chloroxylenol has been researched along with Endometritis in 5 studies
chloroxylenol: topical antiseptic; RN given refers to parent cpd; structure
4-chloro-3,5-dimethylphenol : A member of the class of phenols that is 3,5-xylenol which is substituted at position 4 by chlorine. It is bactericidal against most Gram-positive bacteria but less effective against Staphylococci and Gram-negative bacteria, and often inactive against Pseudomonas species. It is ineffective against bacterial spores.
Endometritis: Inflammation of the ENDOMETRIUM, usually caused by intrauterine infections. Endometritis is the most common cause of postpartum fever.
Excerpt | Relevance | Reference |
---|---|---|
"Skin preparation with an antibacterial scrub in addition to standard povidone-iodine scrub and solution does not appear to play as significant a role in the reduction of post-cesarean endometritis or wound infection as does intraoperative pelvic irrigation with antibiotic solution." | 5.07 | Preoperative skin preparation and intraoperative pelvic irrigation: impact on post-cesarean endometritis and wound infection. ( Dodson, MK; Harris, RL; Magann, EF; Martin, JN; Morrison, JC; Ray, MA, 1993) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 1 (20.00) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 3 (60.00) | 24.3611 |
2020's | 1 (20.00) | 2.80 |
Authors | Studies |
---|---|
Hadiati, DR | 4 |
Hakimi, M | 4 |
Nurdiati, DS | 4 |
Masuzawa, Y | 1 |
da Silva Lopes, K | 2 |
Ota, E | 3 |
Magann, EF | 1 |
Dodson, MK | 1 |
Ray, MA | 1 |
Harris, RL | 1 |
Martin, JN | 1 |
Morrison, JC | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
To Determine the Difference in Positive Bacterial Cultures in Cesarean Sections With 2% Chlorhexidine- Gluconate, 70% Isopropyl Alcohol (Chloraprep) vs. Povidone-iodine 10% (Betadine) Preoperative Surgical Scrub[NCT01975805] | 60 participants (Actual) | Interventional | 2010-01-31 | Completed | |||
Antiseptic Skin Preparation for Preventing Surgical Site Infection at Cesarean Delivery: a Randomized Comparative Effectiveness Trial[NCT01472549] | 1,147 participants (Actual) | Interventional | 2011-09-30 | Completed | |||
A Randomized Trial to Determine if a Pre-operative Wash With a Chlorhexidine Gluconate Cloth and Chlorhexidine Gluconate Vaginal Scrub Reduces Infectious Morbidity in Patients Undergoing Cesarean Section After Labor[NCT03423147] | Phase 2 | 319 participants (Actual) | Interventional | 2018-10-05 | Terminated (stopped due to Poor enrollment, inability to achieve required number of subjects) | ||
The Impact of Preoperative Bathing With Chloroxylenol on the Incidence of Post Caesarean Section Surgical Site Infection at Mbarara Regional Referral Hospital: A Randomized Controlled Trial[NCT03544710] | 96 participants (Actual) | Interventional | 2017-12-07 | Completed | |||
Chlorhexidine Versus Povidone-iodine Antisepsis for Reduction of Post Cesarean Section Surgical Site Infection Rate:a Randomized Controlled Trial[NCT02396329] | Phase 2 | 410 participants (Anticipated) | Interventional | 2014-06-30 | Recruiting | ||
A Randomized Control Trial of Chlorhexidine Gluconate Aqueous Solution vs Chlorhexidine Gluconate With Isopropyl Alcohol Skin Preparations for Prevention of Cesarean Section Wound Infections[NCT05920122] | Phase 4 | 1,470 participants (Anticipated) | Interventional | 2023-10-09 | Recruiting | ||
Chlorhexidine-Alcohol Versus Povidone-Iodine for Surgical Site Antisepsis Prior to Cesarean Delivery[NCT02202577] | 932 participants (Actual) | Interventional | 2014-03-31 | Completed | |||
Comparison of Surgical Skin Preps During Cesarean Deliveries[NCT01870583] | 1,404 participants (Actual) | Interventional | 2013-02-28 | Completed | |||
THE EFFECT OF USING CHLORHEXIDINE GLUCONATE AND POVIDONE IODINE SOLUTION ON THE HEALING PROCESS BEFORE A CESAREAN SECTION[NCT05953714] | 102 participants (Actual) | Interventional | 2020-12-01 | Completed | |||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
(NCT01472549)
Timeframe: 30 days
Intervention | days (Median) |
---|---|
Chlorhexidine-alcohol | 4 |
Iodine-alcohol | 4 |
(NCT01472549)
Timeframe: 30 days
Intervention | Participants (Count of Participants) |
---|---|
Chlorhexidine-alcohol | 2 |
Iodine-alcohol | 1 |
(NCT01472549)
Timeframe: 30 days
Intervention | Participants (Count of Participants) |
---|---|
Chlorhexidine-alcohol | 8 |
Iodine-alcohol | 11 |
(NCT01472549)
Timeframe: 30 days
Intervention | Participants (Count of Participants) |
---|---|
Chlorhexidine-alcohol | 19 |
Iodine-alcohol | 25 |
(NCT01472549)
Timeframe: 30 days
Intervention | Participants (Count of Participants) |
---|---|
Chlorhexidine-alcohol | 0 |
Iodine-alcohol | 3 |
Superficial or deep surgical-site infection within 30 days after cesarean delivery, on the basis of the National Healthcare Safety Network definitions of the Centers for Disease Control and Prevention. (NCT01472549)
Timeframe: 30 days
Intervention | Participants (Count of Participants) |
---|---|
Chlorhexidine-alcohol | 23 |
Iodine-alcohol | 42 |
(NCT03423147)
Timeframe: Day 1
Intervention | mL (Mean) |
---|---|
Chlorhexidine Gluconate Vaginal Scrub and Cloth | 671 |
Standard Treatment | 670 |
(NCT03423147)
Timeframe: up to 6 weeks postpartum
Intervention | days (Mean) |
---|---|
Chlorhexidine Gluconate Vaginal Scrub and Cloth | 2.98 |
Standard Treatment | 2.93 |
(NCT03423147)
Timeframe: up to 6 weeks postpartum
Intervention | Participants (Count of Participants) |
---|---|
Chlorhexidine Gluconate Vaginal Scrub and Cloth | 7 |
Standard Treatment | 1 |
Number of participants with newborn with neonatal ICU admissions (NCT03423147)
Timeframe: up to 6 weeks postpartum
Intervention | Participants (Count of Participants) |
---|---|
Chlorhexidine Gluconate Vaginal Scrub and Cloth | 30 |
Standard Treatment | 36 |
(NCT03423147)
Timeframe: up to 6 weeks postpartum
Intervention | Participants (Count of Participants) |
---|---|
Chlorhexidine Gluconate Vaginal Scrub and Cloth | 6 |
Standard Treatment | 2 |
Surgical site infection will be a composite of wound infection and postpartum endometritis. Endometritis is defined as postoperative fever of 100.4 °F or more occurring 24 hours after delivery associated with uterine tenderness and persistent foul-smelling lochia, requiring broad-spectrum intravenous antibiotic administration. Wound infection is defined as erythema or wound edge separation with purulent discharge involving the cesarean incision site that requires antibiotic therapy and wound care. (NCT03423147)
Timeframe: up to 6 weeks postpartum
Intervention | Participants (Count of Participants) |
---|---|
Chlorhexidine Gluconate Vaginal Scrub and Cloth | 12 |
Standard Treatment | 22 |
(NCT03423147)
Timeframe: Day 1
Intervention | Participants (Count of Participants) | ||
---|---|---|---|
45-60 minutes | 61-90 minutes | 91+ minutes | |
Chlorhexidine Gluconate Vaginal Scrub and Cloth | 46 | 87 | 27 |
Standard Treatment | 46 | 96 | 17 |
Non-infection complications: allergic skin reactions, hematomas, wound separation, dehiscence. (NCT02202577)
Timeframe: 4 weeks after cesarean delivery
Intervention | Participants (Count of Participants) |
---|---|
Chlorhexidine - Isopropyl Alcohol | 19 |
Povidone-Iodine Scrub and Paint | 17 |
Number of Patients with Cesarean-Related surgical site infection by Center for Disease Control (CDC) criteria: superficial, deep, organ space. (NCT02202577)
Timeframe: 4 weeks after cesarean delivery
Intervention | Participants (Count of Participants) |
---|---|
Chlorhexidine - Isopropyl Alcohol | 29 |
Povidone-Iodine Scrub and Paint | 33 |
Surgical site infection will follow CDC guidelines: A) Superficial incisional surgical site infection B) Deep incisional surgical site infection or C) Organ/space surgical site infection. (NCT01870583)
Timeframe: 42 days after delivery
Intervention | Participants (Count of Participants) | |||
---|---|---|---|---|
Any SSI: Total combined | SSI: Superficial | SSI: Deep | SSI: Organ | |
Chlorhexidine | 21 | 15 | 3 | 3 |
Combination Iodine and Chlorhexidine | 18 | 15 | 1 | 2 |
Iodine Povidone | 21 | 16 | 3 | 2 |
4 reviews available for chloroxylenol and Endometritis
Article | Year |
---|---|
Skin preparation for preventing infection following caesarean section.
Topics: Adult; Anti-Infective Agents, Local; Bandages; Cesarean Section; Chlorhexidine; Endometritis; Ethano | 2020 |
Skin preparation for preventing infection following caesarean section.
Topics: Adult; Anti-Infective Agents, Local; Bandages; Cesarean Section; Chlorhexidine; Endometritis; Ethano | 2020 |
Skin preparation for preventing infection following caesarean section.
Topics: Adult; Anti-Infective Agents, Local; Bandages; Cesarean Section; Chlorhexidine; Endometritis; Ethano | 2020 |
Skin preparation for preventing infection following caesarean section.
Topics: Adult; Anti-Infective Agents, Local; Bandages; Cesarean Section; Chlorhexidine; Endometritis; Ethano | 2020 |
Skin preparation for preventing infection following caesarean section.
Topics: Adult; Anti-Infective Agents, Local; Bandages; Cesarean Section; Chlorhexidine; Endometritis; Ethano | 2020 |
Skin preparation for preventing infection following caesarean section.
Topics: Adult; Anti-Infective Agents, Local; Bandages; Cesarean Section; Chlorhexidine; Endometritis; Ethano | 2020 |
Skin preparation for preventing infection following caesarean section.
Topics: Adult; Anti-Infective Agents, Local; Bandages; Cesarean Section; Chlorhexidine; Endometritis; Ethano | 2020 |
Skin preparation for preventing infection following caesarean section.
Topics: Adult; Anti-Infective Agents, Local; Bandages; Cesarean Section; Chlorhexidine; Endometritis; Ethano | 2020 |
Skin preparation for preventing infection following caesarean section.
Topics: Adult; Anti-Infective Agents, Local; Bandages; Cesarean Section; Chlorhexidine; Endometritis; Ethano | 2020 |
Skin preparation for preventing infection following caesarean section.
Topics: Adult; Anti-Infective Agents, Local; Bandages; Cesarean Section; Chlorhexidine; Endometritis; Ethano | 2020 |
Skin preparation for preventing infection following caesarean section.
Topics: Adult; Anti-Infective Agents, Local; Bandages; Cesarean Section; Chlorhexidine; Endometritis; Ethano | 2020 |
Skin preparation for preventing infection following caesarean section.
Topics: Adult; Anti-Infective Agents, Local; Bandages; Cesarean Section; Chlorhexidine; Endometritis; Ethano | 2020 |
Skin preparation for preventing infection following caesarean section.
Topics: Adult; Anti-Infective Agents, Local; Bandages; Cesarean Section; Chlorhexidine; Endometritis; Ethano | 2020 |
Skin preparation for preventing infection following caesarean section.
Topics: Adult; Anti-Infective Agents, Local; Bandages; Cesarean Section; Chlorhexidine; Endometritis; Ethano | 2020 |
Skin preparation for preventing infection following caesarean section.
Topics: Adult; Anti-Infective Agents, Local; Bandages; Cesarean Section; Chlorhexidine; Endometritis; Ethano | 2020 |
Skin preparation for preventing infection following caesarean section.
Topics: Adult; Anti-Infective Agents, Local; Bandages; Cesarean Section; Chlorhexidine; Endometritis; Ethano | 2020 |
Skin preparation for preventing infection following caesarean section.
Topics: Adult; Anti-Infective Agents, Local; Bandages; Cesarean Section; Chlorhexidine; Endometritis; Ethano | 2020 |
Skin preparation for preventing infection following caesarean section.
Topics: Adult; Anti-Infective Agents, Local; Bandages; Cesarean Section; Chlorhexidine; Endometritis; Ethano | 2020 |
Skin preparation for preventing infection following caesarean section.
Topics: Adult; Anti-Infective Agents, Local; Bandages; Cesarean Section; Chlorhexidine; Endometritis; Ethano | 2020 |
Skin preparation for preventing infection following caesarean section.
Topics: Adult; Anti-Infective Agents, Local; Bandages; Cesarean Section; Chlorhexidine; Endometritis; Ethano | 2020 |
Skin preparation for preventing infection following caesarean section.
Topics: Adult; Anti-Infective Agents, Local; Bandages; Cesarean Section; Chlorhexidine; Endometritis; Ethano | 2020 |
Skin preparation for preventing infection following caesarean section.
Topics: Adult; Anti-Infective Agents, Local; Bandages; Cesarean Section; Chlorhexidine; Endometritis; Ethano | 2020 |
Skin preparation for preventing infection following caesarean section.
Topics: Adult; Anti-Infective Agents, Local; Bandages; Cesarean Section; Chlorhexidine; Endometritis; Ethano | 2020 |
Skin preparation for preventing infection following caesarean section.
Topics: Adult; Anti-Infective Agents, Local; Bandages; Cesarean Section; Chlorhexidine; Endometritis; Ethano | 2020 |
Skin preparation for preventing infection following caesarean section.
Topics: Adult; Anti-Infective Agents, Local; Bandages; Cesarean Section; Chlorhexidine; Endometritis; Ethano | 2020 |
Skin preparation for preventing infection following caesarean section.
Topics: Adult; Anti-Infective Agents, Local; Bandages; Cesarean Section; Chlorhexidine; Endometritis; Ethano | 2020 |
Skin preparation for preventing infection following caesarean section.
Topics: Adult; Anti-Infective Agents, Local; Bandages; Cesarean Section; Chlorhexidine; Endometritis; Ethano | 2020 |
Skin preparation for preventing infection following caesarean section.
Topics: Adult; Anti-Infective Agents, Local; Bandages; Cesarean Section; Chlorhexidine; Endometritis; Ethano | 2020 |
Skin preparation for preventing infection following caesarean section.
Topics: Adult; Anti-Infective Agents, Local; Bandages; Cesarean Section; Chlorhexidine; Endometritis; Ethano | 2020 |
Skin preparation for preventing infection following caesarean section.
Topics: Adult; Anti-Infective Agents, Local; Bandages; Cesarean Section; Chlorhexidine; Endometritis; Ethano | 2020 |
Skin preparation for preventing infection following caesarean section.
Topics: Adult; Anti-Infective Agents, Local; Bandages; Cesarean Section; Chlorhexidine; Endometritis; Ethano | 2020 |
Skin preparation for preventing infection following caesarean section.
Topics: Adult; Anti-Infective Agents, Local; Bandages; Cesarean Section; Chlorhexidine; Endometritis; Ethano | 2020 |
Skin preparation for preventing infection following caesarean section.
Topics: Adult; Anti-Infective Agents, Local; Bandages; Cesarean Section; Chlorhexidine; Endometritis; Ethano | 2020 |
Skin preparation for preventing infection following caesarean section.
Topics: Adult; Anti-Infective Agents, Local; Bandages; Cesarean Section; Chlorhexidine; Endometritis; Ethano | 2020 |
Skin preparation for preventing infection following caesarean section.
Topics: Adult; Anti-Infective Agents, Local; Bandages; Cesarean Section; Chlorhexidine; Endometritis; Ethano | 2020 |
Skin preparation for preventing infection following caesarean section.
Topics: Adult; Anti-Infective Agents, Local; Bandages; Cesarean Section; Chlorhexidine; Endometritis; Ethano | 2020 |
Skin preparation for preventing infection following caesarean section.
Topics: Adult; Anti-Infective Agents, Local; Bandages; Cesarean Section; Chlorhexidine; Endometritis; Ethano | 2020 |
Skin preparation for preventing infection following caesarean section.
Topics: Adult; Anti-Infective Agents, Local; Bandages; Cesarean Section; Chlorhexidine; Endometritis; Ethano | 2020 |
Skin preparation for preventing infection following caesarean section.
Topics: Adult; Anti-Infective Agents, Local; Bandages; Cesarean Section; Chlorhexidine; Endometritis; Ethano | 2020 |
Skin preparation for preventing infection following caesarean section.
Topics: Adult; Anti-Infective Agents, Local; Bandages; Cesarean Section; Chlorhexidine; Endometritis; Ethano | 2020 |
Skin preparation for preventing infection following caesarean section.
Topics: Adult; Anti-Infective Agents, Local; Bandages; Cesarean Section; Chlorhexidine; Endometritis; Ethano | 2020 |
Skin preparation for preventing infection following caesarean section.
Topics: Adult; Anti-Infective Agents, Local; Bandages; Cesarean Section; Chlorhexidine; Endometritis; Ethano | 2020 |
Skin preparation for preventing infection following caesarean section.
Topics: Adult; Anti-Infective Agents, Local; Bandages; Cesarean Section; Chlorhexidine; Endometritis; Ethano | 2020 |
Skin preparation for preventing infection following caesarean section.
Topics: Adult; Anti-Infective Agents, Local; Bandages; Cesarean Section; Chlorhexidine; Endometritis; Ethano | 2020 |
Skin preparation for preventing infection following caesarean section.
Topics: Adult; Anti-Infective Agents, Local; Bandages; Cesarean Section; Chlorhexidine; Endometritis; Ethano | 2020 |
Skin preparation for preventing infection following caesarean section.
Topics: Adult; Anti-Infective Agents, Local; Bandages; Cesarean Section; Chlorhexidine; Endometritis; Ethano | 2020 |
Skin preparation for preventing infection following caesarean section.
Topics: Adult; Anti-Infective Agents, Local; Bandages; Cesarean Section; Chlorhexidine; Endometritis; Ethano | 2020 |
Skin preparation for preventing infection following caesarean section.
Topics: Adult; Anti-Infective Agents, Local; Bandages; Cesarean Section; Chlorhexidine; Endometritis; Ethano | 2020 |
Skin preparation for preventing infection following caesarean section.
Topics: Adult; Anti-Infective Agents, Local; Bandages; Cesarean Section; Chlorhexidine; Endometritis; Ethano | 2020 |
Skin preparation for preventing infection following caesarean section.
Topics: Adult; Anti-Infective Agents, Local; Bandages; Cesarean Section; Chlorhexidine; Endometritis; Ethano | 2020 |
Skin preparation for preventing infection following caesarean section.
Topics: Adult; Anti-Infective Agents, Local; Bandages; Cesarean Section; Chlorhexidine; Endometritis; Ethano | 2020 |
Skin preparation for preventing infection following caesarean section.
Topics: Adult; Anti-Infective Agents, Local; Bandages; Cesarean Section; Chlorhexidine; Endometritis; Ethano | 2020 |
Skin preparation for preventing infection following caesarean section.
Topics: Adult; Anti-Infective Agents, Local; Bandages; Cesarean Section; Chlorhexidine; Endometritis; Ethano | 2020 |
Skin preparation for preventing infection following caesarean section.
Topics: Adult; Anti-Infective Agents, Local; Bandages; Cesarean Section; Chlorhexidine; Endometritis; Ethano | 2020 |
Skin preparation for preventing infection following caesarean section.
Topics: Adult; Anti-Infective Agents, Local; Bandages; Cesarean Section; Chlorhexidine; Endometritis; Ethano | 2020 |
Skin preparation for preventing infection following caesarean section.
Topics: Adult; Anti-Infective Agents, Local; Bandages; Cesarean Section; Chlorhexidine; Endometritis; Ethano | 2020 |
Skin preparation for preventing infection following caesarean section.
Topics: Adult; Anti-Infective Agents, Local; Bandages; Cesarean Section; Chlorhexidine; Endometritis; Ethano | 2020 |
Skin preparation for preventing infection following caesarean section.
Topics: Adult; Anti-Infective Agents, Local; Bandages; Cesarean Section; Chlorhexidine; Endometritis; Ethano | 2020 |
Skin preparation for preventing infection following caesarean section.
Topics: Adult; Anti-Infective Agents, Local; Bandages; Cesarean Section; Chlorhexidine; Endometritis; Ethano | 2020 |
Skin preparation for preventing infection following caesarean section.
Topics: Adult; Anti-Infective Agents, Local; Bandages; Cesarean Section; Chlorhexidine; Endometritis; Ethano | 2020 |
Skin preparation for preventing infection following caesarean section.
Topics: Adult; Anti-Infective Agents, Local; Bandages; Cesarean Section; Chlorhexidine; Endometritis; Ethano | 2020 |
Skin preparation for preventing infection following caesarean section.
Topics: Adult; Anti-Infective Agents, Local; Bandages; Cesarean Section; Chlorhexidine; Endometritis; Ethano | 2020 |
Skin preparation for preventing infection following caesarean section.
Topics: Adult; Anti-Infective Agents, Local; Bandages; Cesarean Section; Chlorhexidine; Endometritis; Ethano | 2020 |
Skin preparation for preventing infection following caesarean section.
Topics: Adult; Anti-Infective Agents, Local; Bandages; Cesarean Section; Chlorhexidine; Endometritis; Ethano | 2020 |
Skin preparation for preventing infection following caesarean section.
Topics: Adult; Anti-Infective Agents, Local; Bandages; Cesarean Section; Chlorhexidine; Endometritis; Ethano | 2018 |
Skin preparation for preventing infection following caesarean section.
Topics: Adult; Anti-Infective Agents, Local; Bandages; Cesarean Section; Chlorhexidine; Endometritis; Ethano | 2014 |
Skin preparation for preventing infection following caesarean section.
Topics: Adult; Anti-Infective Agents, Local; Bandages; Cesarean Section; Chlorhexidine; Endometritis; Ethano | 2012 |
1 trial available for chloroxylenol and Endometritis
Article | Year |
---|---|
Preoperative skin preparation and intraoperative pelvic irrigation: impact on post-cesarean endometritis and wound infection.
Topics: Adult; Anti-Infective Agents, Local; Cefazolin; Cesarean Section; Endometritis; Female; Humans; Intr | 1993 |