chlorpheniramine has been researched along with Muscle Contraction in 59 studies
Chlorpheniramine: A histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. It has also been used in veterinary applications. One of the most widely used of the classical antihistaminics, it generally causes less drowsiness and sedation than PROMETHAZINE.
chlorphenamine : A tertiary amino compound that is propylamine which is substituted at position 3 by a pyridin-2-yl group and a p-chlorophenyl group and in which the hydrogens attached to the nitrogen are replaced by methyl groups. A histamine H1 antagonist, it is used to relieve the symptoms of hay fever, rhinitis, urticaria, and asthma.
Muscle Contraction: A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Centipede bites are a constant risk throughout tropical regions and have the rare potential for systemic side effects." | 1.51 | Challenges of Remote Medical Care in South Sudan: Centipede Bites. ( Dickson, N; Moles, I; Pallett, SJC, 2019) |
| "Chlorpheniramine maleate is a stable, most potent, sedative first generation anti-histamine and is effective in the treatment of allergic disorders." | 1.32 | To evaluate and compare the effects of first generation anti-histamine (chlorpheniramine maleate) and second generation anti-histamine (loratadine) on isolated trachea of rabbit. ( Aamir, K; Ashraf, R; Jalbani, GA; Shaikh, AM; Soomro, FM; Unar, MA, 2004) |
| "Substance P was shown to produce rapid, small contractions of trhe lung strip at doses from 10(-9) to 10(-5) M, and there was no apparent dose-response relationship." | 1.27 | The effect of substance P and related peptides on the guinea-pig lung strip. ( Foreman, JC; Webber, SE, 1984) |
| " The H1-antagonist chlorpheniramine shifted to the right the dose-response curves to histamine and to 2-aminoethylthiazole with the kinetics of the competitive antagonism." | 1.27 | Histamine receptors in the human ureter. ( Bertaccini, G; Bezzi, E; Potenzoni, D; Zappia, L, 1983) |
| "A dose-response relationship for substance P and contraction of the lung parenchyma strip of the guinea-pig could only be obtained in the presence of a mixture of bacitracin, 1,4 dithio-L-threitol and ethylenediamine tetracetic acid, all at 100 microM, or in the presence of captopril, 1." | 1.27 | Contraction of guinea-pig lung parenchymal strips by substance P and related peptides. ( Foreman, JC; Shelly, R; Webber, SE, 1985) |
| " A method that avoided tachyphylaxis encountered in prior investigations was developed for isometric measurement of multiple dose-response effects." | 1.27 | Parasympathetic involvement in PAF-induced contraction in canine trachealis in vivo. ( Leff, AR; Munoz, NM; Popovich, KJ; Shioya, T; Stimler-Gerard, NP; White, SR, 1987) |
| " Cimetidine shifted the dose-response curve for histamine to the right, but chlorpheniramine did not alter the response." | 1.27 | Mechanisms of histamine-induced relaxation in isolated monkey and dog coronary arteries. ( Toda, N, 1986) |
| " Cocaine (2 x 10(-6) M and 10(-5) M) produced 2 and 7 fold shifts to the left of the dose-response curve to (-)-noradrenaline recorded isotonically in isolated splenic capsular strips of the cat." | 1.26 | Investigation of the role of calcium in the supersensitivity produced by cocaine in cat spleen strips. ( Summers, RJ; Tillman, J, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 46 (77.97) | 18.7374 |
| 1990's | 8 (13.56) | 18.2507 |
| 2000's | 3 (5.08) | 29.6817 |
| 2010's | 2 (3.39) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Janssens, F | 1 |
| Torremans, J | 1 |
| Janssen, M | 1 |
| Stokbroekx, RA | 1 |
| Luyckx, M | 1 |
| Janssen, PA | 1 |
| Pallett, SJC | 1 |
| Dickson, N | 1 |
| Moles, I | 1 |
| Boskabady, MH | 1 |
| Tabanfar, H | 1 |
| Jalbani, GA | 1 |
| Aamir, K | 1 |
| Shaikh, AM | 1 |
| Unar, MA | 1 |
| Ashraf, R | 1 |
| Soomro, FM | 1 |
| Gupta, A | 1 |
| Gillard, M | 1 |
| Christophe, B | 1 |
| Chatelain, P | 1 |
| Massingham, R | 1 |
| Hammarlund-Udenaes, M | 1 |
| Fujii, K | 1 |
| Yonehara, S | 1 |
| Takasugi, S | 1 |
| Ueda, T | 1 |
| Mukai, M | 1 |
| Longhurst, PA | 1 |
| Belis, JA | 1 |
| O'Donnell, JP | 1 |
| Galie, JR | 1 |
| Westfall, DP | 1 |
| Webber, SE | 2 |
| Foreman, JC | 2 |
| Bertaccini, G | 1 |
| Zappia, L | 1 |
| Bezzi, E | 1 |
| Potenzoni, D | 1 |
| Ohizumi, Y | 1 |
| Kajiwara, A | 1 |
| Yasumoto, T | 1 |
| Satoh, H | 1 |
| Inui, J | 1 |
| Stimler, NP | 1 |
| Hugli, TE | 1 |
| Bloor, CM | 1 |
| Maggi, CA | 1 |
| Santicioli, P | 1 |
| Evangelista, S | 1 |
| Meli, A | 1 |
| Tonini, M | 1 |
| Frigo, G | 1 |
| Lecchini, S | 1 |
| D'Angelo, L | 1 |
| Crema, A | 1 |
| Fang, LB | 1 |
| Yang, QH | 1 |
| Bian, RL | 1 |
| Luo, XX | 1 |
| Tan, YH | 1 |
| Hammerbeck, DM | 1 |
| Brown, DR | 1 |
| KAMEI, CH | 1 |
| Kasamatsu, Y | 1 |
| Osada, M | 1 |
| Ashida, K | 1 |
| Azukari, K | 1 |
| Yoshioka, K | 1 |
| Ohsawa, A | 1 |
| Bytautiene, E | 1 |
| Vedernikov, YP | 1 |
| Saade, GR | 1 |
| Romero, R | 1 |
| Garfield, RE | 1 |
| Chiou, CY | 1 |
| Trzeciakowski, J | 1 |
| Nagai, H | 1 |
| Osuga, K | 1 |
| Koda, A | 1 |
| Wallach, EE | 1 |
| Wright, KH | 1 |
| Hamada, Y | 1 |
| Yen, SS | 1 |
| Kreutner, W | 1 |
| Sanders, J | 1 |
| Miller, DD | 1 |
| Patil, PN | 1 |
| Summers, RJ | 1 |
| Tillman, J | 1 |
| Giannini, G | 1 |
| Starke, K | 1 |
| Weitzell, R | 1 |
| Petersen, EN | 1 |
| Olsson, SO | 1 |
| Squires, RF | 1 |
| Krueger, CA | 2 |
| Cook, DA | 2 |
| Ladeira, AM | 1 |
| Andrade, SO | 1 |
| Sawaya, P | 1 |
| Ortiz, JL | 1 |
| Labat, C | 1 |
| Norel, X | 1 |
| Gorenne, I | 1 |
| Verley, J | 1 |
| Brink, C | 1 |
| Pillai, G | 1 |
| Sutter, MC | 1 |
| Tsuchiya, Y | 1 |
| Hosokawa, T | 1 |
| Kasuya, Y | 1 |
| Shelly, R | 1 |
| Nolan, JC | 1 |
| Stephens, DJ | 1 |
| Proakis, AG | 1 |
| Leonard, CA | 1 |
| Johnson, DN | 1 |
| Kilpatrick, BF | 1 |
| Foxwell, MH | 1 |
| Yanni, JM | 1 |
| Leff, AR | 1 |
| White, SR | 1 |
| Munoz, NM | 1 |
| Popovich, KJ | 1 |
| Shioya, T | 1 |
| Stimler-Gerard, NP | 1 |
| Hand, JM | 1 |
| Schwalm, SF | 1 |
| Lewis, AJ | 1 |
| Tokumura, A | 1 |
| Terao, M | 1 |
| Okamoto, M | 1 |
| Yoshida, K | 1 |
| Tsukatani, H | 1 |
| Smith, PF | 1 |
| Palmer, JD | 1 |
| Holmes, T | 1 |
| Cutcher, A | 1 |
| Dunn, AM | 1 |
| Halonen, M | 1 |
| Toda, N | 1 |
| Watanabe, J | 1 |
| Takahashi, M | 1 |
| Kaneto, H | 1 |
| Michalchuk, A | 1 |
| Moracci, FM | 1 |
| Liberatore, F | 1 |
| Edvinsson, L | 1 |
| Owman, C | 1 |
| Altura, BM | 2 |
| Altura, BT | 1 |
| Wellens, D | 1 |
| Miyake, T | 1 |
| Sekiya, A | 1 |
| Kanda, Z | 1 |
| Farmer, JB | 1 |
| Lehrer, DN | 1 |
| Baum, T | 1 |
| Gluckman, MI | 1 |
| Kiyomoto, A | 1 |
| Iwasawa, Y | 1 |
| Harigaya, S | 1 |
| Benzi, G | 1 |
| Bermudez, E | 1 |
| Arrigoni, E | 1 |
| Okamura, T | 1 |
| Shina, Y | 1 |
| Osman, OH | 1 |
| Ismail, M | 1 |
| el-Asmar, MF | 1 |
| Ibrahim, SA | 1 |
| Müller-Schweinitzer, E | 1 |
| Kalsner, S | 1 |
| Osterberg, RE | 1 |
| Koppanyi, T | 1 |
| Dage, RC | 1 |
| Hardman, HF | 1 |
59 other studies available for chlorpheniramine and Muscle Contraction
| Article | Year |
|---|---|
New antihistaminic N-heterocyclic 4-piperidinamines. 1. Synthesis and antihistaminic activity of N-(4-piperidinyl)-1H-benzimidazol-2-amines.
Topics: Administration, Oral; Animals; Benzimidazoles; Biological Assay; Chemical Phenomena; Chemistry; Guin | 1985 |
Challenges of Remote Medical Care in South Sudan: Centipede Bites.
Topics: Adult; Analgesics, Opioid; Anesthetics, Local; Animals; Anti-Inflammatory Agents; Arthropod Venoms; | 2019 |
Effect of Zataria multiflora Bois L. on histamine (H1) receptor of guinea pig tracheal chains.
Topics: Animals; Chlorpheniramine; Dose-Response Relationship, Drug; Guinea Pigs; Histamine; Histamine H1 An | 2011 |
To evaluate and compare the effects of first generation anti-histamine (chlorpheniramine maleate) and second generation anti-histamine (loratadine) on isolated trachea of rabbit.
Topics: Animals; Chlorpheniramine; Histamine H1 Antagonists; Histamine H1 Antagonists, Non-Sedating; Loratad | 2004 |
Peripheral and central H1 histamine receptor occupancy by levocetirizine, a non-sedating antihistamine; a time course study in the guinea pig.
Topics: Administration, Oral; Animals; Anti-Allergic Agents; Blood-Brain Barrier; Brain; Cerebellum; Cetiriz | 2007 |
[Effect of 1-[3-[4-(diphenylmethyl)-1-priperazinyl]-propyl]-1,3-dihydro-2H-benzimidazol-2- one (oxatomide) on contraction of canine bronchial muscle].
Topics: Animals; Antigens; Ascaris; Bronchi; Chlorpheniramine; Cromolyn Sodium; Dogs; Histamine H1 Antagonis | 1983 |
A study of the atropine-resistant component of the neurogenic response of the rabbit urinary bladder.
Topics: Animals; Atropine; Capsaicin; Chlorpheniramine; Drug Resistance; In Vitro Techniques; Indomethacin; | 1984 |
The effect of substance P and related peptides on the guinea-pig lung strip.
Topics: Animals; Chlorpheniramine; Dose-Response Relationship, Drug; Eledoisin; Female; Guinea Pigs; Histami | 1984 |
Histamine receptors in the human ureter.
Topics: Chlorpheniramine; Dimaprit; Histamine; Humans; In Vitro Techniques; Metiamide; Muscle Contraction; M | 1983 |
Excitatory effect of the most potent marine toxin, maitotoxin, on the guinea-pig vas deferens.
Topics: Animals; Calcium; Calcium Channel Blockers; Cell Membrane; Chlorpheniramine; Dose-Response Relations | 1983 |
Endothelial cell-dependent relaxation and contraction induced by histamine in the isolated guinea-pig pulmonary artery.
Topics: Animals; Chlorpheniramine; Endothelium; Female; Guinea Pigs; Histamine; In Vitro Techniques; Male; M | 1984 |
Pulmonary injury induced by C3a and C5a anaphylatoxins.
Topics: Anaphylatoxins; Animals; Bronchial Spasm; Capillary Permeability; Chlorpheniramine; Complement C3; C | 1980 |
The effect of urethane on histamine-induced contraction of guinea-pig tracheal smooth muscle.
Topics: Animals; Chlorpheniramine; Guinea Pigs; Histamine; Kinetics; Male; Muscle Contraction; Muscle, Smoot | 1982 |
Hyoscine-resistant peristalsis in guinea-pig ileum.
Topics: Animals; Chlorpheniramine; Female; Gastrointestinal Motility; Guinea Pigs; Ileum; In Vitro Technique | 1981 |
Mediator difference in contractions between trachea and bronchus of guinea pig induced by stimulation of C-fibers in vitro.
Topics: Acetylcholine; Animals; Atropine; Bronchi; Chlorpheniramine; Cromolyn Sodium; Electric Stimulation; | 1994 |
Presynaptic histamine H1- and H3-receptors modulate sympathetic neurotransmission in isolated guinea pig vas deferens.
Topics: Animals; Chlorpheniramine; Dimaprit; Dose-Response Relationship, Drug; Guinea Pigs; Histamine Agonis | 1994 |
Selective hyperresponsiveness to ovalbumin-induced epithelial transport in inflamed guinea pig distal colon.
Topics: Animals; Antigens; Chlorpheniramine; Colitis; Cyclooxygenase Inhibitors; Disease Models, Animal; Epi | 1993 |
EFFECTS OF HISTAMINE AND RELATED COMPOUNDS ON THE BOVINE IRIS DILATOR.
Topics: Analysis of Variance; Animals; Cattle; Chlorpheniramine; Cimetidine; Diphenhydramine; Dose-Response | 1996 |
Rhabdomyolysis after infection and taking a cold medicine in a patient who was susceptible to malignant hyperthermia.
Topics: Adult; Caffeine; Chlorpheniramine; Common Cold; Dantrolene; Halothane; Humans; In Vitro Techniques; | 1998 |
Endogenous mast cell degranulation modulates cervical contractility in the guinea pig.
Topics: Animals; Cell Degranulation; Cervix Uteri; Chlorpheniramine; Cimetidine; Dose-Response Relationship, | 2002 |
Histamine mediation of nicotine effects on postganglionic sympathetic neuroeffector junctions.
Topics: Acetyl-CoA C-Acetyltransferase; Animals; Autonomic Fibers, Postganglionic; Chlorpheniramine; Desipra | 1976 |
Inhibition of hypersensitivity reactions by soluble derivatives of baicalein.
Topics: Aminophylline; Anaphylaxis; Animals; Antigens; Arthus Reaction; Asthma; Chlorpheniramine; Female; Fl | 1975 |
Investigation of mammalian ovulation with an in vitro perfused rabbit ovary preparation.
Topics: Animals; Calcium; Chlorpheniramine; Chorionic Gonadotropin; Edetic Acid; Female; Histamine; In Vitro | 1978 |
Histamine H2-receptors in guinea pig peripheral airway smooth muscle.
Topics: Animals; Chlorpheniramine; Drug Synergism; Guinea Pigs; Histamine; Lung; Male; Metiamide; Muscle Con | 1979 |
Alpha adrenergic and histaminergic effects of tolazoline-like imidazolines.
Topics: Adrenergic alpha-Agonists; Animals; Aorta, Thoracic; Chlorpheniramine; Guinea Pigs; Heart Atria; His | 1975 |
Investigation of the role of calcium in the supersensitivity produced by cocaine in cat spleen strips.
Topics: Angiotensin II; Animals; Calcium; Cats; Chlorpheniramine; Cocaine; Desipramine; Drug Interactions; F | 1979 |
[New aspects of the stimulating effect of d-tubocurarine on the guinea pig taenia coli].
Topics: Acetylcholine; Animals; Atropine; Chlorpheniramine; Colon; Guinea Pigs; Histamine; In Vitro Techniqu | 1977 |
Is histamine involved in the sympathomimetic effect of nicotine?
Topics: Animals; Arteries; Chlorpheniramine; Histamine; Hydroxydopamines; In Vitro Techniques; Muscle Contra | 1978 |
Effects of 5HT uptake inhibitors on the pressor response to 5HT in the pithed rat. The significance of the 5HT blocking property.
Topics: Animals; Anisoles; Blood Pressure; Chlorpheniramine; Desipramine; Drug Synergism; Imipramine; Male; | 1977 |
Thermal alterations in onset and offset rate constants for chlorpheniramine.
Topics: Animals; Chlorpheniramine; Guinea Pigs; Histamine; Ileum; In Vitro Techniques; Kinetics; Muscle Cont | 1975 |
Studies on Dieffenbachia picta Schott: toxic effects in guinea pigs.
Topics: Animals; Chlorpheniramine; Chymotrypsin; Guinea Pigs; Ileum; In Vitro Techniques; Lethal Dose 50; Mu | 1975 |
Histamine receptors on human isolated pulmonary arterial muscle preparations: effects of endothelial cell removal and nitric oxide inhibitors.
Topics: Arginine; Burimamide; Chlorpheniramine; Cimetidine; Dimaprit; Endothelium, Vascular; Histamine; Huma | 1992 |
Effect of human plasma proteins on spontaneous contractile activity of rat mesenteric portal vein.
Topics: Alpha-Globulins; Animals; Atropine; Beta-Globulins; Blood Proteins; Chlorpheniramine; gamma-Globulin | 1990 |
Effects of histamine on neurally mediated contraction of canine tracheal smooth muscle.
Topics: Acetylcholine; Animals; Chlorpheniramine; Dogs; Electric Stimulation; Histamine; Histamine Antagonis | 1990 |
Contraction of guinea-pig lung parenchymal strips by substance P and related peptides.
Topics: Animals; Bacitracin; Captopril; Chlorpheniramine; Dithiothreitol; Edetic Acid; Eledoisin; Female; Gu | 1985 |
Rocastine (AHR-11325), a rapid acting, nonsedating antihistamine.
Topics: Anaphylaxis; Animals; Astemizole; Azepines; Benzhydryl Compounds; Benzimidazoles; Brompheniramine; C | 1989 |
Parasympathetic involvement in PAF-induced contraction in canine trachealis in vivo.
Topics: Animals; Atropine; Biomechanical Phenomena; Chlorpheniramine; Dogs; Dose-Response Relationship, Drug | 1987 |
Antagonism of antigen-induced contraction of isolated guinea-pig trachea by 5-lipoxygenase inhibitors.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; 5,8,11,14-Eicosatetraynoic Acid; Anima | 1986 |
Study of platelet activating factor and its antagonists on rat colon strip with a new method avoiding tachyphylaxis.
Topics: Animals; Atropine; Chlorpheniramine; Chromones; Colon; In Vitro Techniques; Indomethacin; Male; Meth | 1988 |
The responsiveness of rabbit bronchial rings to antigen, AGEPC and histamine.
Topics: Animals; Antigens; Atropine; Bronchi; Carbachol; Chlorpheniramine; Female; Histamine; Immunoglobulin | 1986 |
Mechanisms of histamine-induced relaxation in isolated monkey and dog coronary arteries.
Topics: Animals; Benzoquinones; Chlorpheniramine; Cimetidine; Coronary Vessels; Dogs; Female; Histamine; Ind | 1986 |
[Studies on tolerance to and dependence on SS Bron solution-W: effect of major constituents on the action of dihydrocodeine in mice].
Topics: Analgesia; Animals; Caffeine; Chlorpheniramine; Codeine; Drug Interactions; Ephedrine; Guinea Pigs; | 1986 |
Temperature and histamine receptor function--what is really happening?
Topics: Animals; Chlorpheniramine; Colon; Guinea Pigs; Histamine; Ileum; In Vitro Techniques; Metiamide; Mus | 1985 |
Synthesis and pharmacological properties of 5a,6,7,8,9,10,10a,11-octahydrobenzo(b)cyclohepta(e)-(1,4)thiazine derivatives.
Topics: Acetylcholine; Alkylation; Animals; Atropine; Barbiturates; Behavior, Animal; Chlorpheniramine; Cycl | 1974 |
Histamine receptors in extra- and intracranial arteries.
Topics: Animals; Benzyl Compounds; Cats; Cerebral Arteries; Chlorpheniramine; Ethylenediamines; Histamine; H | 1974 |
Contractile actions of antihistamines on isolated arterial smooth muscle.
Topics: Acetylcholine; Anesthetics, Local; Animals; Aorta, Thoracic; Atropine; Calcium; Chlorpheniramine; Di | 1974 |
Pharmacological reactivity of an isolated tracheal preparation of the guinea-pig.
Topics: Acetylcholine; Animals; Atropine; Barium; Chlorisondamine; Chlorpheniramine; Diphenhydramine; Ethano | 1966 |
[Anti-bradykinin action of diphenhydramine on the excised ileum of guinea pigs].
Topics: Animals; Aspirin; Barium; Blood Pressure; Bradykinin; Chlorpheniramine; Diphenhydramine; Ethanol; Gu | 1966 |
The effect of isoprenaline on the contraction of smooth muscle produced by histamine, acetylcholine or other agents.
Topics: Acetylcholine; Animals; Atropine; Bradykinin; Bronchial Spasm; Chlorpheniramine; Creatine; Drug Anta | 1966 |
A new anorexic agent, WY-5244: cardiovascular actions and influence on sympathomimetic amines.
Topics: Acetylcholine; Animals; Appetite Depressants; Atropine; Blood Pressure; Cardiac Output; Chlorphenira | 1967 |
Contractile responses of microvascular smooth muscle to antihistamines.
Topics: Animals; Calcium; Capillaries; Chlorpheniramine; Diphenhydramine; Endotoxins; Epinephrine; Female; H | 1970 |
Studies on tetrahydroisoquinolines (THI). VI. Effects of trimetoquinol on tracheal and some other smooth muscles.
Topics: Adrenergic beta-Agonists; Aminophylline; Anaphylaxis; Animals; Asthma; Atropine; Blood Pressure; Bro | 1970 |
Action of antibiotics on respiratory tract. I. Ampicillin.
Topics: Acetylcholine; Amino Alcohols; Ampicillin; Animals; Atropine; Barium; Bronchi; Bronchial Spasm; Chlo | 1970 |
Inhibitory action of some antihistaminics on the anaphylactic contraction in guinea pig's taenia coli.
Topics: Anaphylaxis; Animals; Antigen-Antibody Reactions; Antigens; Atropine; Barium; Binding, Competitive; | 1972 |
Effect on the rat uterus of the venom from the scorpion Leiurus quinquestriatus.
Topics: Animals; Atropine; Chlorpheniramine; Cocaine; Diphenhydramine; Estrus; Female; Hexamethonium Compoun | 1972 |
Studies on the peripheral mode of action of dihydroergotamine in human and canine veins.
Topics: Animals; Atropine; Chlorpheniramine; Dogs; Dose-Response Relationship, Drug; Ergotamine; Femoral Vei | 1974 |
Effects of tyramine on responses to and inactivation of histamine in aortic strips.
Topics: Amine Oxidase (Copper-Containing); Amodiaquine; Animals; Aorta; Catecholamines; Chlorpheniramine; Co | 1970 |
Effects of chlorpheniramine and pyrilamine on the atrial actions of acetylcholine, tyramine, and ephedrine.
Topics: Acetylcholine; Animals; Atropine; Chlorpheniramine; Cocaine; Ephedrine; Heart; Heart Atria; Heart Ra | 1969 |
Histamine induced changes in tension and contractile force in the turtle ventricle.
Topics: Animals; Calcium Chloride; Chlorpheniramine; Epinephrine; Female; Heart; Heart Ventricles; Histamine | 1970 |