chlorpromazine and Anorexia Nervosa studies

Chlorpromazine: The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking DOPAMINE RECEPTORS. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the treatment of intractable hiccup.
chlorpromazine : A substituted phenothiazine in which the ring nitrogen at position 10 is attached to C-3 of an N,N-dimethylpropanamine moiety.

Anorexia Nervosa: An eating disorder that is characterized by the lack or loss of APPETITE, known as ANOREXIA. Other features include excess fear of becoming OVERWEIGHT; BODY IMAGE disturbance; significant WEIGHT LOSS; refusal to maintain minimal normal weight; and AMENORRHEA. This disorder occurs most frequently in adolescent females. (APA, Thesaurus of Psychological Index Terms, 1994)

Research Excerpts

Excerpt	Relevance	Reference
"Olanzapine may be of benefit in anorexia nervosa by causing a reduction in anorexic rumination."	9.11	Randomized controlled trial of olanzapine in the treatment of cognitions in anorexia nervosa. ( Beumont, P; Birmingham, CL; Chapman, L; Mondraty, N; Sundakov, V; Touyz, S, 2005)
"Chlorpromazine therapy in a patient with anorexia nervosa was associated with haemolytic anaemia."	7.67	Chlorpromazine-associated haemolysis in anorexia nervosa. ( Collecutt, MF; Davidson, A; Faragher, BS; Van der Weyden, MB, 1985)
"Two patients with anorexia nervosa who developed progressive haemolytic anaemia during chlorpromazine therapy are presented."	7.65	Chlorpromazine-induced haemolytic anaemia in anorexia nervosa. ( Davidson, RJ; How, J, 1977)
"Olanzapine may be of benefit in anorexia nervosa by causing a reduction in anorexic rumination."	5.11	Randomized controlled trial of olanzapine in the treatment of cognitions in anorexia nervosa. ( Beumont, P; Birmingham, CL; Chapman, L; Mondraty, N; Sundakov, V; Touyz, S, 2005)
"Chlorpromazine therapy in a patient with anorexia nervosa was associated with haemolytic anaemia."	3.67	Chlorpromazine-associated haemolysis in anorexia nervosa. ( Collecutt, MF; Davidson, A; Faragher, BS; Van der Weyden, MB, 1985)
"Two patients with anorexia nervosa who developed progressive haemolytic anaemia during chlorpromazine therapy are presented."	3.65	Chlorpromazine-induced haemolytic anaemia in anorexia nervosa. ( Davidson, RJ; How, J, 1977)

Research

Studies (32)

Authors

Clinical Trials (1)

Trial Overview

Trial Outcomes

Changes in Follicle Stimulating Hormone (FSH) (Aim 1)

Timeframe	Studies, this research(%)	All Research%
pre-1990	29 (90.63)	18.7374
1990's	0 (0.00)	18.2507
2000's	1 (3.13)	29.6817
2010's	2 (6.25)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
Roche, AE	1
Russell, G	1
KLEINT, W	1
DALLY, PJ	1
SARGANT, W	2
CRISP, AH	2
ROBERTS, FJ	1
UEDA, H	1
YAMAMOTO, M	1
KAMEDA, H	1
YANO, S	1
TAKEUCHI, K	1
Mondraty, N	1
Birmingham, CL	1
Touyz, S	1
Sundakov, V	1
Chapman, L	1
Beumont, P	1
Rockwell, WJ	1
Ellinwood, EH	1
Dougherty, GG	1
Brodie, HK	1
Johnson, C	1
Stuckey, M	1
Mitchell, J	1
Herzog, DB	1
Dally, P	3
Guile, L	1
Horne, M	1
Dunston, R	1
Foster, FG	1
Kupfer, DJ	1
How, J	1
Davidson, RJ	1
Roberts, A	1
Mandin, H	1
Roxburgh, P	1
Van der Weyden, MB	1
Collecutt, MF	1
Davidson, A	1
Faragher, BS	1
Leibowitz, SF	1
Mawson, AR	1
Santen, RJ	1
Bardin, CW	1
Suematsu, H	1
Kurokawa, N	1
Tamai, H	1
Ikemi, Y	1
Kammerer, M	1
Wartel, R	1
Gurfein, L	1
Weil, J	1
Wysoki, V	1
Gelb, F	1
Demoulin, C	1
Roussounis, SH	1
Savage, TS	1
Ghafoor, PK	1
Blendis, LM	1
Tsuchiya, M	1
Shishido, T	1
Alsen, V	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
Reproductive Hormonal Alterations in Obesity, AIMS #1 & #2[NCT01457703]		62 participants (Actual)	Interventional	2010-06-30	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Follicle-stimulating hormone was measured hourly during the 12 hour study visit, and was compared between the obese and normal weight groups. (NCT01457703)
Timeframe: Measured hourly and averaged over the 12 hour study visit

Changes in Follicle Stimulating Hormone (FSH) (Aim 2)

Intervention	IU/L (Mean)
BMI ≥30 kg/m2	3.8
BMI 18-25 kg/m2	3.3

Changes in Luteinizing Hormone (LH) Pulse Amplitude (Aim 1)

Intervention	IU/L (Mean)
BMI ≥30 kg/m2	5.31
BMI 18-25 kg/m2	6.18

Luteinizing Hormone (LH) Pulse Amplitude was measured hourly during the 12 hour study visit, and was compared between the obese and normal weight groups. (NCT01457703)
Timeframe: Measured hourly and averaged over the 12 hour study visit

Changes in Luteinizing Hormone (LH) Pulse Amplitude (Aim 2)

Intervention	IU/L (Mean)
BMI ≥30 kg/m2	4.1
BMI 18-25 kg/m2	3.6

Changes in Pregnanediol Glucuronide (PdG) (Aim 2)

Intervention	IU/L (Mean)
BMI ≥30 kg/m2	2.21
BMI 18-25 kg/m2	4.44

Pregnanediol glucuronide (PdG) was collected daily over the course of one menstrual cycle and averaged. (NCT01457703)
Timeframe: Averaged over the length of menstrual cycle

Article	Year
Anorexia nervosa: review of current treatment practices. Southern medical journal, 1982, Volume: 75, Issue:9 Topics: Amitriptyline; Anorexia Nervosa; Behavior Therapy; Chlorpromazine; Cyproheptadine; Enteral Nutrition	1982
Psychopharmacological treatment of anorexia nervosa and bulimia. Review and synthesis. The Journal of nervous and mental disease, 1983, Volume: 171, Issue:9 Topics: Adrenocorticotropic Hormone; Anorexia Nervosa; Antidepressive Agents, Tricyclic; Chlorpromazine; Cyp	1983
Pharmacotherapy of anorexia nervosa and bulimia. Pediatric annals, 1984, Volume: 13, Issue:12 Topics: Amitriptyline; Anorexia Nervosa; Antidepressive Agents, Tricyclic; Chlorpromazine; Clinical Trials a	1984
Anorexia nervosa and the regulation of intake: a review. Psychological medicine, 1974, Volume: 4, Issue:3 Topics: Adolescent; Adult; Amygdala; Androgens; Animals; Anorexia Nervosa; Appetite Regulation; Brain; Child	1974
[Anorexia nervosa. A general review of recent works]. Annales medico-psychologiques, 1969, Volume: 1, Issue:3 Topics: Anorexia Nervosa; Chlorpromazine; Cyproheptadine; Humans; Hypothalamus; Insulin; Parent-Child Relati	1969

Article	Year
Randomized controlled trial of olanzapine in the treatment of cognitions in anorexia nervosa. Australasian psychiatry : bulletin of Royal Australian and New Zealand College of Psychiatrists, 2005, Volume: 13, Issue:1 Topics: Adult; Anorexia Nervosa; Antipsychotic Agents; Benzodiazepines; Chlorpromazine; Cognition Disorders;	2005
Pharmacotherapy of anorexia nervosa and bulimia. Pediatric annals, 1984, Volume: 13, Issue:12 Topics: Amitriptyline; Anorexia Nervosa; Antidepressive Agents, Tricyclic; Chlorpromazine; Clinical Trials a	1984
[Clinical experimentation with desipramine with statistical control]. Annales medico-psychologiques, 1968, Volume: 1, Issue:1 Topics: Adult; Aged; Anorexia Nervosa; Barbiturates; Bipolar Disorder; Chlordiazepoxide; Chlorpromazine; Cli	1968

Article	Year
From shock therapy to psychotherapy: the role of Peter Dally in the revolutions of anorexia nervosa treatment. European eating disorders review : the journal of the Eating Disorders Association, 2010, Volume: 18, Issue:2 Topics: Anorexia Nervosa; Antiemetics; Chlorpromazine; Convulsive Therapy; History, 20th Century; History, 2	2010
Commentary. From shock therapy to psychotherapy: the role of Peter Dally in the revolutions of anorexia nervosa treatment. European eating disorders review : the journal of the Eating Disorders Association, 2010, Volume: 18, Issue:2 Topics: Anorexia Nervosa; Antiemetics; Chlorpromazine; Convulsive Therapy; History, 20th Century; History, 2	2010
[Propaphenin drops and suppositories in the therapy of habitual vomiting, pylorospasm and anorexia nervosa in infants]. Zeitschrift fur arztliche Fortbildung (Berlin), 1960, Jul-01, Volume: 54 Topics: Anorexia Nervosa; Child; Chlorpromazine; Disease; Humans; Infant; Pessaries; Pylorus; Suppositories;	1960
A new treatment of anorexia nervosa. British medical journal, 1960, Jun-11, Volume: 1, Issue:5188 Topics: Anorexia Nervosa; Chlorpromazine; Humans; Insulin	1960
A case of anorexia nervosa in a male. Postgraduate medical journal, 1962, Volume: 38 Topics: Anorexia Nervosa; Chlorpromazine; Humans; Insulin; Male; Medical Records	1962
[Anorexia nervosa]. Naika. Internal medicine, 1963, Volume: 11 Topics: Anorexia Nervosa; Chlorpromazine; Convulsive Therapy; Fats; Humans; Insulin	1963
[ON THE PITUITARY-ADRENAL FEED-BACK TEST]. Nihon Naibunpi Gakkai zasshi, 1963, Nov-20, Volume: 39 Topics: Addison Disease; Adrenal Cortex Hormones; Adrenal Insufficiency; Adrenogenital Syndrome; Anorexia Ne	1963
Treatment of anorexia nervosa. British journal of hospital medicine, 1981, Volume: 25, Issue:5 Topics: Adolescent; Adult; Anorexia Nervosa; Antidepressive Agents; Chlorpromazine; Electroconvulsive Therap	1981
Anorexia nervosa, sexual behaviour modification as an adjunct to an integrated treatment programme: a case report. The Australian and New Zealand journal of psychiatry, 1978, Volume: 12, Issue:3 Topics: Adult; Anorexia Nervosa; Behavior Therapy; Chlorpromazine; Depression; Desensitization, Psychologic;	1978
Anorexia nervosa: telemetric assessment of family interaction and hospital events. Journal of psychiatric research, 1975, Volume: 12, Issue:1 Topics: Adolescent; Anorexia Nervosa; Arousal; Body Weight; Chlorpromazine; Depersonalization; Diet Therapy;	1975
Chlorpromazine-induced haemolytic anaemia in anorexia nervosa. Postgraduate medical journal, 1977, Volume: 53, Issue:619 Topics: Adult; Anemia, Hemolytic; Anorexia Nervosa; Chlorpromazine; Female; Humans; Oxidation-Reduction	1977
The management of anorexia nervosa. Drug and therapeutics bulletin, 1975, Jun-06, Volume: 13, Issue:12 Topics: Adolescent; Anorexia Nervosa; Chlorpromazine; Clomiphene; Female; Hospitalization; Humans; Nurse-Pat	1975
Unexplained seizure in anorexia nervosa. Canadian journal of psychiatry. Revue canadienne de psychiatrie, 1986, Volume: 31, Issue:7 Topics: Adolescent; Anorexia Nervosa; Behavior Therapy; Chlorpromazine; Female; Humans; Hyponatremia; Seizur	1986
Chlorpromazine-associated haemolysis in anorexia nervosa. Acta haematologica, 1985, Volume: 73, Issue:2 Topics: Adolescent; Anemia, Hemolytic; Anorexia Nervosa; Chlorpromazine; Erythrocytes; Female; Heinz Bodies;	1985
Success and failure in anorexia nervosa. Lancet (London, England), 1971, May-01, Volume: 1, Issue:7705 Topics: Anorexia Nervosa; Attitude of Health Personnel; Child, Preschool; Chlorpromazine; Family; Female; Hu	1971
Central adrenergic receptors and the regulation of hunger and thirst. Research publications - Association for Research in Nervous and Mental Disease, 1972, Volume: 50 Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Agonists; Adrenergic beta-A	1972
Episodic luteinizing hormone secretion in man. Pulse analysis, clinical interpretation, physiologic mechanisms. The Journal of clinical investigation, 1973, Volume: 52, Issue:10 Topics: Adult; Amenorrhea; Anorexia Nervosa; Chlorpromazine; Female; Follicle Stimulating Hormone; Half-Life	1973
Changes of serum growth hormone in psychosomatic disorders. Psychotherapy and psychosomatics, 1974, Volume: 24, Issue:2 Topics: Adjustment Disorders; Anorexia Nervosa; Asthma; Chlorpromazine; Depression, Chemical; Dihydroxypheny	1974
Anorexia nervosa. The British journal of clinical practice, 1972, Volume: 26, Issue:11 Topics: Adolescent; Amenorrhea; Anorexia Nervosa; Body Weight; Chlorpromazine; Female; Humans; Male; Prognos	1972
Anorexia nervosa in a prepubertal male. Proceedings of the Royal Society of Medicine, 1971, Volume: 64, Issue:6 Topics: Anorexia Nervosa; Body Weight; Child; Chlorpromazine; Humans; Male; Phobic Disorders; Prognosis; Pub	1971
Treatment of anorexia nervosa with chlorpromazine and modified insulin therapy. The Journal of the Association of Physicians of India, 1969, Volume: 17, Issue:6 Topics: Adolescent; Adult; Anorexia Nervosa; Chlorpromazine; Female; Humans; Insulin	1969
Serum cholesterol levels in anorexia nervosa. Postgraduate medical journal, 1968, Volume: 44, Issue:510 Topics: Adult; Anorexia Nervosa; Body Weight; Carbohydrates; Chlorpromazine; Cholesterol; Humans; Hunger; Vo	1968
[Anorexia nervosa and its physical characteristics]. Saishin igaku. Modern medicine, 1968, Volume: 23, Issue:4 Topics: Adult; Anorexia Nervosa; Body Constitution; Chlorpromazine; Female; Humans	1968
[On the treatment course in anorexia nervosa using psychopharmacological management]. Der Nervenarzt, 1965, Volume: 36, Issue:9 Topics: Adolescent; Adult; Anorexia Nervosa; Chlorpromazine; Female; Humans	1965
Treatment and outcome of anorexia nervosa. British medical journal, 1966, Oct-01, Volume: 2, Issue:5517 Topics: Adolescent; Adult; Anorexia Nervosa; Chlorpromazine; Diet Therapy; Female; Follow-Up Studies; Humans	1966

chlorpromazine and Anorexia Nervosa