Page last updated: 2024-08-22

chlorproguanil and Malaria

chlorproguanil has been researched along with Malaria in 19 studies

*Malaria: A protozoan disease caused in humans by four species of the PLASMODIUM genus: PLASMODIUM FALCIPARUM; PLASMODIUM VIVAX; PLASMODIUM OVALE; and PLASMODIUM MALARIAE; and transmitted by the bite of an infected female mosquito of the genus ANOPHELES. Malaria is endemic in parts of Asia, Africa, Central and South America, Oceania, and certain Caribbean islands. It is characterized by extreme exhaustion associated with paroxysms of high FEVER; SWEATING; shaking CHILLS; and ANEMIA. Malaria in ANIMALS is caused by other species of plasmodia. [MeSH]

Research

Studies (19)

TimeframeStudies, this research(%)All Research%
pre-199011 (57.89)18.7374
1990's2 (10.53)18.2507
2000's5 (26.32)29.6817
2010's0 (0.00)24.3611
2020's1 (5.26)2.80

Authors

AuthorsStudies
Cheong, SL; Ng, CH; Tibon, NS1
Adjuik, M; Amenga-Etego, S; Asante, KP; Chandramohan, D; Dosoo, DK; Greenwood, B; Gyapong, J; Owusu, R; Owusu-Agyei, S1
CHARLES, LJ1
Bukirwa, H; Critchley, J; Garner, P1
Peters, W; Robinson, BL; Stewart, LB1
Biagini, GA; Edwards, G1
Nyunt, MM; Plowe, CV1
Bengtsson, E; Björkman, A; Brohult, J; Sirleaf, V; Willcox, M1
Björkman, A; Rooth, I; Sinani, HM1
Bjorkman, A; Flacks, H; Hanson, AP; Hogh, B; Petersen, E1
Flachs, H; Havermann, K; Le Bras, J; Ringwald, P1
Brandling-Bennett, AD; Gilles, HM; Howells, RE; Koech, DK; Oloo, AJ; Watkins, WM1
Haworth, SJ; Law, B; O'Neil, AB; Tuersley, LV1
Boriga, DA; Brandling-Bennett, AD; Carter, JY; Howells, RE; Koech, DK; Nevill, CG; Watkins, WM1
Da Costa, F; Schapira, A1
Flachs, H; Hanson, AP; Høgh, B; Petersen, E1
Barutwanayo, M; Coosemans, MH; Gryseels, B; Onori, E; Otoul, C; Wéry, M1
Alestig, K; Bengtsson, E; Björkman, A; Brohult, J; Hanson, A; Hedman, P; Kollie, E; Pehrson, PO; Rombo, L; Willcox, M1
Bengtsson, E; Björkman, A; Brohult, J; Hanson, AP; Hedman, P; Hetland, G; Kollie, E; Pehrson, PO; Rombo, L; Willcox, M1

Reviews

3 review(s) available for chlorproguanil and Malaria

ArticleYear
Current progress in antimalarial pharmacotherapy and multi-target drug discovery.
    European journal of medicinal chemistry, 2020, Feb-15, Volume: 188

    Topics: Animals; Antimalarials; Artemisinins; Drug Discovery; Drug Resistance; Humans; Malaria; Molecular Structure; Paclitaxel; Quinolines

2020
Chlorproguanil-dapsone for treating uncomplicated malaria.
    The Cochrane database of systematic reviews, 2004, Oct-18, Issue:4

    Topics: Adult; Antimalarials; Child; Dapsone; Drug Combinations; Humans; Malaria; Proguanil; Randomized Controlled Trials as Topic

2004
Resisting resistance: dealing with the irrepressible problem of malaria.
    British journal of clinical pharmacology, 2006, Volume: 61, Issue:6

    Topics: Amodiaquine; Antimalarials; Artemisinins; Artesunate; Dapsone; Drug Combinations; Drug Resistance; Humans; Malaria; Proguanil; Sesquiterpenes

2006

Trials

7 trial(s) available for chlorproguanil and Malaria

ArticleYear
An open label, randomised trial of artesunate+amodiaquine, artesunate+chlorproguanil-dapsone and artemether-lumefantrine for the treatment of uncomplicated malaria.
    PloS one, 2008, Jun-25, Volume: 3, Issue:6

    Topics: Amodiaquine; Antimalarials; Artemether; Artemisinins; Artesunate; Child; Child, Preschool; Dapsone; Drug Therapy, Combination; Ethanolamines; Female; Fluorenes; Humans; Infant; Lumefantrine; Malaria; Male; Polymerase Chain Reaction; Proguanil; Treatment Outcome

2008
Proguanil daily or chlorproguanil twice weekly are efficacious against falciparum malaria in a holoendemic area of Tanzania.
    The Journal of tropical medicine and hygiene, 1991, Volume: 94, Issue:1

    Topics: Adolescent; Animals; Child; Drug Administration Schedule; Humans; Malaria; Mefloquine; Plasmodium falciparum; Proguanil; Random Allocation; Tanzania

1991
Inadequacy of chlorproguanil 20 mg per week as chemoprophylaxis for falciparum malaria in Kenya.
    Lancet (London, England), 1987, Jan-17, Volume: 1, Issue:8525

    Topics: Adolescent; Child; Clinical Trials as Topic; Drug Resistance, Microbial; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; In Vitro Techniques; Kenya; Malaria; Male; Plasmodium falciparum; Proguanil; Pyrimethamine; Random Allocation; Sulfadoxine

1987
Chlorproguanil/dapsone for the treatment of non-severe Plasmodium falciparum malaria in Kenya: a pilot study.
    Transactions of the Royal Society of Tropical Medicine and Hygiene, 1988, Volume: 82, Issue:3

    Topics: Animals; Dapsone; Drug Therapy, Combination; Humans; Kenya; Malaria; Pilot Projects; Plasmodium falciparum; Proguanil

1988
Studies on malaria prophylaxis with chlorproguanil or chloroquine in Mozambique.
    The Central African journal of medicine, 1988, Volume: 34, Issue:3

    Topics: Adolescent; Animals; Antimalarials; Child; Chloroquine; Clinical Trials as Topic; Humans; Malaria; Mozambique; Plasmodium falciparum; Proguanil; Random Allocation

1988
Double-blind study to assess the efficacy of chlorproguanil given alone or in combination with chloroquine for malaria chemoprophylaxis in an area with Plasmodium falciparum resistance to chloroquine, pyrimethamine and cycloguanil.
    Transactions of the Royal Society of Tropical Medicine and Hygiene, 1987, Volume: 81, Issue:1

    Topics: Adolescent; Animals; Antimalarials; Child; Chloroquine; Clinical Trials as Topic; Double-Blind Method; Drug Resistance; Drug Therapy, Combination; Female; Humans; Malaria; Male; Plasmodium falciparum; Proguanil; Pyrimethamine; Triazines

1987
Monthly antimalarial chemotherapy to children in a holoendemic area of Liberia.
    Annals of tropical medicine and parasitology, 1986, Volume: 80, Issue:2

    Topics: Antimalarials; Child; Child, Preschool; Chloroquine; Hematocrit; Humans; Immunoglobulin G; Liberia; Malaria; Plasmodium falciparum; Proguanil; Pyrimethamine; Spleen; Time Factors

1986

Other Studies

9 other study(ies) available for chlorproguanil and Malaria

ArticleYear
Field trials with chlorproguanil in the prophylaxis of malaria in Ghana.
    Bulletin of the World Health Organization, 1961, Volume: 24

    Topics: Africa; Antimalarials; Child; Drug Resistance; Ghana; Humans; Infant; Malaria; Malaria, Falciparum; Proguanil; Pyrimethamine

1961
The chemotherapy of rodent malaria. LXIII. Drug combinations to impede the selection of drug resistance, part 6: the potential value of chlorproguanil and dapsone in combination, and with the addition of artesunate.
    Annals of tropical medicine and parasitology, 2005, Volume: 99, Issue:5

    Topics: Animals; Antimalarials; Artemisinins; Artesunate; Dapsone; Drug Resistance; Drug Synergism; Drug Therapy, Combination; Malaria; Male; Mice; Parasitemia; Plasmodium berghei; Plasmodium chabaudi; Plasmodium yoelii; Proguanil; Rodent Diseases; Sesquiterpenes

2005
Pharmacologic advances in the global control and treatment of malaria: combination therapy and resistance.
    Clinical pharmacology and therapeutics, 2007, Volume: 82, Issue:5

    Topics: Amodiaquine; Antimalarials; Artemether; Artemisinins; Artesunate; Chloroquine; Dapsone; Drug Design; Drug Resistance; Drug Therapy, Combination; Ethanolamines; Female; Fluorenes; Global Health; Half-Life; Humans; Lumefantrine; Malaria; Mefloquine; Pregnancy; Pregnancy Complications, Infectious; Proguanil; Pyrimethamine; Quinine; Sesquiterpenes; Sulfadoxine

2007
Plasmodium falciparum resistance to pyrimethamine and chlorproguanil -- host or parasite dependent?
    Annals of tropical medicine and parasitology, 1980, Volume: 74, Issue:2

    Topics: Child; Child, Preschool; Drug Resistance, Microbial; Humans; Malaria; Plasmodium falciparum; Proguanil; Pyrimethamine

1980
In vitro and in vivo susceptibility of Plasmodium falciparum isolates from Liberia to pyrimethamine, cycloguanil and chlorcycloguanil.
    Annals of tropical medicine and parasitology, 1990, Volume: 84, Issue:6

    Topics: Animals; Antimalarials; Dose-Response Relationship, Drug; Drug Resistance; Humans; In Vitro Techniques; Liberia; Malaria; Plasmodium falciparum; Proguanil; Pyrimethamine; Triazines

1990
[A study of the efficacy of the chemoprevention of malaria using chlorproguanil alone or in combination with chloroquine in French expatriates in Dar-es-Salaam, Tanzania].
    Bulletin de la Societe de pathologie exotique et de ses filiales, 1989, Volume: 82, Issue:1

    Topics: Adolescent; Adult; Child; Chloroquine; Drug Therapy, Combination; Female; France; Humans; Malaria; Male; Middle Aged; Proguanil; Tanzania

1989
Chlorproguanil chemoprophylaxis for falciparum malaria in Kenya.
    Lancet (London, England), 1987, Mar-07, Volume: 1, Issue:8532

    Topics: Adolescent; Adult; Child; Child, Preschool; Humans; Kenya; Malaria; Male; Pilot Projects; Plasmodium falciparum; Proguanil

1987
Malaria breakthrough despite chlorproguanil chemoprophylaxis in an area without antifol resistance.
    Transactions of the Royal Society of Tropical Medicine and Hygiene, 1988, Volume: 82, Issue:5

    Topics: Animals; Antimalarials; Drug Resistance; Folic Acid Antagonists; Humans; Malaria; Plasmodium falciparum; Proguanil; Triazines

1988
Malaria control by chlorproguanil. I. Clinical effects and susceptibility of Plasmodium falciparum in vivo after seven years of monthly chlorproguanil administration to children in a Liberian village.
    Annals of tropical medicine and parasitology, 1985, Volume: 79, Issue:6

    Topics: Adolescent; Child; Child, Preschool; Disease Susceptibility; Humans; Leukocytes; Liberia; Malaria; Plasmodium falciparum; Plasmodium malariae; Proguanil; Splenomegaly

1985