chlorpheniramine has been researched along with Bronchial Spasm in 22 studies
Chlorpheniramine: A histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. It has also been used in veterinary applications. One of the most widely used of the classical antihistaminics, it generally causes less drowsiness and sedation than PROMETHAZINE.
chlorphenamine : A tertiary amino compound that is propylamine which is substituted at position 3 by a pyridin-2-yl group and a p-chlorophenyl group and in which the hydrogens attached to the nitrogen are replaced by methyl groups. A histamine H1 antagonist, it is used to relieve the symptoms of hay fever, rhinitis, urticaria, and asthma.
Bronchial Spasm: Spasmodic contraction of the smooth muscle of the bronchi.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effect of an H1 antihistamine, an H2 antihistamine, and the combination of the two drugs on both histamine-induced bronchoconstriction and dermal whealing was examined in five patients with mild asthma." | 9.05 | A comparison of the actions of H1 and H2 antihistamines on histamine-induced bronchoconstriction and cutaneous wheal response in asthmatic patients. ( Nathan, RA; Schocket, AL; Segall, N, 1981) |
| "We compared the effects of two histamine receptor blocking agents, chlorpheniramine (H1) and cimetidine (H2) on the airways of healthy and asthmatic subjects." | 9.05 | Histamine blocking agents in healthy and asthmatic subjects. ( Brown, S; Gerstenhaber, B; Lach, E; Schachter, EN, 1982) |
| "In 15 asthmatic subjects, flow volume loops were recorded before and after quantitative nebulization of increasing concentration of histamine and allergen, until a threshold response (-delta FEV1 > 10%) was obtained." | 7.66 | Effect of an H1 blocker, chlorpheniramine, on inhalation tests with histamine and allergen in allergic asthma. ( Popa, VT, 1980) |
| "The effect of an H1 antihistamine, an H2 antihistamine, and the combination of the two drugs on both histamine-induced bronchoconstriction and dermal whealing was examined in five patients with mild asthma." | 5.05 | A comparison of the actions of H1 and H2 antihistamines on histamine-induced bronchoconstriction and cutaneous wheal response in asthmatic patients. ( Nathan, RA; Schocket, AL; Segall, N, 1981) |
| "We compared the effects of two histamine receptor blocking agents, chlorpheniramine (H1) and cimetidine (H2) on the airways of healthy and asthmatic subjects." | 5.05 | Histamine blocking agents in healthy and asthmatic subjects. ( Brown, S; Gerstenhaber, B; Lach, E; Schachter, EN, 1982) |
| " All the test compounds have protected the animals from histamine induced bronchospasm significantly." | 3.78 | Design and synthesis of novel 3-(4-chlorophenyl)-2-(3-substituted propyl thio) quinazolin-4-(3H)-ones as a new class of H1-antihistaminic agents. ( Alagarsamy, V; Parthiban, P, 2012) |
| " When tested for their in vivo H1-antihistaminic activity on conscious guinea pigs, all test compounds protected the animals from histamine induced bronchospasm significantly." | 3.75 | Synthesis and pharmacological investigation of novel 4-(3-ethylphenyl)-1-substituted-4H-[1,2,4]triazolo[4,3-a] quinazolin-5-ones as a new class of H1-antihistaminic agents. ( Alagarsamy, V; Kavitha, K; Kumar, DS; Kumar, J; Rupeshkumar, M; Sharma, HK; Solomon, VR, 2009) |
| " When tested for their in vivo H(1)-antihistaminic activity on conscious guinea pigs, all the test compounds protected the animals from histamine induced bronchospasm significantly." | 3.74 | Synthesis of 4-butyl-1-substituted-4H-[1,2,4]triazolo[4,3-a]quinazolin-5-ones as new class of H(1)-antihistaminic agents. ( Alagarsamy, V; Murugesan, S; Shankar, D, 2008) |
| " Some of them displayed good inhibition of both histamine-induced bronchospasm in the anesthetized guinea pig at 10 micrograms/kg by the intravenous route and of passive cutaneous anaphylaxis in the rat at 10 mg/kg by the oral route." | 3.67 | New antihistaminic theophylline or theobromine derivatives. ( Beranger, S; Désiles, JP; Pascal, JC; Pinhas, H; Poizot, A, 1985) |
| " The Raw and CDyn changes were prevented and reversed with the bronchodilators salbutamol and aminophylline indicating that reversible bronchospasms are induced in guinea pigs following a period of hyperventilation." | 3.67 | Hyperventilation-induced bronchoconstriction in guinea pigs. ( Chapman, RW; Danko, G, 1985) |
| "Antihistamine-resistant anaphylactic bronchospasm in guinea pigs is increased with increasing doses of antigen (ovalbumin, OA) challenge." | 3.66 | Alteration of drug responsiveness in guinea-pig lung anaphylaxis using different antigen challenge concentrations. ( Blumenthal, A; Dervinis, A; Lewis, AJ, 1983) |
| "In 15 asthmatic subjects, flow volume loops were recorded before and after quantitative nebulization of increasing concentration of histamine and allergen, until a threshold response (-delta FEV1 > 10%) was obtained." | 3.66 | Effect of an H1 blocker, chlorpheniramine, on inhalation tests with histamine and allergen in allergic asthma. ( Popa, VT, 1980) |
| "Chlorpheniramine pretreatment prevented death, delayed the onset of respiratory symptoms and decreased the severity of the hypersensitivity reaction." | 1.27 | Use of a simple in vivo technique to investigate components of the immediate hypersensitivity reaction in conscious guinea pigs. ( Hammerbeck, DM; Swingle, KF, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 16 (72.73) | 18.7374 |
| 1990's | 1 (4.55) | 18.2507 |
| 2000's | 3 (13.64) | 29.6817 |
| 2010's | 2 (9.09) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Pascal, JC | 1 |
| Beranger, S | 1 |
| Pinhas, H | 1 |
| Poizot, A | 1 |
| Désiles, JP | 1 |
| Alagarsamy, V | 5 |
| Kavitha, K | 1 |
| Rupeshkumar, M | 1 |
| Solomon, VR | 1 |
| Kumar, J | 1 |
| Kumar, DS | 1 |
| Sharma, HK | 1 |
| Parthiban, P | 2 |
| Giridhar, R | 1 |
| Yadav, MR | 2 |
| Shankar, D | 1 |
| Murugesan, S | 1 |
| Nathan, RA | 1 |
| Segall, N | 1 |
| Schocket, AL | 1 |
| Williams, JC | 1 |
| Conaty, JM | 1 |
| Townshend-Piala, P | 1 |
| Lewis, AJ | 1 |
| Blumenthal, A | 1 |
| Dervinis, A | 1 |
| Hammerbeck, DM | 1 |
| Swingle, KF | 1 |
| Abraham, WM | 1 |
| Oliver, W | 1 |
| King, MM | 1 |
| Yerger, L | 1 |
| Wanner, A | 1 |
| Stimler, NP | 1 |
| Hugli, TE | 1 |
| Bloor, CM | 1 |
| Schachter, EN | 2 |
| Brown, S | 1 |
| Lach, E | 1 |
| Gerstenhaber, B | 1 |
| Popa, VT | 1 |
| Lampa, E | 1 |
| Apolito, A | 1 |
| Russo, G | 1 |
| Pedone, P | 1 |
| Alise, G | 1 |
| Hey, JA | 1 |
| del Prado, M | 1 |
| Egan, RW | 1 |
| Kreutner, W | 1 |
| Chapman, RW | 3 |
| Mauser, PJ | 1 |
| Edelman, NH | 1 |
| Danko, G | 1 |
| Rubin, M | 1 |
| Gross, GN | 1 |
| Souhrada, JF | 1 |
| Farr, RS | 1 |
| Farmer, JB | 1 |
| Lehrer, DN | 1 |
| Benzi, G | 1 |
| Bermudez, E | 1 |
| Arrigoni, E | 1 |
4 trials available for chlorpheniramine and Bronchial Spasm
| Article | Year |
|---|---|
A comparison of the actions of H1 and H2 antihistamines on histamine-induced bronchoconstriction and cutaneous wheal response in asthmatic patients.
Topics: Asthma; Bronchial Provocation Tests; Bronchial Spasm; Chlorpheniramine; Cimetidine; Clinical Trials | 1981 |
Histamine blocking agents in healthy and asthmatic subjects.
Topics: Asthma; Bronchi; Bronchial Spasm; Chlorpheniramine; Cimetidine; Forced Expiratory Flow Rates; Guanid | 1982 |
The effect of an aerosolized antihistamine, chlorpheniramine maleate, on exercise-induced bronchospasm.
Topics: Adult; Aerosols; Bronchial Spasm; Chlorpheniramine; Female; Humans; Male; Physical Exertion; Placebo | 1985 |
The longterm treatment of an asthmatic patient using phentolamine.
Topics: Administration, Oral; Asthma; Atropine; Blood Pressure; Bronchial Spasm; Bronchodilator Agents; Chlo | 1974 |
18 other studies available for chlorpheniramine and Bronchial Spasm
| Article | Year |
|---|---|
New antihistaminic theophylline or theobromine derivatives.
Topics: Acetylcholine; Animals; Bronchial Spasm; Guinea Pigs; Histamine; Histamine H1 Antagonists; Male; Pas | 1985 |
Synthesis and pharmacological investigation of novel 4-(3-ethylphenyl)-1-substituted-4H-[1,2,4]triazolo[4,3-a] quinazolin-5-ones as a new class of H1-antihistaminic agents.
Topics: Animals; Bronchial Spasm; Chlorpheniramine; Guinea Pigs; Histamine; Histamine H1 Antagonists; Male; | 2009 |
Design and synthesis of novel 2-(3-substituted propyl)-3-(2-methyl phenyl) quinazolin-4-(3H)-ones as a new class of H1-antihistaminic agents.
Topics: Animals; Bronchial Spasm; Chemistry Techniques, Synthetic; Chlorpheniramine; Drug Design; Drug Evalu | 2013 |
Design and synthesis of novel 3-(4-chlorophenyl)-2-(3-substituted propyl thio) quinazolin-4-(3H)-ones as a new class of H1-antihistaminic agents.
Topics: Animals; Bronchial Spasm; Chlorpheniramine; Guinea Pigs; Histamine; Histamine H1 Antagonists; Male; | 2012 |
Synthesis and pharmacological investigation of novel 1-substituted-4-phenyl-1,2,4-triazolo[4,3-a]quinazolin-5(4H)-ones as a new class of H1-antihistaminic agents.
Topics: Animals; Bronchial Spasm; Chlorpheniramine; Cyclization; Guinea Pigs; Histamine H1 Antagonists; Hypn | 2005 |
Synthesis of 4-butyl-1-substituted-4H-[1,2,4]triazolo[4,3-a]quinazolin-5-ones as new class of H(1)-antihistaminic agents.
Topics: Algorithms; Animals; Bronchial Spasm; Chlorpheniramine; Guinea Pigs; Histamine; Histamine H1 Antagon | 2008 |
On the mechanism of histamine-induced bronchodilation in conscious guinea-pigs.
Topics: Aerosols; Animals; Bronchial Spasm; Bronchodilator Agents; Chlorpheniramine; Cimetidine; Guinea Pigs | 1984 |
Alteration of drug responsiveness in guinea-pig lung anaphylaxis using different antigen challenge concentrations.
Topics: Aerosols; Anaphylaxis; Animals; Bronchial Spasm; Chlorpheniramine; Chromones; Guinea Pigs; Immunizat | 1983 |
Use of a simple in vivo technique to investigate components of the immediate hypersensitivity reaction in conscious guinea pigs.
Topics: Aerosols; Anaphylaxis; Animals; Atropine; Bronchial Spasm; Chlorpheniramine; Chromones; Guinea Pigs; | 1984 |
Effect of pharmacologic agents on antigen-induced decreases in specific lung conductance in sheep.
Topics: Airway Resistance; Animals; Antigens; Ascaris; Atropine; Bronchial Spasm; Chlorpheniramine; Chromone | 1981 |
Pulmonary injury induced by C3a and C5a anaphylatoxins.
Topics: Anaphylatoxins; Animals; Bronchial Spasm; Capillary Permeability; Chlorpheniramine; Complement C3; C | 1980 |
Effect of an H1 blocker, chlorpheniramine, on inhalation tests with histamine and allergen in allergic asthma.
Topics: Adult; Allergens; Asthma; Bronchial Provocation Tests; Bronchial Spasm; Chlorpheniramine; Female; Hi | 1980 |
[Specific and aspecific activity of an antihistaminic of the H1 type: HC 20-511 or ketothiphen (benzo-cyclohepta-thiophenone derivative)].
Topics: Albuterol; Anaphylaxis; Animals; Anura; Bronchial Spasm; Cardiovascular System; Chlorpheniramine; Do | 1977 |
(R)-alpha-methylhistamine augments neural, cholinergic bronchospasm in guinea pigs by histamine H1 receptor activation.
Topics: Animals; Bronchial Spasm; Bronchoconstriction; Central Nervous System; Chlorpheniramine; Cholinergic | 1992 |
Central nervous system control of airway tone in guinea pigs: the role of histamine.
Topics: Airway Resistance; Animals; Atropine; Bronchi; Bronchial Spasm; Chlorpheniramine; Guinea Pigs; Hista | 1988 |
Hyperventilation-induced bronchoconstriction in guinea pigs.
Topics: Airway Resistance; Albuterol; Aminophylline; Animals; Atropine; Blood Gas Analysis; Bronchial Spasm; | 1985 |
The effect of isoprenaline on the contraction of smooth muscle produced by histamine, acetylcholine or other agents.
Topics: Acetylcholine; Animals; Atropine; Bradykinin; Bronchial Spasm; Chlorpheniramine; Creatine; Drug Anta | 1966 |
Action of antibiotics on respiratory tract. I. Ampicillin.
Topics: Acetylcholine; Amino Alcohols; Ampicillin; Animals; Atropine; Barium; Bronchi; Bronchial Spasm; Chlo | 1970 |