chlorpromazine has been researched along with Aging in 49 studies
Chlorpromazine: The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking DOPAMINE RECEPTORS. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the treatment of intractable hiccup.
chlorpromazine : A substituted phenothiazine in which the ring nitrogen at position 10 is attached to C-3 of an N,N-dimethylpropanamine moiety.
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Reserpine which promotes catecholamine release from the tissues, leads to the diminution of the rate of the MR of the shudder type in rats of the same age." | 1.27 | [Adrenergic mechanisms regulating the motor reactions of rats in the early postnatal period]. ( Praznikov, VP, 1984) |
| "6 Animals withdrawn following chronic administration of a number of drugs, barbitone, barbitone/bemegride mixture, Mandrax (methaqualone: diphenhydramine; 10: 1), chlordiazepoxide, nitrazepam, chlorpromazine or ethanol, exhibited a significant tolerance to intracerebroventricularly administered pentobarbitone." | 1.25 | A study of the factors affecting the sleeping time following intracerebroventricular administration of pentobarbitone sodium: effect of prior administration of centrally active drugs. ( Stevenson, IH; Turnbull, MJ, 1974) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 44 (89.80) | 18.7374 |
| 1990's | 1 (2.04) | 18.2507 |
| 2000's | 1 (2.04) | 29.6817 |
| 2010's | 2 (4.08) | 24.3611 |
| 2020's | 1 (2.04) | 2.80 |
| Authors | Studies |
|---|---|
| Obara, K | 1 |
| Matsuoka, Y | 1 |
| Iwata, N | 1 |
| Abe, Y | 1 |
| Ikegami, Y | 1 |
| Shioda, N | 1 |
| Hattori, Y | 1 |
| Hamamatsu, S | 1 |
| Yoshioka, K | 1 |
| Yamaki, F | 1 |
| Matsuo, K | 1 |
| Yoshio, T | 1 |
| Tanaka, Y | 1 |
| Basta-Kaim, A | 1 |
| Szczęsny, E | 1 |
| Leśkiewicz, M | 1 |
| Głombik, K | 1 |
| Slusarczyk, J | 1 |
| Budziszewska, B | 1 |
| Regulska, M | 1 |
| Kubera, M | 1 |
| Nowak, W | 1 |
| Wędzony, K | 1 |
| Lasoń, W | 1 |
| Hausott, B | 1 |
| Rietzler, A | 1 |
| Vallant, N | 1 |
| Auer, M | 1 |
| Haller, I | 1 |
| Perkhofer, S | 1 |
| Klimaschewski, L | 1 |
| POLLACK, B | 1 |
| ROZANOVA, VD | 2 |
| BAGDON, WJ | 1 |
| MANN, DE | 1 |
| JILEK, L | 3 |
| TROJAN, S | 3 |
| FROMMEL, E | 1 |
| LAITL, J | 1 |
| DOTY, BA | 1 |
| DOTY, LA | 1 |
| COHEN, S | 1 |
| LEONARD, CV | 1 |
| FARBEROW, NL | 1 |
| SHNEIDMAN, ES | 1 |
| LAPITSKII, VD | 1 |
| Dean, CE | 1 |
| Kuskowski, MA | 1 |
| Caligiuri, MP | 1 |
| Rivera-Calimlim, L | 2 |
| Hershey, L | 1 |
| Lykouras, E | 1 |
| Varsou, E | 1 |
| Rinieris, P | 1 |
| Stefanis, CN | 1 |
| Praznikov, VP | 1 |
| Piekarczyk, A | 1 |
| Prokopczyk, J | 1 |
| Roy, D | 1 |
| Pathak, DN | 1 |
| Singh, R | 1 |
| Takahashi, S | 1 |
| Kawashima, S | 1 |
| Wakabayashi, K | 1 |
| Wode-Helgodt, B | 1 |
| Alfredsson, G | 1 |
| Mezhiborskaia, NA | 1 |
| Stefano, GB | 1 |
| Stanec, A | 1 |
| Catapane, EJ | 1 |
| Abernathy, CO | 1 |
| Lukacs, L | 1 |
| Zimmerman, HJ | 1 |
| Schenker, S | 1 |
| Heikkila, JJ | 1 |
| Brown, IR | 1 |
| Janoff, AS | 1 |
| Rosenberg, B | 1 |
| Taub, H | 1 |
| Peters, DA | 1 |
| Beasley, BA | 1 |
| Ford, DH | 1 |
| Samorajski, T | 1 |
| Rolsten, C | 1 |
| Ghosh, S | 1 |
| Grogan, WM | 1 |
| Cascales, C | 1 |
| Boscá, L | 1 |
| Martin, A | 1 |
| Brindley, DN | 1 |
| Cascales, M | 1 |
| Kachaev, AK | 1 |
| Ponomarev, GN | 1 |
| Mishanich, II | 1 |
| Turianitsa, IM | 1 |
| Pashchenko, AE | 1 |
| Rostoka, LM | 1 |
| Iliushina, SN | 1 |
| Finnen, MJ | 1 |
| Hassall, KA | 1 |
| Massie, HR | 1 |
| Williams, TR | 1 |
| Iodice, AA | 1 |
| Stevenson, IH | 1 |
| Turnbull, MJ | 1 |
| McKinney, WT | 1 |
| Young, LD | 1 |
| Suomi, SJ | 1 |
| Davis, JM | 1 |
| Kawai, H | 1 |
| Matsunaga, R | 1 |
| Hatotani, N | 1 |
| Srebro, Z | 1 |
| Pogády, J | 1 |
| Ruscák, M | 1 |
| Orlický, J | 1 |
| Liu, RK | 1 |
| Walford, RL | 1 |
| Cairns, RB | 1 |
| Scholz, SD | 1 |
| Mankovsky, NB | 1 |
| Belonog, RP | 2 |
| Man'kovskiĭ, NB | 1 |
| Lundon, JR | 1 |
| Barnett, HJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Randomized Controlled Trial of Adjunctive Siltuximab in Schizophrenia[NCT02796859] | Phase 1/Phase 2 | 30 participants (Anticipated) | Interventional | 2016-05-31 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for chlorpromazine and Aging
| Article | Year |
|---|---|
Neuroleptic concentrations and clinical response.
Topics: Aging; Antipsychotic Agents; Chlorpromazine; Chronic Disease; Drug Interactions; Fluphenazine; Halop | 1984 |
Problems in therapeutic blood monitoring of chlorpromazine.
Topics: Adolescent; Adult; Aged; Aging; Biological Availability; Child; Chlorpromazine; Chronic Disease; Dru | 1982 |
Aging and the extrapyramidal system.
Topics: Aged; Aging; Basal Ganglia Diseases; Chlorpromazine; Chorea; Dopamine; Frontal Lobe; Gait; Haloperid | 1976 |
The effect of lowered body temperature on lifespan and immune and non-immune processes.
Topics: Aging; Animals; Body Temperature; Cannabis; Chlorpromazine; Environment; Female; Hypothermia, Induce | 1972 |
1 trial available for chlorpromazine and Aging
| Article | Year |
|---|---|
Concentrations of chlorpromazine and two of its active metabolites in plasma and cerebrospinal fluid of psychotic patients treated with fixed drug doses.
Topics: Adult; Aging; Chlorpromazine; Female; Humans; Male; Middle Aged; Psychotic Disorders; Sex Factors; T | 1981 |
44 other studies available for chlorpromazine and Aging
| Article | Year |
|---|---|
Inhibitory Effects of Antipsychotics on the Contractile Response to Acetylcholine in Rat Urinary Bladder Smooth Muscles.
Topics: Acetylcholine; Aging; Animals; Antipsychotic Agents; Chlorpromazine; Cholinergic Antagonists; Clozap | 2021 |
Maternal immune activation leads to age-related behavioral and immunological changes in male rat offspring - the effect of antipsychotic drugs.
Topics: Age Factors; Aging; Animals; Antipsychotic Agents; Behavior, Animal; Cell Proliferation; Cells, Cult | 2012 |
Inhibition of fibroblast growth factor receptor 1 endocytosis promotes axonal branching of adult sensory neurons.
Topics: Aging; Animals; Apoptosis; Axons; beta-Cyclodextrins; Blotting, Western; Chlorpromazine; Dopamine An | 2011 |
The addition of chlorpromazine to the treatment program for emotional and behavior disorders in the aging.
Topics: Aged; Aging; Behavior; Chlorpromazine; Conduct Disorder; Emotions; Humans; Mental Disorders | 1956 |
[Electroencephalographic analysis of peculiarities of aminazine effects in dogs of various ages].
Topics: Aging; Animals; Chlorpromazine; Dogs; Endopeptidases; Glycation End Products, Advanced; Hydrolases; | 1959 |
Chlorpromazine hyperthermia in young albino mice.
Topics: Aging; Animals; Body Temperature; Chlorpromazine; Mice | 1962 |
[Influences on resistance of the body against oligemia and ischemia of the CNS during the course of ontogenesis].
Topics: Aging; Central Nervous System; Chlorpromazine; Hyperglycemia; Hypoxia; Ischemia; Pentobarbital | 1963 |
[Differences in influencing the course of anoxia and hypoxia of the central nervous system in ontogenesis].
Topics: Aging; Brain; Central Nervous System; Chlorpromazine; Humans; Hypoglycemia; Hypoxia; Pentobarbital | 1962 |
[ON THE DURATION OF SLEEP INDUCED BY PHENOBARBITAL, MORPHINE, MEPROBAMATE, METAMINODIAZEPOXIDE AND CHLORPROMAZINE ACCORDING TO WEIGHT (AGE) IN THE GUINEA PIG].
Topics: Aging; Body Weight; Chlorpromazine; Guinea Pigs; Meprobamate; Morphine; Pharmacology; Phenobarbital; | 1963 |
[RESISTANCE OF THE BODY TO ANOXIA DURING THE COURSE OF ONTOGENESIS AND THE EFFECT OF CHLORPROMAZINE].
Topics: Aging; Body Temperature Regulation; Chlorpromazine; Hyperglycemia; Hypoxia; Metabolism; Pharmacology | 1963 |
EFFECT OF AGE AND CHLORPROMAZINE ON MEMORY CONSOLIDATION.
Topics: Aging; Avoidance Learning; Chlorpromazine; Memory; Pharmacology; Rats; Research | 1964 |
TRANQUILIZERS AND SUICIDE IN THE SCHIZOPHRENIC PATIENT.
Topics: Aging; Alcoholism; Biomedical Research; Chlorpromazine; Drug Therapy; Marriage; Perphenazine; Prochl | 1964 |
[ON THE ANALYSIS OF THE ROLE AND NATURE OF CHOLINERGIC AND ADRENERGIC SUBSTANCES OF THE RETICULAR FORMATION IN DOGS OF VARIOUS AGES].
Topics: Acetylcholine; Adrenergic Agents; Aging; Animals; Atropine; Brain; Cerebral Cortex; Chlorpromazine; | 1964 |
[The effect of chlorpromazine and pentobarbital on the survival of spinal reflexes and activity of the respiration center in rats after decapitation in the course of ontogenesis].
Topics: Aging; Animals; Chlorpromazine; Decapitation; Medulla Oblongata; Pentobarbital; Rats; Reflex; Respir | 1961 |
[Features of the action, in relation to age, of aminazine, hexonium and tetamon].
Topics: Aging; Chlorpromazine; Hexamethonium; Hexamethonium Compounds; Tetraethylammonium | 1962 |
Predictors of neuroleptic-induced dyskinesia and parkinsonism: the influence of measurement methods and definitions.
Topics: Adult; Age Distribution; Age Factors; Aged; Aging; Antipsychotic Agents; Chlorpromazine; Craniocereb | 2006 |
Plasma cyclic AMP in schizophrenics.
Topics: Acute Disease; Aging; Blood Proteins; Chlorpromazine; Chronic Disease; Cyclic AMP; Female; Humans; M | 1980 |
[Adrenergic mechanisms regulating the motor reactions of rats in the early postnatal period].
Topics: Aging; Animals; Animals, Newborn; Chlorpromazine; Levodopa; Motor Activity; Rats; Receptors, Adrener | 1984 |
[Pharmacodynamic reactivity of the growing body].
Topics: Acetylcholine; Aging; Animals; Autonomic Nervous System; Chlorpromazine; Epinephrine; Homeostasis; R | 1984 |
Effects of chlorpromazine on the activities of antioxidant enzymes and lipid peroxidation in the various regions of aging rat brain.
Topics: Aging; Animals; Brain; Catalase; Chlorpromazine; Female; Glutathione Peroxidase; Glutathione Reducta | 1984 |
Effects of gonadectomy and chlorpromazine treatment on prolactin, LH, and FSH secretion in young and old rats of both sexes.
Topics: Aging; Animals; Castration; Chlorpromazine; Female; Follicle Stimulating Hormone; Luteinizing Hormon | 1980 |
[Reactive changes in the capillaries of the mammillary bodies of the brains of aging animals].
Topics: Aging; Animals; Capillaries; Capillary Permeability; Chlorpromazine; Endothelium; Epinephrine; Male; | 1981 |
Aging: decline of dopamine-stimulated adenylate cyclase activity in Mytilus edulis (Bivalvia).
Topics: Adenylyl Cyclases; Aging; Animals; Bivalvia; Chlorpromazine; Dopamine; Ganglia; Kinetics | 1982 |
Cytotoxic effects of erythromycin estolate and chlorpromazine on hepatocytes isolated from rats of varying ages: a brief note.
Topics: Aging; Animals; Aspartate Aminotransferases; Cell Extracts; Chlorpromazine; Erythromycin; Erythromyc | 1980 |
Effects of liver disease and of aging on the disposition and elimination of sedatives.
Topics: Aging; Anti-Anxiety Agents; Chlordiazepoxide; Chlorpromazine; Diazepam; Half-Life; Hepatitis, Viral, | 1978 |
Disaggregation of brain polysomes after LSD in vivo. Involvement of LSD-induced hyperthermia.
Topics: Aging; Animals; Apomorphine; Body Temperature; Brain; Chlorpromazine; Fever; Kidney; Lysergic Acid D | 1979 |
Chemically evoked hypothermia in the mouse: towards a method for investigating thermodynamic parameters of aging and death in mammals.
Topics: Adaptation, Physiological; Aging; Animals; Chlorpromazine; Drug Synergism; Female; Fenclonine; Hypot | 1978 |
Altered 5-hydroxyindole concentrations in brain regions of rats treated with chlorpromazine in infancy.
Topics: Aging; Animals; Animals, Newborn; Brain Chemistry; Chlorpromazine; Female; Hydroxyindoleacetic Acid; | 1978 |
Chlorpromazine and aging in the brain.
Topics: Aging; Animals; Body Weight; Brain; Brain Chemistry; Brain Stem; Chlorpromazine; DNA; Dopamine; Dose | 1976 |
Activation of myelin-associated cholesteryl ester hydrolase in developing rat brain.
Topics: Adenosine Triphosphate; Aging; Animals; Brain; Carboxylic Ester Hydrolases; Chlorpromazine; Cyclic A | 1990 |
Age-related changes in the translocation of phosphatidate phosphohydrolase from the cytosol to microsomal membranes in rat liver.
Topics: Aging; Animals; Chlorpromazine; Cytosol; Intracellular Membranes; Kinetics; Liver; Male; Microsomes, | 1988 |
[Age-related dynamics and conditions for developing male homosexuality].
Topics: Adolescent; Adult; Aging; Chlorpromazine; Homosexuality; Humans; Male; Middle Aged; Psychosexual Dev | 1988 |
[Free amino acids and the total middle molecule fraction of the blood serum in patients with continuously progressive paranoid schizophrenia undergoing treatment].
Topics: Adult; Aging; Amino Acids; Chlorpromazine; Drug Therapy, Combination; Humans; Middle Aged; Molecular | 1988 |
Effects of neonatally administered chlorpromazine and reserpine on the responsiveness of rat hepatic drug-metabolising enzymes to testosterone in adult life.
Topics: Aging; Animals; Animals, Newborn; Chlorpromazine; Dieldrin; Female; Liver; Male; Microsomes, Liver; | 1986 |
Influence of anti-inflammatory agents on the survival of Drosophila.
Topics: Aging; Animals; Anti-Inflammatory Agents; Chlorpromazine; Copper; Dimethyl Sulfoxide; Drosophila mel | 1985 |
A study of the factors affecting the sleeping time following intracerebroventricular administration of pentobarbitone sodium: effect of prior administration of centrally active drugs.
Topics: Aging; Amphetamine; Animals; Anti-Anxiety Agents; Barbiturates; Body Weight; Carbon Radioisotopes; C | 1974 |
Chlorpromazine treatment of disturbed monkeys.
Topics: Administration, Intranasal; Aggression; Aging; Animals; Behavior, Animal; Chlorpromazine; Circadian | 1973 |
[Characteristics of NAD metabolism in the brain--with reference to a comparison with the liver].
Topics: Aging; Animals; Brain; Carbon Tetrachloride Poisoning; Chlorpromazine; Liver; Male; NAD; Niacinamide | 1966 |
Relative electron excess and relative electron deficiency: an explanation for differences in the response of the organism to various factors.
Topics: Aging; Animals; Brain; Chlorpromazine; Electron Transport; Electrons; Female; Glucosephosphate Dehyd | 1974 |
Hypoxia and some therapeutic problems in gerontopsychiatry.
Topics: Aged; Aging; Brain; Brain Chemistry; Chlormethiazole; Chlorpromazine; Glycolysis; Humans; Hypoxia; L | 1972 |
Fighting in mice: dyadic escalation and what is learned.
Topics: Aggression; Aging; Animals; Arousal; Behavior, Animal; Chlorpromazine; Dose-Response Relationship, D | 1973 |
Aging of the human nervous system in the electroencephalographic aspect.
Topics: Action Potentials; Adolescent; Adult; Aged; Aging; Blood Pressure; Brain; Chlorpromazine; Electroenc | 1971 |
[Human aging and cerebral bioelectric activity].
Topics: Adolescent; Adult; Aged; Aging; Blood Glucose; Blood Pressure; Brain; Catecholamines; Chlorpromazine | 1971 |
Subacute inclusion body encephalitis in an Asian in the third decade.
Topics: Adult; Aging; Cerebrospinal Fluid; Chlorpromazine; Diagnosis, Differential; Diffuse Cerebral Scleros | 1966 |