chlorpromazine has been researched along with Brain Neoplasms in 10 studies
Chlorpromazine: The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking DOPAMINE RECEPTORS. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the treatment of intractable hiccup.
chlorpromazine : A substituted phenothiazine in which the ring nitrogen at position 10 is attached to C-3 of an N,N-dimethylpropanamine moiety.
Brain Neoplasms: Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.
| Excerpt | Relevance | Reference |
|---|---|---|
| "On these bases, and assisted by the information on the well-established chlorpromazine toxicity and dosage in humans, we designed a Phase II clinical trial involving the combination of chlorpromazine with the standard treatment, temozolomide, in the adjuvant phase of the therapeutic protocol." | 5.56 | Repurposing chlorpromazine in the treatment of glioblastoma multiforme: analysis of literature and forthcoming steps. ( Abbruzzese, C; Matteoni, S; Paggi, MG; Persico, M; Villani, V, 2020) |
| "Chlorpromazine is a United States Food and Drug Administration-approved phenothiazine widely used as a psychotropic in clinical practice." | 5.46 | Repositioning chlorpromazine for treating chemoresistant glioma through the inhibition of cytochrome c oxidase bearing the COX4-1 regulatory subunit. ( Griguer, CE; Langford, C; Oliva, CR; Suto, MJ; Zhang, W, 2017) |
| "The effects of chlorpromazine and related compounds upon soluble and particulate Ins(1,4,5)P3-5-phosphatase were investigated in rat GH3 pituitary and in human IMR-32 neuroblastoma cells." | 3.68 | Inhibition of inositol-1,4,5-trisphosphate-5-phosphatase by chlorpromazine and related compounds. ( Brännström, G; Fowler, CJ, 1992) |
| "On these bases, and assisted by the information on the well-established chlorpromazine toxicity and dosage in humans, we designed a Phase II clinical trial involving the combination of chlorpromazine with the standard treatment, temozolomide, in the adjuvant phase of the therapeutic protocol." | 1.56 | Repurposing chlorpromazine in the treatment of glioblastoma multiforme: analysis of literature and forthcoming steps. ( Abbruzzese, C; Matteoni, S; Paggi, MG; Persico, M; Villani, V, 2020) |
| "Chlorpromazine is a United States Food and Drug Administration-approved phenothiazine widely used as a psychotropic in clinical practice." | 1.46 | Repositioning chlorpromazine for treating chemoresistant glioma through the inhibition of cytochrome c oxidase bearing the COX4-1 regulatory subunit. ( Griguer, CE; Langford, C; Oliva, CR; Suto, MJ; Zhang, W, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (40.00) | 18.7374 |
| 1990's | 2 (20.00) | 18.2507 |
| 2000's | 1 (10.00) | 29.6817 |
| 2010's | 1 (10.00) | 24.3611 |
| 2020's | 2 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Abbruzzese, C | 1 |
| Matteoni, S | 1 |
| Persico, M | 1 |
| Villani, V | 1 |
| Paggi, MG | 1 |
| Jeng, F | 1 |
| Reynolds, A | 1 |
| Oliva, CR | 1 |
| Zhang, W | 1 |
| Langford, C | 1 |
| Suto, MJ | 1 |
| Griguer, CE | 1 |
| SOURS, JA | 1 |
| Nguyen, JD | 1 |
| Dunleavy, K | 1 |
| Carrasquillo, JA | 1 |
| Chen, CC | 1 |
| Aas, AT | 1 |
| Brun, A | 1 |
| Pero, RW | 1 |
| Salford, LG | 1 |
| Joasson, JM | 1 |
| Saugier, B | 1 |
| Brune, J | 1 |
| Galy, P | 1 |
| Borshchagovskiĭ, ML | 1 |
| Dubikaitis, IuV | 1 |
| Fowler, CJ | 1 |
| Brännström, G | 1 |
| Costin, G | 1 |
| Fefferman, RA | 1 |
| Kogut, MD | 1 |
10 other studies available for chlorpromazine and Brain Neoplasms
| Article | Year |
|---|---|
Repurposing chlorpromazine in the treatment of glioblastoma multiforme: analysis of literature and forthcoming steps.
Topics: Brain Neoplasms; Chlorpromazine; Drug Repositioning; Female; Glioblastoma; Humans; Male | 2020 |
Retrobulbar chlorpromazine injection in a child with gliosarcoma invasion into the orbits.
Topics: Antipsychotic Agents; Blindness; Brain Neoplasms; Chemoradiotherapy; Child; Chlorpromazine; Eye Pain | 2020 |
Repositioning chlorpromazine for treating chemoresistant glioma through the inhibition of cytochrome c oxidase bearing the COX4-1 regulatory subunit.
Topics: Animals; Antineoplastic Agents, Alkylating; Antipsychotic Agents; Brain Neoplasms; Cattle; Cell Line | 2017 |
NEUROPSYCHIATRIC FINDINGS IN INTERNAL CAROTID ARTERY OCCLUSIVE DISEASE WITH CEREBROVASCULAR DAMAGE. REPORT OF NINE CASES AND REVIEW OF THE LITERATURE.
Topics: Anticoagulants; Brain Neoplasms; Carotid Artery Diseases; Carotid Artery Thrombosis; Carotid Artery, | 1964 |
F-18 fluorodeoxyglucose positron emission tomographic imaging in a patient with persistent hiccups.
Topics: Baclofen; Brain; Brain Neoplasms; Chlorpromazine; Diagnosis, Differential; Fluorodeoxyglucose F18; H | 2004 |
Chlorpromazine in combination with nitrosourea inhibits experimental glioma growth.
Topics: Animals; Body Weight; Brain Neoplasms; Calmodulin; Carmustine; Cell Division; Chlorpromazine; Drug S | 1994 |
[Small-celled lung cancer. Results of therapy].
Topics: Adult; Aged; Antineoplastic Agents; Brain Neoplasms; Chlorpromazine; Doxorubicin; Drug Therapy, Comb | 1979 |
[Clinico-electroencephalographic characteristics of the condition of brain stem systems following surgical and non-surgical brain injury].
Topics: Adult; Amphetamine; Anesthesia, General; Autonomic Nervous System; Brain Injuries; Brain Neoplasms; | 1976 |
Inhibition of inositol-1,4,5-trisphosphate-5-phosphatase by chlorpromazine and related compounds.
Topics: Animals; Antidepressive Agents, Tricyclic; Brain Neoplasms; Cells, Cultured; Chlorpromazine; Fluphen | 1992 |
Hypothalamic gigantism.
Topics: Arginine; Brain Neoplasms; Child, Preschool; Chlorpromazine; Cobalt Isotopes; Dexamethasone; Giganti | 1973 |