chlorpromazine has been researched along with Bile Duct Obstruction in 75 studies
Chlorpromazine: The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking DOPAMINE RECEPTORS. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the treatment of intractable hiccup.
chlorpromazine : A substituted phenothiazine in which the ring nitrogen at position 10 is attached to C-3 of an N,N-dimethylpropanamine moiety.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The present work aimed to question as to whether inflammation is a determinant factor in hepatic lesions induced by chlorpromazine (CPZ) using the human HepaRG cell line." | 7.80 | Impact of inflammation on chlorpromazine-induced cytotoxicity and cholestatic features in HepaRG cells. ( Abdel-Razzak, Z; Al-Attrache, H; Antherieu, S; Bachour-El Azzi, P; Guguen-Guillouzo, C; Guillouzo, A; Labbe, G; Lepage, S; Morel, I; Savary, CC; Sharanek, A, 2014) |
| "We describe a 33-yr-old pregnant woman in whom a primary biliary cirrhosis-like syndrome developed after 2 wk of chlorpromazine therapy." | 7.69 | Chlorpromazine-induced vanishing bile duct syndrome leading to biliary cirrhosis. ( Altorfer, J; Flury, R; Greminger, P; Jost, R; Meyenberger, C; Moradpour, D; Schmid, M, 1994) |
| "The present study has demonstrated that tauroursodeoxycholate (TUDC), but not taurocholate, can reverse chlorpromazine (CPZ)-induced cholestasis in the isolated perfused rat liver." | 7.68 | Effects of bile salt infusion on chlorpromazine-induced cholestasis in the isolated perfused rat liver. ( Abernathy, CO; Gillespie, J; Tripodi, MF; Utili, R; Zimmerman, HJ, 1992) |
| "When chlorpromazine hydrochloride was infused at three doses (2." | 5.26 | Effects of chlorpromazine hydrochloride on bile salt synthesis, bile formation and biliary lipid secretion in the rhesus monkey: a model for chlorpromazine-induced cholestasis. ( Carey, MC; Ros, E; Small, DM, 1979) |
| "Chlorpromazine (CPZ) is a neuroleptic drug and prototype compound used to study intrahepatic cholestasis." | 3.91 | Chlorpromazine toxicity is associated with disruption of cell membrane integrity and initiation of a pro-inflammatory response in the HepaRG hepatic cell line. ( Bagnaninchi, P; Brzeszczynska, J; Brzeszczyński, F; Gamal, W; Hayes, P; Kozlowska, A; Martucci, N; Morgan, K; Nelson, L; Plevris, J; Samuel, K; Treskes, P, 2019) |
| " The present work aimed to question as to whether inflammation is a determinant factor in hepatic lesions induced by chlorpromazine (CPZ) using the human HepaRG cell line." | 3.80 | Impact of inflammation on chlorpromazine-induced cytotoxicity and cholestatic features in HepaRG cells. ( Abdel-Razzak, Z; Al-Attrache, H; Antherieu, S; Bachour-El Azzi, P; Guguen-Guillouzo, C; Guillouzo, A; Labbe, G; Lepage, S; Morel, I; Savary, CC; Sharanek, A, 2014) |
| "We describe a 33-yr-old pregnant woman in whom a primary biliary cirrhosis-like syndrome developed after 2 wk of chlorpromazine therapy." | 3.69 | Chlorpromazine-induced vanishing bile duct syndrome leading to biliary cirrhosis. ( Altorfer, J; Flury, R; Greminger, P; Jost, R; Meyenberger, C; Moradpour, D; Schmid, M, 1994) |
| "The present study has demonstrated that tauroursodeoxycholate (TUDC), but not taurocholate, can reverse chlorpromazine (CPZ)-induced cholestasis in the isolated perfused rat liver." | 3.68 | Effects of bile salt infusion on chlorpromazine-induced cholestasis in the isolated perfused rat liver. ( Abernathy, CO; Gillespie, J; Tripodi, MF; Utili, R; Zimmerman, HJ, 1992) |
| " Acute CPZ treatment (25 mg per kg intravenously) produced hemolysis and resulted in increased bilirubin output and stimulation of hepatic heme synthesis." | 3.65 | Effects of chlorpromazine on bilirubin metabolism and biliary secretion in the rat. ( Knodell, RG, 1975) |
| "Cholestasis was induced in mPCLS through a 48-h-incubation with three drugs known to induce cholestasis in humans, namely chlorpromazine (15, 20, and 30 µM), cyclosporin A (1, 3, and 6 µM) or glibenclamide (25, 50, and 65 µM)." | 1.72 | Mouse precision-cut liver slices as an ex vivo model to study drug-induced cholestasis. ( Karsten, REH; Krijnen, NJW; Maho, W; Olinga, P; Permentier, H; Verpoorte, E, 2022) |
| "Cholestasis is one of the major causes of drug-induced liver injury (DILI), which can result in withdrawal of approved drugs from the market." | 1.46 | Mechanism-based risk assessment strategy for drug-induced cholestasis using the transcriptional benchmark dose derived by toxicogenomics. ( Honda, H; Ito, Y; Kawamoto, T; Morita, O, 2017) |
| "Chlorpromazine (CPZ) is a phenothiazine, antipsychotic drug that has caused several idiosyncratic responses during its therapeutic use." | 1.31 | Underlying endotoxemia augments toxic responses to chlorpromazine: is there a relationship to drug idiosyncrasy? ( Buchweitz, JP; Bursian, SJ; Ganey, PE; Roth, RA, 2002) |
| "When chlorpromazine hydrochloride was infused at three doses (2." | 1.26 | Effects of chlorpromazine hydrochloride on bile salt synthesis, bile formation and biliary lipid secretion in the rhesus monkey: a model for chlorpromazine-induced cholestasis. ( Carey, MC; Ros, E; Small, DM, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 56 (74.67) | 18.7374 |
| 1990's | 4 (5.33) | 18.2507 |
| 2000's | 2 (2.67) | 29.6817 |
| 2010's | 12 (16.00) | 24.3611 |
| 2020's | 1 (1.33) | 2.80 |
| Authors | Studies |
|---|---|
| Dawson, S | 1 |
| Stahl, S | 1 |
| Paul, N | 1 |
| Barber, J | 1 |
| Kenna, JG | 1 |
| Karsten, REH | 1 |
| Krijnen, NJW | 1 |
| Maho, W | 1 |
| Permentier, H | 1 |
| Verpoorte, E | 1 |
| Olinga, P | 3 |
| Kawamoto, T | 1 |
| Ito, Y | 1 |
| Morita, O | 1 |
| Honda, H | 1 |
| Van den Hof, WFPM | 1 |
| Coonen, MLJ | 1 |
| van Herwijnen, M | 1 |
| Brauers, K | 1 |
| Jennen, D | 1 |
| Olde Damink, SWM | 1 |
| Schaap, FG | 1 |
| Kleinjans, JCS | 1 |
| Morgan, K | 1 |
| Martucci, N | 1 |
| Kozlowska, A | 1 |
| Gamal, W | 1 |
| Brzeszczyński, F | 1 |
| Treskes, P | 1 |
| Samuel, K | 1 |
| Hayes, P | 1 |
| Nelson, L | 1 |
| Bagnaninchi, P | 1 |
| Brzeszczynska, J | 1 |
| Plevris, J | 1 |
| Szalowska, E | 1 |
| Stoopen, G | 1 |
| Groot, MJ | 1 |
| Hendriksen, PJ | 1 |
| Peijnenburg, AA | 1 |
| Bachour-El Azzi, P | 2 |
| Sharanek, A | 1 |
| Abdel-Razzak, Z | 2 |
| Antherieu, S | 2 |
| Al-Attrache, H | 1 |
| Savary, CC | 1 |
| Lepage, S | 1 |
| Morel, I | 1 |
| Labbe, G | 1 |
| Guguen-Guillouzo, C | 2 |
| Guillouzo, A | 2 |
| Yang, Q | 1 |
| Yang, F | 1 |
| Tang, X | 1 |
| Ding, L | 1 |
| Xu, Y | 1 |
| Xiong, Y | 1 |
| Wang, Z | 1 |
| Yang, L | 1 |
| Vatakuti, S | 2 |
| Pennings, JL | 1 |
| Gore, E | 1 |
| Groothuis, GM | 1 |
| Pennings, JLA | 1 |
| Groothuis, GMM | 1 |
| Hendriks, DF | 1 |
| Fredriksson Puigvert, L | 1 |
| Messner, S | 1 |
| Mortiz, W | 1 |
| Ingelman-Sundberg, M | 1 |
| Searashi, Y | 2 |
| Takagi, I | 2 |
| Dumont, J | 1 |
| Fromenty, B | 1 |
| Robin, MA | 1 |
| MENGUY, RB | 1 |
| ROLLMAN, JL | 1 |
| GRINDLAY, JH | 1 |
| CAIN, JB | 1 |
| WHITE, CS | 1 |
| PAINTER, RW | 1 |
| GUTMAN, AB | 1 |
| SCHOLZ, O | 1 |
| KRETZSCHMAR, E | 1 |
| SPELLBERG, MA | 1 |
| SUMMERSKILL, WH | 1 |
| Matsudaira, H | 1 |
| Barancik, M | 1 |
| Brandborg, LL | 1 |
| Albion, MJ | 1 |
| Roschlau, G | 1 |
| Teschke, R | 1 |
| Stutz, G | 1 |
| Moreno, F | 1 |
| Utili, R | 3 |
| Abernathy, CO | 3 |
| Zimmerman, HJ | 3 |
| Gaeta, GB | 1 |
| Adinolfi, L | 1 |
| Lukacs, L | 1 |
| Fisher, MM | 1 |
| Das, UN | 1 |
| Moradpour, D | 1 |
| Altorfer, J | 1 |
| Flury, R | 1 |
| Greminger, P | 1 |
| Meyenberger, C | 1 |
| Jost, R | 1 |
| Schmid, M | 2 |
| Buchweitz, JP | 1 |
| Ganey, PE | 1 |
| Bursian, SJ | 1 |
| Roth, RA | 1 |
| Ros, E | 1 |
| Small, DM | 1 |
| Carey, MC | 1 |
| Strasberg, SM | 1 |
| Kay, RM | 1 |
| Ilson, RG | 1 |
| Petrunka, CN | 1 |
| Paloheimo, JE | 1 |
| Elias, E | 3 |
| Boyer, JL | 3 |
| Knoblauch, M | 2 |
| Hruban, Z | 1 |
| Tavoloni, N | 1 |
| Reed, JS | 1 |
| Sherlock, S | 1 |
| Drew, R | 1 |
| Piestly, BG | 1 |
| Arnman, R | 1 |
| Iwarson, S | 1 |
| Olsson, R | 1 |
| Nerad, V | 1 |
| Skaunic, V | 1 |
| Bianchi, L | 1 |
| De Groote, J | 1 |
| Desmet, V | 1 |
| Gedigk, P | 1 |
| Korb, G | 1 |
| Popper, H | 2 |
| Poulsen, H | 1 |
| Scheuer, PJ | 1 |
| Thaler, H | 2 |
| Wepler, W | 1 |
| Knodell, RG | 1 |
| Lämmli, J | 1 |
| Funk, C | 1 |
| Balázs, M | 1 |
| Juházs, J | 1 |
| Tripodi, MF | 1 |
| Gillespie, J | 2 |
| Ishak, KG | 1 |
| Akerboom, T | 1 |
| Schneider, I | 1 |
| vom Dahl, S | 1 |
| Sies, H | 1 |
| Bach, N | 1 |
| Thung, SN | 1 |
| Schaffner, F | 2 |
| Tobias, H | 1 |
| Cooper, PJ | 1 |
| Danpure, CJ | 1 |
| Simpson, KJ | 1 |
| Komoda, T | 1 |
| Koyama, I | 1 |
| Nagata, A | 1 |
| Sakagishi, Y | 1 |
| Kurata, M | 1 |
| Kumegawa, M | 1 |
| Watson, RG | 1 |
| Olomu, A | 1 |
| Clements, D | 2 |
| Waring, RH | 2 |
| Mitchell, S | 1 |
| Olomu, AB | 1 |
| Vickers, CR | 1 |
| Babbs, C | 1 |
| Warnes, TW | 1 |
| Kaplowitz, N | 1 |
| Aw, TY | 1 |
| Simon, FR | 1 |
| Stolz, A | 1 |
| Lesser, PB | 1 |
| Berthelot, P | 1 |
| Neuvonen, P | 1 |
| Stacher, G | 1 |
| Franzini, P | 1 |
| Cereda, UG | 1 |
| Kühn, HA | 1 |
| Richter, E | 1 |
| Sinaĭko, GA | 1 |
| Paktoris, EA | 1 |
| Pozdniakova, SL | 1 |
| Kutchak, SN | 1 |
| Shumkina, OB | 1 |
| Bliuger, AF | 1 |
| Maksimova, LA | 1 |
| Kartashova, OIa | 1 |
| Clarke, AE | 2 |
| Maritz, VM | 1 |
| Denborough, MA | 2 |
| Krieger, J | 1 |
| Seaman, WB | 1 |
| Porter, MR | 1 |
| Eastwood, HD | 1 |
| Kaltiala, EH | 1 |
| Abramov, A | 1 |
| Neufeld, E | 1 |
| Chayen, R | 1 |
| Bevan, G | 1 |
| Baldus, WP | 1 |
| Gleich, GJ | 1 |
| Read, AE | 1 |
| Roberts, RJ | 1 |
| Plaa, GL | 1 |
| Wohlgemuth, B | 1 |
| Wruble, LD | 1 |
| Kalser, MH | 1 |
| Jones, RH | 1 |
| Vloedman, D | 1 |
| Bachorik, P | 1 |
| Burke, G | 1 |
| Halko, A | 1 |
7 reviews available for chlorpromazine and Bile Duct Obstruction
| Article | Year |
|---|---|
[Drug-induced cholestasis].
Topics: Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Antineoplastic Agen | 2007 |
Mechanisms of intrahepatic cholestasis.
Topics: Animals; Bile; Bile Acids and Salts; Cell Membrane Permeability; Chlorpromazine; Cholestasis; Cytosk | 1979 |
[Drug induced liver disease (author's transl)].
Topics: Azathioprine; Bile Acids and Salts; Bilirubin; Biotransformation; Chemical and Drug Induced Liver In | 1978 |
Drug-induced hepatotoxicity.
Topics: Acetaminophen; Bile; Bile Acids and Salts; Biotransformation; Cell Survival; Chemical and Drug Induc | 1986 |
Mechanisms and prediction of drug-induced liver disease.
Topics: Adenosine Triphosphate; Age Factors; Animals; Bilirubin; Biotransformation; Carbon Isotopes; Carbon | 1973 |
[Drug induced liver diseases].
Topics: Aminosalicylic Acids; Animals; Chemical and Drug Induced Liver Injury; Chlorpromazine; Cholestasis; | 1974 |
[Pathophysiology and clinical aspects of intrahepatic cholestasis].
Topics: Alkaline Phosphatase; Animals; Arsphenamine; Bile Acids and Salts; Bilirubin; Chlorpromazine; Cholan | 1970 |
68 other studies available for chlorpromazine and Bile Duct Obstruction
| Article | Year |
|---|---|
In vitro inhibition of the bile salt export pump correlates with risk of cholestatic drug-induced liver injury in humans.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters | 2012 |
Mouse precision-cut liver slices as an ex vivo model to study drug-induced cholestasis.
Topics: Animals; Bile Acids and Salts; Chemical and Drug Induced Liver Injury; Chlorpromazine; Cholestasis; | 2022 |
Mechanism-based risk assessment strategy for drug-induced cholestasis using the transcriptional benchmark dose derived by toxicogenomics.
Topics: Administration, Oral; Animals; Chlorpromazine; Cholestasis; Cholesterol; Cyclosporine; Diclofenac; D | 2017 |
Validation of gene expression profiles from cholestatic hepatotoxicants in vitro against human in vivo cholestasis.
Topics: Animals; Bile Acids and Salts; Cells, Cultured; Chemical and Drug Induced Liver Injury; Chlorpromazi | 2017 |
Chlorpromazine toxicity is associated with disruption of cell membrane integrity and initiation of a pro-inflammatory response in the HepaRG hepatic cell line.
Topics: Cell Line; Cell Membrane; Cell Survival; Chlorpromazine; Cholestasis; Cytochrome P-450 Enzyme System | 2019 |
Treatment of mouse liver slices with cholestatic hepatotoxicants results in down-regulation of Fxr and its target genes.
Topics: Animals; Biomarkers; Chlorpromazine; Cholestasis; Cyclosporine; Cytotoxins; Down-Regulation; Gene Ex | 2013 |
Impact of inflammation on chlorpromazine-induced cytotoxicity and cholestatic features in HepaRG cells.
Topics: Actins; Bile Acids and Salts; C-Reactive Protein; Cell Line; Chlorpromazine; Cholestasis; Cytochrome | 2014 |
Chlorpromazine-induced perturbations of bile acids and free fatty acids in cholestatic liver injury prevented by the Chinese herbal compound Yin-Chen-Hao-Tang.
Topics: Animals; Artemisia; Bile Acids and Salts; Chemical and Drug Induced Liver Injury; Chlorpromazine; Ch | 2015 |
Classification of Cholestatic and Necrotic Hepatotoxicants Using Transcriptomics on Human Precision-Cut Liver Slices.
Topics: Acetaminophen; Aged; Benzofurans; Bile Acids and Salts; Chloramphenicol; Chlorpromazine; Cholestasis | 2016 |
Validation of precision-cut liver slices to study drug-induced cholestasis: a transcriptomics approach.
Topics: 1-Naphthylisothiocyanate; Aged; Chlorpromazine; Cholestasis; Cyclosporine; Dose-Response Relationshi | 2017 |
Hepatic 3D spheroid models for the detection and study of compounds with cholestatic liability.
Topics: Bile Acids and Salts; Biological Transport; Cell Culture Techniques; Cell Line; Chemical and Drug In | 2016 |
[Drug-induced cholestasis].
Topics: Anabolic Agents; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; An | 2012 |
Oxidative stress plays a major role in chlorpromazine-induced cholestasis in human HepaRG cells.
Topics: Actins; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B | 2013 |
Biliary stasis produced by chlorpromazine: an experimental study.
Topics: Biliary Tract; Chlorpromazine; Cholestasis; Duodenum; Humans; Jaundice | 1955 |
Intrahepatic biliary obstruction due to chlorpromazine.
Topics: Chlorpromazine; Cholestasis; Jaundice | 1955 |
Drug reactions characterized by cholestasis associated with intrahepatic biliary tract obstruction.
Topics: Arsphenamine; Biliary Tract; Chlorpromazine; Cholestasis; Drug-Related Side Effects and Adverse Reac | 1957 |
[Cholestatic effect of megaphen and influence of choleretics].
Topics: Bile; Chlorpromazine; Cholagogues and Choleretics; Cholestasis; Humans | 1958 |
INTRAHEPATIC CHOLESTASIS VS. POSTHEPATIC JAUNDICE: METHODS OF DIAGNOSIS, WITH A NOTE ON HYPERCHOLESTEREMIC XANTHOMATOSIS IN A PATIENT WITH CHLORPROMAZINE CHOLESTASIS.
Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Alkaline Phosphatase; Androgens; Anti-Bacteria | 1964 |
THE SYNDROME OF BENIGN RECURRENT CHOLESTASIS.
Topics: Bile Ducts; Bile Ducts, Intrahepatic; Chlorpromazine; Cholestasis; Cholestyramine Resin; Drug Therap | 1965 |
Thioridazine-induced cholestasis.
Topics: Adult; Biliary Tract Diseases; Chlorpromazine; Cholestasis; Diagnosis, Differential; Humans; Liver C | 1967 |
[Causes and types of cholestasis from a biopsy viewpoint].
Topics: Anti-Inflammatory Agents; Antihypertensive Agents; Antitubercular Agents; Biopsy; Chlorpromazine; Ch | 1983 |
Cholestasis following chronic alcohol consumption: enhancement after an acute dose of chlorpromazine.
Topics: Alanine Transaminase; Alcoholism; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Chlorp | 1980 |
Endotoxin protects against chlorpromazine-induced cholestasis in the isolated perfused rat liver.
Topics: Animals; Bile Acids and Salts; Chlorpromazine; Cholestasis; Endotoxins; Liver; Male; Rats | 1981 |
Mechanisms of drug-induced cholestasis.
Topics: Bile; Biological Transport, Active; Chlorpromazine; Cholestasis; Estrogens; Hepatic Duct, Common; Hu | 1981 |
Chlorpromazine induced cholestasis and prostaglandins.
Topics: Chlorpromazine; Cholestasis; Humans; Prostaglandins | 1980 |
Chlorpromazine-induced vanishing bile duct syndrome leading to biliary cirrhosis.
Topics: Adult; Bile Ducts; Biopsy; Chlorpromazine; Cholestasis; Female; Humans; Liver; Liver Cirrhosis, Bili | 1994 |
Underlying endotoxemia augments toxic responses to chlorpromazine: is there a relationship to drug idiosyncrasy?
Topics: Animals; Antipsychotic Agents; Chemical and Drug Induced Liver Injury; Chlorpromazine; Cholestasis; | 2002 |
Effects of chlorpromazine hydrochloride on bile salt synthesis, bile formation and biliary lipid secretion in the rhesus monkey: a model for chlorpromazine-induced cholestasis.
Topics: Animals; Bile; Bile Acids and Salts; Chlorpromazine; Cholestasis; Disease Models, Animal; Dose-Respo | 1979 |
Taurolithocholic acid and chlorpromazine cholestasis in the rhesus monkey.
Topics: Animals; Cell Membrane Permeability; Chlorpromazine; Cholestasis; Dose-Response Relationship, Drug; | 1979 |
Ultrastructural changes during cholestasis induced by chlorpromazine in the isolated perfused rat liver.
Topics: Animals; Cell Membrane; Chlorpromazine; Cholestasis; Liver; Male; Membranes; Microscopy, Electron; R | 1978 |
Hepatic reactions to drugs.
Topics: Acetaminophen; Adenoma; Adult; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injur | 1979 |
Effect of chlorpromazine and erythromycin on bile salt-induced cholestasis in the rat.
Topics: Alanine Transaminase; Animals; Bile; Chlorpromazine; Cholestasis; Drug Interactions; Erythromycin; E | 1979 |
Mechanisms of chlorpromazine cholestasis: hypersensitivity or toxic metabolite?
Topics: Chlorpromazine; Cholestasis; Drug Hypersensitivity; Humans; Inactivation, Metabolic; Sulfoxides | 1978 |
The clinical significance of increased plasma levels of liver-synthesized coagulation factors in liver disease.
Topics: Acetaminophen; Acute Disease; Biliary Tract Diseases; Blood Coagulation Factors; Chemical and Drug I | 1977 |
[Chronic intrahepatic cholestasis following chlorpromazine; treated using phenobarbital].
Topics: Adult; Chlorpromazine; Cholestasis; Chronic Disease; Humans; Male; Schizophrenia | 1976 |
[Rules for the histological evaluation of drug-induced liver lesions].
Topics: Biopsy; Chemical and Drug Induced Liver Injury; Chlorpromazine; Cholestasis; Contraceptives, Oral; F | 1975 |
Effects of chlorpromazine on bilirubin metabolism and biliary secretion in the rat.
Topics: Animals; Bile; Bilirubin; Chlorpromazine; Cholestasis; Heme; Hemolysis; Liver; Male; Rats | 1975 |
[Drug-induced liver diseases].
Topics: Acetaminophen; Adult; Alcoholism; Azathioprine; Bilirubin; Chemical and Drug Induced Liver Injury; C | 1975 |
Electron microscopic study on the injurious effects of chlorpromazine on rat liver cells.
Topics: Animals; Chemical and Drug Induced Liver Injury; Chlorpromazine; Cholestasis; Female; Liver; Male; M | 1975 |
Effects of bile salt infusion on chlorpromazine-induced cholestasis in the isolated perfused rat liver.
Topics: Animals; Bile; Chlorpromazine; Cholestasis; In Vitro Techniques; Isomerism; Kinetics; Liver; Male; P | 1992 |
Drug-induced cholestasis in the perfused rat liver and its reversal by tauroursodeoxycholate: an ultrastructural study.
Topics: Animals; Bile; Chlorpromazine; Cholestasis; Estradiol; In Vitro Techniques; Kinetics; Liver; Microsc | 1992 |
Cholestasis and changes of portal pressure caused by chlorpromazine in the perfused rat liver.
Topics: Animals; Bile; Blood Pressure; Chlorpromazine; Cholestasis; Cyclooxygenase Inhibitors; Indomethacin; | 1991 |
Exaggerated cholestasis and hepatic fibrosis following simultaneous administration of chlorpromazine and sodium valproate.
Topics: Chlorpromazine; Cholestasis; Drug Interactions; Hiccup; Humans; Liver Cirrhosis; Male; Middle Aged; | 1989 |
Peroxisomal and mitochondrial proliferation and increased alanine: glyoxylate aminotransferase activity in human liver after chlorpromazine-induced cholestasis.
Topics: Alanine Transaminase; Chlorpromazine; Cholestasis; Female; Humans; Liver; Male; Microbodies; Microsc | 1989 |
A possible mechanism of induction and translocation into blood stream of rat alkaline phosphatase activity by bile duct ligation.
Topics: Alkaline Phosphatase; Animals; Bile Ducts; Bone and Bones; Calmodulin; Chlorpromazine; Cholestasis; | 1986 |
A proposed mechanism for chlorpromazine jaundice--defective hepatic sulphoxidation combined with rapid hydroxylation.
Topics: Adult; Aged; Aged, 80 and over; Carbocysteine; Chlorpromazine; Cholestasis; Female; Humans; Hydroxyl | 1988 |
High incidence of poor sulfoxidation in patients with primary biliary cirrhosis.
Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Carbocysteine; Chlorpromazine; Cholestasis; | 1988 |
Guidelines for diagnosis of therapeutic drug-induced liver injury in liver biopsies.
Topics: Anabolic Agents; Biopsy; Cathartics; Chemical and Drug Induced Liver Injury; Chlorpromazine; Cholest | 1974 |
Drug induced intrahepatic cholestatic jaundice: case reports.
Topics: Adult; Chlorpromazine; Cholestasis; Contraceptives, Oral; Female; Humans; Male; Prognosis | 1974 |
Morphologic studies of cholestasis.
Topics: Bile Ducts, Intrahepatic; Chemical and Drug Induced Liver Injury; Chlorpromazine; Chlorpropamide; Ch | 1968 |
Intrahepatic cholostasis following combined diazepam-barbiturate therapy in patients with tetanus.
Topics: Adult; Aged; Anti-Bacterial Agents; Chlorpromazine; Cholestasis; Diazepam; Drug Combinations; Female | 1973 |
Chlorpromazine contraindicated in delirium tremens.
Topics: Chlordiazepoxide; Chlorpromazine; Cholestasis; Diazepam; Humans; Psychoses, Alcoholic; Seizures | 1973 |
[Medical diagnosis of biliary tract diseases. Points from the physician-surgeon meeting].
Topics: Anabolic Agents; Biliary Tract Diseases; Biopsy; Chlorpromazine; Cholestasis; Drug Hypersensitivity; | 1974 |
[Differential diagnosis of aminazine jaundice and viral hepatitis developing during aminazine treatment].
Topics: Adult; Aged; Alanine Transaminase; Alkaline Phosphatase; Aspartate Aminotransferases; Blood Sediment | 1972 |
[Pathogenesis, pathological anatomy, clinical picture and diagnosis of different types of intrahepatic cholestasis].
Topics: Adult; Aged; Chemical and Drug Induced Liver Injury; Chlorpromazine; Cholestasis; Female; Hepatitis | 1972 |
Interaction of tricyclic drugs and human bile.
Topics: Amitriptyline; Bile Acids and Salts; Chemical Precipitation; Chlorpromazine; Cholestasis; Drug Inter | 1972 |
Interaction of chlorpromazine with bile.
Topics: ABO Blood-Group System; Bile; Blood Group Antigens; Buffers; Centrifugation, Density Gradient; Chemi | 1971 |
[Therapy of cholestatic hepatosis].
Topics: Adrenal Cortex Hormones; Chlorpromazine; Cholestasis; Diagnosis, Differential; Fatty Liver; Female; | 1970 |
The roentgenologic appearance of sclerosing cholangitis.
Topics: Adult; Bile Ducts; Chlorpromazine; Cholangiography; Cholangitis; Cholestasis; Colitis, Ulcerative; D | 1970 |
Causes of jaundice in the elderly. A survey of diagnosis and investigation.
Topics: Aged; Anemia, Hemolytic; Bilirubin; Carcinoma; Chlorpromazine; Cholelithiasis; Cholestasis; Female; | 1971 |
The experimental obstructive jaundice and liver microsomal enzymes in rats.
Topics: Animals; Chlorpromazine; Cholestasis; Hexobarbital; Isonipecotic Acids; Male; Microsomes, Liver; Rat | 1971 |
Study of serum urocanase in liver diseases.
Topics: Acrylates; Adolescent; Aged; Chlorpromazine; Cholestasis; Humans; Hydro-Lyases; Imidazoles; Jaundice | 1971 |
Serum immunoglobulin levels in cholestasis.
Topics: Adult; Aged; Chlorpromazine; Cholelithiasis; Cholestasis; Female; Humans; Immunoglobulin G; Immunogl | 1969 |
Drugs and liver disease.
Topics: Biliary Tract Diseases; Bilirubin; Brain Diseases; Carbon Tetrachloride Poisoning; Chemical and Drug | 1969 |
Potentiation and inhibition of alpha-naphthylisothiocyanate-induced hyperbilirubinemia and cholestasis.
Topics: Animals; Chlorpromazine; Cholestasis; Dactinomycin; Ethionine; Hyperbilirubinemia; In Vitro Techniqu | 1965 |
[Morphologic findings in the liver in intrahepatic and extrahepatic cholestasis].
Topics: Aminosalicylic Acids; Bile Ducts, Intrahepatic; Chemical and Drug Induced Liver Injury; Chlorpromazi | 1965 |
Jaundice. Value of five-day steroid test in differential diagnosis.
Topics: Alkaline Phosphatase; Aspartate Aminotransferases; Bilirubin; Blood; Chlorpromazine; Cholestasis; Ch | 1966 |
Dynamic clinical studies with radioisotopes and the scintillation camera. II. Rose bengal I-131 liver function studies.
Topics: Aged; Alcoholism; Chlorpromazine; Chlorpropamide; Cholestasis; Diabetes Mellitus; Diagnosis, Differe | 1966 |