chlorpheniramine has been researched along with Disease Models, Animal in 32 studies
Chlorpheniramine: A histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. It has also been used in veterinary applications. One of the most widely used of the classical antihistaminics, it generally causes less drowsiness and sedation than PROMETHAZINE.
chlorphenamine : A tertiary amino compound that is propylamine which is substituted at position 3 by a pyridin-2-yl group and a p-chlorophenyl group and in which the hydrogens attached to the nitrogen are replaced by methyl groups. A histamine H1 antagonist, it is used to relieve the symptoms of hay fever, rhinitis, urticaria, and asthma.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Histamine, acting centrally as a neurotransmitter, evokes a reversal of hemorrhagic hypotension in rats due to the activation of the sympathetic and the renin-angiotensin systems as well as the release of arginine vasopressin and proopiomelanocortin-derived peptides." | 7.81 | Centrally injected histamine increases posterior hypothalamic acetylcholine release in hemorrhage-hypotensive rats. ( Altinbas, B; Jochem, J; Savci, V; Yalcin, M; Yilmaz, MS, 2015) |
| "Histamine, acting centrally as a neurotransmitter, evokes a reversal of hemorrhagic hypotension in rats due to the activation of the sympathetic and the renin-angiotensin systems as well as the release of arginine vasopressin and proopiomelanocortin-derived peptides." | 3.81 | Centrally injected histamine increases posterior hypothalamic acetylcholine release in hemorrhage-hypotensive rats. ( Altinbas, B; Jochem, J; Savci, V; Yalcin, M; Yilmaz, MS, 2015) |
| "The anti-asthmatic effects of CS-518 (sodium 2-(1-imidazolylmethyl)-4,5-dihydrobenzo[b]thiophene-6-carboxylate) , a specific thromboxane A2 (TXA2) synthase inhibitor, were investigated in the ovalbumin-sensitized guinea pig asthmatic model." | 3.68 | Effects of CS-518, a thromboxane synthase inhibitor, on the asthmatic response. ( Iizuka, Y; Itoh, K; Mukaiyama, O; Satoh, Y; Terada, A; Yamaguchi, T, 1993) |
| "Imiquimod-treated mice exhibited a significant increase in spontaneous scratching behavior directed to the treated area as well as touch-evoked scratching (alloknesis)." | 1.43 | Mouse model of imiquimod-induced psoriatic itch. ( Akiyama, T; Jensen, L; Sakai, K; Sanders, KM; Yanushefski, KM; Yosipovitch, G; Youssef, MR, 2016) |
| " In study 2 the AMT dosage was increased up to 4-fold by doubling individual doses and switching to a twice daily schedule." | 1.36 | Anti-tumor effects of AMT in the renal cell carcinoma model. ( Caballero, M; Diergarten, K; Drevs, J; Esser, N; Rentschler, J; Schächtele, C; Scheele, J; Soltau, J; Zirrgiebel, U, 2010) |
| ") produced a 12-fold shift in the histamine bronchoconstrictor dose-response curve." | 1.33 | Airway closure after antigen challenge in cynomolgus monkeys: effect of the histamine H1 receptor antagonist, chlorpheniramine maleate. ( Celly, CS; Chapman, RW; Hey, JA; House, A; Lamca, JE; Skeans, S, 2005) |
| "Pruritus is a common, distressing and difficult to manage complication of many autoimmune diseases." | 1.33 | Spontaneous scratching behavior in MRL/lpr mice, a possible model for pruritus in autoimmune diseases, and antipruritic activity of a novel kappa-opioid receptor agonist nalfurafine hydrochloride. ( Aoki, CA; Gershwin, ME; Itoh, M; Kato, T; Kawashima, Y; Kikuchi, K; Kurokawa, T; Miyakawa, H; Nakao, K; Okano, K; Umeuchi, H, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (31.25) | 18.7374 |
| 1990's | 5 (15.63) | 18.2507 |
| 2000's | 7 (21.88) | 29.6817 |
| 2010's | 10 (31.25) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Avdeef, A | 1 |
| Tam, KY | 1 |
| Solinski, HJ | 1 |
| Dranchak, P | 1 |
| Oliphant, E | 1 |
| Gu, X | 1 |
| Earnest, TW | 1 |
| Braisted, J | 1 |
| Inglese, J | 1 |
| Hoon, MA | 1 |
| Nishimura, T | 1 |
| Kaminuma, O | 1 |
| Saeki, M | 1 |
| Kitamura, N | 1 |
| Gotoh, M | 1 |
| Mori, A | 1 |
| Hiroi, T | 1 |
| Altinbas, B | 1 |
| Yilmaz, MS | 1 |
| Savci, V | 1 |
| Jochem, J | 1 |
| Yalcin, M | 1 |
| Serafim, KR | 2 |
| Russo, PS | 1 |
| Fernandes, CE | 2 |
| Gianlorenço, AC | 3 |
| Mattioli, R | 3 |
| Sakai, K | 1 |
| Sanders, KM | 1 |
| Youssef, MR | 1 |
| Yanushefski, KM | 1 |
| Jensen, L | 1 |
| Yosipovitch, G | 1 |
| Akiyama, T | 1 |
| Yamada, Y | 1 |
| Ueda, Y | 1 |
| Nakamura, A | 1 |
| Kanayama, S | 1 |
| Tamura, R | 1 |
| Hashimoto, K | 1 |
| Matsumoto, T | 1 |
| Ishii, R | 1 |
| Tokunaga, S | 1 |
| Tsutsui, R | 1 |
| Obara, Y | 1 |
| Ishida, T | 1 |
| Kamei, C | 4 |
| Caballero, M | 1 |
| Scheele, J | 1 |
| Zirrgiebel, U | 1 |
| Esser, N | 1 |
| Schächtele, C | 1 |
| Soltau, J | 1 |
| Rentschler, J | 1 |
| Diergarten, K | 1 |
| Drevs, J | 1 |
| Canto-de-Souza, A | 1 |
| Skeans, S | 1 |
| Lamca, JE | 1 |
| House, A | 1 |
| Celly, CS | 1 |
| Hey, JA | 1 |
| Chapman, RW | 1 |
| Umeuchi, H | 2 |
| Kawashima, Y | 1 |
| Aoki, CA | 1 |
| Kurokawa, T | 1 |
| Nakao, K | 1 |
| Itoh, M | 1 |
| Kikuchi, K | 1 |
| Kato, T | 1 |
| Okano, K | 2 |
| Gershwin, ME | 1 |
| Miyakawa, H | 1 |
| Tsumuro, T | 2 |
| Ogawa, M | 1 |
| Minami, K | 1 |
| Takubo, M | 1 |
| Rahman, A | 1 |
| Fujii, Y | 2 |
| Alejandra Hossen, M | 1 |
| Kishi, Y | 1 |
| Lloret, S | 1 |
| Moreno, JJ | 1 |
| Hammerbeck, DM | 1 |
| Brown, DR | 1 |
| Yamaguchi, T | 1 |
| Mukaiyama, O | 1 |
| Itoh, K | 1 |
| Satoh, Y | 1 |
| Terada, A | 1 |
| Iizuka, Y | 1 |
| Kalish, R | 1 |
| Wood, JA | 1 |
| Wille, JJ | 1 |
| Kydonieus, A | 1 |
| Sugimoto, Y | 1 |
| Kawamoto, E | 1 |
| Chen, Z | 1 |
| Togashi, Y | 1 |
| Ando, N | 1 |
| Yoshizawa, Y | 1 |
| Honda, T | 1 |
| Kawamura, K | 1 |
| Endoh, T | 1 |
| Utsumi, J | 1 |
| Kamei, J | 1 |
| Tanaka, T | 1 |
| Nagase, H | 1 |
| Kobrine, AI | 1 |
| Doyle, TF | 1 |
| Rizzoli, HV | 1 |
| Garovoy, MR | 1 |
| Kupor, LR | 1 |
| Mullins, JD | 1 |
| McPhaul, JJ | 1 |
| Takahashi, N | 1 |
| Aramaki, Y | 1 |
| Tsuchiya, S | 1 |
| Misawa, M | 3 |
| Takenouchi, K | 3 |
| Shirakawa, Y | 1 |
| Yanaura, S | 2 |
| Kamishiro, T | 1 |
| Yoshino, Y | 1 |
| Ranadive, NS | 1 |
| Menon, IA | 1 |
| Shirwadkar, S | 1 |
| Persad, SD | 1 |
| Kawamura, T | 1 |
| Abraham, WM | 1 |
| Stevenson, JS | 1 |
| Garrido, R | 1 |
| Babington, RG | 1 |
| Wedeking, PW | 1 |
| Knox, GE | 1 |
| Baum, T | 1 |
| Eckfeld, DK | 1 |
| Shropshire, AT | 1 |
| Rowles, G | 1 |
| Varner, LL | 1 |
32 other studies available for chlorpheniramine and Disease Models, Animal
| Article | Year |
|---|---|
How well can the Caco-2/Madin-Darby canine kidney models predict effective human jejunal permeability?
Topics: Animals; Disease Models, Animal; Dogs; Humans; Jejunal Diseases; Kidney Diseases; Models, Biological | 2010 |
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, S | 2019 |
Effects of anti-allergic drugs on T cell-mediated nasal hyperresponsiveness in a murine model of allergic rhinitis.
Topics: Acetates; Animals; Anti-Allergic Agents; CD4-Positive T-Lymphocytes; Chlorpheniramine; Cyclopropanes | 2018 |
Centrally injected histamine increases posterior hypothalamic acetylcholine release in hemorrhage-hypotensive rats.
Topics: Acetylcholine; Animals; Blood Pressure; Chlorpheniramine; Choline; Disease Models, Animal; Dose-Resp | 2015 |
Intra-amygdala microinjections of chlorpheniramine impair memory formation or memory retrieval in anxiety- and fear-mediated models.
Topics: Amygdala; Animals; Anxiety; Avoidance Learning; Chlorpheniramine; Disease Models, Animal; Fear; Hist | 2016 |
Mouse model of imiquimod-induced psoriatic itch.
Topics: Adjuvants, Immunologic; Aminoquinolines; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antipruri | 2016 |
Cholinergic agonist reverses H1-induced memory deficit in mice.
Topics: Amygdala; Analysis of Variance; Animals; Benzamides; Bridged Bicyclo Compounds; Chlorpheniramine; Di | 2017 |
Immediate-type allergic and protease-mediated reactions are involved in scratching behaviour induced by topical application of Dermatophagoides farinae extract in NC/Nga mice.
Topics: Animals; Antibodies; Antipruritics; Behavior, Animal; Capillary Permeability; Chlorpheniramine; Comp | 2018 |
Effects of histamine H1-antagonists on sleep-awake state in rats placed on a grid suspended over water or on sawdust.
Topics: Analysis of Variance; Animals; Anxiety; Behavior, Animal; Chlorpheniramine; Diphenhydramine; Disease | 2009 |
Anti-tumor effects of AMT in the renal cell carcinoma model.
Topics: Animals; Antineoplastic Agents; Calcium; Carcinoma, Renal Cell; Cell Line, Tumor; Chlorpheniramine; | 2010 |
l-histidine induces state-dependent memory deficit in mice mediated by H(1) receptor.
Topics: Analysis of Variance; Animals; Chlorpheniramine; Disease Models, Animal; Emotions; Histamine H1 Anta | 2011 |
Airway closure after antigen challenge in cynomolgus monkeys: effect of the histamine H1 receptor antagonist, chlorpheniramine maleate.
Topics: Airway Obstruction; Animals; Ascaris suum; Blood Gas Analysis; Chlorpheniramine; Cross-Over Studies; | 2005 |
Spontaneous scratching behavior in MRL/lpr mice, a possible model for pruritus in autoimmune diseases, and antipruritic activity of a novel kappa-opioid receptor agonist nalfurafine hydrochloride.
Topics: Age Factors; Animals; Antipruritics; Autoimmune Diseases; Behavior, Animal; Chlorpheniramine; Dermis | 2005 |
Effects of mometasone furoate on a rat allergic rhinitis model.
Topics: Administration, Intranasal; Animals; Anti-Allergic Agents; Antigens; Behavior, Animal; Chlorpheniram | 2005 |
Nasal congestion model in Brown Norway rats and the effects of some H1-antagonists.
Topics: Animals; Chlorpheniramine; Dibenzazepines; Disease Models, Animal; Histamine; Histamine H1 Antagonis | 2006 |
Effect of nonapeptide fragments of uteroglobin and lipocortin I on oedema and mast cell degranulation.
Topics: Animals; Annexin A1; Aristolochic Acids; Carrageenan; Cell Degranulation; Chlorpheniramine; Dexameth | 1994 |
Selective hyperresponsiveness to ovalbumin-induced epithelial transport in inflamed guinea pig distal colon.
Topics: Animals; Antigens; Chlorpheniramine; Colitis; Cyclooxygenase Inhibitors; Disease Models, Animal; Epi | 1993 |
Effects of CS-518, a thromboxane synthase inhibitor, on the asthmatic response.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Asthma; Bronchial Hyper | 1993 |
Sensitization of mice to topically applied drugs: albuterol, chlorpheniramine, clonidine and nadolol.
Topics: Administration, Cutaneous; Albuterol; Animals; Anti-Asthmatic Agents; Antihypertensive Agents; Biolo | 1996 |
A new model of allergic rhinitis in rats by topical sensitization and evaluation of H(1)-receptor antagonists.
Topics: Allergens; Animals; Anti-Allergic Agents; Astemizole; Chlorpheniramine; Dibenzazepines; Disease Mode | 2000 |
Antipruritic activity of the kappa-opioid receptor agonist, TRK-820.
Topics: Animals; Antipruritics; Chlorpheniramine; Disease Models, Animal; Histamine; Histamine H1 Antagonist | 2002 |
The effect of antihistamines on experimental posttraumatic edema of the spinal cord.
Topics: Animals; Blood-Brain Barrier; Chlorpheniramine; Disease Models, Animal; Edema; Haplorhini; Histamine | 1976 |
Treatment of autologous immune complex glomerulonephritis with vasoactive amine antagonists.
Topics: Animals; Capillary Permeability; Chlorpheniramine; Cyproheptadine; Disease Models, Animal; Drug Ther | 1977 |
Allergic rhinitis model with Brown Norway rat and evaluation of antiallergic drugs.
Topics: Acetylglucosaminidase; Administration, Topical; Animals; Anti-Inflammatory Agents; Antigens; Biomark | 1990 |
Effects of mast cell stabilizers on a new bronchial asthma model using compound 48/80 in dogs.
Topics: Airway Resistance; Animals; Asthma; Blood Pressure; Chlorpheniramine; Cromolyn Sodium; Cyclohexaneca | 1987 |
Effects of antiallergic drugs on bronchial and cutaneous anaphylaxis in Lewis rats.
Topics: Anaphylaxis; Animals; Asthma; Chlorpheniramine; Cromolyn Sodium; Cyclohexanecarboxylic Acids; Diseas | 1988 |
Quantitation of cutaneous inflammation induced by reactive species generated by UV-visible irradiation of rose bengal.
Topics: Animals; beta Carotene; Capillary Permeability; Carotenoids; Chlorpheniramine; Disease Models, Anima | 1989 |
A new bronchial asthma model using calcium ionophore A23187 in guinea pigs.
Topics: Administration, Inhalation; Animals; Asthma; Calcimycin; Chlorpheniramine; Chromones; Disease Models | 1989 |
A possible role for PAF in allergen-induced late responses: modification by a selective antagonist.
Topics: Aerosols; Allergens; Animals; Antigens, Helminth; Ascaris; Asthma; Azepines; Chlorpheniramine; Chrom | 1989 |
The influence of cinanserin and selected pharmacologic agents on experimental allergic encephalomyelitis (EAE).
Topics: 5-Hydroxytryptophan; Amphetamine; Anilides; Animals; Azathioprine; Body Weight; Chlorpheniramine; Ci | 1971 |
Antihistamine blockade of the ovarian hyperstimulation syndrome.
Topics: Animals; Ascitic Fluid; Chlorpheniramine; Disease Models, Animal; Female; Humans; Menotropins; Ovari | 1974 |
Observations on models used for the evaluation of antiarrhythmic drugs.
Topics: Alkaloids; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Atrial Fibrillation; Atrial Flutte | 1971 |