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chlorpromazine and Agranulocytosis

chlorpromazine has been researched along with Agranulocytosis in 99 studies

Chlorpromazine: The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking DOPAMINE RECEPTORS. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the treatment of intractable hiccup.
chlorpromazine : A substituted phenothiazine in which the ring nitrogen at position 10 is attached to C-3 of an N,N-dimethylpropanamine moiety.

Agranulocytosis: A decrease in the number of GRANULOCYTES; (BASOPHILS; EOSINOPHILS; and NEUTROPHILS).

Research Excerpts

ExcerptRelevanceReference
" Therefore, we conducted a 12-week double-blind comparison study to assess the efficacy and tolerability of clozapine and chlorpromazine in a group of elderly inpatients with chronic schizophrenia."9.09The efficacy and safety of clozapine versus chlorpromazine in geriatric schizophrenia. ( Eisenstein, N; Engelhart, C; Howanitz, E; Losonczy, MF; Pardo, M; Smelson, DA; Stern, RG, 1999)
"Agranulocytosis, a severe decrease or absence of neutrophils, is a side effect of several medications, including chlorpromazine."8.12A Medication Hiccup: Chlorpromazine-Induced Agranulocytosis in a 72-Year-Old Male. ( Kobylarz, Z; Lambert, D; Nothem, ME; Scholcoff, C, 2022)
"We report the case of a 50-year-old man, treated with chlorpromazine for schizophrenia, who developed an agranulocytosis."7.75[Chlorpromazine-induced agranulocytosis: a case report]. ( Guillin, O; Kerleau, JM; Petit, M; Podlipski, MA; Stephan, F, 2009)
"Chlorpromazine-induced agranulocytosis is an uncommon disorder associated with a high frequency of fatality."7.68First use of G-CSF in chlorpromazine-induced agranulocytosis: a report of two cases. ( Barton, A; Flaherty, TA; Horsfield, N; Kendra, JR; Myers, A; Rugman, FP; Russell, L, 1993)
"A 5-year-old child is reported who, after an acute ingestion of chlorpromazine, developed an absolute neutropenia."7.66Neutropenia following acute chlorpromazine ingestion. ( Bruce, W; Burckart, GJ; Snidow, J, 1981)
"A case of death associated with chlorpromazine agranulocytosis and the pertinent literature is reviewed."7.66Agranulocytosis and chlorpromazine. ( Marcus, J; Mulvihill, FJ, 1978)
"A fatal case of agranulocytosis due to chlorpromazine is reported."7.64A drug-specific leuco-agglutinin in a fatal case of agranulocytosis due to chlorpromazine. ( GARZON, FL; HEWLETT, JS; HOFFMAN, GC, 1963)
"Hypoplastic bone marrow associated with agranulocytosis is a well-known side effect of chlorpromazine treatment."5.28Chlorpromazine-induced liver and bone marrow granulomas associated with agranulocytosis. ( Ben-Yehuda, A; Bloom, A; Flusser, D; Lijovetzky, G; Tur-Kaspa, R, 1990)
" Therefore, we conducted a 12-week double-blind comparison study to assess the efficacy and tolerability of clozapine and chlorpromazine in a group of elderly inpatients with chronic schizophrenia."5.09The efficacy and safety of clozapine versus chlorpromazine in geriatric schizophrenia. ( Eisenstein, N; Engelhart, C; Howanitz, E; Losonczy, MF; Pardo, M; Smelson, DA; Stern, RG, 1999)
" A third type involves development of agranulocytosis following a latent period during which a sensitive patient is treated with large amounts of chlorpromazine."4.75Drug-induced agranulocytosis. ( Pisciotta, V, 1978)
"Agranulocytosis, a severe decrease or absence of neutrophils, is a side effect of several medications, including chlorpromazine."4.12A Medication Hiccup: Chlorpromazine-Induced Agranulocytosis in a 72-Year-Old Male. ( Kobylarz, Z; Lambert, D; Nothem, ME; Scholcoff, C, 2022)
"We report the case of a 50-year-old man, treated with chlorpromazine for schizophrenia, who developed an agranulocytosis."3.75[Chlorpromazine-induced agranulocytosis: a case report]. ( Guillin, O; Kerleau, JM; Petit, M; Podlipski, MA; Stephan, F, 2009)
"Agranulocytosis developed in three patients subsequent to chlorpromazine therapy and in one patient following treatment with methotrimeprazine and trifluoperazine."3.67Agranulocytosis in the course of phenothiazine therapy: case reports. ( Yassa, R, 1985)
"A 5-year-old child is reported who, after an acute ingestion of chlorpromazine, developed an absolute neutropenia."3.66Neutropenia following acute chlorpromazine ingestion. ( Bruce, W; Burckart, GJ; Snidow, J, 1981)
"A fatal case of agranulocytosis due to chlorpromazine is reported."3.64A drug-specific leuco-agglutinin in a fatal case of agranulocytosis due to chlorpromazine. ( GARZON, FL; HEWLETT, JS; HOFFMAN, GC, 1963)
"Drug-induced agranulocytosis (DIA) is a potentially fatal disorder."1.31Hematopoietic growth factors in drug-induced agranulocytosis. ( Pavithran, K; Thomas, M, 2002)
"Hypoplastic bone marrow associated with agranulocytosis is a well-known side effect of chlorpromazine treatment."1.28Chlorpromazine-induced liver and bone marrow granulomas associated with agranulocytosis. ( Ben-Yehuda, A; Bloom, A; Flusser, D; Lijovetzky, G; Tur-Kaspa, R, 1990)
"Two cases of agranulocytosis occurring after addition of a butyrophenone to a course of phenothiazine treatment are reported and possible mechanisms for this interaction are discussed."1.28Two cases of agranulocytosis on addition of a butyrophenone to a long-standing course of phenothiazine treatment. ( Kehoe, R; Young, A, 1989)
"The report of a recent fatality due to agranulocytosis provoked an examination of the plausible mechanisms of neutropenia and agranulocytosis."1.27A new concept in the relationship between biochemical reaction mechanisms and molecular basis of agranulocytosis. ( Akintonwa, DA, 1984)
"Aplastic anaemia and agranulocytosis are uncommon but serious adverse effects of drug therapy."1.27Drug-induced aplastic anaemia and agranulocytosis. Incidence and mechanisms. ( Vincent, PC, 1986)
"Aminopyrine alone was responsible for eight cases."1.24Agranulocytosis: a report of 30 cases. ( Colpron, G; Gosselin, G; Long, LA; Pretty, HM, 1965)

Research

Studies (99)

TimeframeStudies, this research(%)All Research%
pre-199091 (91.92)18.7374
1990's5 (5.05)18.2507
2000's2 (2.02)29.6817
2010's0 (0.00)24.3611
2020's1 (1.01)2.80

Authors

AuthorsStudies
Lambert, D1
Nothem, ME1
Kobylarz, Z1
Scholcoff, C1
Stephan, F1
Podlipski, MA1
Kerleau, JM1
Petit, M1
Guillin, O1
Pavithran, K1
Thomas, M1
MUNCH-PETERSEN, S1
SHAPIRO, N1
GOLDMAN, D1
FORMAN, GW1
IDE, LW1
ROTSTEIN, J1
FRICK, PS1
SCHIELE, BC1
PROKOPOWYCZ, V1
CAREY, JB1
MAGRAW, RM1
THERIAULT, JC1
HOLMES, CR1
STONE, HM1
BARSA, JA1
KLINE, NS1
BERNHARD, WG1
ECHIKSON, J1
GRUBIN, H1
ZINS, EI1
TILLIM, SJ1
JOURDRAN, M1
GABRIELLE, P1
LANDRY, M2
ADAMS, JC1
CORTI, KD1
HOBSON, QJ1
TUTEUR, W4
JEUB, RP2
MICHIENZI, LJ2
CRADDOCK, WL2
RASKIN, N1
PLATZER, RF1
GLASER, GL1
BRANDON, LH1
ROEBUCK, BE1
ANDRESEN, P1
TINDINGE, G1
ZELMAN, S1
HENNEMANN, HH1
COOK, IA1
MELROSE, AG1
ROY, JR1
WEISSMAN, L1
MARGOLIS, A1
CALLAHAN, D1
BURRELL, ZL1
JOHNSON, FL1
ROSENTHAL, M1
O'DONNELL, AE1
MILLON, R1
BILLAUD, R1
JACOBY, MG1
VETNE, G1
PISCIOTTA, AV11
EBBE, S1
LENNON, EJ1
METZGER, GO1
MADISON, FW1
MAUREL, H1
NITZAN, L1
SPIELMANN, JP1
GILES, C1
VEREKER, R1
KENT, G1
STILLER, R1
KORST, DR1
CAMPBELL, JE1
CARFAGNO, SC1
MAGEE, JT1
CUNINGHAM, JA1
HANNAH, EE1
FAU, R1
FLANDRIN, P1
HOLLARD, D1
VINGGARD, HE1
NORRIS, TS1
HOFFMAN, GC1
HEWLETT, JS1
GARZON, FL1
BENNETT, NM1
MEYLER, L1
HUGULEY, CM1
WIEK, K1
HAEFNER, H1
KUTSCHER, I1
SANTOS, AS2
KELLER, C1
PRUSAK, Y1
LURIE, E1
DUHAMEL, M1
TASKER, JR1
HODGES, HH1
LAZERTE, GD1
GORMSEN, J1
SHELTON, JG1
KINGSTON, WR1
McRAE, C1
KALDAHL, J1
Westring, DW1
DePrey, C1
Cheongvee, EM1
Hurst, L1
Smith, RH1
Akintonwa, DA1
Burckart, GJ1
Snidow, J1
Bruce, W1
Kendra, JR1
Rugman, FP1
Flaherty, TA1
Myers, A1
Horsfield, N1
Barton, A1
Russell, L1
Yen, CF1
Chong, MY1
Kuo, MC1
Chang, CS1
Howanitz, E1
Pardo, M1
Smelson, DA1
Engelhart, C1
Eisenstein, N1
Stern, RG1
Losonczy, MF1
Naess, K1
Weitzman, SA1
Stossel, TP1
Pisciotta, V1
Marcus, J1
Mulvihill, FJ1
Ducomb, L1
Baldessarini, RJ1
Means, RT1
Sandidge, DR1
Rankin, KM1
Robichaux, MR1
Ben-Yehuda, A1
Bloom, A1
Lijovetzky, G1
Flusser, D1
Tur-Kaspa, R1
Young, A1
Kehoe, R1
Yassa, R1
Vincent, PC1
Thomas, J1
Clark, ML1
Ramsey, HR1
Ragland, RE1
Rahhal, DK1
Serafetinides, EA1
Costiloe, JP1
Palleschi, M1
Palleschi, A1
D'Amore, F1
Denber, HC1
Schulterbrandt, JG1
Raskin, A1
Reatig, N1
Westwick, WJ1
Allsop, J1
Watts, RW2
Blackburn, MJ1
Andrews, TM1
Litvak, R1
Kaelbling, R1
Cassileth, PA1
McCurrach, PH1
Park, JK1
Perry, WL1
Fréjaville, JP1
Guyochin, A1
Gaultier, M1
Mandel, A1
Gross, M1
Roos, BE1
Pretty, HM1
Gosselin, G1
Colpron, G1
Long, LA1

Reviews

6 reviews available for chlorpromazine and Agranulocytosis

ArticleYear
[COMPLICATIONS DURING CLINICAL THERAPY WITH PSYCHOPHARMACA].
    Arztliche Forschung, 1964, Jan-10, Volume: 18

    Topics: Agranulocytosis; Autonomic Nervous System Diseases; Chemical and Drug Induced Liver Injury; Chlorpro

1964
Drug-induced agranulocytosis.
    Haematologica, 1982, Volume: 67, Issue:2

    Topics: Agranulocytosis; Autoantibodies; Bone Marrow; Chlorpromazine; Female; Hematopoiesis; Humans; Leukocy

1982
Drug-induced agranulocytosis.
    Drugs, 1978, Volume: 15, Issue:2

    Topics: Agranulocytosis; Aminopyrine; Antibodies; Antibodies, Antinuclear; Bone Marrow; Chlorpromazine; Huma

1978
Immune and toxic mechanisms in drug-induced agranulocytosis.
    Seminars in hematology, 1973, Volume: 10, Issue:4

    Topics: Agranulocytosis; Aminopyrine; Animals; Anti-Bacterial Agents; Antigen-Antibody Reactions; Antithyroi

1973
[Drug induced cytopenias].
    La Clinica terapeutica, 1967, Dec-15, Volume: 43, Issue:5

    Topics: Agranulocytosis; Aminopyrine; Anti-Bacterial Agents; Anti-Inflammatory Agents; Antihypertensive Agen

1967
Agranulocytosis induced by certain phenothiazine derivatives.
    JAMA, 1969, Jun-09, Volume: 208, Issue:10

    Topics: Age Factors; Agranulocytosis; Bone Marrow; Bone Marrow Cells; Chlorpromazine; DNA; Female; Hematopoi

1969

Trials

4 trials available for chlorpromazine and Agranulocytosis

ArticleYear
The efficacy and safety of clozapine versus chlorpromazine in geriatric schizophrenia.
    The Journal of clinical psychiatry, 1999, Volume: 60, Issue:1

    Topics: Age Factors; Aged; Agranulocytosis; Antipsychotic Agents; Chlorpromazine; Clozapine; Double-Blind Me

1999
Chlorpromazine in chronic schizophrenia: behavioral dose-response relationships.
    Psychopharmacologia, 1970, Volume: 18, Issue:3

    Topics: Adult; Agranulocytosis; Analysis of Variance; Anemia; Behavior; Chlorpromazine; Chronic Disease; Cli

1970
True and apparent side effects in a controlled trial of chlorpromazine and imipramine in depression.
    Psychopharmacologia, 1974, Volume: 38, Issue:4

    Topics: Adult; Agranulocytosis; Chlorpromazine; Clinical Trials as Topic; Depression; Dermatitis; Edema; Eva

1974
Agranulocytosis and phenothiazines.
    Diseases of the nervous system, 1968, Volume: 29, Issue:1

    Topics: Adolescent; Adult; Age Factors; Aged; Agranulocytosis; Chlorpromazine; Chronic Disease; Ethnology; F

1968

Other Studies

89 other studies available for chlorpromazine and Agranulocytosis

ArticleYear
A Medication Hiccup: Chlorpromazine-Induced Agranulocytosis in a 72-Year-Old Male.
    WMJ : official publication of the State Medical Society of Wisconsin, 2022, Volume: 121, Issue:3

    Topics: Aged; Agranulocytosis; Chlorpromazine; Hiccup; Humans; Male; Sepsis

2022
[Chlorpromazine-induced agranulocytosis: a case report].
    L'Encephale, 2009, Volume: 35, Issue:2

    Topics: Agranulocytosis; Antipsychotic Agents; Chlorpromazine; Dose-Response Relationship, Drug; Drug Intera

2009
Hematopoietic growth factors in drug-induced agranulocytosis.
    The Journal of the Association of Physicians of India, 2002, Volume: 50, Issue:5

    Topics: Adolescent; Adult; Agranulocytosis; Chlorpromazine; Dapsone; Dipyrone; Female; Granulocyte-Macrophag

2002
[A case of agranulocytosis during largactil therapy].
    Ugeskrift for laeger, 1954, Dec-23, Volume: 116, Issue:51

    Topics: Agranulocytosis; Chlorpromazine; Humans

1954
Agranulocytic angina following chlorpromazine (largactil).
    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1955, Jul-16, Volume: 29, Issue:29

    Topics: Agranulocytosis; Anti-Bacterial Agents; Chlorpromazine; Cortisone; Dermatologic Agents; Humans

1955
Agranulocytosis associated with administration of chlorpromazine; report of three cases with description of treatment and recovery.
    A.M.A. archives of internal medicine, 1955, Volume: 96, Issue:4

    Topics: Agranulocytosis; Biological Phenomena; Chlorpromazine; Humans; Physiological Phenomena

1955
Agranulocytosis, associated with thorazine therapy.
    Missouri medicine, 1955, Volume: 52, Issue:10

    Topics: Agranulocytosis; Chlorpromazine; Humans

1955
Agranulocytosis associated with chlorpromazine therapy.
    A.M.A. archives of internal medicine, 1955, Volume: 96, Issue:6

    Topics: Agranulocytosis; Chlorpromazine; Humans

1955
Agranulocytosis following chlorpromazine therapy.
    Journal - Michigan State Medical Society, 1955, Volume: 54, Issue:12

    Topics: Agranulocytosis; Chlorpromazine; Electroconvulsive Therapy; Humans; Mental Disorders; Psychosurgery;

1955
Agranulocytosis with chlorpromazine.
    The American journal of psychiatry, 1956, Volume: 112, Issue:7

    Topics: Agranulocytosis; Chlorpromazine; Humans

1956
A fatality associated with chlorpromazine (largactil) therapy.
    Canadian Medical Association journal, 1956, Jan-15, Volume: 74, Issue:2

    Topics: Agranulocytosis; Chlorpromazine; Schizophrenia

1956
Agranulocytosis due to chlorpromazine; report of a case with recovery.
    Journal of the South Carolina Medical Association, 1956, Volume: 52, Issue:2

    Topics: Agranulocytosis; Chlorpromazine; Humans

1956
Agranulocytosis while receiving combined reserpine-chlorpromazine therapy; report of two cases.
    Diseases of the nervous system, 1956, Volume: 17, Issue:3

    Topics: Agranulocytosis; Chlorpromazine; Mental Disorders; Psychosurgery; Psychotherapy; Psychotherapy, Mult

1956
Severe granulocytopenia in patient treated with chlorpromazine; report of a case with recovery.
    American journal of clinical pathology, 1956, Volume: 26, Issue:4

    Topics: Agranulocytosis; Chlorpromazine; Humans

1956
Agranulocytosis associated with chlorpromazine therapy.
    The American journal of psychiatry, 1956, Volume: 112, Issue:12

    Topics: Agranulocytosis; Chlorpromazine; Humans

1956
[A case of agranulocytosis during treatment with chlorpromazine].
    Annales medico-psychologiques, 1956, Volume: 114, Issue:3

    Topics: Agranulocytosis; Chlorpromazine; Humans

1956
Agranulocytosis and severe leucopenia after chlorpromazine hydrochloride.
    British medical journal, 1956, May-12, Volume: 1, Issue:4975

    Topics: Agranulocytosis; Chlorpromazine; Humans; Leukocyte Count; Leukocyte Disorders; Leukopenia

1956
A case of fatal agranulocytosis due to chlorpromazine.
    The American journal of psychiatry, 1956, Volume: 113, Issue:1

    Topics: Agranulocytosis; Chlorpromazine; Humans

1956
Fatal agranulocytosis due to chlorpromazine.
    The Illinois medical journal, 1956, Volume: 110, Issue:5

    Topics: Agranulocytosis; Chlorpromazine; Humans

1956
Fatal agranulocytosis due to chlorpromazine.
    The Illinois medical journal, 1956, Volume: 110, Issue:5

    Topics: Agranulocytosis; Chlorpromazine; Humans

1956
Fatal agranulocytosis due to chlorpromazine.
    The Illinois medical journal, 1956, Volume: 110, Issue:5

    Topics: Agranulocytosis; Chlorpromazine; Humans

1956
Fatal agranulocytosis due to chlorpromazine.
    The Illinois medical journal, 1956, Volume: 110, Issue:5

    Topics: Agranulocytosis; Chlorpromazine; Humans

1956
Chlorpromazine therapy complicated by agranulocytosis and jaundice.
    Minnesota medicine, 1956, Volume: 39, Issue:11

    Topics: Agranulocytosis; Chlorpromazine; Humans; Jaundice; Minnesota

1956
Chlorpromazine therapy complicated by agranulocytosis and jaundice.
    Minnesota medicine, 1956, Volume: 39, Issue:11

    Topics: Agranulocytosis; Chlorpromazine; Humans; Jaundice; Minnesota

1956
Chlorpromazine therapy complicated by agranulocytosis and jaundice.
    Minnesota medicine, 1956, Volume: 39, Issue:11

    Topics: Agranulocytosis; Chlorpromazine; Humans; Jaundice; Minnesota

1956
Chlorpromazine therapy complicated by agranulocytosis and jaundice.
    Minnesota medicine, 1956, Volume: 39, Issue:11

    Topics: Agranulocytosis; Chlorpromazine; Humans; Jaundice; Minnesota

1956
Toxic effects of chlorpromazine; hepatitis and agranulocytosis.
    United States Armed Forces medical journal, 1956, Volume: 7, Issue:12

    Topics: Agranulocytosis; Chlorpromazine; Hepatitis; Hepatitis A; Humans; Viral Vaccines

1956
Toxic effects of chlorpromazine; hepatitis and agranulocytosis.
    United States Armed Forces medical journal, 1956, Volume: 7, Issue:12

    Topics: Agranulocytosis; Chlorpromazine; Hepatitis; Hepatitis A; Humans; Viral Vaccines

1956
Toxic effects of chlorpromazine; hepatitis and agranulocytosis.
    United States Armed Forces medical journal, 1956, Volume: 7, Issue:12

    Topics: Agranulocytosis; Chlorpromazine; Hepatitis; Hepatitis A; Humans; Viral Vaccines

1956
Toxic effects of chlorpromazine; hepatitis and agranulocytosis.
    United States Armed Forces medical journal, 1956, Volume: 7, Issue:12

    Topics: Agranulocytosis; Chlorpromazine; Hepatitis; Hepatitis A; Humans; Viral Vaccines

1956
Agranulocytosis in patients treated with thorazine; report of a fatal case.
    The American journal of psychiatry, 1957, Volume: 113, Issue:11

    Topics: Agranulocytosis; Chlorpromazine; Humans

1957
Agranulocytosis due to chlorpromazine.
    New York state journal of medicine, 1957, Apr-15, Volume: 57, Issue:8

    Topics: Agranulocytosis; Chlorpromazine; Humans

1957
Agranulocytosis due to chlorpromazine.
    Southern medical journal, 1957, Volume: 50, Issue:4

    Topics: Agranulocytosis; Chlorpromazine; Humans

1957
Agranulocytosis associated with chlorpromazine therapy.
    The Journal of nervous and mental disease, 1956, Volume: 124, Issue:3

    Topics: Agranulocytosis; Chlorpromazine; Humans

1956
[Agranulocytosis following therapeutic use of chlorpromazine and its derivatives].
    Ugeskrift for laeger, 1957, Mar-28, Volume: 119, Issue:13

    Topics: Agranulocytosis; Chlorpromazine; Humans

1957
Agranulocytosis; report of case following use of chlorpromazine.
    The Journal of the Kansas Medical Society, 1957, Volume: 58, Issue:6

    Topics: Agranulocytosis; Chlorpromazine; Humans

1957
[Acute immunologically induced agranulocytosis after administration of chlorpromazine].
    Medizinische Klinik, 1957, May-10, Volume: 52, Issue:19

    Topics: Agranulocytosis; Chlorpromazine; Humans; Schizophrenia

1957
Agranulocytosis with recovery during promazine therapy.
    British medical journal, 1957, Aug-03, Volume: 2, Issue:5039

    Topics: Agranulocytosis; Biological Phenomena; Chlorpromazine; Humans; Physiological Phenomena; Promazine

1957
Agranulocytosis following chlorpromazine.
    The Journal of the Medical Society of New Jersey, 1957, Volume: 54, Issue:8

    Topics: Agranulocytosis; Chlorpromazine; Humans

1957
Agranulocytosis-iatrogenic disease.
    American practitioner and digest of treatment, 1957, Volume: 8, Issue:11

    Topics: Agranulocytosis; Aminopyrine; Chlorpromazine; Humans; Hydantoins; Iatrogenic Disease

1957
Agranulocytosis following administration of chlorpromazine and pacatal: report of a case.
    The Medical journal of Australia, 1957, Nov-16, Volume: 44, Issue:20

    Topics: Agranulocytosis; Autonomic Agents; Chlorpromazine; Humans; Phenothiazines

1957
Agranulocytosis due to chlorpromazine.
    The Ohio State medical journal, 1957, Volume: 53, Issue:12

    Topics: Agranulocytosis; Chlorpromazine; Humans

1957
[Agranulocytosis during chlorpromazine therapy; further case; recovery].
    La Presse medicale, 1958, Jan-08, Volume: 66, Issue:2

    Topics: Agranulocytosis; Chlorpromazine; Electroconvulsive Therapy; Mental Disorders; Psychosurgery; Psychot

1958
High dosage chlorpromazine therapy after previous agranulocytosis.
    The American journal of psychiatry, 1958, Volume: 114, Issue:11

    Topics: Agranulocytosis; Chlorpromazine; Humans

1958
Granulocytopenia associated with chlorpromazine therapy.
    Journal - Michigan State Medical Society, 1958, Volume: 57, Issue:5

    Topics: Agranulocytosis; Chlorpromazine

1958
Agranulocytosis following administration of phenothiazine derivatives.
    The American journal of medicine, 1958, Volume: 25, Issue:2

    Topics: Agranulocytosis; Chlorpromazine; Humans; Phenothiazines

1958
[Fatal agranulocytosis during chlorpromazine therapy].
    Annales medico-psychologiques, 1958, Volume: 116, Issue:1

    Topics: Agranulocytosis; Chlorpromazine; Humans

1958
Fatal case of agranulocytosis due to chlorpromazine.
    British medical journal, 1958, Aug-02, Volume: 2, Issue:5091

    Topics: Agranulocytosis; Chlorpromazine; Humans

1958
Agranulocytosis and jaundice following chlorpromazine therapy.
    The Illinois medical journal, 1958, Volume: 114, Issue:5

    Topics: Agranulocytosis; Chlorpromazine; Humans; Jaundice

1958
Agranulocytosis caused by phenothiazine derivatives.
    Journal of the American Medical Association, 1959, Aug-22, Volume: 170, Issue:17

    Topics: Agranulocytosis; Antipsychotic Agents; Chlorpromazine; Humans; Phenothiazines

1959
Myocardial lesions and granulocytopenia associated with chlorpromazine therapy. Liver necrosis resulting from unsuspected carbon tetrachloride poisoning.
    American journal of clinical pathology, 1960, Volume: 34

    Topics: Agranulocytosis; Carbon Tetrachloride Poisoning; Chlorpromazine; Liver; Liver Diseases; Myocardium

1960
Granulocytopenia due to chlorpromazine: a report of 11 cases.
    The American journal of the medical sciences, 1961, Volume: 241

    Topics: Agranulocytosis; Chlorpromazine; Counseling; Humans; Mental Disorders

1961
Fatal agranulocytosis due to chlorpromazine.
    The New Zealand medical journal, 1960, Volume: 59

    Topics: Agranulocytosis; Chlorpromazine; Humans

1960
[Fatal agranulocytosis associated with chlorpromazine therapy: myelogram of lymphosis].
    Annales medico-psychologiques, 1962, Volume: 120(1)

    Topics: Agranulocytosis; Chlorpromazine; Fluoroscopy; Humans; Myelography

1962
[3 cases of medicamentous agranulocytosis: Largactil, Cibalgin, Salazopyrine].
    Ugeskrift for laeger, 1962, Feb-02, Volume: 124

    Topics: Agranulocytosis; Aminopyrine; Barbiturates; Chlorpromazine; Drug Combinations; Glucosamine; Humans;

1962
Promethazine and drug-induced jaundice.
    Lancet (London, England), 1963, Feb-16, Volume: 1, Issue:7277

    Topics: Agranulocytosis; Chlorpromazine; Jaundice; Promethazine

1963
Some comments on the pathogenesis of agranulocytosis.
    Wisconsin medical journal, 1963, Volume: 62

    Topics: Agranulocytosis; Chlorpromazine; Nucleosides; Thymidine

1963
A drug-specific leuco-agglutinin in a fatal case of agranulocytosis due to chlorpromazine.
    Journal of clinical pathology, 1963, Volume: 16

    Topics: Agglutinins; Agranulocytosis; Antibodies; Asthma; Chlorpromazine; Chlorpropamide; Drug Hypersensitiv

1963
DRUG-INDUCED AGRANULOCYTOSIS AND SEPTICAEMIA.
    The Medical journal of Australia, 1963, Oct-05, Volume: 2

    Topics: Agranulocytosis; Antipsychotic Agents; Benzene; Chlorpromazine; Methylthiouracil; Phenothiazines; Ph

1963
[CHANGES IN THE BLOOD CAUSED BY DRUGS].
    Nederlands tijdschrift voor geneeskunde, 1963, Nov-09, Volume: 107

    Topics: Agranulocytosis; Anemia; Anemia, Aplastic; Anemia, Hemolytic; Chloramphenicol; Chlorpromazine; Drug

1963
DRUG-INDUCED BLOOD DYSCRASIAS. II. AGRANULOCYTOSIS.
    JAMA, 1964, Jun-01, Volume: 188

    Topics: Agranulocytosis; Analgesics; Analgesics, Non-Narcotic; Anti-Bacterial Agents; Antipyretics; Antithyr

1964
[ON THE CLINICAL ASPECTS OF AGRANULOCYTOSIS].
    Medizinische Klinik, 1964, Jan-10, Volume: 59

    Topics: Agranulocytosis; Aminopyrine; Analgesics; Analgesics, Non-Narcotic; Antipyretics; Chlorpromazine; Dr

1964
STUDIES ON AGRANULOCYTOSIS. V. PATTERNS OF RECOVERY FROM DRUG-INDUCED BONE MARROW DAMAGE.
    The Journal of laboratory and clinical medicine, 1964, Volume: 63

    Topics: Agranulocytosis; Biomedical Research; Blood Cell Count; Bone Marrow; Bone Marrow Diseases; Chlorprom

1964
[DRUG-INDUCED AGRANULOCYTOSIS].
    Harefuah, 1964, Jul-01, Volume: 67

    Topics: Agranulocytosis; Aminopyrine; Chloramphenicol; Chlorpromazine; Diuretics; Humans; Organomercury Comp

1964
[AGRANULOCYTOSIS AND NEUTROPENIA].
    Journal des sciences medicales de Lille, 1964, Volume: 82

    Topics: Adrenal Cortex Hormones; Agranulocytosis; Aminopyrine; Analgesics; Analgesics, Non-Narcotic; Antipyr

1964
STUDIES ON AGRANULOCYTOSIS. VII. LIMITED PROLIFERATIVE POTENTIAL OF CPZ-SENSITIVE PATIENTS.
    The Journal of laboratory and clinical medicine, 1965, Volume: 65

    Topics: Agranulocytosis; Bone Marrow Cells; Cell Division; Chlorpromazine; DNA; Drug Tolerance; Humans; Leuk

1965
STUDIES ON AGRANULOCYTOSIS. VI. THE EFFECT OF CLINICAL TREATMENT WITH CHLORPROMAZINE ON NUCLEIC-ACID SYNTHESIS OF GRANULOCYTE PRECURSORS IN NORMAL PERSONS.
    The Journal of laboratory and clinical medicine, 1965, Volume: 65

    Topics: Agranulocytosis; Bone Marrow Cells; Cell Division; Chlorpromazine; DNA; Drug Tolerance; Granulocytes

1965
Fatal agranulocytosis during treatment with chlorpromazine.
    British medical journal, 1955, Apr-16, Volume: 1, Issue:4919

    Topics: Agranulocytosis; Chlorpromazine; Electroconvulsive Therapy; Humans; Mental Disorders; Psychosurgery;

1955
Jaundice and agranulocytosis with fatality following chlorpromazine therapy.
    Journal of the American Medical Association, 1955, May-14, Volume: 158, Issue:2

    Topics: Agranulocytosis; Chlorpromazine; Humans; Jaundice

1955
Agranulocytosis and thrombocytopenia in a case of tetanus treated with curare and chlorpromazine.
    Danish medical bulletin, 1955, Volume: 2, Issue:3

    Topics: Agranulocytosis; Blood Platelets; Chlorpromazine; Curare; Humans; Tetanus; Thrombocytopenia

1955
Aplastic anaemia and agranulocytosis following chlorpromazine therapy.
    The Medical journal of Australia, 1960, Jan-23, Volume: 47(1)

    Topics: Agranulocytosis; Anemia; Anemia, Aplastic; Chlorpromazine; Humans

1960
Studies on agranulocytosis. IV. Effects of chlorpromazine on nucleic acid synthesis of bone marrow cells in vitro.
    Blood, 1962, Volume: 20

    Topics: Agranulocytosis; Bone Marrow; Bone Marrow Cells; Chlorpromazine; In Vitro Techniques; Nucleic Acids;

1962
Studies on agranulocytosis. 8. Inhibition of mitosis in phytohemagglutinin-stimulated lymphocytes by chlorpromazine.
    The Journal of laboratory and clinical medicine, 1967, Volume: 70, Issue:2

    Topics: Agranulocytosis; Antibodies; Cell Division; Chlorpromazine; Colchicine; Culture Techniques; Humans;

1967
Agranulocytosis and jaundice associated with chlorpromazine.
    The British journal of clinical practice, 1967, Volume: 21, Issue:2

    Topics: Adolescent; Agranulocytosis; Chlorpromazine; Humans; Jaundice; Male; Mental Disorders

1967
A new concept in the relationship between biochemical reaction mechanisms and molecular basis of agranulocytosis.
    Biochemical medicine, 1984, Volume: 32, Issue:2

    Topics: Agranulocytosis; Aminopyrine; Autoantibodies; Biotransformation; Blood Proteins; Chloramphenicol; Ch

1984
Neutropenia following acute chlorpromazine ingestion.
    Clinical toxicology, 1981, Volume: 18, Issue:7

    Topics: Agranulocytosis; Child, Preschool; Chlorpromazine; Female; Humans; Male; Neutropenia; Time Factors

1981
First use of G-CSF in chlorpromazine-induced agranulocytosis: a report of two cases.
    Postgraduate medical journal, 1993, Volume: 69, Issue:817

    Topics: Adult; Agranulocytosis; Chlorpromazine; Female; Granulocyte Colony-Stimulating Factor; Humans; Middl

1993
Severe granulocytopenia secondary to chlorpromazine despite concurrent lithium treatment: a case report.
    The Kaohsiung journal of medical sciences, 1997, Volume: 13, Issue:10

    Topics: Aged; Agranulocytosis; Antipsychotic Agents; Chlorpromazine; Humans; Lithium; Male

1997
[Leukopenia and agranulocytosis induced by drugs].
    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1976, Mar-30, Volume: 96, Issue:9-10

    Topics: Agranulocytosis; Antithyroid Agents; Chlorpromazine; Humans; Leukopenia; Phenylbutazone; Thiourea

1976
Drug-induced immunological neutropenia.
    Lancet (London, England), 1978, May-20, Volume: 1, Issue:8073

    Topics: Adolescent; Adult; Aged; Agranulocytosis; Chlorothiazide; Chlorpromazine; Complement C3; Drug Hypers

1978
Agranulocytosis and chlorpromazine.
    The Journal of clinical psychiatry, 1978, Volume: 39, Issue:10

    Topics: Age Factors; Aged; Agranulocytosis; Chlorpromazine; Dose-Response Relationship, Drug; Female; Humans

1978
Timing and risk of bone marrow depression by psychotropic drugs.
    The American journal of psychiatry, 1977, Volume: 134, Issue:11

    Topics: Adult; Agranulocytosis; Bone Marrow; Chlorpromazine; Dose-Response Relationship, Drug; Humans; Leuko

1977
Treatment of phenothiazine-induced agranulocytosis with recombinant granulocyte colony-stimulating factor.
    American journal of hematology, 1992, Volume: 41, Issue:4

    Topics: Adult; Agranulocytosis; Chlorpromazine; Granulocyte Colony-Stimulating Factor; Humans; Male; Recombi

1992
Chlorpromazine-induced liver and bone marrow granulomas associated with agranulocytosis.
    Israel journal of medical sciences, 1990, Volume: 26, Issue:8

    Topics: Adult; Agranulocytosis; Bone Marrow Diseases; Chemical and Drug Induced Liver Injury; Chlorpromazine

1990
Two cases of agranulocytosis on addition of a butyrophenone to a long-standing course of phenothiazine treatment.
    The British journal of psychiatry : the journal of mental science, 1989, Volume: 154

    Topics: Agranulocytosis; Antipsychotic Agents; Chlorpromazine; Clomipramine; Depressive Disorder; Dose-Respo

1989
Agranulocytosis in the course of phenothiazine therapy: case reports.
    The Journal of clinical psychiatry, 1985, Volume: 46, Issue:8

    Topics: Adult; Agranulocytosis; Antipsychotic Agents; Chlorpromazine; Female; Humans; Male; Middle Aged; Psy

1985
Drug-induced aplastic anaemia and agranulocytosis. Incidence and mechanisms.
    Drugs, 1986, Volume: 31, Issue:1

    Topics: Agranulocytosis; Aminopyrine; Anemia, Aplastic; Animals; Bone Marrow; Chloramphenicol; Chlorpromazin

1986
Fatal case of agranulocytosis due to chlorpromazine.
    Lancet (London, England), 1970, Jan-03, Volume: 1, Issue:7636

    Topics: Adult; Age Factors; Agranulocytosis; Bronchopneumonia; Chlorpromazine; Depression; Female; Humans

1970
An unusual case of chlorpromazine agranulocytosis.
    Diseases of the nervous system, 1970, Volume: 31

    Topics: Agranulocytosis; Chlorpromazine; Female; Fluphenazine; Humans; Middle Aged; Phenothiazines

1970
A study of the effect of some drugs which cause agranulocytosis on the biosynthesis of pyrimidines in human granulocytes.
    Biochemical pharmacology, 1972, Jul-15, Volume: 21, Issue:14

    Topics: Agranulocytosis; Amidohydrolases; Aspartate Carbamoyltransferase; Blood Proteins; Carbimazole; Carbo

1972
Drug-induced neutropenia-effects of drugs on granulocyte protein synthesis in vitro.
    Clinical science and molecular medicine, 1973, Volume: 45, Issue:3

    Topics: Agranulocytosis; Chloramphenicol; Chlorpromazine; Humans; Leukocytes; Neutrophils; Phenylbutazone; P

1973
Studies on agranulocytosis. IX. A biochemical defect in chlorpromazine-sensitive marrow cells.
    The Journal of laboratory and clinical medicine, 1971, Volume: 78, Issue:3

    Topics: Adenosine; Adult; Aged; Agranulocytosis; Bone Marrow; Bone Marrow Cells; Cell Division; Cells, Cultu

1971
Agranulocytosis, leukopenia, and psychotropic drugs.
    Archives of general psychiatry, 1971, Volume: 24, Issue:3

    Topics: Adult; Agranulocytosis; Amitriptyline; Chlordiazepoxide; Chlorpromazine; Diazepam; Humans

1971
Monocytosis in chlorpromazine-associated agranulocytosis. Ter mination in acute leukemia.
    The American journal of medicine, 1967, Volume: 43, Issue:3

    Topics: Agranulocytosis; Bone Marrow; Bone Marrow Cells; Chlorpromazine; Female; Humans; Leukemia, Myeloid,

1967
The effects of some drugs which induce agranulocytosis on the metabolism of separated human polymorphonuclear leucocytes and lymphocytes.
    British journal of pharmacology, 1970, Volume: 38, Issue:3

    Topics: Agranulocytosis; Aminopyrine; Chloramphenicol; Chlorpromazine; Depression, Chemical; Glucose; Humans

1970
[152 cases of acute poisoning by phenothiazine amines].
    European journal of toxicology, 1970, Volume: 3, Issue:3

    Topics: Absorption; Adolescent; Adult; Aged; Agranulocytosis; Anesthesia, General; Anesthesia, Obstetrical;

1970
[Adverse effects of phenothiazines].
    Nordisk psykiatrisk tidsskrift. Nordic journal of psychiatry, 1968, Volume: 22, Issue:2

    Topics: Agranulocytosis; Chlorpromazine; Eye Manifestations; Female; Humans; Hypnotics and Sedatives; Male;

1968
Agranulocytosis: a report of 30 cases.
    Canadian Medical Association journal, 1965, Nov-13, Volume: 93, Issue:20

    Topics: Adult; Aged; Agranulocytosis; Aminopyrine; Aspirin; Bone Marrow; Bone Marrow Examination; Chlorproma

1965