chlorpromazine has been researched along with Cancer of Lung in 14 studies
Chlorpromazine: The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking DOPAMINE RECEPTORS. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the treatment of intractable hiccup.
chlorpromazine : A substituted phenothiazine in which the ring nitrogen at position 10 is attached to C-3 of an N,N-dimethylpropanamine moiety.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The therapeutic usefulness of chlorpromazine (CPZ) and caffeine (CAF) in combination with selected nitrosoureas was investigated in mice bearing L1210 leukemia, Lewis lung carcinoma, and B16 melanoma." | 3.66 | Therapeutic potentiation of nitrosoureas using chlorpromazine and caffeine in the treatment of murine tumors. ( Dykes, DJ; Laster, WR; Rose, WC; Schabel, FM; Trader, MW, 1978) |
| "Chlorpromazine is a potent and specific inhibitor of the mitotic kinesin KSP/Eg5 and inhibits tumor cell proliferation through mitotic arrest and accumulation of monopolar spindles." | 1.34 | The novel combination of chlorpromazine and pentamidine exerts synergistic antiproliferative effects through dual mitotic action. ( Avery, W; Borisy, AA; Elliott, P; Johansen, L; Keegan, M; Keith, CT; Lee, MS; Wilson, A; Zhang, Y, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (64.29) | 18.7374 |
| 1990's | 1 (7.14) | 18.2507 |
| 2000's | 1 (7.14) | 29.6817 |
| 2010's | 1 (7.14) | 24.3611 |
| 2020's | 2 (14.29) | 2.80 |
| Authors | Studies |
|---|---|
| Xu, F | 1 |
| Xi, H | 1 |
| Liao, M | 1 |
| Zhang, Y | 3 |
| Ma, H | 1 |
| Wu, M | 1 |
| Xue, Q | 1 |
| Sun, H | 1 |
| Xia, Y | 1 |
| Fujiwara, R | 1 |
| Taniguchi, Y | 1 |
| Rai, S | 1 |
| Iwata, Y | 1 |
| Fujii, A | 1 |
| Fujimoto, K | 1 |
| Kumode, T | 1 |
| Serizawa, K | 1 |
| Morita, Y | 1 |
| Espinoza, JL | 1 |
| Tanaka, H | 1 |
| Hanamoto, H | 1 |
| Matsumura, I | 1 |
| de Arriba Méndez, JJ | 1 |
| AMATRUDA, TT | 1 |
| MULROW, PJ | 1 |
| GALLAGHER, JC | 1 |
| SAWYER, WH | 1 |
| Lee, MS | 1 |
| Johansen, L | 1 |
| Wilson, A | 1 |
| Keegan, M | 1 |
| Avery, W | 1 |
| Elliott, P | 1 |
| Borisy, AA | 1 |
| Keith, CT | 1 |
| Kakinuma, R | 1 |
| Nishiwaki, Y | 1 |
| Yano, H | 1 |
| Kajita, M | 1 |
| Nishiyama, H | 1 |
| Kitaya, T | 1 |
| Matsuyama, T | 1 |
| Fukushima, J | 1 |
| Zhu, YL | 1 |
| Zhu, YJ | 1 |
| Guo, ZJ | 1 |
| Joasson, JM | 1 |
| Saugier, B | 1 |
| Brune, J | 1 |
| Galy, P | 1 |
| Rose, WC | 1 |
| Trader, MW | 1 |
| Dykes, DJ | 1 |
| Laster, WR | 1 |
| Schabel, FM | 1 |
| Balanski, RM | 1 |
| Dzhioev, FK | 1 |
| Aasebø, U | 2 |
| Slørdal, L | 1 |
| Prytz, PS | 1 |
| Aarbakke, J | 1 |
| Himsel, CA | 1 |
| Richardson, RC | 1 |
| Craig, JA | 1 |
| Myhr, K | 1 |
| Homburger, F | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Repurposing the Antipsychotic Drug Chlorpromazine as a Therapeutic Agent in the Combined Treatment of Newly Diagnosed Glioblastoma Multiforme[NCT04224441] | Phase 2 | 41 participants (Anticipated) | Interventional | 2019-12-15 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for chlorpromazine and Cancer of Lung
| Article | Year |
|---|---|
[Dexamethasone-induced hiccup].
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Chlorpromazine; Dex | 2016 |
1 trial available for chlorpromazine and Cancer of Lung
| Article | Year |
|---|---|
High-dose metoclopramide and chlorpromazine in the treatment of cisplatin-induced emesis.
Topics: Adult; Aged; Chlorpromazine; Cisplatin; Clinical Trials as Topic; Etoposide; Female; Humans; Kinetic | 1987 |
12 other studies available for chlorpromazine and Cancer of Lung
| Article | Year |
|---|---|
Repurposed antipsychotic chlorpromazine inhibits colorectal cancer and pulmonary metastasis by inducing G2/M cell cycle arrest, apoptosis, and autophagy.
Topics: Animals; Antineoplastic Agents; Antipsychotic Agents; Apoptosis; Autophagy; Cell Cycle; Cell Cycle C | 2022 |
Chlorpromazine cooperatively induces apoptosis with tyrosine kinase inhibitors in EGFR-mutated lung cancer cell lines and restores the sensitivity to gefitinib in T790M-harboring resistant cells.
Topics: Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Chlorpromazine; Drug Resistance, Neopla | 2022 |
CARCINOMA OF THE LUNG WITH INAPPROPRIATE ANTIDIURESIS. DEMONSTRATION OF ANTIDIURETIC-HORMONE-LIKE ACTIVITY IN TUMOR EXTRACT.
Topics: Autonomic Nerve Block; Carcinoma; Chlorpromazine; Geriatrics; Histocytochemistry; Humans; Kidney Dis | 1963 |
The novel combination of chlorpromazine and pentamidine exerts synergistic antiproliferative effects through dual mitotic action.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Antiprotozoal Agents; Antipsychotic Agents; | 2007 |
[Experience with psychotropic agents Pyrethia and Contomin in the terminal care of lung cancer patients].
Topics: Adult; Aged; Anxiety; Chlorpromazine; Circadian Rhythm; Drug Therapy, Combination; Fear; Female; Hum | 1984 |
[Effects of calcium blockers and calmodulin inhibitors on the proliferation of fibroblast in alveolar macrophage condition medium].
Topics: Bronchoalveolar Lavage Fluid; Carcinoma, Bronchogenic; Cell Division; Chlorpromazine; Culture Media, | 1993 |
[Small-celled lung cancer. Results of therapy].
Topics: Adult; Aged; Antineoplastic Agents; Brain Neoplasms; Chlorpromazine; Doxorubicin; Drug Therapy, Comb | 1979 |
Therapeutic potentiation of nitrosoureas using chlorpromazine and caffeine in the treatment of murine tumors.
Topics: Animals; Caffeine; Carmustine; Chlorpromazine; Drug Synergism; Drug Therapy, Combination; Female; Le | 1978 |
[The relationship between the activity of microsomal enzymes and pulmonary carcinogenesis in mice].
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adenoma; Animals; Antineoplastic Agents; Barbital; Chlorpromazine; | 1976 |
Cisplatin chemotherapy for metastatic squamous cell carcinoma in two dogs.
Topics: Animals; Carcinoma, Squamous Cell; Chlorpromazine; Cisplatin; Dog Diseases; Dogs; Foot Diseases; Lun | 1986 |
[Cisplatin drug therapy. Antiemetic treatment. Experiences with the use of high-dose metoclopramide combined with chlopromazine and prochlorperazine].
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Chlorpromazine; Cisplatin; Dose-Response Relat | 1985 |
Chemical carcinogenesis in Syrian hamsters.
Topics: Adenocarcinoma, Bronchiolo-Alveolar; Animals; Azo Compounds; Benz(a)Anthracenes; Benzopyrenes; Bronc | 1972 |