chlorpromazine has been researched along with Abnormalities, Autosome in 27 studies
Chlorpromazine: The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking DOPAMINE RECEPTORS. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the treatment of intractable hiccup.
chlorpromazine : A substituted phenothiazine in which the ring nitrogen at position 10 is attached to C-3 of an N,N-dimethylpropanamine moiety.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Induction of gene mutation and chromosomal aberrations have been observed in appropriately designed photomutagenesis experiments." | 2.39 | Review of the genotoxic properties of chlorpromazine and related phenothiazines. ( Gocke, E, 1996) |
| "0159 microg/mL with UV) while CLZ was negative up to a toxic concentration of 35 microg/mL." | 1.31 | Photoclastogenicity-an improved protocol, its validation, and investigation of the photogenotoxicity of DMBA. ( Aardema, M; Lawlor, T; Murli, H; Spicer, C, 2002) |
| "The nature of the psychoses and the significance of the association are discussed." | 1.29 | Prader-Willi syndrome and psychoses. ( Clarke, DJ, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 20 (74.07) | 18.7374 |
| 1990's | 6 (22.22) | 18.2507 |
| 2000's | 1 (3.70) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Murli, H | 1 |
| Aardema, M | 1 |
| Lawlor, T | 1 |
| Spicer, C | 1 |
| Chételat, A | 1 |
| Dresp, JH | 1 |
| Gocke, E | 2 |
| Karmakar, P | 1 |
| Dasgupta, UB | 1 |
| Poddar, RK | 1 |
| Clarke, DJ | 1 |
| Asanami, S | 1 |
| Shimono, K | 1 |
| Kaneda, S | 1 |
| Speit, G | 1 |
| Vogel, W | 1 |
| Saxena, V | 1 |
| Lalchev, S | 1 |
| Tsoneva, M | 1 |
| Matsuyama, SS | 1 |
| Jarvik, LF | 2 |
| Feng, ZY | 1 |
| Yu, JF | 1 |
| Yang, YS | 1 |
| Wang, WY | 1 |
| Xiong, GX | 1 |
| Chen, MS | 1 |
| Bishun, NP | 1 |
| Williams, DC | 1 |
| Mills, J | 1 |
| Lloyd, N | 1 |
| Raven, RW | 1 |
| Parke, DV | 1 |
| Rendon, OR | 1 |
| Cohen, MM | 3 |
| Lieber, E | 1 |
| Schwartz, HN | 1 |
| Shapiro, IuL | 1 |
| Vaĭntrub, MIa | 1 |
| Grinberg, KN | 1 |
| Zhurkov, VS | 1 |
| Voĭtkevich, ND | 1 |
| Palyga, GF | 1 |
| Kelly-Garvert, F | 1 |
| Legator, MS | 1 |
| Hirschhorn, K | 2 |
| Frosch, WA | 2 |
| Fischer, R | 1 |
| Jenkins, EC | 1 |
| Kamada, N | 1 |
| Brecher, G | 1 |
| Tjio, JH | 1 |
| Abdullah, S | 1 |
| Miller, OJ | 1 |
| Nielsen, J | 1 |
| Friedrich, U | 1 |
| Tsuboi, T | 1 |
6 reviews available for chlorpromazine and Abnormalities, Autosome
| Article | Year |
|---|---|
Review of the genotoxic properties of chlorpromazine and related phenothiazines.
Topics: Animals; Chlorpromazine; Chromosome Aberrations; Genes, Lethal; Humans; Intestinal Absorption; Mutag | 1996 |
Cytogenetic effects of psychoactive drugs.
Topics: Adolescent; Adult; Aged; Animals; Cannabis; Child; Child, Preschool; Chlordiazepoxide; Chlorpromazin | 1975 |
Chromosome damage induced by chemicals.
Topics: Antineoplastic Agents; Aspirin; Benzene; Caffeine; Chloramphenicol; Chlorine; Chlorpromazine; Chromo | 1973 |
[Teratogenic and mutagenic effects of anticonvulsive and psychotropic drugs (review of the literature)].
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Animals; Anticonvulsants; Antidepressive Agent | 1972 |
[Antiradiation effect of mexamine].
Topics: 5-Methoxytryptamine; Animals; beta-Aminoethyl Isothiourea; Blood Coagulation; Bone Marrow; Bone Marr | 1974 |
Cytogenetic aspects of psychopathology.
Topics: Aggression; Animals; Body Height; Chlorpromazine; Chromosome Aberrations; Cytogenetics; Epilepsy; Hu | 1969 |
3 trials available for chlorpromazine and Abnormalities, Autosome
| Article | Year |
|---|---|
In-vivo cytogenetic effects of perphenazine and chlorpromazine: a negative study.
Topics: Adult; Chlorpromazine; Chromosome Aberrations; Chromosomes; Clinical Trials as Topic; Humans; Male; | 1972 |
In vivo and in vitro chromosomal damage induced by LSD-25.
Topics: Adult; Child; Child, Preschool; Chlorpromazine; Chromosome Aberrations; Chromosome Disorders; Clinic | 1967 |
Psychotropic drugs.
Topics: Animals; Brain; Cerebral Cortex; Chlorpromazine; Chromosome Aberrations; Chromosome Disorders; Chrom | 1972 |
18 other studies available for chlorpromazine and Abnormalities, Autosome
| Article | Year |
|---|---|
Photoclastogenicity-an improved protocol, its validation, and investigation of the photogenotoxicity of DMBA.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Chlorpromazine; CHO Cells; Chromosome Aberrations; Cricet | 2002 |
Photomutagenesis test development: II. 8-Methoxypsoralen, chlorpromazine and sunscreen compounds in chromosomal aberration assays using CHO cells.
Topics: Animals; Chlorpromazine; CHO Cells; Chromosome Aberrations; Cricetinae; Methoxsalen; Mutagenesis; Mu | 1993 |
Cytotoxic and genetic effects of X-irradiation of human cells in the presence of chlorpromazine.
Topics: Adult; Cell Survival; Chlorpromazine; Chromosome Aberrations; Humans; Karyotyping; Lymphocytes; Radi | 1994 |
Prader-Willi syndrome and psychoses.
Topics: Adolescent; Adult; Age of Onset; Chlorpromazine; Chromosome Aberrations; Chromosome Disorders; Chrom | 1993 |
Transient hypothermia induces micronuclei in mice.
Topics: Animals; Bone Marrow; Cell Line; Chlorpromazine; Chromosome Aberrations; Cricetinae; Cricetulus; Hyp | 1998 |
The effect on sister-chromatid exchanges of drugs and dyes by intercalation and photoactivation.
Topics: Acridines; Animals; Antipsychotic Agents; Cell Line; Chlorpromazine; Chlorprothixene; Chromosome Abe | 1979 |
Chlorpromazine induced anomalies in Saccobranchus fossilis.
Topics: Animals; Chlorpromazine; Chromosome Aberrations; Dose-Response Relationship, Drug; Fishes; Germ Cell | 1979 |
[Comparative study of the mutagenic effect of several chemical substances on Syrian hamsters].
Topics: Animals; Bone Marrow; Bone Marrow Cells; Chlorpromazine; Chromosome Aberrations; Cricetinae; Mitotic | 1976 |
[Frequency of sex chromatin among mental patients].
Topics: Adolescent; Adult; Aged; Bipolar Disorder; Chlorpromazine; Chromosome Aberrations; Chromosome Disord | 1992 |
Mutagenicity and teratogenicity of chlorpromazine and scopolamine.
Topics: Abnormalities, Drug-Induced; Animals; Chlorpromazine; Chromosome Aberrations; Female; Limb Deformiti | 1988 |
The effect of psychotomimetic drugs upon human chromosomes in tissue culture.
Topics: Adolescent; Adult; Cells, Cultured; Chlorpromazine; Chromosome Aberrations; Chromosomes; Female; Hal | 1974 |
Photoactivation of chlorpromazine: cytogenetic and mutagenic effects.
Topics: Animals; Cell Line; Chlorpromazine; Chromosome Aberrations; Cricetinae; Humans; Lung; Mutagens; Muta | 1973 |
Phenothiazines and chromosome damage.
Topics: Adolescent; Adult; Chlorpromazine; Chromatids; Chromosome Aberrations; Chromosomes; Humans | 1970 |
In vitro effects of chlorpromazine and meprobamate on blast transformation and chromosomes.
Topics: Adult; Chlorpromazine; Chromosome Aberrations; Culture Techniques; Humans; Leukocytes; Lymphocyte Ac | 1971 |
A gentic trip.
Topics: Chlorpromazine; Chromosome Aberrations; Chromosome Disorders; Humans; Infant, Newborn; Lysergic Acid | 1968 |
Effect of drugs on nucleic acid synthesis and cell division in vitro.
Topics: Cell Division; Chlorpromazine; Chromatids; Chromosome Aberrations; Chromosomes; Diphenhydramine; Dip | 1968 |
Chromosome abnormalities in patients treated with chlorpromazine, perphenazine, and lysergide.
Topics: Adolescent; Adult; Age Factors; Aged; Chlorpromazine; Chromosome Aberrations; Culture Techniques; Er | 1969 |
Cytogenetic effects of tranquilizing drugs in vivo and in vitro.
Topics: Adolescent; Adult; Child; Chlordiazepoxide; Chlorpromazine; Chromosome Aberrations; Culture Techniqu | 1969 |