chlorpromazine has been researched along with Acute Liver Injury, Drug-Induced in 125 studies
Chlorpromazine: The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking DOPAMINE RECEPTORS. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the treatment of intractable hiccup.
chlorpromazine : A substituted phenothiazine in which the ring nitrogen at position 10 is attached to C-3 of an N,N-dimethylpropanamine moiety.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Hypoplastic bone marrow associated with agranulocytosis is a well-known side effect of chlorpromazine treatment." | 5.28 | Chlorpromazine-induced liver and bone marrow granulomas associated with agranulocytosis. ( Ben-Yehuda, A; Bloom, A; Flusser, D; Lijovetzky, G; Tur-Kaspa, R, 1990) |
| "Cholestasis was induced in mPCLS through a 48-h-incubation with three drugs known to induce cholestasis in humans, namely chlorpromazine (15, 20, and 30 µM), cyclosporin A (1, 3, and 6 µM) or glibenclamide (25, 50, and 65 µM)." | 1.72 | Mouse precision-cut liver slices as an ex vivo model to study drug-induced cholestasis. ( Karsten, REH; Krijnen, NJW; Maho, W; Olinga, P; Permentier, H; Verpoorte, E, 2022) |
| " We proposed a systematic classification scheme using FDA-approved drug labeling to assess the DILI potential of drugs, which yielded a benchmark dataset with 287 drugs representing a wide range of therapeutic categories and daily dosage amounts." | 1.37 | FDA-approved drug labeling for the study of drug-induced liver injury. ( Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V, 2011) |
| " An understanding of structure-activity relationships (SARs) of chemicals can make a significant contribution to the identification of potential toxic effects early in the drug development process and aid in avoiding such problems." | 1.36 | Developing structure-activity relationships for the prediction of hepatotoxicity. ( Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ, 2010) |
| "Chlorpromazine (CPZ) is a phenothiazine, antipsychotic drug that has caused several idiosyncratic responses during its therapeutic use." | 1.31 | Underlying endotoxemia augments toxic responses to chlorpromazine: is there a relationship to drug idiosyncrasy? ( Buchweitz, JP; Bursian, SJ; Ganey, PE; Roth, RA, 2002) |
| "Hypoplastic bone marrow associated with agranulocytosis is a well-known side effect of chlorpromazine treatment." | 1.28 | Chlorpromazine-induced liver and bone marrow granulomas associated with agranulocytosis. ( Ben-Yehuda, A; Bloom, A; Flusser, D; Lijovetzky, G; Tur-Kaspa, R, 1990) |
| "Chlorpromazine-treated mice displayed variation in liver nuclei size and in cell structure definition." | 1.27 | Effect of alkali metals on chlorpromazine toxicity in the mouse. ( Messiha, FS; Sproat, HF, 1983) |
| "During the decade 1968-1978 the Danish Board of Adverse Reactions to Drugs received 572 (6% of the total number) reports on hepatotoxicity." | 1.26 | Drug-induced liver disease in Denmark. An analysis of 572 cases of hepatotoxicity reported to the Danish Board of Adverse Reactions to Drugs. ( Andreasen, PB; Døssing, M, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 99 (79.20) | 18.7374 |
| 1990's | 4 (3.20) | 18.2507 |
| 2000's | 3 (2.40) | 29.6817 |
| 2010's | 18 (14.40) | 24.3611 |
| 2020's | 1 (0.80) | 2.80 |
| Authors | Studies |
|---|---|
| Fourches, D | 1 |
| Barnes, JC | 1 |
| Day, NC | 1 |
| Bradley, P | 1 |
| Reed, JZ | 1 |
| Tropsha, A | 1 |
| Greene, N | 1 |
| Fisk, L | 1 |
| Naven, RT | 1 |
| Note, RR | 1 |
| Patel, ML | 1 |
| Pelletier, DJ | 1 |
| Morgan, RE | 2 |
| Trauner, M | 1 |
| van Staden, CJ | 2 |
| Lee, PH | 1 |
| Ramachandran, B | 1 |
| Eschenberg, M | 1 |
| Afshari, CA | 2 |
| Qualls, CW | 1 |
| Lightfoot-Dunn, R | 1 |
| Hamadeh, HK | 2 |
| Ekins, S | 1 |
| Williams, AJ | 1 |
| Xu, JJ | 1 |
| Chen, M | 2 |
| Vijay, V | 1 |
| Shi, Q | 2 |
| Liu, Z | 2 |
| Fang, H | 2 |
| Tong, W | 3 |
| Dawson, S | 1 |
| Stahl, S | 2 |
| Paul, N | 1 |
| Barber, J | 1 |
| Kenna, JG | 2 |
| Ding, D | 1 |
| Kelly, R | 1 |
| Sakatis, MZ | 1 |
| Reese, MJ | 1 |
| Harrell, AW | 1 |
| Taylor, MA | 1 |
| Baines, IA | 1 |
| Chen, L | 1 |
| Bloomer, JC | 1 |
| Yang, EY | 1 |
| Ellens, HM | 1 |
| Ambroso, JL | 1 |
| Lovatt, CA | 1 |
| Ayrton, AD | 1 |
| Clarke, SE | 1 |
| Warner, DJ | 1 |
| Chen, H | 1 |
| Cantin, LD | 1 |
| Walker, CL | 1 |
| Noeske, T | 1 |
| Chen, Y | 1 |
| Kalyanaraman, N | 1 |
| Kalanzi, J | 1 |
| Dunn, RT | 1 |
| Suzuki, A | 1 |
| Thakkar, S | 1 |
| Yu, K | 1 |
| Hu, C | 1 |
| Karsten, REH | 1 |
| Krijnen, NJW | 1 |
| Maho, W | 1 |
| Permentier, H | 1 |
| Verpoorte, E | 1 |
| Olinga, P | 1 |
| Ogihara, T | 1 |
| Arakawa, H | 1 |
| Jomura, T | 1 |
| Idota, Y | 1 |
| Koyama, S | 1 |
| Yano, K | 1 |
| Kojima, H | 1 |
| Van den Hof, WFPM | 1 |
| Coonen, MLJ | 1 |
| van Herwijnen, M | 1 |
| Brauers, K | 1 |
| Jennen, D | 1 |
| Olde Damink, SWM | 1 |
| Schaap, FG | 1 |
| Kleinjans, JCS | 1 |
| Parmentier, C | 1 |
| Truisi, GL | 1 |
| Moenks, K | 1 |
| Stanzel, S | 1 |
| Lukas, A | 1 |
| Kopp-Schneider, A | 1 |
| Alexandre, E | 1 |
| Hewitt, PG | 1 |
| Mueller, SO | 1 |
| Richert, L | 1 |
| Eun, JW | 1 |
| Bae, HJ | 1 |
| Shen, Q | 1 |
| Park, SJ | 1 |
| Kim, HS | 1 |
| Shin, WC | 1 |
| Yang, HD | 1 |
| Jin, CY | 1 |
| You, JS | 1 |
| Kang, HJ | 1 |
| Kim, H | 1 |
| Ahn, YM | 1 |
| Park, WS | 1 |
| Lee, JY | 1 |
| Nam, SW | 1 |
| Yang, Q | 1 |
| Yang, F | 1 |
| Tang, X | 1 |
| Ding, L | 1 |
| Xu, Y | 1 |
| Xiong, Y | 1 |
| Wang, Z | 1 |
| Yang, L | 1 |
| Xuan, J | 1 |
| Chen, S | 1 |
| Ning, B | 1 |
| Tolleson, WH | 1 |
| Guo, L | 1 |
| Hendriks, DF | 1 |
| Fredriksson Puigvert, L | 1 |
| Messner, S | 1 |
| Mortiz, W | 1 |
| Ingelman-Sundberg, M | 1 |
| BOARDMAN, RH | 1 |
| RODIN, AE | 1 |
| ROBERTSON, DM | 1 |
| BERNSTEIN, A | 1 |
| SIMON, F | 1 |
| IAKSON, ZP | 1 |
| JOGLEKAR, GV | 1 |
| CHITALE, GK | 1 |
| BALWANI, JH | 1 |
| KIDD, HB | 1 |
| BELL, JL | 1 |
| WILLIAMS, R | 1 |
| SCHALM, L | 1 |
| SAPHIER, E | 1 |
| WATTS, C | 1 |
| GRIFFITHS, HE | 1 |
| HAEFNER, H | 1 |
| KUTSCHER, I | 1 |
| INVERNIZZI, G | 1 |
| SPELLBERG, MA | 1 |
| SCHNACK, H | 1 |
| SCHEDIFKA, R | 1 |
| COOK, GC | 1 |
| SHERLOCK, S | 2 |
| HOLDSWORTH, CD | 1 |
| ATKINSON, M | 1 |
| DOSSETT, JA | 1 |
| HALL, R | 1 |
| SMAGA, MF | 3 |
| READ, AE | 2 |
| KUSCH, T | 1 |
| PREVOST, AG | 1 |
| LEBRUN, JH | 1 |
| WOROBEC, T | 1 |
| PETZOLD, H | 1 |
| ZIMMERMANN, S | 1 |
| AMER, S | 1 |
| BREUER, RI | 1 |
| PEITERSEN, E | 1 |
| Sulaiman, AA | 1 |
| Al-Shawi, NN | 1 |
| Jwaied, AH | 1 |
| Mahmood, DM | 1 |
| Hussain, SA | 1 |
| Minondo Amuchasteguia, L | 1 |
| Egiguren Urrosolo, L | 1 |
| Zapata Morcillo, E | 1 |
| Castiella Eguzkiza, A | 1 |
| Cachin, M | 1 |
| Rüttner, JR | 1 |
| Dostert, P | 1 |
| Benedetti, MS | 1 |
| Sproat, HF | 1 |
| Messiha, FS | 1 |
| Sandler, BB | 1 |
| Shersneva, AD | 1 |
| Valerdiz Casasola, S | 1 |
| Linares Rodríguez, A | 1 |
| Recarte Alvarez, J | 1 |
| Rodrigo Sáez, L | 1 |
| Paumgartner, G | 1 |
| Paumgartner, D | 1 |
| Matsui, T | 1 |
| Kitagawa, H | 1 |
| Kobayashi, Y | 1 |
| Mizoguchi, Y | 1 |
| Monna, T | 1 |
| Yamamoto, S | 1 |
| Morisawa, S | 1 |
| Salaspuro, M | 1 |
| Døssing, M | 1 |
| Andreasen, PB | 1 |
| Roĭzin, L | 1 |
| Holzbach, RT | 1 |
| Seeff, LB | 1 |
| Araki, H | 1 |
| Peck, RC | 1 |
| Lefer, AM | 1 |
| Kinze, W | 1 |
| Pröhl, L | 1 |
| Brauer, H | 1 |
| Marzi, A | 1 |
| de Toranzo, EG | 1 |
| Castro, JA | 1 |
| Berson, A | 1 |
| Fréneaux, E | 1 |
| Larrey, D | 1 |
| Lepage, V | 1 |
| Douay, C | 1 |
| Mallet, C | 1 |
| Fromenty, B | 1 |
| Benhamou, JP | 1 |
| Pessayre, D | 1 |
| Harris, SR | 1 |
| Hamrick, ME | 1 |
| Buchweitz, JP | 1 |
| Ganey, PE | 1 |
| Bursian, SJ | 1 |
| Roth, RA | 1 |
| Gopinath, C | 1 |
| Ford, JH | 1 |
| Knoblauch, M | 2 |
| Johnson, EI | 1 |
| Lanford, RE | 1 |
| Solomon, K | 1 |
| Glazier, RL | 1 |
| Crowell, EB | 1 |
| Rimalis, BTs | 1 |
| Bochkarnikov, VV | 1 |
| Weinreb, M | 1 |
| Kraus, V | 1 |
| Krausová, J | 1 |
| Hudcová, T | 1 |
| Swett, C | 1 |
| Korolenko, RA | 1 |
| Tsilli, EI | 1 |
| Rusova, TV | 1 |
| Tsytsorina, TN | 1 |
| Iakobson, GS | 1 |
| Arnman, R | 1 |
| Iwarson, S | 1 |
| Olsson, R | 1 |
| Gopinath, G | 1 |
| Ford, EJ | 1 |
| Bianchi, L | 1 |
| De Groote, J | 1 |
| Desmet, V | 1 |
| Gedigk, P | 1 |
| Korb, G | 1 |
| Popper, H | 3 |
| Poulsen, H | 1 |
| Scheuer, PJ | 1 |
| Schmid, M | 1 |
| Thaler, H | 1 |
| Wepler, W | 1 |
| Tareev, EM | 1 |
| Semendiaeva, ME | 1 |
| Mukhin, AS | 2 |
| Rozanova, LB | 1 |
| Blinkov, IL | 1 |
| Lämmli, J | 1 |
| Funk, C | 1 |
| Balázs, M | 1 |
| Juházs, J | 1 |
| Chen, EY | 1 |
| Lee, AS | 1 |
| Ben-Yehuda, A | 1 |
| Bloom, A | 1 |
| Lijovetzky, G | 1 |
| Flusser, D | 1 |
| Tur-Kaspa, R | 1 |
| Kondoh, M | 1 |
| Aoki, Y | 1 |
| Ogawa, Z | 1 |
| Hata, Y | 1 |
| Suzuki, H | 1 |
| Itoh, H | 1 |
| Ungemach, FR | 1 |
| Kaplowitz, N | 1 |
| Aw, TY | 1 |
| Simon, FR | 1 |
| Stolz, A | 1 |
| Itsubo, M | 1 |
| Kameda, H | 1 |
| Yoshiba, M | 1 |
| Yoshikawa, Y | 1 |
| Yamada, H | 1 |
| Oka, H | 1 |
| Schaffner, F | 1 |
| Davies, GE | 1 |
| Holmes, JE | 1 |
| Tartarini, S | 1 |
| Bartoli, GM | 1 |
| Gaudiano, A | 1 |
| Montorsi, F | 1 |
| Petti, G | 1 |
| Polizzi, M | 1 |
| Zimmerman, HJ | 4 |
| Kendler, J | 1 |
| Libber, S | 1 |
| Lukacs, L | 1 |
| Serafetinides, EA | 1 |
| Collins, S | 1 |
| Clark, ML | 1 |
| Berthelot, P | 1 |
| Greene, NM | 1 |
| Neuvonen, P | 1 |
| Ahmed, A | 1 |
| Alexander, GJ | 1 |
| Machiz, S | 1 |
| Alexander, RB | 1 |
| Russell, RI | 1 |
| Allan, JG | 1 |
| Patrick, R | 1 |
| Bednár, B | 1 |
| Efrain Salvioli, J | 1 |
| Kehoe, MJ | 1 |
| Ishak, KG | 1 |
| Irey, NS | 1 |
| Bliuger, AF | 1 |
| Maksimova, LA | 1 |
| Kartashova, OIa | 1 |
| Nikiforov, GN | 1 |
| Avrutskiĭ, GIa | 1 |
| Gurovich, IIa | 1 |
| Romanov, IuD | 1 |
| Khmelevskiĭ, DL | 2 |
| Levine, RA | 1 |
| Briggs, GW | 1 |
| Lowell, DM | 1 |
| Hollister, LE | 1 |
| Hall, RA | 1 |
| Savicheva, TS | 1 |
| de Walden, JK | 1 |
| Ichikawa, T | 1 |
| Fréjaville, JP | 1 |
| Guyochin, A | 1 |
| Gaultier, M | 1 |
| Dediu, S | 1 |
| Szanto, PB | 1 |
| Van Woert, MH | 1 |
| Dereux, J | 1 |
| Dereux, JF | 1 |
| Carbonnelle, B | 1 |
| Guffroy, M | 1 |
| Cacheux, S | 1 |
| Wohlgemuth, B | 1 |
| Reinhart, MJ | 1 |
| Benson, RM | 1 |
| Kwass, SK | 1 |
| Storey, WF | 1 |
| Mao, R | 1 |
| Israsena, S | 1 |
| Ushio, K | 1 |
| Taguchi, I | 1 |
| Suwa, K | 1 |
| Uehara, K | 1 |
| Ishida, K | 1 |
18 reviews available for chlorpromazine and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Pr | 2016 |
[COMPLICATIONS DURING CLINICAL THERAPY WITH PSYCHOPHARMACA].
Topics: Agranulocytosis; Autonomic Nervous System Diseases; Chemical and Drug Induced Liver Injury; Chlorpro | 1964 |
[APROPOS OF LIVER DAMAGE DUE TO PROLONGED BARBITURATE AND HYDANTOIN THERAPY].
Topics: Anticonvulsants; Barbiturates; Chemical and Drug Induced Liver Injury; Chlorpromazine; Hepatitis A; | 1964 |
[Biochemical mechanisms of the hepatotoxicity of psychotropic drugs].
Topics: Acute Disease; Anti-Anxiety Agents; Anticonvulsants; Antidepressive Agents, Tricyclic; Antipsychotic | 1984 |
[Hepatitis caused by drugs. 5].
Topics: Chemical and Drug Induced Liver Injury; Chlorpromazine; Deoxyepinephrine; Erythromycin; Gold; Humans | 1982 |
[Multifactorial nature of the pathogenesis of pathological reactions observed following the administration of psychotropic drugs].
Topics: Animals; Brain; Chemical and Drug Induced Liver Injury; Chlorpromazine; Female; Humans; Liver; Liver | 1980 |
Drug-induced liver disease.
Topics: Analgesics; Antineoplastic Agents; Chemical and Drug Induced Liver Injury; Chlorpromazine; Contracep | 1981 |
Drug-induced chronic liver disease, with emphasis on chronic active hepatitis.
Topics: Biopsy; Chemical and Drug Induced Liver Injury; Chlorpromazine; Dantrolene; Diagnosis, Differential; | 1981 |
[Drug induced liver disease (author's transl)].
Topics: Azathioprine; Bile Acids and Salts; Bilirubin; Biotransformation; Chemical and Drug Induced Liver In | 1978 |
Drug-induced hepatotoxicity.
Topics: Acetaminophen; Bile; Bile Acids and Salts; Biotransformation; Cell Survival; Chemical and Drug Induc | 1986 |
[Definition and classification of toxic hepatitis].
Topics: Animals; Chemical and Drug Induced Liver Injury; Chlorpromazine; Contraceptive Agents; Female; Hepat | 1985 |
[Prevention and therapy of severe toxic hepatitis].
Topics: Chemical and Drug Induced Liver Injury; Chlorpromazine; Halothane; Humans; Isoniazid; Methyldopa; Pe | 1985 |
Drug-induced immunological effects on the liver.
Topics: Aminosalicylic Acids; Anaphylaxis; Chemical and Drug Induced Liver Injury; Chlorpromazine; Drug Erup | 1972 |
Mechanisms and prediction of drug-induced liver disease.
Topics: Adenosine Triphosphate; Age Factors; Animals; Bilirubin; Biotransformation; Carbon Isotopes; Carbon | 1973 |
Halothane anesthesia and hepatitis in a high-risk population.
Topics: Chemical and Drug Induced Liver Injury; Chlorpromazine; Diazepam; Enzyme Induction; Halothane; Human | 1973 |
[Drug induced liver diseases].
Topics: Aminosalicylic Acids; Animals; Chemical and Drug Induced Liver Injury; Chlorpromazine; Cholestasis; | 1974 |
[Liver diseases induced by drugs].
Topics: Animals; Arsenicals; Chemical and Drug Induced Liver Injury; Chloroform; Chlorpromazine; Contracepti | 1967 |
II. Major tranquilizers.
Topics: Animals; Chemical and Drug Induced Liver Injury; Chlordiazepoxide; Chlorpromazine; Fluphenazine; Hem | 1971 |
3 trials available for chlorpromazine and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
Adverse reactions to chlorpromazine in medical patients: a report from the Boston Collaborative Drug Surveillance Program, Boston University Medical Center.
Topics: Adult; Aged; Boston; Cardiovascular Diseases; Chemical and Drug Induced Liver Injury; Chlorpromazine | 1975 |
Haloperidol, clopenthixol, and chlorpromazine in chronic schizophrenia. Chemically unrelated antipsychotics as therapeutic alternatives.
Topics: Adult; Alanine Transaminase; Alkaline Phosphatase; Analysis of Variance; Bilirubin; Blood Cell Count | 1972 |
Phenothiazine derivatives and morphologic changes in the liver.
Topics: Biopsy; Chemical and Drug Induced Liver Injury; Chlorpromazine; Clinical Trials as Topic; Humans; Li | 1966 |
104 other studies available for chlorpromazine and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLI | 2010 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
FDA-approved drug labeling for the study of drug-induced liver injury.
Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Des | 2011 |
In vitro inhibition of the bile salt export pump correlates with risk of cholestatic drug-induced liver injury in humans.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters | 2012 |
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Da | 2011 |
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme | 2012 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters | 2012 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily | 2013 |
Mouse precision-cut liver slices as an ex vivo model to study drug-induced cholestasis.
Topics: Animals; Bile Acids and Salts; Chemical and Drug Induced Liver Injury; Chlorpromazine; Cholestasis; | 2022 |
Utility of human hepatocyte spheroids without feeder cells for evaluation of hepatotoxicity.
Topics: Alanine Transaminase; Albumins; Aspartate Aminotransferases; Cells, Cultured; Chemical and Drug Indu | 2017 |
Validation of gene expression profiles from cholestatic hepatotoxicants in vitro against human in vivo cholestasis.
Topics: Animals; Bile Acids and Salts; Cells, Cultured; Chemical and Drug Induced Liver Injury; Chlorpromazi | 2017 |
Transcriptomic hepatotoxicity signature of chlorpromazine after short- and long-term exposure in primary human sandwich cultures.
Topics: Aged; Cells, Cultured; Chemical and Drug Induced Liver Injury; Chlorpromazine; Female; Hepatocytes; | 2013 |
Characteristic molecular and proteomic signatures of drug-induced liver injury in a rat model.
Topics: Animals; Biomarkers; Carbamazepine; Chemical and Drug Induced Liver Injury; Chlorpromazine; Disease | 2015 |
Chlorpromazine-induced perturbations of bile acids and free fatty acids in cholestatic liver injury prevented by the Chinese herbal compound Yin-Chen-Hao-Tang.
Topics: Animals; Artemisia; Bile Acids and Salts; Chemical and Drug Induced Liver Injury; Chlorpromazine; Ch | 2015 |
Development of HepG2-derived cells expressing cytochrome P450s for assessing metabolism-associated drug-induced liver toxicity.
Topics: Amiodarone; Antimalarials; Antipsychotic Agents; Cell Line; Chemical and Drug Induced Liver Injury; | 2016 |
Hepatic 3D spheroid models for the detection and study of compounds with cholestatic liability.
Topics: Bile Acids and Salts; Biological Transport; Cell Culture Techniques; Cell Line; Chemical and Drug In | 2016 |
Fatal case of toxic hepatitis implicating chlorpromazine.
Topics: Autonomic Agents; Chemical and Drug Induced Liver Injury; Chlorpromazine; Hepatitis; Mental Disorder | 1954 |
Fatal toxic hepatitis following chlorpromazine therapy; report of a case with autopsy findings.
Topics: Autopsy; Chemical and Drug Induced Liver Injury; Chlorpromazine; Hepatitis; Hepatitis A; Humans | 1958 |
Chlorpromazine and iproniazid toxic hepatitis in the same patient.
Topics: Chemical and Drug Induced Liver Injury; Chlorpromazine; Hepatitis; Hepatitis A; Iproniazid; Niacin; | 1959 |
[On the differential diagnosis of aminazin hepatitis and Botkin's disease].
Topics: Chemical and Drug Induced Liver Injury; Chlorpromazine; Communicable Diseases; Diagnosis, Differenti | 1963 |
PROTECTION BY INDIGENOUS DRUGS AGAINST HEPATOTOXIC EFFECTS OF CARBON TETRACHLORIDE IN MICE.
Topics: Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Chlorp | 1963 |
ANTIDEPRESSANT DRUGS AND LIVER DAMAGE.
Topics: Antidepressive Agents; Chemical and Drug Induced Liver Injury; Chlordiazepoxide; Chlorpromazine; Hep | 1964 |
THE VALUE OF JIRGL'S FLOCCULATION TEST IN THE DIAGNOSIS OF JAUNDICE.
Topics: Alkaline Phosphatase; Carcinoma, Hepatocellular; Chemical and Drug Induced Liver Injury; Chlorpromaz | 1964 |
[LIVER DAMAGE BY DRUGS].
Topics: Aminosalicylic Acid; Aminosalicylic Acids; Arsphenamine; Chemical and Drug Induced Liver Injury; Chl | 1963 |
ANTIDEPRESSANT DRUGS AND LIVER DAMAGE.
Topics: Antidepressive Agents; Chemical and Drug Induced Liver Injury; Chlorpromazine; Hepatitis; Hepatitis | 1964 |
BIOCHEMICAL STUDIES OF SEVERE LIVER DAMAGE CAUSED BY P-AMINOSALICYLIC ACID.
Topics: Alanine Transaminase; Aminosalicylic Acid; Aminosalicylic Acids; Aspartate Aminotransferases; Biliru | 1964 |
[OBSERVATIONS ON THE USE OF PHENYLPYRROLIDINOPENTANE AS AN ANTIASTHENIC AGENT IN TREATMENT WITH PSYCHOPHARMACOLOGICAL DRUGS].
Topics: Amitriptyline; Anxiety; Anxiety Disorders; Asthenia; Bipolar Disorder; Chemical and Drug Induced Liv | 1964 |
INTRAHEPATIC CHOLESTASIS VS. POSTHEPATIC JAUNDICE: METHODS OF DIAGNOSIS, WITH A NOTE ON HYPERCHOLESTEREMIC XANTHOMATOSIS IN A PATIENT WITH CHLORPROMAZINE CHOLESTASIS.
Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Alkaline Phosphatase; Androgens; Anti-Bacteria | 1964 |
[ON THE ETIOLOGY OF CHLORPROMAZINE ICTERUS: ANIMAL EXPERIMENTAL AND CLINICAL OBSERVATIONS].
Topics: Chemical and Drug Induced Liver Injury; Chlorpromazine; Hepatitis; Hepatitis A; Jaundice; Liver Func | 1964 |
JAUNDICE AND ITS RELATION TO THERAPEUTIC AGENTS.
Topics: Alkaline Phosphatase; Antidepressive Agents; Aspartate Aminotransferases; Bilirubin; Chemical and Dr | 1965 |
AN ASSESSMENT OF THE DIAGNOSTIC AND PROGNOSTIC VALUE OF SERUM VITAMIN B12 LEVELS IN LIVER DISEASE.
Topics: Blood; Chemical and Drug Induced Liver Injury; Chlorpromazine; Cholangitis; Diagnosis; Hepatitis; He | 1964 |
[DISCUSSION ON Z. P. IAKSON'S ARTICLE, "DIFFERENTIAL DIAGNOSIS OF AMINAZIN HEPATITIS AND BOTKIN'S DISEASE].
Topics: Chemical and Drug Induced Liver Injury; Chlorpromazine; Communicable Diseases; Diagnosis, Differenti | 1964 |
[DISCUSSION OF Z. P. IAKSON'S ARTICLE, "DIFFERENTIAL DIAGNOSIS OF AMINAZIN HEPATITIS AND BOTKIN'S DISEASE"].
Topics: Chemical and Drug Induced Liver Injury; Chlorpromazine; Communicable Diseases; Diagnosis, Differenti | 1964 |
DRUGS AND LIVER DISEASE.
Topics: Androgens; Anti-Bacterial Agents; Antihypertensive Agents; Antineoplastic Agents; Arsphenamine; Chem | 1965 |
[THE ACTIVITY OF HISTIDASE UNDER THE INFLUENCE OF EXPERIMENTAL LIVER DAMAGE AND PSYCHOPHARMACOLOGICAL AGENTS].
Topics: Bile Ducts; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Chlorpromazine; | 1964 |
[APROPOS OF A CASE OF JAUNDICE OCCURRING IN THE COURSE OF CHLORPROMAZINE TREATMENT].
Topics: Chemical and Drug Induced Liver Injury; Chlorpromazine; Hepatitis; Hepatitis A; Jaundice; Pathology; | 1964 |
BLOOD DYSCRASIAS ASSOCIATED WITH ANTITUBERCULOSIS AND/OR TRANQUILIZING CHEMOTHERAPY. A LONG-TERM CLINICAL OBSERVATION.
Topics: Aminosalicylic Acid; Aminosalicylic Acids; Antitubercular Agents; Chemical and Drug Induced Liver In | 1965 |
[THE EFFECT OF DIFFERENT SUBSTANCES ON ACUTE CARBON TETRACHLORIDE NECROSIS OF THE RAT LIVER].
Topics: Aspartate Aminotransferases; Blood Chemical Analysis; Carbon Tetrachloride; Carbon Tetrachloride Poi | 1965 |
CHLORPROMAZINE HEPATOTOXICITY MANIFESTED BY A SELECTIVE AND SUSTAINED RISE OF SERUM ALKALINE PHOSPHATASE ACTIVITY; REPORT OF A CASE.
Topics: Alkaline Phosphatase; Chemical and Drug Induced Liver Injury; Chlorpromazine; Clinical Enzyme Tests; | 1965 |
[Fatal toxic hepatitis after largactil treatment].
Topics: Chemical and Drug Induced Liver Injury; Chlorpromazine; Hepatitis; Viral Vaccines | 1959 |
Protective effect of melatonin against chlorpromazine-induced liver disease in rats.
Topics: Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Chlorpromazine; Disease Models, Anima | 2006 |
[Chlorpromazine-induced cholestatic hepatitis in intractable hiccups].
Topics: Aged; Antipsychotic Agents; Bile Duct Diseases; Chemical and Drug Induced Liver Injury; Chlorpromazi | 2007 |
[Jaundices of therapeutic origin].
Topics: Antineoplastic Agents; Antitubercular Agents; Arsenicals; Chemical and Drug Induced Liver Injury; Ch | 1967 |
[Toxic hepatosis].
Topics: Adult; Animals; Chemical and Drug Induced Liver Injury; Chlorpromazine; Humans; Rats; Thiocyanates | 1967 |
Effect of alkali metals on chlorpromazine toxicity in the mouse.
Topics: Animals; Cesium; Chemical and Drug Induced Liver Injury; Chlorides; Chlorpromazine; Drug Synergism; | 1983 |
[Severe medicamentous disease induced by aminazine and barbiturates].
Topics: Adult; Barbiturates; Chemical and Drug Induced Liver Injury; Chlorpromazine; Drug Eruptions; Epileps | 1981 |
[Damage to liver and biliary tracts by long-term drug therapy (author's transl)].
Topics: Chemical and Drug Induced Liver Injury; Chlorpromazine; Cholestasis, Intrahepatic; Dose-Response Rel | 1980 |
[Studies on the drug-induced injury and changes of membrane structure in the isolated liver cells].
Topics: Ajmaline; Animals; Cell Membrane; Cell Separation; Chemical and Drug Induced Liver Injury; Chlorprom | 1983 |
[Drug-induced liver damage; new aspects on its mechanism].
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Chlorpromazine; Contraceptives, Oral; Drug-Re | 1980 |
Drug-induced liver disease in Denmark. An analysis of 572 cases of hepatotoxicity reported to the Danish Board of Adverse Reactions to Drugs.
Topics: Adolescent; Adult; Aged; Anti-Infective Agents, Urinary; Antidepressive Agents, Tricyclic; Antituber | 1982 |
Biphasic actions of chlorpromazine and mepacrine on modulation of hepatic cell injury in the perfused cat liver.
Topics: Amines; Animals; Cathepsin D; Cathepsins; Cats; Chemical and Drug Induced Liver Injury; Chlorpromazi | 1981 |
[On the question of parenchyma damage caused by long-term therapy with psychotropics in adolescence].
Topics: Adolescent; Adult; Chemical and Drug Induced Liver Injury; Child; Chlorpromazine; Creatinine; Follow | 1980 |
Mechanism of chlorpromazine prevention of carbon tetrachloride-induced liver necrosis.
Topics: Animals; Body Temperature; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; C | 1980 |
Possible role of HLA in hepatotoxicity. An exploratory study in 71 patients with drug-induced idiosyncratic hepatitis.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Chemical and Drug Induced Liver Injury; Chlorpromazine; | 1994 |
Antagonism of acetaminophen hepatotoxicity by phospholipase A2 inhibitors.
Topics: Acetaminophen; Animals; Calcium; Cell Nucleus; Chemical and Drug Induced Liver Injury; Chlorpromazin | 1993 |
Underlying endotoxemia augments toxic responses to chlorpromazine: is there a relationship to drug idiosyncrasy?
Topics: Animals; Antipsychotic Agents; Chemical and Drug Induced Liver Injury; Chlorpromazine; Cholestasis; | 2002 |
The role of microsomal hydroxylases in the modification of chloroform hepatotoxicity in rats.
Topics: Animals; Carbon Disulfide; Chemical and Drug Induced Liver Injury; Chloroform; Chlorpromazine; DDT; | 1975 |
Chlorpromazine, eosinophilia, and hepatotoxicity.
Topics: Adult; Chemical and Drug Induced Liver Injury; Chlorpromazine; Eosinophilia; Humans; Liver; Male | 1979 |
Hepatic reactions to drugs.
Topics: Acetaminophen; Adenoma; Adult; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injur | 1979 |
Factor VIII inhibition associated with chlorpromazine-induced hepatic injury.
Topics: Aged; Chemical and Drug Induced Liver Injury; Chlorpromazine; Factor VIII; Humans; Male | 1977 |
[Acute renal-hepatic insufficiency in various types of rare acute exogenous poisoning].
Topics: Acute Disease; Acute Kidney Injury; Adolescent; Chemical and Drug Induced Liver Injury; Chlorofluoro | 1978 |
Negligible hepatotoxicity of chlorpromazine in long-term therapy.
Topics: Adult; Aged; Chemical and Drug Induced Liver Injury; Chlorpromazine; Humans; Liver; Liver Diseases; | 1978 |
[Increased damage to the liver lysosomes of rats with cc14-hepatitis following preliminary protracted administration of aminazine].
Topics: Acid Phosphatase; Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; C | 1977 |
The clinical significance of increased plasma levels of liver-synthesized coagulation factors in liver disease.
Topics: Acetaminophen; Acute Disease; Biliary Tract Diseases; Blood Coagulation Factors; Chemical and Drug I | 1977 |
The influence of hepatic microsomal amidopyrine demethylase activity on halothane hepatotoxicity in the horse.
Topics: Aminopyrine N-Demethylase; Animals; Carbon Disulfide; Chemical and Drug Induced Liver Injury; Chlorp | 1976 |
[Rules for the histological evaluation of drug-induced liver lesions].
Topics: Biopsy; Chemical and Drug Induced Liver Injury; Chlorpromazine; Cholestasis; Contraceptives, Oral; F | 1975 |
[Liver pathology and drugs].
Topics: Anti-Bacterial Agents; Biotransformation; Chemical and Drug Induced Liver Injury; Chlorpromazine; Di | 1975 |
[Drug-induced liver diseases].
Topics: Acetaminophen; Adult; Alcoholism; Azathioprine; Bilirubin; Chemical and Drug Induced Liver Injury; C | 1975 |
Electron microscopic study on the injurious effects of chlorpromazine on rat liver cells.
Topics: Animals; Chemical and Drug Induced Liver Injury; Chlorpromazine; Cholestasis; Female; Liver; Male; M | 1975 |
Neuroleptic-induced priapism, hepatotoxicity and subsequent impotence in a patient with depressive psychosis.
Topics: Chemical and Drug Induced Liver Injury; Chlorpromazine; Depressive Disorder; Dose-Response Relations | 1990 |
Chlorpromazine-induced liver and bone marrow granulomas associated with agranulocytosis.
Topics: Adult; Agranulocytosis; Bone Marrow Diseases; Chemical and Drug Induced Liver Injury; Chlorpromazine | 1990 |
Effect of chlorpromazine on transmigration of mitochondrial aspartate aminotransferase in rat liver.
Topics: Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Chlorpromazine; Choles | 1989 |
Prevention of liver cell damage following lipid peroxidation by depression of lysophosphatide formation.
Topics: Animals; Bromotrichloromethane; Chemical and Drug Induced Liver Injury; Chlorpromazine; Enzyme Activ | 1989 |
Guidelines for diagnosis of therapeutic drug-induced liver injury in liver biopsies.
Topics: Anabolic Agents; Biopsy; Cathartics; Chemical and Drug Induced Liver Injury; Chlorpromazine; Cholest | 1974 |
Morphologic studies of cholestasis.
Topics: Bile Ducts, Intrahepatic; Chemical and Drug Induced Liver Injury; Chlorpromazine; Chlorpropamide; Ch | 1968 |
[Study of the changes of some enzyme activities in the liver of rats subjected to acute intoxication with allyl alcohol and of the effect of the preventive administration of chlorpromazine].
Topics: Alcohols; Animals; Cathepsins; Chemical and Drug Induced Liver Injury; Chlorpromazine; Electron Tran | 1968 |
The spectrum of hepatotoxicity.
Topics: Aminosalicylic Acids; Anti-Bacterial Agents; Antimetabolites; Benzene Derivatives; Carbon Tetrachlor | 1968 |
Hepatocyte suspensions as a model for demonstration of drug hepatotoxicity.
Topics: Animals; Aspartate Aminotransferases; Cells, Cultured; Chemical and Drug Induced Liver Injury; Chlor | 1974 |
Hepatitis and phenothiazines.
Topics: Aged; Chemical and Drug Induced Liver Injury; Chlorpromazine; Humans; Male; Promazine | 1972 |
Phenothiazine tranquillizers: effect of prolonged intake.
Topics: Animals; Birth Weight; Chemical and Drug Induced Liver Injury; Chlorpromazine; Ethionine; Female; Fe | 1972 |
Active chronic hepatitis after chlorpromazine ingestion.
Topics: Autoimmune Diseases; Chemical and Drug Induced Liver Injury; Chlorpromazine; Chronic Disease; Humans | 1973 |
[Pathomorphology of toxic liver lesions].
Topics: Adult; Aflatoxins; Aged; Animals; Biopsy; Chemical and Drug Induced Liver Injury; Child; Chlorpromaz | 1973 |
Hepatic injury associated with the phenothiazines. Clinicopathologic and follow-up study of 36 patients.
Topics: Administration, Oral; Adult; Aged; Autopsy; Biliary Tract; Biliary Tract Diseases; Biopsy; Chemical | 1972 |
[Pathogenesis, pathological anatomy, clinical picture and diagnosis of different types of intrahepatic cholestasis].
Topics: Adult; Aged; Chemical and Drug Induced Liver Injury; Chlorpromazine; Cholestasis; Female; Hepatitis | 1972 |
[Differential diagnosis of aminazine-induced toxico-allergic hepatitis].
Topics: Adult; Aged; Chemical and Drug Induced Liver Injury; Chlorpromazine; Diagnosis, Differential; Drug H | 1972 |
[Effect of long-term therapy with aminazin on the structure and function of the liver].
Topics: Adult; Chemical and Drug Induced Liver Injury; Chlorpromazine; Female; Humans; Liver; Male; Middle A | 1972 |
Chronic chlorpromazine cholangiolitic hepatitis. Report of a case with immunofluorescent studies.
Topics: Adult; Chemical and Drug Induced Liver Injury; Chlorpromazine; Cholangitis; Diagnosis, Differential; | 1966 |
[Acute hepatitis arising during treatment with neuroleptics].
Topics: Acute Disease; Adult; Bilirubin; Blood Cell Count; Chemical and Drug Induced Liver Injury; Chlorprom | 1969 |
[Influence of chlorpromazine on the hepatic functions].
Topics: Age Factors; Chemical and Drug Induced Liver Injury; Chlorpromazine; Humans; Liver; Liver Function T | 1969 |
[Histo-pathological study of viral and drug-induced hepatitis using biopsy material].
Topics: Adult; Anabolic Agents; Biopsy; Chemical and Drug Induced Liver Injury; Chlorpromazine; Diagnosis, D | 1970 |
[152 cases of acute poisoning by phenothiazine amines].
Topics: Absorption; Adolescent; Adult; Aged; Agranulocytosis; Anesthesia, General; Anesthesia, Obstetrical; | 1970 |
[Hepatitis caused by drug allergy. (Clinico-morphological study)].
Topics: Aminosalicylic Acids; Chemical and Drug Induced Liver Injury; Chlorpromazine; Drug Hypersensitivity; | 1967 |
Toxic hepatopathy.
Topics: Aminosalicylic Acids; Anabolic Agents; Animals; Anti-Bacterial Agents; Antineoplastic Agents; Arseni | 1968 |
Intrahepatic cholestasis ("Cholangiolitis").
Topics: Bile Ducts, Intrahepatic; Biopsy; Chemical and Drug Induced Liver Injury; Chlorpromazine; Cholangiti | 1968 |
Isolation of chlorpromazine pigments in man.
Topics: Centrifugation; Chemical and Drug Induced Liver Injury; Chlorpromazine; Female; Humans; Infrared Ray | 1968 |
Drugs and liver disease.
Topics: Biliary Tract Diseases; Bilirubin; Brain Diseases; Carbon Tetrachloride Poisoning; Chemical and Drug | 1969 |
[Jaundice due to chlorpromazine].
Topics: Adult; Chemical and Drug Induced Liver Injury; Chlorpromazine; Humans; In Vitro Techniques; Jaundice | 1965 |
[On the problem of acute dystrophy of the liver following aminazin therapy].
Topics: Adult; Chemical and Drug Induced Liver Injury; Chlorpromazine; Humans; Male; Schizophrenia | 1965 |
[Morphologic findings in the liver in intrahepatic and extrahepatic cholestasis].
Topics: Aminosalicylic Acids; Bile Ducts, Intrahepatic; Chemical and Drug Induced Liver Injury; Chlorpromazi | 1965 |
Suggestive evidence of hepatotoxicity concomitant with thioridazine hydrochloride use.
Topics: Alanine Transaminase; Alkaline Phosphatase; Aspartate Aminotransferases; Chemical and Drug Induced L | 1966 |
Phenothiazine inhibition of carbon tetrachloride cytotoxicity in vitro.
Topics: Aspartate Aminotransferases; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chlorprom | 1966 |
[6 recent cases of toxic hepatitis].
Topics: Adolescent; Adult; Aged; Chemical and Drug Induced Liver Injury; Chlorpromazine; Erythromycin; Femal | 1966 |