chlorpromazine has been researched along with Breast Neoplasms in 18 studies
Chlorpromazine: The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking DOPAMINE RECEPTORS. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the treatment of intractable hiccup.
chlorpromazine : A substituted phenothiazine in which the ring nitrogen at position 10 is attached to C-3 of an N,N-dimethylpropanamine moiety.
Breast Neoplasms: Tumors or cancer of the human BREAST.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In this study, we identified that the antipsychotic chlorpromazine (CPZ) exhibited potent anti-breast cancer and anti-CSC capabilities." | 7.91 | The antipsychotic chlorpromazine suppresses YAP signaling, stemness properties, and drug resistance in breast cancer cells. ( Cheng, HW; Chung, CH; Lee, WY; Lin, CW; Mi, FL; Yang, CE, 2019) |
| "Thioridazine is an antipsychotic that has been shown to induce cell death and inhibit self-renewal in a broad spectrum of cancer cells." | 5.48 | Thioridazine inhibits self-renewal in breast cancer cells via DRD2-dependent STAT3 inhibition, but induces a G ( Baldwin, AS; Fan, C; Tegowski, M, 2018) |
| "Tamoxifen resistance is a major clinical problem in the treatment of estrogen receptor alpha-positive breast tumors." | 5.35 | The antipsychotic drug chlorpromazine enhances the cytotoxic effect of tamoxifen in tamoxifen-sensitive and tamoxifen-resistant human breast cancer cells. ( Bennetzen, MV; Clausen, MP; Guerra, B; Lykkesfeldt, AE; Mouritsen, OG; Yde, CW, 2009) |
| " In this study, we identified that the antipsychotic chlorpromazine (CPZ) exhibited potent anti-breast cancer and anti-CSC capabilities." | 3.91 | The antipsychotic chlorpromazine suppresses YAP signaling, stemness properties, and drug resistance in breast cancer cells. ( Cheng, HW; Chung, CH; Lee, WY; Lin, CW; Mi, FL; Yang, CE, 2019) |
| "Thioridazine is an antipsychotic that has been shown to induce cell death and inhibit self-renewal in a broad spectrum of cancer cells." | 1.48 | Thioridazine inhibits self-renewal in breast cancer cells via DRD2-dependent STAT3 inhibition, but induces a G ( Baldwin, AS; Fan, C; Tegowski, M, 2018) |
| "Tamoxifen resistance is a major clinical problem in the treatment of estrogen receptor alpha-positive breast tumors." | 1.35 | The antipsychotic drug chlorpromazine enhances the cytotoxic effect of tamoxifen in tamoxifen-sensitive and tamoxifen-resistant human breast cancer cells. ( Bennetzen, MV; Clausen, MP; Guerra, B; Lykkesfeldt, AE; Mouritsen, OG; Yde, CW, 2009) |
| "Selective destruction of cancerous tissue can be achieved by modulating energy metabolism in malignant cells." | 1.29 | Successful cancer therapy with promethazine: the rationale. ( Jones, GR, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (50.00) | 18.7374 |
| 1990's | 1 (5.56) | 18.2507 |
| 2000's | 3 (16.67) | 29.6817 |
| 2010's | 4 (22.22) | 24.3611 |
| 2020's | 1 (5.56) | 2.80 |
| Authors | Studies |
|---|---|
| Aliabadi, HM | 1 |
| Bahadur K C, R | 1 |
| Bousoik, E | 1 |
| Hall, R | 1 |
| Barbarino, A | 1 |
| Thapa, B | 1 |
| Coyle, M | 1 |
| Mahdipoor, P | 1 |
| Uludağ, H | 1 |
| Guo, P | 1 |
| Liu, D | 1 |
| Subramanyam, K | 1 |
| Wang, B | 1 |
| Yang, J | 1 |
| Huang, J | 1 |
| Auguste, DT | 1 |
| Moses, MA | 1 |
| Tegowski, M | 1 |
| Fan, C | 1 |
| Baldwin, AS | 1 |
| Xu, W | 1 |
| Bae, EJ | 1 |
| Lee, MK | 1 |
| Yang, CE | 1 |
| Lee, WY | 1 |
| Cheng, HW | 1 |
| Chung, CH | 1 |
| Mi, FL | 1 |
| Lin, CW | 1 |
| Barr, DJ | 1 |
| Ostermeyer-Fay, AG | 1 |
| Matundan, RA | 1 |
| Brown, DA | 1 |
| Yde, CW | 1 |
| Clausen, MP | 1 |
| Bennetzen, MV | 1 |
| Lykkesfeldt, AE | 1 |
| Mouritsen, OG | 1 |
| Guerra, B | 1 |
| GUIMARAES, JP | 1 |
| Greco, F | 1 |
| Vicent, MJ | 1 |
| Gee, S | 1 |
| Jones, AT | 1 |
| Gee, J | 1 |
| Nicholson, RI | 1 |
| Duncan, R | 1 |
| Jones, GR | 1 |
| DiNicola, AF | 1 |
| Sicard, RE | 1 |
| Wilson, RG | 2 |
| Hamilton, JR | 1 |
| Boyd, WD | 1 |
| Forrest, AP | 2 |
| Cole, EN | 1 |
| Boyns, AR | 2 |
| Griffiths, K | 1 |
| Santen, RJ | 1 |
| Wells, SA | 1 |
| Cohn, N | 1 |
| Demers, LM | 1 |
| Misbin, RI | 1 |
| Foltz, EL | 1 |
| Spellacy, WN | 1 |
| Buhi, WC | 1 |
| Birk, SA | 1 |
| Greene, PG | 1 |
| Seime, RJ | 1 |
| Lister, RC | 1 |
| Underwood, LE | 1 |
| Marshall, RN | 1 |
| Friesen, HG | 1 |
| Van Wyk, JJ | 1 |
| Frantz, AG | 1 |
| Suh, HK | 1 |
| Cole, BN | 1 |
1 review available for chlorpromazine and Breast Neoplasms
| Article | Year |
|---|---|
L-DOPA and the control of prolactin secretion.
Topics: Adenoma, Chromophobe; Animals; Aromatic Amino Acid Decarboxylase Inhibitors; Brain Diseases; Breast | 1974 |
17 other studies available for chlorpromazine and Breast Neoplasms
| Article | Year |
|---|---|
A systematic comparison of lipopolymers for siRNA delivery to multiple breast cancer cell lines: In vitro studies.
Topics: Breast Neoplasms; Cell Line, Tumor; Chlorpromazine; Drug Carriers; Endocytosis; Fatty Acids; Gene Si | 2020 |
Nanoparticle elasticity directs tumor uptake.
Topics: Animals; Breast Neoplasms; Cell Line; Cell Line, Tumor; Chlorpromazine; Elastic Modulus; Endocytosis | 2018 |
Thioridazine inhibits self-renewal in breast cancer cells via DRD2-dependent STAT3 inhibition, but induces a G
Topics: Apoptosis; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Self Renewal; Cell Survival; | 2018 |
Enhanced anticancer activity and intracellular uptake of paclitaxel-containing solid lipid nanoparticles in multidrug-resistant breast cancer cells.
Topics: Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Breast Neop | 2018 |
The antipsychotic chlorpromazine suppresses YAP signaling, stemness properties, and drug resistance in breast cancer cells.
Topics: Antipsychotic Agents; Breast Neoplasms; Cell Cycle Proteins; Cell Line, Tumor; Cell Survival; Chlorp | 2019 |
Clathrin-independent endocytosis of ErbB2 in geldanamycin-treated human breast cancer cells.
Topics: ADP-Ribosylation Factor 6; ADP-Ribosylation Factors; Bacterial Toxins; Benzoquinones; Biomarkers; Br | 2008 |
The antipsychotic drug chlorpromazine enhances the cytotoxic effect of tamoxifen in tamoxifen-sensitive and tamoxifen-resistant human breast cancer cells.
Topics: Binding, Competitive; Breast Neoplasms; Calorimetry, Differential Scanning; Cell Death; Cell Line, T | 2009 |
A note on the effects on the growth of tumors of a combined treatment with chlorpromazine and a "mitotic poison".
Topics: Adenocarcinoma; Animals; Breast Neoplasms; Chlorpromazine; Colchicine; Humans; Mammary Neoplasms, An | 1963 |
Investigating the mechanism of enhanced cytotoxicity of HPMA copolymer-Dox-AGM in breast cancer cells.
Topics: Aminoglutethimide; Antineoplastic Agents; Apoptosis; beta-Cyclodextrins; Breast Neoplasms; Cell Surv | 2007 |
Successful cancer therapy with promethazine: the rationale.
Topics: Antineoplastic Agents; Breast Neoplasms; Chlorpromazine; Cyclophosphamide; Female; Humans; Male; Neo | 1996 |
Letter: Orthostatic hypotension, lactation, and breast cancer secondary to chlorpromazine administration.
Topics: Breast Neoplasms; Chlorpromazine; Female; Growth Hormone; Humans; Hypotension, Orthostatic; Lactatio | 1975 |
The effect of long term phenothiazine therapy on plasma prolactin.
Topics: Aged; Antipsychotic Agents; Breast; Breast Neoplasms; Chlorpromazine; Female; Galactorrhea; Growth H | 1975 |
Compensatory increase in TSH secretion without effect on prolactin secretion in patients treated with aminoglutethimide.
Topics: Adult; Aminoglutethimide; Breast Neoplasms; Chlorpromazine; Female; Follicle Stimulating Hormone; Hu | 1977 |
Stimulated plasma prolactin levels in women using medroxyprogesterone acetate or an intrauterine device for contraception.
Topics: Adult; Animals; Breast Neoplasms; Chlorpromazine; Dogs; Female; Haplorhini; Humans; Intrauterine Dev | 1975 |
Stimulus control of anticipatory nausea in cancer chemotherapy.
Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chlorpromazine; Combined Modality | 1987 |
Evidence for a direct effect of thyrotropin-releasing hormone (TRH) on prolactin release in humans.
Topics: Adrenal Insufficiency; Aged; Binding, Competitive; Breast Neoplasms; Chlorpromazine; Cortisone; Fema | 1974 |
Proceedings: Chlorpromazine stimulation of prolactin secretion: a test of pituitary function.
Topics: Breast Neoplasms; Chlorpromazine; Female; Humans; Pituitary Function Tests; Pituitary Gland; Prolact | 1974 |