chlorpheniramine has been researched along with Itching in 39 studies
Chlorpheniramine: A histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. It has also been used in veterinary applications. One of the most widely used of the classical antihistaminics, it generally causes less drowsiness and sedation than PROMETHAZINE.
chlorphenamine : A tertiary amino compound that is propylamine which is substituted at position 3 by a pyridin-2-yl group and a p-chlorophenyl group and in which the hydrogens attached to the nitrogen are replaced by methyl groups. A histamine H1 antagonist, it is used to relieve the symptoms of hay fever, rhinitis, urticaria, and asthma.
| Excerpt | Relevance | Reference |
|---|---|---|
| " dexchlorpheniramine in reducing uremic pruritus." | 9.27 | Gabapentin versus dexchlorpheniramine as treatment for uremic pruritus: a randomised controlled trial. ( Abbade, LP; Gobo-Oliveira, M; Miot, HA; Ogata, MS; Pigari, VG; Ponce, D, 2018) |
| "Limb activity meters, otherwise modified self-winding watches that can record limb agitative movements such as in itch-provoked scratch, were introduced for an objective evaluation of the relative effectiveness of three antipruritic drugs: chlorpheniramine, cyproheptadine, and sulphapyridine for palliating pruritus associated with chloroquine chemosuppressive treatment of acute malarial febrile paroxysms in eighteen adult patients." | 9.08 | The antipruritic effects of chlorpheniramine, cyproheptadine and sulphapyridine monitored with limb activity meters on chloroquine induced pruritus among patients with malaria. ( Osifo, NG, 1995) |
| "The efficacy of chlorpheniramine in the prevention of choroquine-induced pruritus was assessed in a trial involving 132 malaria patients with a history of chloroquine-induced pruritus." | 9.07 | The efficacy of piriton on chloroquine-induced pruritus in patients with malaria. ( Mnyika, KS, 1991) |
| " The antipruritic ability of histamine (H1 and H2) antagonists alone and in combination in experimentally induced pruritus has been investigated in 12 normal human volunteers." | 9.04 | The efficacy of histamine antagonists as antipruritics in experimentally induced pruritus. ( Davies, MG; Horton, RJ; Marks, R; Storari, FE, 1979) |
| "Aspirin appears to be more effective than chlorpheniramine for relief of itching in pregnancy when no rash is present." | 8.86 | WITHDRAWN: Antihistamines versus aspirin for itching in late pregnancy. ( Jewell, D; Young, G, 2010) |
| "Aspirin appears to be more effective than chlorpheniramine for relief of itching in pregnancy when no rash is present." | 8.80 | Antihistamines versus aspirin for itching in late pregnancy. ( Jewell, D; Young, GL, 2000) |
| "We have studied a 50-year-old white man with chronic urticaria and angioedema who has responded to treatment with cimetidine alone for over 2 yr." | 7.67 | Successful treatment of chronic idiopathic urticaria and angioedema with cimetidine alone. ( Farnam, J; Grant, JA; Guernsey, BG; Jorizzo, JL; Petrusa, ER, 1984) |
| " All 43 dogs were known to be unresponsive to chlorpheniramine and the manufacturer's recommended dosage of the fatty acid supplement when either drug was used alone." | 6.67 | Nonsteroidal management of canine pruritus: chlorpheniramine and a fatty acid supplement (DVM Derm Caps) in combination, and the fatty acid supplement at twice the manufacturer's recommended dosage. ( Miller, WH; Scott, DW, 1990) |
| "Chlorpheniramine maleate was administered orally (2 mg, q12 h) to 26 cats with pruritic skin disease." | 5.28 | Efficacy of chlorpheniramine maleate for management of pruritus in cats. ( Miller, WH; Scott, DW, 1990) |
| " dexchlorpheniramine in reducing uremic pruritus." | 5.27 | Gabapentin versus dexchlorpheniramine as treatment for uremic pruritus: a randomised controlled trial. ( Abbade, LP; Gobo-Oliveira, M; Miot, HA; Ogata, MS; Pigari, VG; Ponce, D, 2018) |
| "Limb activity meters, otherwise modified self-winding watches that can record limb agitative movements such as in itch-provoked scratch, were introduced for an objective evaluation of the relative effectiveness of three antipruritic drugs: chlorpheniramine, cyproheptadine, and sulphapyridine for palliating pruritus associated with chloroquine chemosuppressive treatment of acute malarial febrile paroxysms in eighteen adult patients." | 5.08 | The antipruritic effects of chlorpheniramine, cyproheptadine and sulphapyridine monitored with limb activity meters on chloroquine induced pruritus among patients with malaria. ( Osifo, NG, 1995) |
| "The efficacy of chlorpheniramine in the prevention of choroquine-induced pruritus was assessed in a trial involving 132 malaria patients with a history of chloroquine-induced pruritus." | 5.07 | The efficacy of piriton on chloroquine-induced pruritus in patients with malaria. ( Mnyika, KS, 1991) |
| " The antipruritic ability of histamine (H1 and H2) antagonists alone and in combination in experimentally induced pruritus has been investigated in 12 normal human volunteers." | 5.04 | The efficacy of histamine antagonists as antipruritics in experimentally induced pruritus. ( Davies, MG; Horton, RJ; Marks, R; Storari, FE, 1979) |
| "Aspirin appears to be more effective than chlorpheniramine for relief of itching in pregnancy when no rash is present." | 4.86 | WITHDRAWN: Antihistamines versus aspirin for itching in late pregnancy. ( Jewell, D; Young, G, 2010) |
| "Aspirin appears to be more effective than chlorpheniramine for relief of itching in pregnancy when no rash is present." | 4.80 | Antihistamines versus aspirin for itching in late pregnancy. ( Jewell, D; Young, GL, 2000) |
| "The effectiveness of an antihistamine, chlorpheniramine, in suppressing chloroquine-related pruritus has been investigated in 38 patients, employing two modes of therapy." | 3.68 | Onset of pruritogenicity of chloroquine and the implication for the timing of suppressive therapy. ( Okor, RS, 1991) |
| "We have studied a 50-year-old white man with chronic urticaria and angioedema who has responded to treatment with cimetidine alone for over 2 yr." | 3.67 | Successful treatment of chronic idiopathic urticaria and angioedema with cimetidine alone. ( Farnam, J; Grant, JA; Guernsey, BG; Jorizzo, JL; Petrusa, ER, 1984) |
| " All 43 dogs were known to be unresponsive to chlorpheniramine and the manufacturer's recommended dosage of the fatty acid supplement when either drug was used alone." | 2.67 | Nonsteroidal management of canine pruritus: chlorpheniramine and a fatty acid supplement (DVM Derm Caps) in combination, and the fatty acid supplement at twice the manufacturer's recommended dosage. ( Miller, WH; Scott, DW, 1990) |
| "Pruritus was not obtained with either 4-methyl histamine or dimaprit." | 2.65 | Sensory responses of human skin to synthetic histamine analogues and histamine. ( Davies, MG; Greaves, MW, 1980) |
| "Centipede bites are a constant risk throughout tropical regions and have the rare potential for systemic side effects." | 1.51 | Challenges of Remote Medical Care in South Sudan: Centipede Bites. ( Dickson, N; Moles, I; Pallett, SJC, 2019) |
| "Imiquimod-treated mice exhibited a significant increase in spontaneous scratching behavior directed to the treated area as well as touch-evoked scratching (alloknesis)." | 1.43 | Mouse model of imiquimod-induced psoriatic itch. ( Akiyama, T; Jensen, L; Sakai, K; Sanders, KM; Yanushefski, KM; Yosipovitch, G; Youssef, MR, 2016) |
| "Pruritus is a common, distressing and difficult to manage complication of many autoimmune diseases." | 1.33 | Spontaneous scratching behavior in MRL/lpr mice, a possible model for pruritus in autoimmune diseases, and antipruritic activity of a novel kappa-opioid receptor agonist nalfurafine hydrochloride. ( Aoki, CA; Gershwin, ME; Itoh, M; Kato, T; Kawashima, Y; Kikuchi, K; Kurokawa, T; Miyakawa, H; Nakao, K; Okano, K; Umeuchi, H, 2005) |
| "pretreatment with chlorpheniramine." | 1.31 | Norbinaltorphimine, a selective kappa-opioid receptor antagonist, induces an itch-associated response in mice. ( Kamei, J; Nagase, H, 2001) |
| "Chlorpheniramine maleate was administered orally (2 mg, q12 h) to 26 cats with pruritic skin disease." | 1.28 | Efficacy of chlorpheniramine maleate for management of pruritus in cats. ( Miller, WH; Scott, DW, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 14 (35.90) | 18.7374 |
| 1990's | 6 (15.38) | 18.2507 |
| 2000's | 7 (17.95) | 29.6817 |
| 2010's | 12 (30.77) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Solinski, HJ | 1 |
| Dranchak, P | 1 |
| Oliphant, E | 1 |
| Gu, X | 1 |
| Earnest, TW | 1 |
| Braisted, J | 1 |
| Inglese, J | 1 |
| Hoon, MA | 1 |
| Gobo-Oliveira, M | 1 |
| Pigari, VG | 1 |
| Ogata, MS | 1 |
| Miot, HA | 1 |
| Ponce, D | 1 |
| Abbade, LP | 1 |
| Pallett, SJC | 1 |
| Dickson, N | 1 |
| Moles, I | 1 |
| Nakasone, T | 2 |
| Sato, T | 1 |
| Matsushima, Y | 1 |
| Inoue, T | 1 |
| Kamei, C | 2 |
| Gómez-Traseira, C | 1 |
| Boyano-Martínez, T | 1 |
| Escosa-García, L | 1 |
| Pedrosa, M | 1 |
| Martín-Muñoz, F | 1 |
| Quirce, S | 1 |
| Demirel, F | 1 |
| Gulec, M | 1 |
| Kartal, O | 1 |
| Yesıllik, S | 1 |
| Baysan, A | 1 |
| Musabak, U | 1 |
| Sener, O | 1 |
| Sugimoto, Y | 1 |
| Sakai, K | 1 |
| Sanders, KM | 1 |
| Youssef, MR | 1 |
| Yanushefski, KM | 1 |
| Jensen, L | 1 |
| Yosipovitch, G | 1 |
| Akiyama, T | 1 |
| Yamada, Y | 1 |
| Ueda, Y | 1 |
| Nakamura, A | 1 |
| Kanayama, S | 1 |
| Tamura, R | 1 |
| Hashimoto, K | 1 |
| Matsumoto, T | 1 |
| Ishii, R | 1 |
| Alvarez-Perea, A | 1 |
| García, AP | 1 |
| Hernández, AL | 1 |
| de Barrio, M | 1 |
| Baeza, ML | 1 |
| Young, G | 1 |
| Jewell, D | 2 |
| Paniz-Mondolfi, AE | 1 |
| Pérez-Alvarez, AM | 1 |
| Lundberg, U | 1 |
| Fornés, L | 1 |
| Reyes-Jaimes, O | 1 |
| Hernández-Pérez, M | 1 |
| Hossler, E | 1 |
| Munday, J | 1 |
| Bloomfield, R | 1 |
| Goldman, M | 1 |
| Robey, H | 1 |
| Kitowska, GJ | 1 |
| Gwiezdziski, Z | 1 |
| Wankiewicz, A | 1 |
| Marks, R | 2 |
| Protas-Drozd, F | 1 |
| Mikaszewska, M | 1 |
| LACKENBACHER, RS | 2 |
| Takano, N | 1 |
| Arai, I | 1 |
| Hashimoto, Y | 1 |
| Kurachi, M | 1 |
| Umeuchi, H | 2 |
| Kawashima, Y | 1 |
| Aoki, CA | 1 |
| Kurokawa, T | 1 |
| Nakao, K | 1 |
| Itoh, M | 1 |
| Kikuchi, K | 1 |
| Kato, T | 1 |
| Okano, K | 2 |
| Gershwin, ME | 1 |
| Miyakawa, H | 1 |
| Tamura, T | 1 |
| Amano, T | 1 |
| Ohmori, K | 1 |
| Manabe, H | 1 |
| Vaughan, JH | 1 |
| Barnett, EV | 1 |
| Leadley, PJ | 1 |
| Van Stee, EW | 1 |
| Duncan, JS | 1 |
| Kennedy, HJ | 1 |
| Triger, DR | 1 |
| Davies, MG | 3 |
| Greaves, MW | 2 |
| Farnam, J | 1 |
| Grant, JA | 1 |
| Guernsey, BG | 1 |
| Jorizzo, JL | 1 |
| Petrusa, ER | 1 |
| Osifo, NG | 1 |
| Box, SA | 1 |
| Lee, MR | 1 |
| Young, GL | 1 |
| Kamei, J | 2 |
| Nagase, H | 2 |
| Togashi, Y | 1 |
| Ando, N | 1 |
| Yoshizawa, Y | 1 |
| Honda, T | 1 |
| Kawamura, K | 1 |
| Endoh, T | 1 |
| Utsumi, J | 1 |
| Tanaka, T | 1 |
| Horton, RJ | 1 |
| Storari, FE | 1 |
| Read, MD | 1 |
| Okor, RS | 1 |
| Mnyika, KS | 1 |
| Scott, DW | 2 |
| Miller, WH | 2 |
| Youngchaiyud, U | 1 |
| Krause, LB | 1 |
| Shuster, S | 1 |
| Peirone, F | 1 |
2 reviews available for chlorpheniramine and Itching
| Article | Year |
|---|---|
WITHDRAWN: Antihistamines versus aspirin for itching in late pregnancy.
Topics: Antipruritics; Aspirin; Chlorpheniramine; Female; Histamine H1 Antagonists; Humans; Pregnancy; Pregn | 2010 |
Antihistamines versus aspirin for itching in late pregnancy.
Topics: Antipruritics; Aspirin; Chlorpheniramine; Female; Histamine H1 Antagonists; Humans; Pregnancy; Pregn | 2000 |
10 trials available for chlorpheniramine and Itching
| Article | Year |
|---|---|
Gabapentin versus dexchlorpheniramine as treatment for uremic pruritus: a randomised controlled trial.
Topics: Aged; Chlorpheniramine; Double-Blind Method; Excitatory Amino Acid Antagonists; Female; Gabapentin; | 2018 |
Chlorpheniramine is no more effective than placebo in relieving the symptoms of childhood atopic dermatitis with a nocturnal itching and scratching component.
Topics: Antipruritics; Child; Child, Preschool; Chlorpheniramine; Dermatitis, Atopic; Double-Blind Method; E | 2002 |
Treatment of pruritus due to chronic obstructive liver disease.
Topics: Benzhydryl Compounds; Chlorpheniramine; Cholangitis; Cholestyramine Resin; Clinical Trials as Topic; | 1984 |
Sensory responses of human skin to synthetic histamine analogues and histamine.
Topics: Adult; Chlorpheniramine; Dimaprit; Female; Histamine; Humans; Male; Methylhistamines; Pruritus; Rece | 1980 |
The antipruritic effects of chlorpheniramine, cyproheptadine and sulphapyridine monitored with limb activity meters on chloroquine induced pruritus among patients with malaria.
Topics: Adolescent; Adult; Antimalarials; Antipruritics; Chloroquine; Chlorpheniramine; Cyproheptadine; Derm | 1995 |
The efficacy of histamine antagonists as antipruritics in experimentally induced pruritus.
Topics: Adult; Chlorpheniramine; Cimetidine; Clinical Trials as Topic; Double-Blind Method; Drug Therapy, Co | 1979 |
The efficacy of piriton on chloroquine-induced pruritus in patients with malaria.
Topics: Chloroquine; Chlorpheniramine; Female; Humans; Malaria; Male; Pruritus | 1991 |
Nonsteroidal management of canine pruritus: chlorpheniramine and a fatty acid supplement (DVM Derm Caps) in combination, and the fatty acid supplement at twice the manufacturer's recommended dosage.
Topics: Animals; Chlorpheniramine; Dog Diseases; Dogs; Fatty Acids; Female; Hypersensitivity; Intradermal Te | 1990 |
Comparison of the efficacy of four antihistamines in chronic urticaria.
Topics: Adolescent; Adult; Chlorpheniramine; Chronic Disease; Cimetidine; Clemastine; Double-Blind Method; D | 1988 |
A comparison of astemizole and chlorpheniramine in dermographic urticaria.
Topics: Adolescent; Adult; Aged; Astemizole; Benzimidazoles; Chlorpheniramine; Clinical Trials as Topic; Dou | 1985 |
27 other studies available for chlorpheniramine and Itching
| Article | Year |
|---|---|
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, S | 2019 |
Challenges of Remote Medical Care in South Sudan: Centipede Bites.
Topics: Adult; Analgesics, Opioid; Anesthetics, Local; Animals; Anti-Inflammatory Agents; Arthropod Venoms; | 2019 |
Characteristics of scratching behavior in ADJM mice (atopic dermatitis from Japanese mice).
Topics: Animals; Antipruritics; Behavior, Animal; Chlorpheniramine; Dermatitis, Atopic; Dose-Response Relati | 2015 |
Trimethoprim-sulfamethoxazole (cotrimoxazole) desensitization in an HIV-infected 5-yr-old girl.
Topics: Administration, Oral; AIDS-Related Opportunistic Infections; Antibiotic Prophylaxis; Child, Preschoo | 2015 |
Allergic reaction to chlorpheniramine maleate.
Topics: Adult; Chlorpheniramine; Drug Hypersensitivity; Dyspnea; Erythema; Female; Histamine H1 Antagonists; | 2015 |
The interaction between histamine H1 receptor and μ- opioid receptor in scratching behavior in ICR mice.
Topics: Animals; Behavior, Animal; Chlorpheniramine; Histamine; Male; Mice; Mice, Inbred ICR; Morphine; Nalo | 2016 |
Mouse model of imiquimod-induced psoriatic itch.
Topics: Adjuvants, Immunologic; Aminoquinolines; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antipruri | 2016 |
Immediate-type allergic and protease-mediated reactions are involved in scratching behaviour induced by topical application of Dermatophagoides farinae extract in NC/Nga mice.
Topics: Animals; Antibodies; Antipruritics; Behavior, Animal; Capillary Permeability; Chlorpheniramine; Comp | 2018 |
Urticaria due to aloe vera: a new sensitizer?
Topics: Allergens; Aloe; Anti-Inflammatory Agents; Antigens, Plant; Chlorpheniramine; Erythema; Female; Hist | 2010 |
Cutaneous lepidopterism: dermatitis from contact with moths of Hylesia metabus (Cramer 1775) (Lepidoptera: Saturniidae), the causative agent of caripito itch.
Topics: Adolescent; Adult; Anesthetics, Local; Animals; Antipruritics; Chlorpheniramine; Dermatitis, Contact | 2011 |
Oral and injectible chlorprophenpyridamine maleate (chlortrimeton maleate) in the treatment of pruritic dermatoses.
Topics: Anti-Allergic Agents; Chlorpheniramine; Histamine H1 Antagonists; Humans; Maleates; Pruritus; Skin D | 1955 |
Treatment of pruritic dermatoses with a combination of dexamethasone and dextro-chlorpheniramine.
Topics: Anti-Allergic Agents; Chlorpheniramine; Dexamethasone; Histamine H1 Antagonists; Prednisolone; Pruri | 1960 |
Evaluation of antipruritic effects of several agents on scratching behavior by NC/Nga mice.
Topics: Alprostadil; Animals; Antipruritics; Behavior, Animal; Capsaicin; Chlorpheniramine; Cyproheptadine; | 2004 |
Spontaneous scratching behavior in MRL/lpr mice, a possible model for pruritus in autoimmune diseases, and antipruritic activity of a novel kappa-opioid receptor agonist nalfurafine hydrochloride.
Topics: Age Factors; Animals; Antipruritics; Autoimmune Diseases; Behavior, Animal; Chlorpheniramine; Dermis | 2005 |
The effects of olopatadine hydrochloride on the number of scratching induced by repeated application of oxazolone in mice.
Topics: Animals; Anti-Inflammatory Agents; Antipruritics; Chlorpheniramine; Cytokines; Dermatitis, Contact; | 2005 |
Serum sickness. Evidence in man of antigen-antibody complexes and free light chains in the circulation during the acute reaction.
Topics: Adult; Animals; Antigen-Antibody Reactions; Blood Sedimentation; Chlorpheniramine; Fluorescence; Hor | 1967 |
Alternative to corticosteroids in the management of pruritus in dogs.
Topics: Animals; Chlorpheniramine; Cimetidine; Dog Diseases; Dogs; Glucocorticoids; Guanidines; Histamine H1 | 1981 |
Successful treatment of chronic idiopathic urticaria and angioedema with cimetidine alone.
Topics: Angioedema; Chlorpheniramine; Cimetidine; Double-Blind Method; Drug Therapy, Combination; Histamine; | 1984 |
Histamine receptors in human skin: indirect evidence.
Topics: Capillary Permeability; Chlorpheniramine; Cimetidine; Humans; Methylhistamines; Mitosis; Pruritus; R | 1982 |
A systemic reaction following exposure to a pyrethroid insecticide.
Topics: Abdominal Pain; Agricultural Workers' Diseases; Analgesics, Opioid; Animals; Anti-Allergic Agents; A | 1996 |
Norbinaltorphimine, a selective kappa-opioid receptor antagonist, induces an itch-associated response in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; A | 2001 |
Antipruritic activity of the kappa-opioid receptor agonist, TRK-820.
Topics: Animals; Antipruritics; Chlorpheniramine; Disease Models, Animal; Histamine; Histamine H1 Antagonist | 2002 |
A new hypothesis of itching in pregnancy.
Topics: Aspirin; Chlorpheniramine; Female; Humans; Liver Function Tests; Models, Biological; Pregnancy; Preg | 1977 |
Onset of pruritogenicity of chloroquine and the implication for the timing of suppressive therapy.
Topics: Adult; Chloroquine; Chlorpheniramine; Humans; Pruritus | 1991 |
Efficacy of chlorpheniramine maleate for management of pruritus in cats.
Topics: Animals; Cat Diseases; Cats; Chi-Square Distribution; Chlorpheniramine; Female; Male; Pruritus | 1990 |
Choice of antihistamines.
Topics: Chlorpheniramine; Costs and Cost Analysis; Histamine H1 Antagonists; Humans; Hypersensitivity; Hypno | 1971 |
[Corticosteroids and antihistaminics combined in the treatment of dermatoses].
Topics: Adolescent; Adult; Aged; Betamethasone; Chlorpheniramine; Dermatitis; Dexamethasone; Eczema; Histami | 1967 |