chlorpheniramine has been researched along with Middle Ear Effusion in 8 studies
Chlorpheniramine: A histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. It has also been used in veterinary applications. One of the most widely used of the classical antihistaminics, it generally causes less drowsiness and sedation than PROMETHAZINE.
chlorphenamine : A tertiary amino compound that is propylamine which is substituted at position 3 by a pyridin-2-yl group and a p-chlorophenyl group and in which the hydrogens attached to the nitrogen are replaced by methyl groups. A histamine H1 antagonist, it is used to relieve the symptoms of hay fever, rhinitis, urticaria, and asthma.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In a randomized, double-blind, placebo-controlled trial involving 518 infants and children who had otitis media with effusion ("secretory" otitis media), we evaluated the efficacy of a two-week course of amoxicillin (40 mg per kilogram of body weight per day) with and without a four-week course of an oral decongestant-antihistamine combination." | 9.06 | Efficacy of amoxicillin with and without decongestant-antihistamine for otitis media with effusion in children. Results of a double-blind, randomized trial. ( Bluestone, CD; Mandel, EM; Nozza, RJ; Paradise, JL; Rockette, HE, 1987) |
| "Twenty-four children with secretory otitis media awaiting operation for removal of adenoids were studied to investigate the effects of an antihistamine/nasal decongestant combination ('Dimotapp') and sodium cromoglycate nasal drops on the histamine content of adenoids, middle ear fluid and nasopharyngeal secretions." | 9.05 | The effect of an anti-allergic, nasal decongestant combination ('Dimotapp') and sodium cromoglycate nose drops on the histamine content of adenoids, middle ear fluid and nasopharyngeal secretions of children with secretory otitis media. ( Church, MK; Collins, MP, 1983) |
| "In a randomized, double-blind, placebo-controlled trial involving 518 infants and children who had otitis media with effusion ("secretory" otitis media), we evaluated the efficacy of a two-week course of amoxicillin (40 mg per kilogram of body weight per day) with and without a four-week course of an oral decongestant-antihistamine combination." | 5.06 | Efficacy of amoxicillin with and without decongestant-antihistamine for otitis media with effusion in children. Results of a double-blind, randomized trial. ( Bluestone, CD; Mandel, EM; Nozza, RJ; Paradise, JL; Rockette, HE, 1987) |
| "In a double-blind, randomized trial of 553 infants and children who had otitis media with effusion ("secretory" otitis media), we compared the efficacy of a four-week course of an oral decongestant-antihistamine combination (pseudoephedrine hydrochloride, 4 mg per kilogram of body weight per day, and chlorpheniramine maleate, 0." | 5.05 | Lack of efficacy of a decongestant-antihistamine combination for otitis media with effusion ("secretory" otitis media) in children. Results of a double-blind, randomized trial. ( Bluestone, CD; Cantekin, EI; Fria, TJ; Mandel, EM; Paradise, JL; Rockette, HE; Rogers, KD; Stool, SE, 1983) |
| "Twenty-four children with secretory otitis media awaiting operation for removal of adenoids were studied to investigate the effects of an antihistamine/nasal decongestant combination ('Dimotapp') and sodium cromoglycate nasal drops on the histamine content of adenoids, middle ear fluid and nasopharyngeal secretions." | 5.05 | The effect of an anti-allergic, nasal decongestant combination ('Dimotapp') and sodium cromoglycate nose drops on the histamine content of adenoids, middle ear fluid and nasopharyngeal secretions of children with secretory otitis media. ( Church, MK; Collins, MP, 1983) |
| "In a randomized study, 53 children were treated for acute otitis media with antibiotics and either Naldecon or placebo." | 2.65 | The use of an antihistamine-decongestant in conjunction with an anti-infective drug in the treatment of acute otitis media. ( Higbee, MD; Moran, DM; Mutchie, KD; Paul, LD, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (87.50) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (12.50) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| McCormick, DP | 1 |
| Saeed, K | 1 |
| Uchida, T | 1 |
| Baldwin, CD | 1 |
| Deskin, R | 1 |
| Lett-Brown, MA | 1 |
| Heikkinen, T | 1 |
| Chonmaitree, T | 1 |
| Moran, DM | 1 |
| Mutchie, KD | 1 |
| Higbee, MD | 1 |
| Paul, LD | 1 |
| Cantekin, EI | 1 |
| Mandel, EM | 2 |
| Bluestone, CD | 2 |
| Rockette, HE | 2 |
| Paradise, JL | 2 |
| Stool, SE | 1 |
| Fria, TJ | 1 |
| Rogers, KD | 1 |
| Marks, NJ | 1 |
| Mills, RP | 1 |
| Shaheen, OH | 1 |
| Collins, MP | 1 |
| Church, MK | 1 |
| Nozza, RJ | 1 |
| Lesser, TH | 1 |
| Clayton, MI | 1 |
| Skinner, D | 1 |
| Dusdieker, LB | 1 |
| Smith, G | 1 |
| Booth, BM | 1 |
| Woodhead, JC | 1 |
| Milavetz, G | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| [NCT00000363] | Phase 3 | 0 participants | Interventional | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
8 trials available for chlorpheniramine and Middle Ear Effusion
| Article | Year |
|---|---|
Middle ear fluid histamine and leukotriene B4 in acute otitis media: effect of antihistamine or corticosteroid treatment.
Topics: Acute Disease; Anti-Bacterial Agents; Anti-Inflammatory Agents; Ceftriaxone; Child; Child, Preschool | 2003 |
The use of an antihistamine-decongestant in conjunction with an anti-infective drug in the treatment of acute otitis media.
Topics: Acoustic Impedance Tests; Adolescent; Amoxicillin; Benzhydryl Compounds; Child; Child, Preschool; Ch | 1982 |
Lack of efficacy of a decongestant-antihistamine combination for otitis media with effusion ("secretory" otitis media) in children. Results of a double-blind, randomized trial.
Topics: Child; Child, Preschool; Chlorpheniramine; Clinical Trials as Topic; Double-Blind Method; Drug Combi | 1983 |
Cotrimoxazole in the treatment of serous otitis. A follow-up report.
Topics: Child; Chlorpheniramine; Clinical Trials as Topic; Drug Combinations; Follow-Up Studies; Humans; Mul | 1983 |
The effect of an anti-allergic, nasal decongestant combination ('Dimotapp') and sodium cromoglycate nose drops on the histamine content of adenoids, middle ear fluid and nasopharyngeal secretions of children with secretory otitis media.
Topics: Adenoids; Child; Chlorpheniramine; Cromolyn Sodium; Drug Combinations; Ear, Middle; Exudates and Tra | 1983 |
Efficacy of amoxicillin with and without decongestant-antihistamine for otitis media with effusion in children. Results of a double-blind, randomized trial.
Topics: Amoxicillin; Audiometry; Child; Child, Preschool; Chlorpheniramine; Double-Blind Method; Drug Therap | 1987 |
Efficacy of medical treatment as an adjunct to surgery in the treatment of secretory otitis media.
Topics: Adenoidectomy; Carbocysteine; Child; Child, Preschool; Chlorpheniramine; Clinical Trials as Topic; C | 1986 |
The long-term outcome of nonsuppurative otitis media with effusion.
Topics: Child; Child, Preschool; Chlorpheniramine; Clinical Trials as Topic; Double-Blind Method; Ephedrine; | 1985 |