Page last updated: 2024-08-22

chlorproguanil and Malaria, Falciparum

chlorproguanil has been researched along with Malaria, Falciparum in 28 studies

Research

Studies (28)

Timeframe	Studies, this research(%)	All Research%
pre-1990	1 (3.57)	18.7374
1990's	6 (21.43)	18.2507
2000's	19 (67.86)	29.6817
2010's	2 (7.14)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Björkman, A; Jovel, IT; Mårtensson, A; Roper, C; Ursing, J	1
Avellino, P; Bancone, G; d'Alessandro, U; Fanello, CI; Karema, C; Lee, SJ; Modiano, D; Uwimana, A	1
Bandyopadhyay, N; Duparc, S; Kirby, PL; Miller, AK; Ward, SA; Winstanley, PA; Wootton, DG	1
Borrmann, S; Duparc, S; Esamai, F; Ezedinachi, EU; Greenwood, B; Guiguemdé, R; Kellam, L; Kirby, PL; Oguche, S; Owusu-Agyei, S; Pamba, A; Premji, Z; Sowunmi, A; Umeh, RE; Ward, SA; Winstanley, PA	1
Agbenyega, T; Awobusuyi, J; Carter, N; Dicko, A; Duparc, S; Goh, LE; Greenwood, B; Harrell, E; Ndububa, DA; Pamba, A; Pitmang, S; Tiono, AB; Ward, SA; Winstanley, PA	1
Bardsley, B; Barry, SJ; Drozdz, MA; Hancock, SA; Okafo, GN; Szafran, MM	1
Chimpeni, P; Hatcher, J; Kublin, JG; Marsh, K; Molyneux, ME; Plowe, CV; Sulo, J; Taylor, TE; Watkins, WM; Winstanley, PA	1
Greenwood, B; Lang, T	1
CHARLES, LJ	1
Carneiro, IA; Chambo, W; Curtis, CF; Magogo, F; Maxwell, CA; Mwaimu, M	1
Zimmerman, PA	1
Imwong, M; Looareesuwan, S; Wilairatana, P	1
Alloueche, A; Bailey, W; Barton, S; Bwika, J; Chimpeni, P; Falade, CO; Fehintola, FA; Horton, J; Jaffar, S; Kanyok, T; Kremsner, PG; Kublin, JG; Lang, T; Missinou, MA; Mkandala, C; Oduola, AM; Premji, Z; Robertson, L; Sowunmi, A; Ward, SA; Winstanley, PA	1
Alloueche, A; Bates, SJ; Bwika, J; Happi, TC; Kremsner, PG; Kublin, JG; Premji, Z; Sibley, CH; Watkins, WM; Winstanley, PA	1
Peters, W; Robinson, BL; Stewart, LB	1
Alker, AP; Chaluluka, E; Kamwendo, DD; Meshnick, SR; Molyneux, ME; Mwapasa, V; Purfield, A; Rogerson, SJ; Tadesse, E	1
Garner, P; Jones, K; Taylor-Robinson, D	1
Aarons, L; Bojang, K; Edwards, G; Hughes, D; Manyando, C; Simpson, JA; Ward, S; Watkins, WA; Winstanley, P	1
Curtis, J; D'Alessandro, U; Fanello, CI; Karema, C; Ndahindwa, V; Ngamije, D; Uwimana, A; Van Doren, W; Van Overmeir, C	1
Chambo, O; Curtis, CF; Hills, E; Mbwana, H; Trigg, JK; Watkins, W	1
Amradee, S; Chinwongprom, K; Kyle, DE; Looareesuwan, S; Watkins, WM; White, NJ; Wilairatana, P	1
Amukoye, E; Hatcher, J; Lowe, B; Marsh, K; Minyiri, G; Mosobo, M; Ngumbao, E; Snow, RW; Ton, M; Watkins, WM; Winstanley, PA	1
Curtis, J; Duraisingh, MT; Warhurst, DC	1
Breckenridge, AM; Winstanley, PA	1
Curtis, J; Maxwell, CA; Ortelli, F; Watkins, WM	1
Hills, E; Mberu, E; Mutabingwa, T; Nduati, E; Nzila, A; Watkins, W; Winstanley, P	1
Winstanley, P	1
Chimpeni, P; Cortese, JF; Dzinjalamala, FK; Kamwendo, DD; Kublin, JG; Lescano, AG; Malkin, EM; Martino, LM; Molyneux, ME; Mukadam, RA; Plowe, CV; Rogerson, SJ; Taylor, TE; Winstanley, PA	1

Reviews

3 review(s) available for chlorproguanil and Malaria, Falciparum

Article	Year
Malaria: uncomplicated, caused by Plasmodium falciparum. Clinical evidence, 2005, Issue:13 Topics: Amodiaquine; Antimalarials; Artemether; Artemisinins; Artesunate; Chloroquine; Dapsone; Drug Combinations; Drug Therapy, Combination; Ethanolamines; Fluorenes; Humans; Lumefantrine; Malaria, Falciparum; Mefloquine; Proguanil; Pyrimethamine; Sesquiterpenes; Sulfadoxine	2005
Clinical pharmacology and malaria. Annals of tropical medicine and parasitology, 1997, Volume: 91, Issue:7 Topics: Amodiaquine; Antimalarials; Cost-Benefit Analysis; Humans; Malaria, Falciparum; Proguanil; Quinine; Risk Assessment	1997
Studies on anti-folate antimalarials in east Africa. Parassitologia, 1999, Volume: 41, Issue:1-3 Topics: Africa, Eastern; Animals; Antimalarials; Dapsone; Drug Therapy, Combination; Folic Acid Antagonists; Half-Life; Humans; Malaria, Falciparum; Plasmodium falciparum; Proguanil; Pyrimethamine; Sulfadoxine	1999

Trials

10 trial(s) available for chlorproguanil and Malaria, Falciparum

Article	Year
High risk of severe anaemia after chlorproguanil-dapsone+artesunate antimalarial treatment in patients with G6PD (A-) deficiency. PloS one, 2008, Volume: 3, Issue:12 Topics: Amodiaquine; Antimalarials; Artemisinins; Artesunate; Child; Child, Preschool; Dapsone; Drug Combinations; Drug Therapy, Combination; Female; Glucosephosphate Dehydrogenase Deficiency; Humans; Infant; Malaria, Falciparum; Male; Oxidants; Polymorphism, Genetic; Proguanil; Pyrimethamine; Sulfadoxine	2008
Pharmacokinetics of chlorproguanil, dapsone, artesunate and their major metabolites in patients during treatment of acute uncomplicated Plasmodium falciparum malaria. European journal of clinical pharmacology, 2009, Volume: 65, Issue:10 Topics: Adult; Antimalarials; Area Under Curve; Artemisinins; Artesunate; Dapsone; Dose-Response Relationship, Drug; Drug Combinations; Drug Synergism; Drug Therapy, Combination; Female; Gambia; Humans; Malaria, Falciparum; Malawi; Male; Middle Aged; Parasitic Sensitivity Tests; Proguanil; Time Factors	2009
Chlorproguanil-dapsone-artesunate versus artemether-lumefantrine: a randomized, double-blind phase III trial in African children and adolescents with uncomplicated Plasmodium falciparum malaria. PloS one, 2009, Aug-19, Volume: 4, Issue:8 Topics: Adolescent; Africa; Antimalarials; Artemisinins; Artesunate; Child; Dapsone; Double-Blind Method; Ethanolamines; Female; Fluorenes; Humans; Lumefantrine; Malaria, Falciparum; Male; Patient Compliance; Proguanil; Treatment Outcome	2009
Chlorproguanil-dapsone-artesunate versus chlorproguanil-dapsone: a randomized, double-blind, phase III trial in African children, adolescents, and adults with uncomplicated Plasmodium falciparum malaria. The American journal of tropical medicine and hygiene, 2009, Volume: 81, Issue:6 Topics: Adolescent; Adult; Africa South of the Sahara; Animals; Antimalarials; Artemisinins; Artesunate; Child; Child, Preschool; Dapsone; Double-Blind Method; Drug Therapy, Combination; Female; Glycogen Storage Disease Type I; Hemolysis; Humans; Malaria, Falciparum; Male; Plasmodium falciparum; Proguanil; Time Factors	2009
Chlorproguanil-dapsone versus sulfadoxine-pyrimethamine for sequential episodes of uncomplicated falciparum malaria in Kenya and Malawi: a randomised clinical trial. Lancet (London, England), 2002, Oct-12, Volume: 360, Issue:9340 Topics: Antimalarials; Cause of Death; Child, Preschool; Dapsone; Developing Countries; Drug Combinations; Drug Therapy, Combination; Female; Hemoglobinometry; Humans; Infant; Kenya; Malaria, Falciparum; Malawi; Male; Proguanil; Pyrimethamine; Recurrence; Retreatment; Sulfadoxine; Survival Rate	2002
Comparison of chlorproguanil-dapsone with sulfadoxine-pyrimethamine for the treatment of uncomplicated falciparum malaria in young African children: double-blind randomised controlled trial. Lancet (London, England), 2004, Jun-05, Volume: 363, Issue:9424 Topics: Africa; Animals; Antimalarials; Child; Child, Preschool; Dapsone; Double-Blind Method; Drug Combinations; Drug Resistance; Female; Hemoglobins; Humans; Infant; Malaria, Falciparum; Male; Methemoglobin; Plasmodium falciparum; Proguanil; Pyrimethamine; Sulfadoxine; Treatment Outcome	2004
A randomised trial to assess the efficacy and safety of chlorproguanil/dapsone + artesunate for the treatment of uncomplicated Plasmodium falciparum malaria. Transactions of the Royal Society of Tropical Medicine and Hygiene, 2008, Volume: 102, Issue:5 Topics: Animals; Antimalarials; Artemisinins; Artesunate; Child, Preschool; Dapsone; Drug Administration Schedule; Drug Therapy, Combination; Female; Genotype; Humans; Infant; Malaria, Falciparum; Male; Proguanil; Rural Health; Rwanda; Treatment Outcome	2008
Chlorproguanil-dapsone: effective treatment for uncomplicated falciparum malaria. Antimicrobial agents and chemotherapy, 1997, Volume: 41, Issue:10 Topics: Antimalarials; Child; Child, Preschool; Dapsone; Double-Blind Method; Drug Combinations; Drug Resistance; Female; Hemoglobins; Humans; Infant; Malaria, Falciparum; Male; Proguanil; Pyrimethamine; Sulfadoxine	1997
In vivo selection for a specific genotype of dihydropteroate synthetase of Plasmodium falciparum by pyrimethamine-sulfadoxine but not chlorproguanil-dapsone treatment. The Journal of infectious diseases, 1998, Volume: 177, Issue:5 Topics: Amino Acid Sequence; Animals; Antimalarials; Arginine; Asparagine; Child; Dapsone; Dihydropteroate Synthase; Drug Therapy, Combination; Genes, Protozoan; Genetic Variation; Genotype; Humans; Isoleucine; Malaria, Falciparum; Plasmodium falciparum; Point Mutation; Polymerase Chain Reaction; Proguanil; Pyrimethamine; Sulfadoxine	1998
Molecular markers for failure of sulfadoxine-pyrimethamine and chlorproguanil-dapsone treatment of Plasmodium falciparum malaria. The Journal of infectious diseases, 2002, Feb-01, Volume: 185, Issue:3 Topics: Antimalarials; Biomarkers; Child; Child, Preschool; Dapsone; Dihydropteroate Synthase; Double-Blind Method; Drug Combinations; Drug Resistance, Bacterial; Humans; Infant; Malaria, Falciparum; Mutation; Proguanil; Prospective Studies; Pyrimethamine; Sensitivity and Specificity; Sulfadoxine; Tetrahydrofolate Dehydrogenase; Treatment Failure	2002

Other Studies

15 other study(ies) available for chlorproguanil and Malaria, Falciparum

Article	Year
Unexpected selections of Plasmodium falciparum polymorphisms in previously treatment-naïve areas after monthly presumptive administration of three different anti-malarial drugs in Liberia 1976-78. Malaria journal, 2017, 03-13, Volume: 16, Issue:1 Topics: Antimalarials; Child; Child, Preschool; Chloroquine; Drug Resistance; Humans; Liberia; Malaria, Falciparum; Plasmodium falciparum; Polymerase Chain Reaction; Polymorphism, Genetic; Proguanil; Protozoan Proteins; Pyrimethamine; Selection, Genetic	2017
Formation and identification of a degradant in chlorproguanil-dapsone-artesunate (Dacart™) tablets. Journal of pharmaceutical and biomedical analysis, 2011, Feb-20, Volume: 54, Issue:3 Topics: Antimalarials; Artemisinins; Artesunate; Chromatography, High Pressure Liquid; Chromatography, Liquid; Dapsone; Drug Combinations; Drug Stability; Drug Therapy, Combination; Hot Temperature; Humans; Humidity; Magnetic Resonance Spectroscopy; Malaria, Falciparum; Mass Spectrometry; Proguanil; Tablets	2011
The development of Lapdap, an affordable new treatment for malaria. The Lancet. Infectious diseases, 2003, Volume: 3, Issue:3 Topics: Animals; Antimalarials; Child; Clinical Trials as Topic; Dapsone; Drug Approval; Drug Combinations; Female; Humans; Malaria, Falciparum; Male; Proguanil; Time Factors; United Kingdom	2003
Field trials with chlorproguanil in the prophylaxis of malaria in Ghana. Bulletin of the World Health Organization, 1961, Volume: 24 Topics: Africa; Antimalarials; Child; Drug Resistance; Ghana; Humans; Infant; Malaria; Malaria, Falciparum; Proguanil; Pyrimethamine	1961
Variation of malaria transmission and morbidity with altitude in Tanzania and with introduction of alphacypermethrin treated nets. Malaria journal, 2003, Sep-10, Volume: 2 Topics: Altitude; Animals; Anopheles; Antigens, Protozoan; Child; Child, Preschool; Dapsone; Drug Therapy, Combination; Humans; Incidence; Infant; Insecticides; Malaria, Falciparum; Plasmodium falciparum; Prevalence; Proguanil; Protective Devices; Pyrethrins; Secondary Prevention; Tanzania	2003
Roll back of Plasmodium falciparum antifolate resistance by insecticide-treated nets. The American journal of tropical medicine and hygiene, 2003, Volume: 69, Issue:3 Topics: Animals; Antimalarials; Bedding and Linens; Culicidae; Dapsone; Drug Combinations; Drug Resistance; Folic Acid Antagonists; Humans; Insecticides; Malaria, Falciparum; Mosquito Control; Mutation; Plants; Plasmodium falciparum; Proguanil; Pyrimethamine; Sulfadoxine	2003
Chlorproguanil-dapsone for malaria in Africa. Lancet (London, England), 2004, Jun-05, Volume: 363, Issue:9424 Topics: Africa; Animals; Antimalarials; Dapsone; Drug Combinations; Drug Resistance; Humans; Malaria, Falciparum; Plasmodium falciparum; Proguanil; Pyrimethamine; Sulfadoxine	2004
Rare, highly pyrimethamine-resistant alleles of the Plasmodium falciparum dihydrofolate reductase gene from 5 African sites. The Journal of infectious diseases, 2004, Nov-15, Volume: 190, Issue:10 Topics: Alleles; Amino Acid Substitution; Animals; Antimalarials; Dapsone; Drug Resistance; Gabon; Genes, Protozoan; Humans; Kenya; Malaria, Falciparum; Malawi; Molecular Epidemiology; Mutation, Missense; Nigeria; Parasitic Sensitivity Tests; Plasmodium falciparum; Point Mutation; Proguanil; Pyrimethamine; Sulfadoxine; Tanzania; Tetrahydrofolate Dehydrogenase	2004
The chemotherapy of rodent malaria. LXII. Drug combinations to impede the selection of drug resistance, part 5: rates of development of resistance to some inhibitors of folate metabolism and to artesunate. Annals of tropical medicine and parasitology, 2004, Volume: 98, Issue:8 Topics: Animals; Antimalarials; Artemisinins; Artesunate; Dapsone; Drug Resistance; Drug Therapy, Combination; Folic Acid Antagonists; Malaria, Falciparum; Male; Mice; Parasitemia; Plasmodium berghei; Plasmodium chabaudi; Plasmodium yoelii; Proguanil; Sesquiterpenes; Triazines	2004
Mutations associated with sulfadoxine-pyrimethamine and chlorproguanil resistance in Plasmodium falciparum isolates from Blantyre, Malawi. Antimicrobial agents and chemotherapy, 2005, Volume: 49, Issue:9 Topics: Animals; Antimalarials; DNA Primers; Drug Combinations; Drug Resistance; Folic Acid Antagonists; Humans; Malaria, Falciparum; Malawi; Mutation; Plasmodium falciparum; Proguanil; Pyrimethamine; Reverse Transcriptase Polymerase Chain Reaction; Sulfadoxine; Tetrahydrofolate Dehydrogenase	2005
Population pharmacokinetic and pharmacodynamic modelling of the antimalarial chemotherapy chlorproguanil/dapsone. British journal of clinical pharmacology, 2006, Volume: 61, Issue:3 Topics: Adolescent; Adult; Animals; Antimalarials; Child; Child, Preschool; Dapsone; Humans; Infant; Malaria, Falciparum; Middle Aged; Plasmodium falciparum; Proguanil; Prospective Studies; Triazines	2006
Resistance to pyrimethamine/sulfadoxine in Plasmodium falciparum in 12 villages in north east Tanzania and a test of chlorproguanil/dapsone. Acta tropica, 1997, Volume: 63, Issue:2-3 Topics: Anti-Infective Agents; Antimalarials; Child; Child, Preschool; Dapsone; Drug Resistance, Microbial; Drug Therapy, Combination; Humans; Infant; Malaria, Falciparum; Proguanil; Pyrimethamine; Sulfadoxine; Tanzania	1997
Poor efficacy of antimalarial biguanide-dapsone combinations in the treatment of acute, uncomplicated, falciparum malaria in Thailand. Annals of tropical medicine and parasitology, 1997, Volume: 91, Issue:2 Topics: Adolescent; Adult; Animals; Antimalarials; Dapsone; Drug Resistance; Drug Therapy, Combination; Female; Folic Acid Antagonists; Follow-Up Studies; Humans; Malaria, Falciparum; Male; Middle Aged; Parasitemia; Pilot Projects; Plasmodium falciparum; Proguanil; Thailand; Treatment Outcome	1997
Chlorproguanil-dapsone for treatment of drug-resistant falciparum malaria in Tanzania. Lancet (London, England), 2001, Oct-13, Volume: 358, Issue:9289 Topics: Adolescent; Adult; Animals; Antimalarials; Child; Child, Preschool; Dapsone; Drug Combinations; Drug Resistance; Genotype; Humans; Malaria, Falciparum; Middle Aged; Plasmodium falciparum; Point Mutation; Proguanil; Pyrimethamine; Sulfadoxine; Tanzania	2001
Chlorproguanil-dapsone (LAPDAP) for uncomplicated falciparum malaria. Tropical medicine & international health : TM & IH, 2001, Volume: 6, Issue:11 Topics: Antimalarials; Artemisinins; Clinical Trials, Phase III as Topic; Dapsone; Drug Approval; Drug Combinations; Drug Therapy, Combination; Health Services Accessibility; Humans; Malaria, Falciparum; Proguanil; Sesquiterpenes	2001