chlorpromazine has been researched along with Adverse Drug Event in 47 studies
Chlorpromazine: The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking DOPAMINE RECEPTORS. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the treatment of intractable hiccup.
chlorpromazine : A substituted phenothiazine in which the ring nitrogen at position 10 is attached to C-3 of an N,N-dimethylpropanamine moiety.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Tardive dyskinesia (TD), the choreoathetoid movements of fingers, arms, legs, and trunk and irregular stereotypical movements of the mouth, face, and tongue, has been the scourge of antipsychotic medications since the approval of chlorpromazine." | 3.91 | Tardive Dyskinesia: New Treatments Available. ( Limandri, BJ, 2019) |
| " Thus, the aim of this study was to analyze the toxic effects of pharmaceuticals in non-standard endpoints on two macrophyte species, Lemna minor and Lemna gibba." | 1.51 | Evaluation of pharmaceutical toxic effects of non-standard endpoints on the macrophyte species Lemna minor and Lemna gibba. ( Alkimin, GD; Barata, C; Daniel, D; Frankenbach, S; Nunes, B; Serôdio, J; Soares, AMVM, 2019) |
| "Phospholipidosis (PLD) is a lysosomal storage disorder induced by compounds, notably cationic amphiphilic drugs, which although reversible interferes with cellular phospholipids." | 1.38 | In silico assay for assessing phospholipidosis potential of small druglike molecules: training, validation, and refinement using several data sets. ( Atzpodien, EA; Csato, M; Doessegger, L; Fischer, H; Lenz, B; Schmitt, G; Singer, T, 2012) |
| " We proposed a systematic classification scheme using FDA-approved drug labeling to assess the DILI potential of drugs, which yielded a benchmark dataset with 287 drugs representing a wide range of therapeutic categories and daily dosage amounts." | 1.37 | FDA-approved drug labeling for the study of drug-induced liver injury. ( Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V, 2011) |
| "barbital, which was not, using strictly the same experimental procedure." | 1.30 | The popliteal lymph node assay: results of a preliminary interlaboratory validation study. ( Carleer, J; Descotes, J; Legrain, B; Verdier, F; Vial, T, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 32 (68.09) | 18.7374 |
| 1990's | 1 (2.13) | 18.2507 |
| 2000's | 2 (4.26) | 29.6817 |
| 2010's | 12 (25.53) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Pedersen, JM | 1 |
| Matsson, P | 1 |
| Bergström, CA | 1 |
| Norinder, U | 1 |
| Hoogstraate, J | 1 |
| Artursson, P | 1 |
| Hajjo, R | 1 |
| Grulke, CM | 1 |
| Golbraikh, A | 1 |
| Setola, V | 1 |
| Huang, XP | 1 |
| Roth, BL | 1 |
| Tropsha, A | 1 |
| Chen, M | 1 |
| Vijay, V | 1 |
| Shi, Q | 2 |
| Liu, Z | 2 |
| Fang, H | 2 |
| Tong, W | 2 |
| Dawson, S | 1 |
| Stahl, S | 1 |
| Paul, N | 1 |
| Barber, J | 1 |
| Kenna, JG | 1 |
| Fischer, H | 1 |
| Atzpodien, EA | 1 |
| Csato, M | 1 |
| Doessegger, L | 1 |
| Lenz, B | 1 |
| Schmitt, G | 1 |
| Singer, T | 1 |
| Ding, D | 1 |
| Kelly, R | 1 |
| Sakatis, MZ | 1 |
| Reese, MJ | 1 |
| Harrell, AW | 1 |
| Taylor, MA | 1 |
| Baines, IA | 1 |
| Chen, L | 1 |
| Bloomer, JC | 1 |
| Yang, EY | 1 |
| Ellens, HM | 1 |
| Ambroso, JL | 1 |
| Lovatt, CA | 1 |
| Ayrton, AD | 1 |
| Clarke, SE | 1 |
| Morgan, RE | 1 |
| van Staden, CJ | 1 |
| Chen, Y | 1 |
| Kalyanaraman, N | 1 |
| Kalanzi, J | 1 |
| Dunn, RT | 1 |
| Afshari, CA | 1 |
| Hamadeh, HK | 1 |
| Sano, T | 1 |
| Inoue, M | 1 |
| Takizawa, M | 1 |
| Shimamori, Y | 1 |
| Kurosawa, N | 1 |
| Bustillo, M | 1 |
| Zabala, A | 1 |
| Querejeta, I | 1 |
| Carton, JI | 1 |
| Mentxaka, O | 1 |
| González-Pinto, A | 1 |
| García, S | 1 |
| Meana, JJ | 1 |
| Eguiluz, JI | 1 |
| Segarra, R | 1 |
| Alkimin, GD | 1 |
| Daniel, D | 1 |
| Frankenbach, S | 1 |
| Serôdio, J | 1 |
| Soares, AMVM | 1 |
| Barata, C | 1 |
| Nunes, B | 1 |
| Limandri, BJ | 1 |
| Vatakuti, S | 1 |
| Pennings, JL | 1 |
| Gore, E | 1 |
| Olinga, P | 1 |
| Groothuis, GM | 1 |
| BRUNE, A | 1 |
| VIALLIER, J | 1 |
| ROCHE, L | 1 |
| MADJEREK, Z | 1 |
| STERN, P | 1 |
| GUTMAN, AB | 1 |
| MANCA, P | 1 |
| MISSERE, G | 1 |
| BABBINI, M | 1 |
| TONINI, G | 1 |
| WUETSCHKE, J | 1 |
| COLE, PV | 1 |
| Onoue, S | 1 |
| Kawamura, K | 1 |
| Igarashi, N | 1 |
| Zhou, Y | 1 |
| Fujikawa, M | 1 |
| Yamada, H | 1 |
| Tsuda, Y | 1 |
| Seto, Y | 1 |
| Yamada, S | 1 |
| Cairella, M | 1 |
| Pilger, IS | 1 |
| Salaspuro, M | 1 |
| Holzbach, RT | 1 |
| Vial, T | 1 |
| Carleer, J | 1 |
| Legrain, B | 1 |
| Verdier, F | 1 |
| Descotes, J | 1 |
| Bowers, MB | 1 |
| Sherlock, S | 1 |
| Schwarz, JA | 1 |
| Stirrat, GM | 1 |
| Tareev, EM | 1 |
| Semendiaeva, ME | 1 |
| Mukhin, AS | 1 |
| Rozanova, LB | 1 |
| Blinkov, IL | 1 |
| Quadbeck, G | 1 |
| Harpey, JP | 1 |
| Koch, HR | 1 |
| Hockwin, O | 1 |
| Palleschi, M | 1 |
| Palleschi, A | 1 |
| D'Amore, F | 1 |
| Persianinov, LS | 1 |
| Kiriushchenkov, AP | 1 |
| Skosyreva, AM | 1 |
| Hollister, LE | 1 |
| Wepler, R | 1 |
| Rommel, K | 1 |
| Bruinsma, W | 1 |
| Girdwood, RH | 1 |
| Kleberger, E | 1 |
| Marzulli, FN | 1 |
| Reynolds, HH | 1 |
| Penn, AS | 1 |
| Rowland, LP | 1 |
| Fraser, DW | 1 |
| Ter-Grigorova, EN | 1 |
| Afanas'eva, VM | 1 |
| Ivanovskaia, TE | 1 |
| Brückner, R | 1 |
9 reviews available for chlorpromazine and Adverse Drug Event
| Article | Year |
|---|---|
Drug-induced liver disease.
Topics: Analgesics; Antineoplastic Agents; Chemical and Drug Induced Liver Injury; Chlorpromazine; Contracep | 1981 |
Prescribing problems in the second half of pregnancy and during lactation.
Topics: Analgesics; Anesthetics; Anti-Infective Agents; Anticoagulants; Antihypertensive Agents; Barbiturate | 1976 |
Lupus-like syndromes induced by drugs.
Topics: Antibodies, Antinuclear; Antibody Formation; Arthritis, Rheumatoid; Chlorpromazine; DNA, Single-Stra | 1974 |
[Drug induced cytopenias].
Topics: Agranulocytosis; Aminopyrine; Anti-Bacterial Agents; Anti-Inflammatory Agents; Antihypertensive Agen | 1967 |
Clinical use of psychotherapeutic drugs. I. Antipsychotic and antimanic drugs.
Topics: Affective Symptoms; Behavior; Bipolar Disorder; Chlorpromazine; Drug Hypersensitivity; Drug-Related | 1972 |
[Drugs and parameters in the laboratory medicine].
Topics: Aminosalicylic Acids; Aspirin; Blood Cell Count; Chlorpromazine; Chlorpropamide; Circadian Rhythm; C | 1973 |
[Damage to eyes through conservative therapy].
Topics: Accommodation, Ocular; Animals; Chlorpromazine; Chymotrypsin; Conjunctiva; Conjunctivitis; Cornea; D | 1967 |
Ocular side effects of drugs.
Topics: Animals; Cataract; Chlorpromazine; Dogs; Drug-Related Side Effects and Adverse Reactions; Electroret | 1968 |
Nonhuman primates in the study of toxicological effects on the central nervous system: a review.
Topics: Amphetamine; Animals; Central Nervous System; Chlordiazepoxide; Chlorpromazine; Drug-Related Side Ef | 1969 |
38 other studies available for chlorpromazine and Adverse Drug Event
| Article | Year |
|---|---|
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Bi | 2008 |
Development, validation, and use of quantitative structure-activity relationship models of 5-hydroxytryptamine (2B) receptor ligands to identify novel receptor binders and putative valvulopathic compounds among common drugs.
Topics: Algorithms; Binding, Competitive; Databases, Factual; Dexfenfluramine; Drug-Related Side Effects and | 2010 |
FDA-approved drug labeling for the study of drug-induced liver injury.
Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Des | 2011 |
In vitro inhibition of the bile salt export pump correlates with risk of cholestatic drug-induced liver injury in humans.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters | 2012 |
In silico assay for assessing phospholipidosis potential of small druglike molecules: training, validation, and refinement using several data sets.
Topics: Animals; Cattle; Cells, Cultured; Computer Simulation; Cornea; Drug-Related Side Effects and Adverse | 2012 |
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Da | 2011 |
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme | 2012 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily | 2013 |
The Effect of Pharmacist-led Psychiatric Pharmacotherapy Conferences on the Appropriate Use of Antipsychotics.
Topics: Adult; Antipsychotic Agents; Chlorpromazine; Cost Savings; Drug Costs; Drug-Related Side Effects and | 2017 |
Therapeutic Drug Monitoring of Second-Generation Antipsychotics for the Estimation of Early Drug Effect in First-Episode Psychosis: A Cross-sectional Assessment.
Topics: Adolescent; Adult; Antipsychotic Agents; Chlorpromazine; Cross-Sectional Studies; Drug Monitoring; D | 2018 |
Evaluation of pharmaceutical toxic effects of non-standard endpoints on the macrophyte species Lemna minor and Lemna gibba.
Topics: Acetaminophen; Anthocyanins; Aquatic Organisms; Araceae; Carotenoids; Catalase; Chlorophyll A; Chlor | 2019 |
Tardive Dyskinesia: New Treatments Available.
Topics: Antipsychotic Agents; Chlorpromazine; Drug-Related Side Effects and Adverse Reactions; Humans; Psych | 2019 |
Classification of Cholestatic and Necrotic Hepatotoxicants Using Transcriptomics on Human Precision-Cut Liver Slices.
Topics: Acetaminophen; Aged; Benzofurans; Bile Acids and Salts; Chloramphenicol; Chlorpromazine; Cholestasis | 2016 |
[Experimental study of treatment of pentachlorophenolate sodium derivatives].
Topics: Blood Transfusion; Chlorpromazine; Drug-Related Side Effects and Adverse Reactions; Hibernation; Ion | 1954 |
[Effect of chlorpromazine on the emetic action and toxicity of digitalis].
Topics: Chlorpromazine; Digitalis; Digitalis Glycosides; Drug-Related Side Effects and Adverse Reactions; Em | 1956 |
Drug reactions characterized by cholestasis associated with intrahepatic biliary tract obstruction.
Topics: Arsphenamine; Biliary Tract; Chlorpromazine; Cholestasis; Drug-Related Side Effects and Adverse Reac | 1957 |
[Modifications of the course of experimental procaine poisoning after treatment with chlorpromazine].
Topics: Chlorpromazine; Drug-Related Side Effects and Adverse Reactions; Procaine | 1958 |
[Research on chronic morphine poisoning. II. Effects of reserpine, chlorpromazine & N-allylnormorphine on activity manifestations induced by morphine].
Topics: Chlorpromazine; Chronic Disease; Drug-Related Side Effects and Adverse Reactions; Morphine; Nalorphi | 1959 |
[Acute intoxication with the phenothiazine derivative chlorpromazine].
Topics: Antipsychotic Agents; Chlorpromazine; Drug-Related Side Effects and Adverse Reactions; Heterocyclic | 1960 |
A NEW CHLORPROMAZINE SIDE-EFFECT?
Topics: Amenorrhea; Chlorpromazine; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Toxicol | 1964 |
Reactive oxygen species assay-based risk assessment of drug-induced phototoxicity: classification criteria and application to drug candidates.
Topics: Animals; BALB 3T3 Cells; Benzophenones; Biological Assay; Chlorpromazine; Dermatitis, Phototoxic; Di | 2008 |
[Drugs inducing obesity].
Topics: Adrenal Cortex Hormones; Amitriptyline; Antidepressive Agents; Antihypertensive Agents; Antipsychoti | 1984 |
Pigmentation of the cornea: a review and classification.
Topics: Adult; Child; Chloroquine; Chlorpromazine; Corneal Diseases; Drug-Related Side Effects and Adverse R | 1983 |
[Drug-induced liver damage; new aspects on its mechanism].
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Chlorpromazine; Contraceptives, Oral; Drug-Re | 1980 |
The popliteal lymph node assay: results of a preliminary interlaboratory validation study.
Topics: Animals; Anti-Bacterial Agents; Barbital; Chlorpromazine; Drug-Related Side Effects and Adverse Reac | 1997 |
Psychoses precipitated by psychotomimetic drugs. A follow-up study.
Topics: Adolescent; Adult; Aftercare; Amphetamines; Bipolar Disorder; Chlorpromazine; Disease Susceptibility | 1977 |
Hepatic reactions to drugs.
Topics: Acetaminophen; Adenoma; Adult; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injur | 1979 |
[Drug-induced disorders of lupus erythematosus type (author's transl)].
Topics: Animals; Antibody Formation; Anticonvulsants; Chlorpromazine; Drug-Related Side Effects and Adverse | 1977 |
[Liver pathology and drugs].
Topics: Anti-Bacterial Agents; Biotransformation; Chemical and Drug Induced Liver Injury; Chlorpromazine; Di | 1975 |
[Drug injuries and central nervous system (pathochemistry) (report) (author's transl)].
Topics: Adult; Aged; Animals; Blood-Brain Barrier; Central Nervous System; Chlorpromazine; Drug-Related Side | 1972 |
Guidelines for diagnosis of therapeutic drug-induced liver injury in liver biopsies.
Topics: Anabolic Agents; Biopsy; Cathartics; Chemical and Drug Induced Liver Injury; Chlorpromazine; Cholest | 1974 |
[Iatrogenic cataracts].
Topics: Aged; Anesthetics, Local; Anthelmintics; Azathioprine; Cataract; Chloroquine; Chlorpromazine; Dimeth | 1974 |
[Cultivation of rat embryos in vitro by New's method in pharmacoembryology].
Topics: Animals; Chlorpromazine; Culture Techniques; Drug-Related Side Effects and Adverse Reactions; Embryo | 1974 |
Adverse reaction profiles of drug eruptions.
Topics: Ampicillin; Analgesics; Aspirin; Chlorpromazine; Drug-Related Side Effects and Adverse Reactions; Er | 1972 |
Death after taking medicaments.
Topics: Adrenal Cortex Hormones; Analgesics; Anti-Bacterial Agents; Antidepressive Agents; Aspirin; Chlorpro | 1974 |
Drugs, coma, and myoglobinuria.
Topics: Acute Kidney Injury; Adult; Aspartate Aminotransferases; Barbiturates; Chlorpromazine; Coma; Drug-Re | 1972 |
[Pathology of therapy and pathomorphosis of some diseases in children].
Topics: Adrenal Cortex Hormones; Adrenal Insufficiency; Anti-Bacterial Agents; Antimetabolites; Bone and Bon | 1967 |
[Early diagnosis of drug damage to the retina and optic nerve].
Topics: Adult; Aged; Anti-Bacterial Agents; Anticoagulants; Antimalarials; Chlorpromazine; Contraceptives, O | 1969 |