chlorpheniramine has been researched along with Aging in 7 studies
Chlorpheniramine: A histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. It has also been used in veterinary applications. One of the most widely used of the classical antihistaminics, it generally causes less drowsiness and sedation than PROMETHAZINE.
chlorphenamine : A tertiary amino compound that is propylamine which is substituted at position 3 by a pyridin-2-yl group and a p-chlorophenyl group and in which the hydrogens attached to the nitrogen are replaced by methyl groups. A histamine H1 antagonist, it is used to relieve the symptoms of hay fever, rhinitis, urticaria, and asthma.
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Chlorpheniramine has a serum half-life of approximately 20 hours in adults, and elimination from the body is primarily by metabolism to monodesmethyl and didesmethyl compounds." | 2.37 | Clinical pharmacokinetics of chlorpheniramine. ( Rumore, MM, 1984) |
| " Furthermore, long-term administration of chlorpheniramine was found to diminish age-related deficits in motor capacities." | 1.30 | Intraventricular infusion of the histamine H(1) receptor antagonist chlorpheniramine improves maze performance and has anxiolytic-like effects in aged hybrid Fischer 344xBrown Norway rats. ( Hasenöhrl, RU; Huston, JP; Weth, K, 1999) |
| "Histamine was infused at 1." | 1.28 | Developmental changes in effects of histamine on segmental pulmonary vascular resistances. ( Chu, K; Clément de Cléty, S; Gordon, JB, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (28.57) | 18.7374 |
| 1990's | 5 (71.43) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Melillo, G | 1 |
| D'Amato, G | 1 |
| Zanussi, C | 1 |
| Ortolani, C | 1 |
| Pastorello, E | 1 |
| Loy, M | 1 |
| Di Tucci, A | 1 |
| Locci, F | 1 |
| Del Giacco, GS | 1 |
| Lenzini, L | 1 |
| Sestini, P | 1 |
| Rottoli, P | 1 |
| Rumore, MM | 1 |
| Nomura, A | 1 |
| Sakurai, E | 1 |
| Hikichi, N | 1 |
| Frisch, C | 1 |
| Hasenöhrl, RU | 2 |
| Huston, JP | 2 |
| Weth, K | 1 |
| Gordon, JB | 1 |
| Clément de Cléty, S | 1 |
| Chu, K | 1 |
| Simons, KJ | 1 |
| Martin, TJ | 1 |
| Watson, WT | 1 |
| Simons, FE | 1 |
1 review available for chlorpheniramine and Aging
| Article | Year |
|---|---|
Clinical pharmacokinetics of chlorpheniramine.
Topics: Aging; Biological Availability; Chlorpheniramine; Drug Interactions; Half-Life; Humans; Intestinal A | 1984 |
2 trials available for chlorpheniramine and Aging
| Article | Year |
|---|---|
A multicentre controlled trial of terfenadine, dexchlorpheniramine, and placebo in allergic rhinitis.
Topics: Adolescent; Adult; Aging; Benzhydryl Compounds; Chlorpheniramine; Clinical Trials as Topic; Double-B | 1982 |
Pharmacokinetics and pharmacodynamics of terfenadine and chlorpheniramine in the elderly.
Topics: Aged; Aging; Benzhydryl Compounds; Chlorpheniramine; Chromatography, High Pressure Liquid; Double-Bl | 1990 |
4 other studies available for chlorpheniramine and Aging
| Article | Year |
|---|---|
[Stereoselective N-demethylation of chlorpheniramine in rat liver microsomes: studies on age and sex differences].
Topics: Aging; Animals; Chlorpheniramine; Chromatography, High Pressure Liquid; Dealkylation; Female; In Vit | 1995 |
The histamine H1-antagonist chlorpheniramine facilitates learning in aged rats.
Topics: Aging; Animals; Chlorpheniramine; Histamine H1 Antagonists; Learning; Male; Rats; Rats, Wistar | 1997 |
Intraventricular infusion of the histamine H(1) receptor antagonist chlorpheniramine improves maze performance and has anxiolytic-like effects in aged hybrid Fischer 344xBrown Norway rats.
Topics: Aging; Animals; Anti-Anxiety Agents; Cerebral Ventricles; Chlorpheniramine; Histamine H1 Antagonists | 1999 |
Developmental changes in effects of histamine on segmental pulmonary vascular resistances.
Topics: Aging; Animals; Animals, Newborn; Chlorpheniramine; Cimetidine; Histamine; Histamine H1 Antagonists; | 1991 |