chlorpromazine has been researched along with Brain Ischemia in 9 studies
Chlorpromazine: The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking DOPAMINE RECEPTORS. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the treatment of intractable hiccup.
chlorpromazine : A substituted phenothiazine in which the ring nitrogen at position 10 is attached to C-3 of an N,N-dimethylpropanamine moiety.
Brain Ischemia: Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Spinal cord ischemia was obtained by clamping the abdominal aorta caudally to the renal arteries for 30 min, after which it was released and the animals were observed for a period of 48 hrs." | 1.31 | The protective action of chlorpromazine on the spinal cord of rabbits submitted to ischemia and reperfusion is dose-dependent. ( Alves, P; Barbieri-Neto, J; Mazzetto, SA; Sader, AA; Sader, SL; Vanni, JC, 2002) |
| "Chlorpromazine was effective despite reduction of blood pressure, and trifluoperazine did not alter blood pressure." | 1.28 | Phenothiazines reduce ischemic damage to the central nervous system. ( Kochhar, A; Saitoh, T; Zivin, JA, 1989) |
| "The neuroleptic malignant syndrome is a rare but dangerous complication of treatment with neuroleptics." | 1.28 | Neuroleptic malignant syndrome: a case report with post-mortem brain and muscle pathology. ( Dawson, A; Jones, EM, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (44.44) | 18.7374 |
| 1990's | 1 (11.11) | 18.2507 |
| 2000's | 1 (11.11) | 29.6817 |
| 2010's | 3 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Monjas, L | 1 |
| Arce, MP | 1 |
| León, R | 1 |
| Egea, J | 1 |
| Pérez, C | 1 |
| Villarroya, M | 1 |
| López, MG | 1 |
| Gil, C | 1 |
| Conde, S | 1 |
| Rodríguez-Franco, MI | 1 |
| Li, F | 1 |
| Geng, X | 2 |
| Yip, J | 1 |
| Ding, Y | 2 |
| Liu, S | 1 |
| Forreider, B | 1 |
| Xiao, Y | 1 |
| Kong, Q | 1 |
| Ji, X | 1 |
| Sader, AA | 1 |
| Barbieri-Neto, J | 1 |
| Sader, SL | 1 |
| Mazzetto, SA | 1 |
| Alves, P | 1 |
| Vanni, JC | 1 |
| Ishihara, N | 1 |
| Gotoh, F | 1 |
| Seif el Nasr, M | 1 |
| Nuglisch, J | 1 |
| Krieglstein, J | 1 |
| Zivin, JA | 1 |
| Kochhar, A | 1 |
| Saitoh, T | 1 |
| Jones, EM | 1 |
| Dawson, A | 1 |
1 review available for chlorpromazine and Brain Ischemia
| Article | Year |
|---|---|
[Cerebral metabolic activator (author's transl)].
Topics: Adenosine Triphosphate; Animals; Barbiturates; Biogenic Amines; Biotransformation; Brain; Brain Isch | 1979 |
1 trial available for chlorpromazine and Brain Ischemia
| Article | Year |
|---|---|
Cerebral symptoms and blood pressure during parenteral administration of chlorpromazine, dihydralazine and diazoxide. Danish multicenter study on acute severe hypertension.
Topics: Blood Pressure; Brain Diseases; Brain Ischemia; Chlorpromazine; Clinical Trials as Topic; Diazoxide; | 1983 |
7 other studies available for chlorpromazine and Brain Ischemia
| Article | Year |
|---|---|
Enzymatic and solid-phase synthesis of new donepezil-based L- and d-glutamic acid derivatives and their pharmacological evaluation in models related to Alzheimer's disease and cerebral ischemia.
Topics: Alzheimer Disease; Animals; Brain Ischemia; Calcium Channel Blockers; Cholinesterase Inhibitors; Don | 2017 |
Therapeutic Target and Cell-signal Communication of Chlorpromazine and Promethazine in Attenuating Blood-Brain Barrier Disruption after Ischemic Stroke.
Topics: Animals; Blood-Brain Barrier; Brain Ischemia; Chlorpromazine; Male; Promethazine; Rats; Rats, Spragu | 2019 |
Enhanced beneficial effects of mild hypothermia by phenothiazine drugs in stroke therapy.
Topics: Animals; Body Temperature; Brain; Brain Ischemia; Chlorpromazine; Hypothermia, Induced; Male; Motor | 2015 |
The protective action of chlorpromazine on the spinal cord of rabbits submitted to ischemia and reperfusion is dose-dependent.
Topics: Animals; Biopsy, Needle; Brain Ischemia; Chlorpromazine; Disease Models, Animal; Dose-Response Relat | 2002 |
Prevention of ischemia-induced cerebral hypothermia by controlling the environmental temperature.
Topics: Animals; Body Temperature; Body Temperature Regulation; Brain; Brain Ischemia; Chlorpromazine; Disea | 1992 |
Phenothiazines reduce ischemic damage to the central nervous system.
Topics: Animals; Brain Ischemia; Chlorpromazine; Ischemia; Phenothiazines; Rabbits; Spinal Cord; Trifluopera | 1989 |
Neuroleptic malignant syndrome: a case report with post-mortem brain and muscle pathology.
Topics: Aged; Brain; Brain Ischemia; Chlorpromazine; Depressive Disorder; Drug Therapy, Combination; Female; | 1989 |