chlorpromazine has been researched along with Cholera in 11 studies
Chlorpromazine: The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking DOPAMINE RECEPTORS. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the treatment of intractable hiccup.
chlorpromazine : A substituted phenothiazine in which the ring nitrogen at position 10 is attached to C-3 of an N,N-dimethylpropanamine moiety.
Cholera: An acute diarrheal disease endemic in India and Southeast Asia whose causative agent is VIBRIO CHOLERAE. This condition can lead to severe dehydration in a matter of hours unless quickly treated.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A randomised controlled trial was conducted to investigate the ability of chlorpromazine to reduce intestinal secretion in cholera." | 9.05 | Controlled trial of chlorpromazine as antisecretory agent in patients with cholera hydrated intravenously. ( Greenough, WB; Holmgren, J; Kirkwood, B; Rabbani, GH, 1982) |
| "Four hundred and ten patients with severe watery diarrhea; including 316 patients with cholera, were studied in a double-blind, randomized, placebo controlled trial to determine if chlorpromazine (1 mg/kg) would be useful in the management of such patients." | 9.05 | The use of chlorpromazine in the treatment of cholera and other severe acute watery diarrheal diseases. ( Bardhan, PK; Holmgren, J; Islam, MR; Rabbani, GH; Sack, DA, 1982) |
| "Because chlorpromazine inhibited cholera-toxin-stimulated intestinal adenylate cyclase and fluid secretion in laboratory animals its ability to reduce fluid-loss in human cholera was investigated." | 9.04 | Chlorpromazine reduces fluid-loss in cholera. ( Greenough, WB; Holmgren, J; Lönnroth, I; Rabbani, GH, 1979) |
| "The effect of chlorpromazine on cholera-toxin-induced intestinal fluid secretion (experimental cholera) has been tested in vivo in the mouse." | 7.65 | Chlorpromazine inhibits cholera toxin-induced intestinal hypersecretion. ( Holmgren, J; Lange, S; Lönnroth, I, 1977) |
| "A randomised controlled trial was conducted to investigate the ability of chlorpromazine to reduce intestinal secretion in cholera." | 5.05 | Controlled trial of chlorpromazine as antisecretory agent in patients with cholera hydrated intravenously. ( Greenough, WB; Holmgren, J; Kirkwood, B; Rabbani, GH, 1982) |
| "Four hundred and ten patients with severe watery diarrhea; including 316 patients with cholera, were studied in a double-blind, randomized, placebo controlled trial to determine if chlorpromazine (1 mg/kg) would be useful in the management of such patients." | 5.05 | The use of chlorpromazine in the treatment of cholera and other severe acute watery diarrheal diseases. ( Bardhan, PK; Holmgren, J; Islam, MR; Rabbani, GH; Sack, DA, 1982) |
| "Because chlorpromazine inhibited cholera-toxin-stimulated intestinal adenylate cyclase and fluid secretion in laboratory animals its ability to reduce fluid-loss in human cholera was investigated." | 5.04 | Chlorpromazine reduces fluid-loss in cholera. ( Greenough, WB; Holmgren, J; Lönnroth, I; Rabbani, GH, 1979) |
| "The effect of chlorpromazine on cholera-toxin-induced intestinal fluid secretion (experimental cholera) has been tested in vivo in the mouse." | 3.65 | Chlorpromazine inhibits cholera toxin-induced intestinal hypersecretion. ( Holmgren, J; Lange, S; Lönnroth, I, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| GALLUT, J | 1 |
| Hughes, S | 1 |
| Gyr, K | 1 |
| Rabbani, GH | 3 |
| Greenough, WB | 2 |
| Holmgren, J | 5 |
| Kirkwood, B | 1 |
| Hopkin, DA | 1 |
| Islam, MR | 1 |
| Sack, DA | 1 |
| Bardhan, PK | 1 |
| Black, RE | 1 |
| Lönnroth, I | 2 |
| Lange, S | 1 |
| Ostberg, S | 1 |
2 reviews available for chlorpromazine and Cholera
| Article | Year |
|---|---|
Toxin receptors and their pathogenetic significance.
Topics: Adenylyl Cyclases; Animals; Chlorpromazine; Cholera; Cholera Toxin; Cholera Vaccines; Combined Modal | 1984 |
The prophylaxis and therapy of secretory diarrhea.
Topics: Anti-Infective Agents, Urinary; Antidiarrheals; Chloramphenicol; Chlorpromazine; Cholera; Diarrhea; | 1982 |
3 trials available for chlorpromazine and Cholera
| Article | Year |
|---|---|
Controlled trial of chlorpromazine as antisecretory agent in patients with cholera hydrated intravenously.
Topics: Adult; Chlorpromazine; Cholera; Clinical Trials as Topic; Diarrhea; Fluid Therapy; Humans; Intestina | 1982 |
The use of chlorpromazine in the treatment of cholera and other severe acute watery diarrheal diseases.
Topics: Acute Disease; Adult; Child; Child, Preschool; Chlorpromazine; Cholera; Clinical Trials as Topic; Di | 1982 |
Chlorpromazine reduces fluid-loss in cholera.
Topics: Administration, Oral; Adult; Chlorpromazine; Cholera; Dehydration; Diarrhea; Drug Evaluation; Humans | 1979 |
6 other studies available for chlorpromazine and Cholera
| Article | Year |
|---|---|
[Action of chlorpromazine on experimental poisoning and infection of the mouse by the choleric toxin and vibrions].
Topics: Animals; Antitoxins; Chlorpromazine; Cholera; Mice; Toxins, Biological | 1960 |
Acute secretory diarrheas. Current concepts in pathogenesis and treatment.
Topics: Acute Disease; Anti-Bacterial Agents; Chlorpromazine; Cholera; Cholera Toxin; Diarrhea; Escherichia | 1983 |
Controlled trial of chlorpromazine as antisecretory agent in patients with cholera hydrated intravenously.
Topics: Animals; Bacterial Toxins; Chlorpromazine; Cholera; Dogs; Humans; Reticular Formation | 1982 |
Pathogenesis and prevention of cholera.
Topics: Animals; Chlorpromazine; Cholera; Cholera Toxin; Cholera Vaccines; G(M1) Ganglioside; Humans; Rats; | 1982 |
Chlorpromazine inhibits cholera toxin-induced intestinal hypersecretion.
Topics: Animals; Antitoxins; Chlorpromazine; Cholera; Cyclic AMP; Female; Injections, Intramuscular; Intesti | 1977 |
[Cholera---the tip of an iceberg].
Topics: Chlorpromazine; Cholera; Cholera Toxin; Cholera Vaccines; Humans | 1979 |