Page last updated: 2024-10-24

chlorothiazide and Kidney Diseases

chlorothiazide has been researched along with Kidney Diseases in 51 studies

Chlorothiazide: A thiazide diuretic with actions and uses similar to those of HYDROCHLOROTHIAZIDE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p812)
thiazide : Heterocyclic compound with sulfur and nitrogen in the ring.
chlorothiazide : 4H-1,2,4-benzothiadiazine 1,1-dioxide in which the hydrogen at position is substituted by chlorine and that at position 7 is substituted by a sulfonamide group. A diuretic, it is used for treatment of oedema and hypertension.

Kidney Diseases: Pathological processes of the KIDNEY or its component tissues.

Research

Studies (51)

Timeframe	Studies, this research(%)	All Research%
pre-1990	50 (98.04)	18.7374
1990's	1 (1.96)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
SCHREINER, GE	1
WALKER, WG	1
IBER, FL	1
WALSER, M	1
LASAGNA, L	1
BUZZI, RM	1
SAMMARTINO, F	1
MAS, FR	1
LA ROSA, C	1
GELFAND, ML	1
DREIFUS, LS	1
DUARTE, C	1
KODAMA, R	1
MOYER, JH	1
REERINK, H	1
REUBI, FC	2
COTTIER, PT	1
VERCELLONE, A	1
PELLEGRINI, A	1
PICCOLI, G	1
ABRY, J	1
CAVUSOGLU, M	1
BRUNNER, H	2
CROSLEY, AP	2
CULLEN, RC	2
WHITE, D	2
FREEMAN, JF	2
CASTILLO, CA	2
ROWE, GG	2
CRUMPTON, CW	1
WHYTE, HM	1
WINTER, M	1
WALTNER, K	1
SINGH, D	1
PANDEY, GN	1
BRETTELL, HR	1
SMITH, JG	1
AIKAWA, JK	1
DUNLOP, D	1
JANUARY, LE	1
KIRKENDALL, WM	1
THEILEN, EO	1
ECKSTEIN, JW	1
BAGROS, P	1
MIHAILESCU, VV	1
CLEJ, V	1
ENESCU, R	1
SBENGHE, S	1
WACKER, WE	1
MERZON, AK	1
KASIANOVA, TN	1
KESSLER, RH	1
TOKUMARU, M	1
FUJIMOTO, S	1
ANICHINI, M	1
GARGANO, N	1
BARTORELLI, C	1
PANITZ, F	1
SHINABERGER, JH	1
MORGAN, JM	1
BUTLER, HE	1
HODGES, LE	1
KJELLBO, H	1
STAKEBERG, H	1
MELLGREN, J	1
ROSSER, PL	1
HERTL, M	1
ROSSI, L	1
DAGA, G	1
Vorburger, C	2
Cottier, P	1
Lau, K	1
Eby, BK	1
Murphy, BF	1
Whitworth, JA	1
Kincaid-Smith, P	1
Breitschwerdt, EB	1
Verlander, JW	1
Hribernik, TN	1
Blachar, Y	1
Zadik, Z	1
Shemesh, M	1
Kaplan, BS	1
Levin, S	1
Kato, A	1
Hishida, A	1
Ishibashi, R	1
Nakajima, T	1
Ohura, M	1
Furuya, R	1
Kumagai, H	1
Kimura, M	1
Kaneko, E	1
Vogin, EE	1
Chou, SY	1
Porush, JG	1
Slater, PA	1
Flombaum, CD	1
Shafi, T	1
Fein, PA	1
Deray, G	1
Baumelou, B	1
Le Hoang, P	1
Aupetit, B	1
Girard, B	1
Baumelou, A	1
Legrand, JC	1
Jacobs, C	1
Gray, JA	1
Kavlock, RJ	1
Groover, ME	1
Fulghum, JE	1
Simpson, WG	1
Catt, KJ	1
Cain, MD	1
Coghlan, JP	1
Zimmet, PZ	1
Cran, E	1
Best, JB	1
Chaimovitz, C	1
Levi, J	1
Better, OS	1
Oslander, L	1
Benderli, A	1
Gross, A	1
Girard, V	1
Joynt, MS	1
Morrin, PA	1
Dumont, M	1
Fargier, P	1
Curtillet, H	1
Reubi, F	1
Kuzemko, JA	1
Robson, JE	1

Clinical Trials (2)

Trial Overview

Trial	Phase	Enrollment	Study Type	Start Date	Status
Chlortalidone and Bumetanide in Advanced Chronic Kidney Disease: HEBE-CKD Trial[NCT03923933]	Phase 2	34 participants (Actual)	Interventional	2019-06-18	Completed
Severe Impairment of Solute-Free Water Clearance in Patients With HIV Infection[NCT01869010]		30 participants (Actual)	Observational	2010-01-31	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Change in Diastolic Blood Pressure

(NCT03923933)
Timeframe: Change from Basal to day 28

Intervention	mmHg (Mean)
Placebo	-3.4
Treatment Grup	-13.5

Change in Extracellular Water

Decrease in extracellular water measured by bioelectrical impedance analysis (NCT03923933)
Timeframe: Change from Basal to day 28

Intervention	litres (Mean)
Placebo	-0.15
Treatment Grup	2.55

Change in Extracellular Water / Total Body Water Ratio

Decrease in extracellular water / total body water ratio measured by bioelectrical impedance analysis (NCT03923933)
Timeframe: Change from Basal to day 28

Intervention	percentage of ECW/TBW (Mean)
Placebo	-0.24
Treatment Grup	-2.92

Change in Mean Arterial Pressure

decrease in blood pressure compared wit baseline measure (mmhg) (NCT03923933)
Timeframe: Change from Basal to day 28

Intervention	mmHg (Mean)
Placebo	-5.4
Treatment Grup	-18.1

Change in Systolic Blood Pressure

(NCT03923933)
Timeframe: Change from Basal to day 28

Intervention	mmHg (Mean)
Placebo	-10
Treatment Grup	-26.1

Change in the Fractional Excretion of Sodium

Increase in the fractional excretion of sodium compared with the baseline measure (NCT03923933)
Timeframe: Change from Basal to day 28

Intervention	percentage of sodium excreted (Mean)
Placebo	-0.348
Treatment Grup	0.598

Change in Total Body Water

Measured by bioelectrical impedance analysis, compared to the initial measurement (NCT03923933)
Timeframe: Change from Basal to day 28

Intervention	litres (Mean)
Placebo	-0.075
Treatment Grup	-4.36

Reviews

2 reviews available for chlorothiazide and Kidney Diseases

Article	Year
[MECHANISM OF ACTION AND CLINICAL USE OF DIURETICS]. Recenti progressi in medicina, 1963, Volume: 35 Topics: Bendroflumethiazide; Benzothiadiazines; Chlorothiazide; Chlorthalidone; Diuretics; Hydrochlorothiazi	1963
MAGNESIUM METABOLISM. Journal of the American Dietetic Association, 1964, Volume: 44 Topics: Bicarbonates; Blood Chemical Analysis; Calcium; Calcium, Dietary; Chlorothiazide; Deficiency Disease	1964

Trials

1 trial available for chlorothiazide and Kidney Diseases

Article	Year
[Effect of benzbromarone in uricemia and uricosuria]. Die Medizinische Welt, 1972, Jan-22, Volume: 23, Issue:4 Topics: Aspirin; Benzofurans; Chlorothiazide; Clinical Trials as Topic; Colchicine; Drug Combinations; Human	1972

Other Studies

48 other studies available for chlorothiazide and Kidney Diseases

Article	Year
Chlorothiazide in renal disease. Annals of the New York Academy of Sciences, 1958, Feb-03, Volume: 71, Issue:4 Topics: Acetazolamide; Chlorothiazide; Kidney Diseases	1958
A controlled study of chlorothiazide as a diuretic agent; with a note on untoward reactions in the presence of renal insufficiency. Journal of chronic diseases, 1959, Volume: 10, Issue:1 Topics: Acetazolamide; Chlorothiazide; Diuretics; Kidney Diseases; Renal Insufficiency; Research Design	1959
[Hydrochlorothiazide in clinical practice]. Prensa medica argentina, 1960, Nov-04, Volume: 47 Topics: Chlorothiazide; Coronary Disease; Diuretics; Hydrochlorothiazide; Hypertension; Kidney Diseases; Liv	1960
Renal colic associated with chlorothiazide and hydrochlorothiazide therapy. The New England journal of medicine, 1961, Jul-20, Volume: 265 Topics: Chlorothiazide; Hydrochlorothiazide; Kidney; Kidney Diseases; Renal Colic	1961
The effect of thiazide diuretics on the abnormal kidney. Annals of internal medicine, 1960, Dec-15, Volume: 53 Topics: Chlorothiazide; Kidney; Kidney Diseases; Sodium Chloride Symporter Inhibitors	1960
[Nephrogenic diabetes insipidus: some tests on the effects of chlorothiazide]. Maandschrift voor kindergeneeskunde, 1960, Volume: 28 Topics: Child; Chlorothiazide; Diabetes Insipidus; Diabetes Insipidus, Nephrogenic; Diabetes Insipidus, Neur	1960
Effects of reduced glomerular filtration rate on responsiveness to chlorothiazide and mercurial diuretics. Circulation, 1961, Volume: 23 Topics: Chlorothiazide; Diuretics; Glomerular Filtration Rate; Humans; Kidney Diseases; Organomercury Compou	1961
[Clinical experience with a new diuretic of the benzothiodiazine series: benzhydroflumethiazide]. Minerva medica, 1960, Nov-03, Volume: 51 Topics: Anti-Arrhythmia Agents; Chlorothiazide; Diuretics; Heart Diseases; Humans; Hypertension; Kidney Dise	1960
Fatal tubular necrosis during chlorothiazide administration. New York state journal of medicine, 1960, May-15, Volume: 60 Topics: Chlorothiazide; Kidney; Kidney Cortex Necrosis; Kidney Diseases	1960
[Renal effects of acetazolamide, chlorothiazide and chlormerodrin in experimental renal insufficiency. III. Disorder of renal function due to partial nephrectomy]. Zeitschrift fur die gesamte experimentelle Medizin, 1959, Volume: 132 Topics: Acetazolamide; Chlormerodrin; Chlorothiazide; Diuretics; Kidney; Kidney Diseases; Nephrectomy; Organ	1959
Studies of the mechanism of action of chlorothiazide in cardiac and renal diseases. I. Acute effects on renal and systemic hemodynamics and metabolism. The Journal of laboratory and clinical medicine, 1960, Volume: 55 Topics: Chlorothiazide; Heart Diseases; Hemodynamics; Humans; Kidney; Kidney Diseases	1960
Studies of the mechanism of action of chlorothiazide in cardiac and renal diseases. II. Acute effects on electrolyte and acid-base metabolism. The Journal of laboratory and clinical medicine, 1960, Volume: 55 Topics: Chlorothiazide; Electrolytes; Heart; Heart Diseases; Kidney Diseases; Water-Electrolyte Balance	1960
Chlorothiazide in renal disease. The Medical journal of Australia, 1960, Jan-16, Volume: 47(1) Topics: Chlorothiazide; Kidney Diseases	1960
[Experiences with the use of chlorothiazide and hydrochlorothiazide in kidney diseases]. Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete, 1959, Nov-15, Volume: 14 Topics: Chlorothiazide; Hydrochlorothiazide; Kidney Diseases	1959
[Renal effects of acetazolamide, chlorothiazide and chlormerodrin in experimental renal insufficiency. Part IV. Comparison of the influences of various kidney function disorders]. Klinische Wochenschrift, 1959, Nov-01, Volume: 37 Topics: Acetazolamide; Chlormerodrin; Chlorothiazide; Diuretics; Humans; Kidney; Kidney Diseases; Organomerc	1959
Clinical evaluation of hydrochlorothiazide in renal oedema. Journal of the Indian Medical Association, 1962, May-01, Volume: 38 Topics: Chlorothiazide; Edema; Edetic Acid; Humans; Hydrochlorothiazide; Kidney; Kidney Diseases	1962
S35-LABELED BENDROFLUMETHIAZIDE IN HUMAN BEINGS: CLINICAL STUDIES. Archives of internal medicine, 1964, Volume: 113 Topics: Adolescent; Bendroflumethiazide; Chlorothiazide; Geriatrics; Heart Failure; Humans; Hydrochlorothiaz	1964
CONCEPTS IN THE PATHOGENESIS AND TREATMENT OF CONGESTIVE HEART FAILURE. Journal of the Iowa Medical Society, 1964, Volume: 54 Topics: Chlorothiazide; Digitalis Glycosides; Diuretics; Heart Failure; Heparin; Humans; Kidney Diseases; Po	1964
[THE TREATMENT OF EDEMA WITH SULFONAMIDE DIURETICS]. Vie medicale (Paris, France : 1920), 1964, Volume: 45 Topics: Acetazolamide; Acidosis; Benzothiadiazines; Chlorothiazide; Chlorthalidone; Dehydration; Diuretics;	1964
[CONSIDERATIONS ON THE RENAL SIDE-EFFECTS DURING TREATMENT OF ARTERIAL HYPERTENSION]. Medicina interna, 1964, Volume: 16 Topics: Bretylium Compounds; Chlorothiazide; Guanethidine; Hydralazine; Hydrochlorothiazide; Hypertension; K	1964
[CLINICAL AND BIOCHEMICAL EVALUATION OF THE DIURETIC ACTION OF HYPOTHIAZIDE]. Klinicheskaia meditsina, 1964, Volume: 42 Topics: Biomedical Research; Blood; Chlorine; Chlorothiazide; Diuretics; Drug Therapy; Edema; Heart Failure;	1964
DIURETICS IN RENAL DISEASE. Modern treatment, 1964, Volume: 1 Topics: Blood Circulation; Chlorides; Chlormerodrin; Chlorothiazide; Diuretics; Dogs; Edema; Injections, Int	1964
[2 CASES OF NEPHROGENIC DIABETES INSIPIDUS IN SIBLINGS]. Nihon Shonika Gakkai zasshi. Acta paediatrica Japonica, 1964, Volume: 68 Topics: Child; Chlorothiazide; Diabetes Insipidus; Diabetes Insipidus, Nephrogenic; Diabetes Insipidus, Neur	1964
[SECONDARY ASPECIFIC EFFECTS OF BENZOTHIAZINIC DIURETICS]. Minerva medica, 1964, Sep-08, Volume: 55 Topics: Agranulocytosis; Amylases; Blood Glucose; Chlorothiazide; Diabetes Mellitus; Diuretics; Drug Eruptio	1964
NEPHROGENIC DIABETES INSIPIDUS DUE TO SARCOIDOSIS WITHOUT HYPERCALCEMIA. Annals of internal medicine, 1965, Volume: 62 Topics: Biopsy; Black People; Chlorothiazide; Diabetes Insipidus; Diabetes Insipidus, Nephrogenic; Diagnosis	1965
RESULTS OF METHYLDOPA-CHLOROTHIAZIDE THERAPY IN HYPERTENSIVE PATIENTS WITH RENAL DISEASE. Journal of the South Carolina Medical Association, 1965, Volume: 61 Topics: Chlorothiazide; Drug Therapy; Humans; Hypertension; Kidney Diseases; Methyldopa; Toxicology	1965
POSSIBLY THIAZIDE-INDUCED RENAL NECROTISING VASCULITIS. Lancet (London, England), 1965, May-15, Volume: 1, Issue:7394 Topics: Chlorothiazide; Hydrochlorothiazide; Inflammation; Kidney Diseases; Necrosis; Pathology; Skin Diseas	1965
NEPHROGENIC DIABETES INSIPIDUS. THIS REPORT DESCRIBES AN INFANT WITH CHARACTERISTIC SYMPTOMS, THE INVESTIGATIONS WHICH LED TO THE DIAGNOSIS, AND THE PRINCIPLES OF MANAGEMENT. Clinical pediatrics, 1965, Volume: 4 Topics: Blood; Chlorides; Chlorothiazide; Diabetes Insipidus; Diabetes Insipidus, Nephrogenic; Diagnosis; Di	1965
[Inhibitory effect of ACTH and cortisone derivatives on diuretics. Observations in nephritis-nephrosis]. Munchener medizinische Wochenschrift (1950), 1960, May-27, Volume: 102 Topics: Adrenocorticotropic Hormone; Chlorothiazide; Cortisone; Diuretics; Kidney Diseases; Nephritis; Nephr	1960
[On the action of chlorothiazide in subjects with altered renal function]. Bollettino della Societa italiana di biologia sperimentale, 1959, Oct-31, Volume: 35 Topics: Chlorothiazide; Humans; Kidney Diseases; Urinary Tract Physiological Phenomena	1959
[Saluretics in the treatment of cardiac and renal edema]. Munchener medizinische Wochenschrift (1950), 1966, Dec-23, Volume: 108, Issue:51 Topics: Blood Circulation; Body Weight; Chlorothiazide; Diuretics; Edema; Ethacrynic Acid; Furosemide; Heart	1966
Tubular mechanism for the spontaneous hypercalciuria in laboratory rat. The Journal of clinical investigation, 1982, Volume: 70, Issue:4 Topics: Animals; Calcium; Chlorothiazide; Creatinine; Cyclic AMP; Female; Kidney Diseases; Kidney Tubules; M	1982
Renal insufficiency with combinations of angiotensin converting enzyme inhibitors and diuretics. British medical journal (Clinical research ed.), 1984, Mar-17, Volume: 288, Issue:6420 Topics: Adult; Angiotensin-Converting Enzyme Inhibitors; Captopril; Chlorothiazide; Dipeptides; Diuretics; E	1984
Nephrogenic diabetes insipidus in three dogs. Journal of the American Veterinary Medical Association, 1981, Aug-01, Volume: 179, Issue:3 Topics: Ampicillin; Animals; Chlorothiazide; Dexamethasone; Diabetes Insipidus; Dog Diseases; Dogs; Female;	1981
The effect of inhibition of prostaglandin synthesis on free water and osmolar clearances in patients with hereditary nephrogenic diabetes insipidus. The International journal of pediatric nephrology, 1980, Volume: 1, Issue:1 Topics: Adolescent; Child; Chlorothiazide; Diabetes Insipidus; Drug Combinations; Humans; Indomethacin; Kidn	1980
Nephrogenic diabetes insipidus associated with bilateral ureteral obstruction. Internal medicine (Tokyo, Japan), 1994, Volume: 33, Issue:4 Topics: Adult; Chlorothiazide; Diabetes Insipidus; Diclofenac; Humans; Ileal Neoplasms; Kidney Diseases; Lei	1994
Renal function testing: differentiation between a nephrotoxic agent and diuretic drugs. Journal of pharmaceutical sciences, 1977, Volume: 66, Issue:4 Topics: Acetazolamide; Animals; Chlorothiazide; Diuretics; Dogs; Ethacrynic Acid; Female; Hydrochlorothiazid	1977
Effects of acetazolamide on proximal tubule C1, Na, and HCO3 transport in normal and acidotic dogs during distal blockade. The Journal of clinical investigation, 1977, Volume: 60, Issue:1 Topics: Acetazolamide; Acidosis; Ammonium Chloride; Animals; Bicarbonates; Chlorides; Chlorothiazide; Dogs;	1977
Enhancement of cyclosporin nephrotoxicity by diuretic therapy. Clinical nephrology, 1989, Volume: 32, Issue:1 Topics: Adult; Chlorothiazide; Cyclosporins; Drug Interactions; Female; Humans; Kidney Diseases	1989
Pharmacologic probing of mercuric chloride-induced renal dysfunction in the neonatal rat. The Journal of pharmacology and experimental therapeutics, 1987, Volume: 242, Issue:1 Topics: Acetazolamide; Amiloride; Animals; Animals, Newborn; Chlorothiazide; Diuretics; Furosemide; Kidney;	1987
Arterial hypertension--northwest Florida public health survey. II. Diagnosis and treatment. Current therapeutic research, clinical and experimental, 1974, Volume: 16, Issue:11 Topics: Adult; Aged; Antihypertensive Agents; Blood Pressure; Blood Urea Nitrogen; Chlorothiazide; Diuretics	1974
Metabolism and blood levels of angiotensin II in normal subjects, renal disease, and essential hypertension. Circulation research, 1970, Volume: 27 Topics: Angiotensin II; Arteries; Blood Pressure; Chlorothiazide; Chromatography, Paper; Contraceptives, Ora	1970
Studies on the site of renal salt loss in a patient with Bartter's syndrome. Pediatric research, 1973, Volume: 7, Issue:2 Topics: Adolescent; Adult; Alkalosis; Angiotensin II; Biological Transport, Active; Blood Pressure; Child; C	1973
Clinical use of furosemide. Annals of the New York Academy of Sciences, 1966, Nov-22, Volume: 139, Issue:2 Topics: Blood Pressure; Blood Urea Nitrogen; Chlorothiazide; Diuresis; Furosemide; Glomerular Filtration Rat	1966
Diuretic response of a severely diseased kidney to furosemide. Canadian Medical Association journal, 1968, Dec-28, Volume: 99, Issue:25 Topics: Adult; Aged; Chlorothiazide; Diet, Sodium-Restricted; Diuresis; Drug Synergism; Female; Furosemide;	1968
[Value of blood uric acid determination during pregnancy]. La Presse medicale, 1968, Dec-14, Volume: 76, Issue:49 Topics: Chlorothiazide; Eclampsia; Female; Glomerular Filtration Rate; Humans; Kidney Diseases; Kidney Funct	1968
[Chlorothiazide and uric acid elimination]. Helvetica medica acta, 1963, Volume: 30, Issue:4 Topics: Chlorothiazide; Humans; Injections, Intravenous; Kidney Diseases; Uric Acid	1963
Chlorothiazide in the treatment of nephrogenic diabetes insipidus. The British journal of clinical practice, 1966, Volume: 20, Issue:10 Topics: Child, Preschool; Chlorothiazide; Diabetes Insipidus; Female; Humans; Infant; Kidney Diseases; Male	1966