic Agents; Asian People; Chlorpromazine; Cognition; Cognition Disorder

2015
The influence of idiomatic salience during the comprehension of ambiguous idioms by patients with schizophrenia.
    Psychiatry research, 2010, May-15, Volume: 177, Issue:1-2

    Topics: Adult; Analysis of Variance; Antipsychotic Agents; Chlorpromazine; Cognition Disorders; Comprehensio

2010
Symptoms of schizophrenia and neurocognitive test performance.
    Journal of clinical psychology, 2002, Volume: 58, Issue:7

    Topics: Adolescent; Adult; Antipsychotic Agents; Chlorpromazine; Cognition Disorders; Female; Follow-Up Stud

2002
Altered hemispheric asymmetry and positive symptoms in schizophrenia: equivalent current dipole of auditory mismatch negativity.
    Schizophrenia research, 2003, Feb-01, Volume: 59, Issue:2-3

    Topics: Adult; Antipsychotic Agents; Auditory Perceptual Disorders; Chlorpromazine; Cognition Disorders; Ele

2003
Prefrontal cortex dysfunction mediates deficits in working memory and prepotent responding in schizophrenia.
    Biological psychiatry, 2003, Jan-01, Volume: 53, Issue:1

    Topics: Adult; Antipsychotic Agents; Chlorpromazine; Cognition Disorders; Delayed-Action Preparations; Femal

2003
Selective, sustained, and shift in attention in patients with diagnoses of schizophrenia.
    Perceptual and motor skills, 2002, Volume: 95, Issue:3 Pt 2

    Topics: Adolescent; Adult; Antipsychotic Agents; Attention; Chlorpromazine; Cognition Disorders; Diagnostic

2002
Cognitive impairment in euthymic bipolar patients: implications for clinical and functional outcome.
    Bipolar disorders, 2004, Volume: 6, Issue:3

    Topics: Adult; Anticonvulsants; Antipsychotic Agents; Chlorpromazine; Cognition Disorders; Dysthymic Disorde

2004
Social cognitive bias and neurocognitive deficit in paranoid symptoms: evidence for an interaction effect and changes during treatment.
    Schizophrenia research, 2004, Dec-01, Volume: 71, Issue:2-3

    Topics: Adolescent; Adult; Aged; Antipsychotic Agents; Brief Psychiatric Rating Scale; Chlorpromazine; Cogni

2004
Early treatment-induced improvement of negative symptoms predicts cognitive functioning in treatment-naive first episode schizophrenia: a 2-year followup.
    Schizophrenia bulletin, 2004, Volume: 30, Issue:4

    Topics: Adolescent; Adult; Antipsychotic Agents; Chlorpromazine; Cognition Disorders; Diagnostic and Statist

2004
A longitudinal study of learning potential and rehabilitation outcome in schizophrenia.
    Psychiatric services (Washington, D.C.), 2008, Volume: 59, Issue:3

    Topics: Adolescent; Adult; Aged; Antipsychotic Agents; Chlorpromazine; Cognition Disorders; Diagnostic and S

2008
Neuroleptic malignant syndrome and catatonia in a patient with dementia.
    The Australian and New Zealand journal of psychiatry, 2008, Volume: 42, Issue:6

    Topics: Aged; Anti-Anxiety Agents; Antipsychotic Agents; Benzodiazepines; Catatonia; Chlorpromazine; Choline

2008
Diagnosis and treatment of Huntington's disease.
    Comprehensive therapy, 1981, Volume: 7, Issue:4

    Topics: Affective Symptoms; Amitriptyline; Chlorpromazine; Cognition Disorders; Counseling; Deglutition Diso

1981
Specific cognitive flexibility rehabilitation in schizophrenia.
    Psychological medicine, 1993, Volume: 23, Issue:1

    Topics: Adult; Antipsychotic Agents; Brain Diseases; Chlorpromazine; Cognition Disorders; Cognitive Behavior

1993
Molecular forms of somatostatin-like immunoreactivity in the cerebrospinal fluid of patients with senile dementia of the Alzheimer type.
    Biological psychiatry, 1997, Jun-01, Volume: 41, Issue:11

    Topics: Aged; Alzheimer Disease; Antipsychotic Agents; Chlorpromazine; Chromatography, High Pressure Liquid;

1997
How do early stages of information processing influence social skills in patients with schizophrenia?
    Schizophrenia research, 1999, Feb-15, Volume: 35, Issue:3

    Topics: Adult; Antipsychotic Agents; Chlorpromazine; Cognition Disorders; Dose-Response Relationship, Drug;

1999
Cognitive deficits and psychopathology in institutionalized versus community-dwelling elderly schizophrenia patients.
    Journal of geriatric psychiatry and neurology, 1999,Spring, Volume: 12, Issue:1

    Topics: Aged; Antipsychotic Agents; Basal Ganglia Diseases; Chlorpromazine; Chronic Disease; Cognition Disor

1999
Neuropsychological and conditioned blocking performance in patients with schizophrenia: assessment of the contribution of neuroleptic dose, serum levels and dopamine D2-receptor occupancy.
    Behavioural pharmacology, 2000, Volume: 11, Issue:3-4

    Topics: Adult; Antipsychotic Agents; Attention; Case-Control Studies; Chlorpromazine; Cognition Disorders; C

2000
Butyrylcholinesterase and cognitive function.
    International psychogeriatrics, 2001, Volume: 13, Issue:4

    Topics: Adult; Brain; Butyrylcholinesterase; Chlorpromazine; Cholinergic Antagonists; Cognition Disorders; D

2001
Cognitive abnormality in schizophrenia: a dual-process model.
    Biological psychiatry, 1979, Volume: 14, Issue:1

    Topics: Adolescent; Adult; Arousal; Attention; Chlorpromazine; Cognition Disorders; Color Perception; Concep

1979
Schizophrenia with good and poor outcome. I: Early clinical features, response to neuroleptics and signs of organic dysfunction.
    The British journal of psychiatry : the journal of mental science, 1985, Volume: 146

    Topics: Adult; Antiparkinson Agents; Antipsychotic Agents; Brain; Chlorpromazine; Cognition Disorders; Femal

1985
Toxic "ictal" confusion in middle age: treatment with benzodiazepines.
    Journal of neurology, neurosurgery, and psychiatry, 1985, Volume: 48, Issue:5

    Topics: Adult; Benzodiazepinones; Chlorpromazine; Cimetidine; Clonazepam; Cognition Disorders; Confusion; Di

1985
Serum cortisol in chronic schizophrenia. A study of the adrenocortical response to intravenously administered insulin and ACTH.
    Acta psychiatrica Scandinavica, 1971, Volume: 47, Issue:1

    Topics: Adrenal Glands; Adrenocorticotropic Hormone; Age Factors; Aged; Amitriptyline; Blood Glucose; Chlorp

1971
Age-sex differences in response to antidepressant drugs.
    The Journal of nervous and mental disease, 1974, Volume: 159, Issue:2

    Topics: Adjustment Disorders; Adolescent; Adult; Age Factors; Aged; Antidepressive Agents; Anxiety; Chlorpro

1974
A 5-year follow-up study of 91 hyperactive school children.
    Journal of the American Academy of Child Psychiatry, 1972, Volume: 11, Issue:3

    Topics: Adolescent; Child; Chlorpromazine; Cognition Disorders; Dextroamphetamine; Female; Follow-Up Studies

1972
[On the results of treatment and complications during the use of haloperidol in patients with long-term schizophrenia].
    Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1969, Volume: 69, Issue:5

    Topics: Adult; Blood Pressure; Cardiovascular Diseases; Catatonia; Chlorpromazine; Cognition Disorders; Hall

1969
Organic psychosis.
    British medical journal, 1968, Nov-23, Volume: 4, Issue:5629

    Topics: Acute Disease; Affective Symptoms; Bender-Gestalt Test; Chlordiazepoxide; Chlorpromazine; Chronic Di

1968
Temporal lobe "spike focus" associated with confusion, complete amnesia and fugues in a paranoid schizophrenic.
    The Psychiatric quarterly, 1968, Volume: 42, Issue:4

    Topics: Adult; Amnesia; Chlorpromazine; Cognition Disorders; Dissociative Disorders; Electroencephalography;

1968
Drug withdrawal in male and female chronic schizophrenics.
    The British journal of psychiatry : the journal of mental science, 1969, Volume: 115, Issue:525

    Topics: Chlorpromazine; Chronic Disease; Cognition Disorders; Female; Humans; Male; Paranoid Disorders; Phen

1969
SKF 14336 versus schizophrenia.
    Diseases of the nervous system, 1969, Volume: 30, Issue:6

    Topics: Acridines; Adult; Chlorpromazine; Cognition Disorders; Female; Humans; Male; Middle Aged; Perceptual

1969