chlorothiazide has been researched along with Heart Failure in 157 studies
Chlorothiazide: A thiazide diuretic with actions and uses similar to those of HYDROCHLOROTHIAZIDE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p812)
thiazide : Heterocyclic compound with sulfur and nitrogen in the ring.
chlorothiazide : 4H-1,2,4-benzothiadiazine 1,1-dioxide in which the hydrogen at position is substituted by chlorine and that at position 7 is substituted by a sulfonamide group. A diuretic, it is used for treatment of oedema and hypertension.
Heart Failure: A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Piretanide, a diuretic that acts on the loop of Henle, was used to treat patients with cardiac failure." | 9.05 | Comparison of piretanide and chlorothiazide in the treatment of cardiac failure. ( Gillies, A; Morgan, T; Myers, J, 1980) |
| "The efficacy of treatment with spironolactone for congestive heart failure secondary to congenital heart disease was studied in 21 infants under 1 year of age." | 9.05 | Spironolactone therapy in infants with congestive heart failure secondary to congenital heart disease. ( Fowler, RS; Hobbins, SM; Korey, AG; Rowe, RD, 1981) |
| "Metolazone and intravenous (IV) chlorothiazide are commonly used diuretics for sequential nephron blockade (SNB) in patients with acute decompensated heart failure (ADHF)." | 8.12 | Metolazone Versus Intravenous Chlorothiazide for Decompensated Heart Failure Sequential Nephron Blockade: A Retrospective Cohort Study. ( Biskupiak, J; Cisowska, T; Fang, JC; Jacobs, JA; Pan, IZ; Shah, KS, 2022) |
| "To assess the efficacy of intravenous chlorothiazide in patients with acute decompensated heart failure (ADHF) who were determined to be loop diuretic resistant and refractory to metolazone." | 7.83 | Efficacy of Intravenous Chlorothiazide for Refractory Acute Decompensated Heart Failure Unresponsive to Adjunct Metolazone. ( Altshuler, J; Cardinale, M; Testani, JM, 2016) |
| "To assess the efficacy and safety of intravenous (IV) chlorothiazide versus oral metolazone when added to loop diuretics in patients with acute decompensated heart failure (ADHF) and loop diuretic resistance." | 7.83 | Efficacy and Safety of Intravenous Chlorothiazide versus Oral Metolazone in Patients with Acute Decompensated Heart Failure and Loop Diuretic Resistance. ( Devabhakthuni, S; Ivaturi, V; Jiang, A; Liu, T; Reed, BN; Shulenberger, CE, 2016) |
| "To compare the effects of combination diuretic therapy with oral hydrochlorothiazide or intravenous chlorothiazide added to background intravenous loop diuretic therapy among patients hospitalized with heart failure." | 7.80 | Comparison of the effects of combination diuretic therapy with oral hydrochlorothiazide or intravenous chlorothiazide in patients receiving intravenous furosemide therapy for the treatment of heart failure. ( Kissling, KT; Pickworth, KK, 2014) |
| "The efficacy and side effects of the combination therapy of thiazide and furosemide administered to patients with refractory heart failure, for a prolonged period of time, were assessed." | 7.69 | Prolonged therapy by the combination of furosemide and thiazides in refractory heart failure and other fluid retaining conditions. ( Brif, I; Farfel, Z; Mayan, H; Mouallem, M, 1995) |
| "Metolazone was as effective as chlorothiazide to augment loop diuretic therapy in ADHF in most studies with no pooled difference in net or total urine output." | 6.66 | A Systematic Review and Meta-Analysis of Metolazone Compared to Chlorothiazide for Treatment of Acute Decompensated Heart Failure. ( Howard, ML; Janzen, KM; Steuber, TD, 2020) |
| "Piretanide, a diuretic that acts on the loop of Henle, was used to treat patients with cardiac failure." | 5.05 | Comparison of piretanide and chlorothiazide in the treatment of cardiac failure. ( Gillies, A; Morgan, T; Myers, J, 1980) |
| "The efficacy of treatment with spironolactone for congestive heart failure secondary to congenital heart disease was studied in 21 infants under 1 year of age." | 5.05 | Spironolactone therapy in infants with congestive heart failure secondary to congenital heart disease. ( Fowler, RS; Hobbins, SM; Korey, AG; Rowe, RD, 1981) |
| "Metolazone and intravenous (IV) chlorothiazide are commonly used diuretics for sequential nephron blockade (SNB) in patients with acute decompensated heart failure (ADHF)." | 4.12 | Metolazone Versus Intravenous Chlorothiazide for Decompensated Heart Failure Sequential Nephron Blockade: A Retrospective Cohort Study. ( Biskupiak, J; Cisowska, T; Fang, JC; Jacobs, JA; Pan, IZ; Shah, KS, 2022) |
| "To assess the efficacy of intravenous chlorothiazide in patients with acute decompensated heart failure (ADHF) who were determined to be loop diuretic resistant and refractory to metolazone." | 3.83 | Efficacy of Intravenous Chlorothiazide for Refractory Acute Decompensated Heart Failure Unresponsive to Adjunct Metolazone. ( Altshuler, J; Cardinale, M; Testani, JM, 2016) |
| "To assess the efficacy and safety of intravenous (IV) chlorothiazide versus oral metolazone when added to loop diuretics in patients with acute decompensated heart failure (ADHF) and loop diuretic resistance." | 3.83 | Efficacy and Safety of Intravenous Chlorothiazide versus Oral Metolazone in Patients with Acute Decompensated Heart Failure and Loop Diuretic Resistance. ( Devabhakthuni, S; Ivaturi, V; Jiang, A; Liu, T; Reed, BN; Shulenberger, CE, 2016) |
| "To compare the effects of combination diuretic therapy with oral hydrochlorothiazide or intravenous chlorothiazide added to background intravenous loop diuretic therapy among patients hospitalized with heart failure." | 3.80 | Comparison of the effects of combination diuretic therapy with oral hydrochlorothiazide or intravenous chlorothiazide in patients receiving intravenous furosemide therapy for the treatment of heart failure. ( Kissling, KT; Pickworth, KK, 2014) |
| "The efficacy and side effects of the combination therapy of thiazide and furosemide administered to patients with refractory heart failure, for a prolonged period of time, were assessed." | 3.69 | Prolonged therapy by the combination of furosemide and thiazides in refractory heart failure and other fluid retaining conditions. ( Brif, I; Farfel, Z; Mayan, H; Mouallem, M, 1995) |
| "Metolazone was as effective as chlorothiazide to augment loop diuretic therapy in ADHF in most studies with no pooled difference in net or total urine output." | 2.66 | A Systematic Review and Meta-Analysis of Metolazone Compared to Chlorothiazide for Treatment of Acute Decompensated Heart Failure. ( Howard, ML; Janzen, KM; Steuber, TD, 2020) |
| "This metolazone emulsion was capable of increasing urine volume output and demonstrated both natriuretic and kaliuretic properties." | 1.72 | Formulation, Characterization, and the Diuretic Effects of a New Intravenous Metolazone Emulsion. ( Ahlschwede, KM; Andey, T; Ofori, E; Osei, A; Somberg, JS, 2022) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 147 (93.63) | 18.7374 |
| 1990's | 1 (0.64) | 18.2507 |
| 2000's | 1 (0.64) | 29.6817 |
| 2010's | 4 (2.55) | 24.3611 |
| 2020's | 4 (2.55) | 2.80 |
| Authors | Studies |
|---|---|
| Ahlschwede, KM | 1 |
| Ofori, E | 1 |
| Andey, T | 1 |
| Osei, A | 1 |
| Somberg, JS | 1 |
| Cisowska, T | 1 |
| Pan, IZ | 1 |
| Biskupiak, J | 1 |
| Shah, KS | 1 |
| Fang, JC | 1 |
| Jacobs, JA | 1 |
| Cox, ZL | 1 |
| Hung, R | 1 |
| Lenihan, DJ | 1 |
| Testani, JM | 2 |
| Steuber, TD | 1 |
| Janzen, KM | 1 |
| Howard, ML | 1 |
| Kissling, KT | 1 |
| Pickworth, KK | 1 |
| Moranville, MP | 1 |
| Choi, S | 1 |
| Hogg, J | 1 |
| Anderson, AS | 1 |
| Rich, JD | 1 |
| Cardinale, M | 1 |
| Altshuler, J | 1 |
| Shulenberger, CE | 1 |
| Jiang, A | 1 |
| Devabhakthuni, S | 1 |
| Ivaturi, V | 1 |
| Liu, T | 1 |
| Reed, BN | 1 |
| SCHREINER, GE | 1 |
| BLOOMER, HA | 1 |
| LARAGH, JH | 3 |
| HEINEMANN, HO | 2 |
| DEMARTINI, FE | 1 |
| GOODKIND, MJ | 1 |
| HARVEY, RM | 1 |
| RICHARDS, DW | 1 |
| BAYLISS, RI | 1 |
| MARRACK, D | 1 |
| PIRKIS, J | 1 |
| REES, JR | 1 |
| ZILVA, JF | 1 |
| SLATER, JD | 1 |
| NABARRO, JD | 1 |
| DAVIES, DW | 1 |
| EVANS, B | 1 |
| WENER, J | 2 |
| FRIEDMAN, R | 2 |
| SCHUCHER, R | 2 |
| PECKENSCHNEIDER, LE | 1 |
| POKORNY, C | 1 |
| BECKER, MC | 2 |
| DI MASCOLO, R | 1 |
| DE NYSE, DL | 1 |
| ZUCKERMAN, AJ | 1 |
| CHAZAN, AA | 1 |
| NICROSINI, F | 1 |
| PICCINELLI, O | 1 |
| KEYES, JW | 4 |
| BERLACHER, FJ | 1 |
| VAN DER MEER, C | 1 |
| LINDEBOOM, GA | 1 |
| BEYER, T | 1 |
| ZONDAG, HA | 1 |
| VAN DER KOOI, MW | 1 |
| HARTOG, HA | 1 |
| BERRETA, JA | 1 |
| SALITA, S | 1 |
| ZUNDER, J | 1 |
| ROISINBLIT, R | 1 |
| ANUNZIATO, L | 1 |
| WARSHAW, LJ | 1 |
| FAIRWEATHER, MJ | 1 |
| LEWIS, JM | 1 |
| CHAPMAN, DW | 1 |
| FORD, RV | 1 |
| PLANCHEREL, P | 1 |
| HOFSTETTER, JR | 1 |
| KAINDL, F | 2 |
| KOHN, P | 2 |
| WATSCHINGER, B | 1 |
| DI PERRI, T | 1 |
| RAVENNI, G | 1 |
| HARVEY, SD | 1 |
| MANOR, B | 1 |
| DEGRAFF, AC | 1 |
| FITZPATRICK, DP | 1 |
| WYSO, EM | 2 |
| RICHARDSON, DW | 2 |
| SHAPIRA, A | 1 |
| CRAMER, G | 1 |
| BJORNTORP, P | 1 |
| GESSA, GL | 1 |
| VARGIU, L | 1 |
| ZANDA, CE | 1 |
| BREST, AN | 2 |
| BRENEMAN, GM | 3 |
| ALVAREZ, H | 2 |
| ARMAS CRUZ, R | 1 |
| HARNECKER, J | 1 |
| KUSMANIC, A | 1 |
| SAAVEDRA, J | 1 |
| MELFI, M | 1 |
| SCHIAFFINO, M | 1 |
| SUNNAH, E | 1 |
| VILLANUEVA, S | 1 |
| ACUNA, M | 1 |
| DONOSO, P | 1 |
| GUERRA, V | 1 |
| IBANEZ, E | 1 |
| GOFFARD, G | 1 |
| CONTI, E | 1 |
| FANCINI, P | 2 |
| DE BIASI, R | 1 |
| MANES, L | 1 |
| NOUAILLE, J | 2 |
| AUZEPY, P | 1 |
| OGDEN, DA | 1 |
| SCHERR, L | 1 |
| SPRITZ, N | 1 |
| RUBIN, AL | 1 |
| PORTER, GA | 2 |
| DAVID, NA | 1 |
| ROSENBLUM, MA | 1 |
| RUTISHAUSER, W | 1 |
| RHOMBERG, F | 1 |
| SACK, P | 1 |
| SETTEL, E | 2 |
| KOVACEVIC, M | 1 |
| BRCELJ, S | 1 |
| PERISIC, Z | 1 |
| LICHTIG, C | 1 |
| YOUNES, A | 1 |
| AJZEN, H | 1 |
| de MELLO, H | 1 |
| MAYER-BIRKHOF, K | 1 |
| TEODORESCU, P | 1 |
| LILIS, M | 1 |
| STEFAN, I | 1 |
| TINCU, S | 1 |
| SIRBULESCU, R | 1 |
| POMPILIAN, P | 1 |
| CUCU, N | 1 |
| STERIAN, I | 1 |
| CASTOLDI, P | 1 |
| CAVELL, GF | 1 |
| D'ALESANDRO, S | 1 |
| GURMINDO, BJ | 1 |
| ESEREQUIS, M | 1 |
| CERROTTI, MI | 1 |
| DATEY, KK | 1 |
| SHAH, PM | 1 |
| KURIEN, J | 1 |
| EILERSEN, P | 1 |
| BERTHELSEN, HC | 1 |
| FERRERO, C | 1 |
| LENEGRE, J | 1 |
| SCEBAT, L | 1 |
| DORET, JP | 1 |
| LOIZEAU, E | 1 |
| FUCHS, M | 1 |
| MALLIN, SR | 1 |
| IRIE, S | 1 |
| LIPPMANN, E | 1 |
| WEINER, AA | 1 |
| LEVINE, J | 1 |
| RUSSO, JL | 1 |
| ZAGALA, J | 1 |
| WEISSEL, W | 1 |
| MAYMAN, A | 1 |
| DJORDJEVIC, BS | 1 |
| LAMBIE, I | 1 |
| BUDIMIR, M | 1 |
| FORTIN, P | 1 |
| BERNARD-BRUNEL, J | 1 |
| GAY, A | 1 |
| SANTI, ML | 1 |
| PERASSO, F | 1 |
| GLAUBITT, D | 1 |
| RAUSCH-STROOMANN, JG | 1 |
| HARNAGEA, P | 2 |
| OLINESCU, R | 1 |
| SUTIANU, A | 1 |
| SHARAPOV, UB | 1 |
| SPRING, M | 1 |
| STEIN, I | 1 |
| KATABI, G | 1 |
| VERTES, V | 1 |
| KATZ, JB | 1 |
| ROBINOW, SH | 1 |
| VILLARREAL, H | 1 |
| LINTRUP, J | 2 |
| FRIIS, T | 2 |
| NISSEN, NI | 2 |
| BENATI, E | 1 |
| TOLVA, D | 1 |
| ADAMSKA-MARCINKOWSKA, H | 1 |
| KREIDBERG, MB | 1 |
| CHERNOFF, HL | 1 |
| LOPEZ, WL | 1 |
| JUNG, I | 1 |
| CSERNAY, L | 1 |
| VARRO, V | 1 |
| HAUCK, AJ | 1 |
| NADAS, AS | 1 |
| BARNETT, AJ | 1 |
| BAUMGARTEN, A | 1 |
| BRANDSTATER, M | 1 |
| DOBREANU-ENESCU, V | 1 |
| TEODORINI, S | 1 |
| VLADESCU, C | 1 |
| CHIAVERINI, R | 1 |
| BRETTELL, HR | 1 |
| SMITH, JG | 1 |
| AIKAWA, JK | 1 |
| EVANS, DW | 1 |
| FLEAR, CT | 1 |
| DOMENET, JG | 1 |
| JANUARY, LE | 1 |
| KIRKENDALL, WM | 2 |
| THEILEN, EO | 1 |
| ECKSTEIN, JW | 1 |
| SALVAGGIO, JE | 1 |
| KEITT, AS | 1 |
| LOWELL, FC | 1 |
| FRANKLIN, W | 1 |
| YOSHIDA, T | 1 |
| NIMURA, Y | 1 |
| SAKAKIBARA, H | 1 |
| MATSUTANI, K | 1 |
| NISHIZAKI, K | 1 |
| NAKATA, T | 1 |
| LEDINGHAM, JG | 1 |
| ARMASCRUZ, R | 1 |
| GOMEZ, R | 1 |
| MARDONES, J | 1 |
| PLAZADELOSREYES, M | 1 |
| POLIMENI, R | 1 |
| MARCHESE, G | 1 |
| BAGROS, P | 1 |
| PLATT, MA | 1 |
| NIELSEN, OE | 1 |
| WILLUMSEN, J | 1 |
| GARFUNKEL, JM | 1 |
| WELLS, CR | 1 |
| LIEBMAN, J | 1 |
| GADBOYS, HL | 1 |
| WISOFF, G | 1 |
| LITWAK, RS | 1 |
| MERZON, AK | 1 |
| KASIANOVA, TN | 1 |
| WALSH, AC | 1 |
| MOYES, A | 1 |
| KROPP, AD | 1 |
| LIUM, O | 1 |
| TVETER, KJ | 1 |
| BERLYNE, GM | 1 |
| TAVILL, AS | 1 |
| DE BAKER, SB | 1 |
| CANNON, PJ | 2 |
| STASON, WB | 1 |
| SILBERSTEIN, EB | 1 |
| HUTCHEON, DE | 1 |
| MEHTA, D | 1 |
| ROMANO, A | 1 |
| PELTOLA, P | 1 |
| JACONO, A | 1 |
| GUERRIERI, R | 1 |
| DE CIUTIIS, D | 1 |
| ARPINO, E | 1 |
| LOURENCO, RV | 1 |
| TELES, EM | 1 |
| MALTEZ, JS | 1 |
| PERRIN, A | 2 |
| FATH, A | 2 |
| DESCROIX, M | 2 |
| DUPORTET, B | 2 |
| PRINO, G | 1 |
| ROMANI, JD | 1 |
| KUTTNER, H | 1 |
| SABBAGA, E | 1 |
| SALDANHA, RV | 1 |
| de FARIA, C | 1 |
| NUSSENZVEIG, I | 1 |
| HUEDEPOHL, M | 1 |
| LEDERBOGEN, K | 1 |
| KARTUN, P | 1 |
| AZERAD, E | 1 |
| KHAJAVI, A | 1 |
| KRAVCHENKO, GT | 1 |
| OLESEN, K | 3 |
| SANDOE, E | 3 |
| PINTO, IJ | 1 |
| DIVEKAR, MV | 1 |
| RAGHAVAN, P | 1 |
| MEHTA, DJ | 1 |
| SHETH, UK | 1 |
| PUDDU, HS | 1 |
| Vorburger, C | 1 |
| Cottier, P | 1 |
| Pyle, RL | 1 |
| Gillies, A | 1 |
| Morgan, T | 1 |
| Myers, J | 1 |
| Hobbins, SM | 1 |
| Fowler, RS | 1 |
| Rowe, RD | 1 |
| Korey, AG | 1 |
| Mouallem, M | 1 |
| Brif, I | 1 |
| Mayan, H | 1 |
| Farfel, Z | 1 |
| Puschett, JB | 1 |
| Rosenquist, GC | 1 |
| Taylor, JF | 1 |
| Stark, J | 1 |
| Viles, PH | 1 |
| Manning, JA | 1 |
| Hastings, SG | 1 |
| Johnston, DJ | 1 |
| Blouin, LT | 1 |
| Sycheva, IM | 1 |
| Vinogradov, AV | 1 |
| Bennett, WM | 1 |
| Bagby, GC | 1 |
| Antonovic, JN | 1 |
| Lindy, S | 1 |
| Tarssanen, L | 1 |
| Kabakov, AI | 2 |
| Bucur, V | 1 |
| Bunghez, G | 1 |
| Bull, MB | 1 |
| Kumbhani, AP | 1 |
| Votchal, BE | 1 |
| Vagnucci, AH | 1 |
| Nash, HL | 1 |
| Fitz, AE | 1 |
| Wilson, WR | 1 |
| Kioschos, JM | 1 |
| Moyer, JH | 1 |
| Arnott, WM | 1 |
| Botticelli, JT | 1 |
| Schlueter, DP | 1 |
| Lange, RL | 1 |
| Hickie, JB | 1 |
| Lazarus, L | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Comparison of Oral Thiazides vs Intravenous Thiazides vs Tolvaptan in Combination With Loop Diuretics for Diuretic Resistant Decompensated Heart Failure[NCT02606253] | Phase 4 | 60 participants (Actual) | Interventional | 2016-02-29 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Change in estimated glomerular filtration rate (ml/min/m2) from baseline to 48 hours (NCT02606253)
Timeframe: 48 hours
| Intervention | ml/min/m2 (Mean) |
|---|---|
| Metolazone | -6 |
| Chlorothiazide | -9 |
| Tolvaptan | 2 |
"Participants will score their congestion on a 10cm scale ranging from Best (10cm) to Worst (0cm). Change in score (units in centimeters) from baseline to 48 hours." (NCT02606253)
Timeframe: 48 hours
| Intervention | cm of dyspena analog scale (Median) |
|---|---|
| Metolazone | 4.0 |
| Chlorothiazide | 3.0 |
| Tolvaptan | 3.0 |
Change in serum chloride (mEq/L) from baseline to 48 hrs (NCT02606253)
Timeframe: 48 hours
| Intervention | mEq/L (Mean) |
|---|---|
| Metolazone | -7 |
| Chlorothiazide | -7 |
| Tolvaptan | 2 |
Diuretic Efficiency is calculated as 48hr urine output/ 48hr Furosemide equivalents in milligrams (NCT02606253)
Timeframe: 48 hours
| Intervention | UOP / 40mg IV furosemide (Mean) |
|---|---|
| Metolazone | 217 |
| Chlorothiazide | 294 |
| Tolvaptan | 326 |
Mean change in glomerular filtration rate from enrollment to end of study at hospital discharge, an average of 5 days (NCT02606253)
Timeframe: hospital discharge an average of 5 days
| Intervention | ml/min/m2 (Mean) |
|---|---|
| Metolazone | -2 |
| Chlorothiazide | -2 |
| Tolvaptan | -6 |
Mean change in serum creatinine (mg/dl) from enrollment to end of study at 48 hours (NCT02606253)
Timeframe: 48 hours
| Intervention | mg/dl (Mean) |
|---|---|
| Metolazone | 0.3 |
| Chlorothiazide | 0.5 |
| Tolvaptan | 0.03 |
Mean change in serum potassium (mEq/L) from enrollment to end of study at 48 hours (NCT02606253)
Timeframe: 48 hours
| Intervention | mEq/L (Mean) |
|---|---|
| Metolazone | -0.1 |
| Chlorothiazide | -0.2 |
| Tolvaptan | 0.1 |
Mean change in serum sodium (mEq/L) from enrollment to end of study at 48 hours (NCT02606253)
Timeframe: 48 hours
| Intervention | mEq/L (Mean) |
|---|---|
| Metolazone | -1 |
| Chlorothiazide | -1 |
| Tolvaptan | 4 |
Net urine output from enrollment to the end of study at 48 hours measured in liters (NCT02606253)
Timeframe: 48 hours
| Intervention | liters (Median) |
|---|---|
| Metolazone | -7.8 |
| Chlorothiazide | -8.8 |
| Tolvaptan | -9.8 |
Incidence of new atrial or ventricular arrhythmias from enrollment to end of study at 48 hours (NCT02606253)
Timeframe: 48 hours
| Intervention | Participants (Count of Participants) |
|---|---|
| Metolazone | 0 |
| Chlorothiazide | 0 |
| Tolvaptan | 0 |
Provider escalation of loop diuretic dosage at 24 hours for urine output less than 3 L at 24 hours (NCT02606253)
Timeframe: 24 hours
| Intervention | Participants (Count of Participants) |
|---|---|
| Metolazone | 4 |
| Chlorothiazide | 4 |
| Tolvaptan | 2 |
Incidence of hypokalemia (serum potassium less than 3.5mEq/L ) from enrollment to end of study (NCT02606253)
Timeframe: 48 hours
| Intervention | Participants (Count of Participants) |
|---|---|
| Metolazone | 3 |
| Chlorothiazide | 2 |
| Tolvaptan | 2 |
Incidence of death from study enrollment to hospital discharge, an average of 5 days (NCT02606253)
Timeframe: Enrollment to hospital discharge an average of 5 days
| Intervention | Participants (Count of Participants) |
|---|---|
| Metolazone | 0 |
| Chlorothiazide | 0 |
| Tolvaptan | 0 |
Incidence of new initiation of dopamine, dobutamine, or milrinone from enrollment to end of study at 48 hours (NCT02606253)
Timeframe: 48 hours
| Intervention | Participants (Count of Participants) |
|---|---|
| Metolazone | 1 |
| Chlorothiazide | 0 |
| Tolvaptan | 2 |
Incidence of Renal replacement therapy utilization (hemodialysis, ultrafiltration) from enrollment to hospital discharge, an average of 5 days (NCT02606253)
Timeframe: enrollment to hospital discharge an average of 5 days
| Intervention | Participants (Count of Participants) |
|---|---|
| Metolazone | 0 |
| Chlorothiazide | 0 |
| Tolvaptan | 0 |
SBP < 85 mmHg plus medical intervention for symptomatic hypotension (NCT02606253)
Timeframe: 48 hours
| Intervention | Participants (Count of Participants) |
|---|---|
| Metolazone | 2 |
| Chlorothiazide | 0 |
| Tolvaptan | 2 |
Cumulative dose of potassium supplementation (mEq) administered from enrollment to end of study at 48 hours (NCT02606253)
Timeframe: 48 hours
| Intervention | mEq (Mean) |
|---|---|
| Metolazone | 103 |
| Chlorothiazide | 63 |
| Tolvaptan | 58 |
The primary outcome will be 48-hour standing scale weight change (kg) from enrollment among the metolazone, intravenous chlorothiazide, and tolvaptan arms, using metolazone group as the comparator group for all other groups. (NCT02606253)
Timeframe: 48 hours
| Intervention | kg (Mean) |
|---|---|
| Metolazone | -4.6 |
| Chlorothiazide | -5.8 |
| Tolvaptan | -4.1 |
7 reviews available for chlorothiazide and Heart Failure
| Article | Year |
|---|---|
A Systematic Review and Meta-Analysis of Metolazone Compared to Chlorothiazide for Treatment of Acute Decompensated Heart Failure.
Topics: Chlorothiazide; Diuretics; Heart Failure; Humans; Metolazone | 2020 |
HEART FAILURE IN INFANTS AND CHILDREN. SURVEY OF RECENT LITERATURE, ETIOLOGIC CONSIDERATIONS AND RECOMMENDATIONS FOR THERAPY.
Topics: Arrhythmias, Cardiac; Cardiac Surgical Procedures; Child; Chlorothiazide; Coxsackievirus Infections; | 1963 |
[THE WATER-ELECTROLYTE STATE IN EDEMA CAUSED BY CONGESTIVE CARDIO-CIRCULATORY INSUFFICIENCY. PHYSIOPATHOGENETIC CONSIDERATIONS AND THERAPEUTIC TRENDS].
Topics: Adrenal Cortex Hormones; Aldosterone; Chlorothiazide; Diet; Diet Therapy; Diuretics; Edema; Electrol | 1964 |
Diuretics and the therapy of hypertension.
Topics: Antihypertensive Agents; Blood Pressure; Chlorothiazide; Diuretics; Edema; Furosemide; Guidelines as | 2000 |
[Pathogenesis and therapy of Cardiac edema].
Topics: Capillary Permeability; Chlorothiazide; Diuretics; Glomerular Filtration Rate; Heart Failure; Heart | 1972 |
Diuretics in edema: how they work; how to pick the best one.
Topics: Carbonic Anhydrase Inhibitors; Chlorothiazide; Diuretics; Edema; Ethacrynic Acid; Furosemide; Heart | 1972 |
Recent advances in the treatment of congenital heart disease.
Topics: Age Factors; Arrhythmias, Cardiac; Child; Child, Preschool; Chlorothiazide; Diet, Sodium-Restricted; | 1974 |
3 trials available for chlorothiazide and Heart Failure
| Article | Year |
|---|---|
Diuretic Strategies for Loop Diuretic Resistance in Acute Heart Failure: The 3T Trial.
Topics: Administration, Oral; Aged; Chlorothiazide; Diuretics; Dose-Response Relationship, Drug; Double-Blin | 2020 |
Comparison of piretanide and chlorothiazide in the treatment of cardiac failure.
Topics: Adult; Aged; Body Weight; Chlorothiazide; Clinical Trials as Topic; Diuretics; Heart Failure; Humans | 1980 |
Spironolactone therapy in infants with congestive heart failure secondary to congenital heart disease.
Topics: Chlorothiazide; Clinical Trials as Topic; Digoxin; Drug Therapy, Combination; Female; Heart Defects, | 1981 |
147 other studies available for chlorothiazide and Heart Failure
| Article | Year |
|---|---|
Formulation, Characterization, and the Diuretic Effects of a New Intravenous Metolazone Emulsion.
Topics: Administration, Intravenous; Animals; Chlorothiazide; Diuretics; Emulsions; Heart Failure; Metolazon | 2022 |
Metolazone Versus Intravenous Chlorothiazide for Decompensated Heart Failure Sequential Nephron Blockade: A Retrospective Cohort Study.
Topics: Chlorothiazide; Diuretics; Furosemide; Heart Failure; Humans; Metolazone; Nephrons; Retrospective St | 2022 |
Comparison of the effects of combination diuretic therapy with oral hydrochlorothiazide or intravenous chlorothiazide in patients receiving intravenous furosemide therapy for the treatment of heart failure.
Topics: Administration, Intravenous; Administration, Oral; Aged; Chlorothiazide; Diuretics; Drug Therapy, Co | 2014 |
Comparison of metolazone versus chlorothiazide in acute decompensated heart failure with diuretic resistance.
Topics: Acute Disease; Administration, Intravenous; Administration, Oral; Aged; Chicago; Chlorothiazide; Dru | 2015 |
Efficacy of Intravenous Chlorothiazide for Refractory Acute Decompensated Heart Failure Unresponsive to Adjunct Metolazone.
Topics: Acute Disease; Administration, Intravenous; Adult; Aged; Chlorothiazide; Diuretics; Female; Heart Fa | 2016 |
Efficacy and Safety of Intravenous Chlorothiazide versus Oral Metolazone in Patients with Acute Decompensated Heart Failure and Loop Diuretic Resistance.
Topics: Acute Disease; Administration, Intravenous; Administration, Oral; Adult; Aged; Chlorothiazide; Cohor | 2016 |
Effect of chlorothiazide on the edema of cirrhosis, nephrosis, congestive heart failure and chronic renal insufficiency.
Topics: Chlorothiazide; Diuretics; Edema; Fibrosis; Heart Failure; Humans; Nephrosis; Renal Insufficiency, C | 1957 |
Effect of chlorothiazide on electrolyte transport in man; its use in the treatment of edema of congestive heart failure, nephrosis, and cirrhosis.
Topics: Acetazolamide; Chlorothiazide; Edema; Electrolytes; Heart Failure; Liver Cirrhosis; Nephrosis | 1958 |
Use of chlorothiazide in the treatment of edema.
Topics: Acetazolamide; Chlorothiazide; Edema; Heart Failure | 1958 |
Chlorothiazide: an oral diuretic.
Topics: Acetazolamide; Chlorothiazide; Diuretics; Edema; Heart Failure | 1958 |
Clinical experience with chlorothiazide.
Topics: Acetazolamide; Ascites; Chlorothiazide; Gastrointestinal Diseases; Heart Failure; Hypertension; Hype | 1958 |
Early observations on the diuretic effort of oral chlorothiazide.
Topics: Chlorothiazide; Diuretics; Heart Failure | 1958 |
Chlorothiazide in the management of cardiac oedema.
Topics: Acetazolamide; Chlorothiazide; Disease Management; Edema, Cardiac; Heart Failure | 1958 |
Oral diuril; its use in therapy of chronic heart failure.
Topics: Acetazolamide; Chlorothiazide; Chronic Disease; Heart Failure | 1958 |
Chlorothiazide as a diuretic and hypotensive agent.
Topics: Acetazolamide; Antihypertensive Agents; Chlorothiazide; Diuretics; Heart Failure; Hypertension | 1958 |
[Research on the diuretic effect of chlorothiazide in heart diseases].
Topics: Acetazolamide; Chlorothiazide; Diuretics; Heart Diseases; Heart Failure; Research | 1958 |
Clinical evaluation with serum concentration studies of chlorothiazide (diuril).
Topics: Acetazolamide; Chlorothiazide; Heart Failure; Hypertension; Research | 1958 |
Agranulocytosis with thrombocytopenia following chlorothiazide therapy.
Topics: Acetazolamide; Agranulocytosis; Blood Platelets; Chlorothiazide; Heart Failure; Thrombocytopenia | 1958 |
[First observations on the combined use of prednisone & chlorothiazide in the treatment of water retention states].
Topics: Acetazolamide; Chlorothiazide; Edema; Extremities; Heart Failure; Prednisone; Water-Electrolyte Bala | 1958 |
Chlorothiazide (diuril): a new, nonmercurial, orally given diuretic.
Topics: Acetazolamide; Chlorothiazide; Diuresis; Diuretics; Heart Failure | 1959 |
Chlorothiazide in congestive heart failure.
Topics: Acetazolamide; Chlorothiazide; Heart Failure | 1958 |
[Treatment of cardiac decompensation with chlorothiazide].
Topics: Acetazolamide; Chlorothiazide; Heart Failure | 1958 |
[Clinical evaluation of a new oral diuretic: chlorothiazide].
Topics: Acetazolamide; Chlorothiazide; Diuretics; Heart Failure | 1958 |
Evaluation of chlorothiazide in the diuretic therapy of congestive heart failure.
Topics: Acetazolamide; Chlorothiazide; Diuretics; Heart Failure; Humans | 1959 |
Comparison of the diuretic effects of oral administration of chlorothiazide and parenteral administration of mercaptomerin.
Topics: Acetazolamide; Administration, Oral; Chlorothiazide; Diuretics; Heart Failure; Humans; Liver Cirrhos | 1959 |
[Treatment of cardiac edema with chlorothiazide (chlotride)].
Topics: Acetazolamide; Chlorothiazide; Edema, Cardiac; Heart Failure | 1959 |
[Chlorothiazide (chlotride) treatment of cardiac and liver insufficiency with water retention].
Topics: Acetazolamide; Chlorothiazide; Heart Failure; Hepatic Insufficiency; Liver Diseases; Water-Electroly | 1959 |
[Effectiveness of chlorothiazide (chlotride) in cardiac decompensation].
Topics: Acetazolamide; Chlorothiazide; Heart Failure | 1958 |
[Chlorothiazide in depletive therapy of congestive heart failure].
Topics: Acetazolamide; Chlorothiazide; Heart Failure | 1959 |
Clinical experience with chlorothiazide in the treatment of congestive heart failure.
Topics: Acetazolamide; Chlorothiazide; Heart Failure | 1959 |
Chlorothiazide in the treatment of severe congestive heart failure.
Topics: Acetazolamide; Chlorothiazide; Heart Failure | 1959 |
[Chlorothiazide in the treatment of cardiac failure].
Topics: Acetazolamide; Chlorothiazide; Heart Failure | 1959 |
[Extraordinary diuresis induced by chlorothiazide in posthypertensive cardiac insufficiency].
Topics: Acetazolamide; Chlorothiazide; Diuresis; Heart Failure; Hypertension | 1959 |
[Chlorothiazide in cardiac insufficiency].
Topics: Acetazolamide; Chlorothiazide; Heart Failure | 1959 |
[Diuretic activity of chlorothiazide. I. Action of chlorothiazide on drug-induced water retention].
Topics: Acetazolamide; Chlorothiazide; Diuretics; Edema; Extremities; Heart Failure; Water-Electrolyte Balan | 1959 |
The use of chlorothiazide and hydrochlorothiazide in the treatment of congestive heart failure.
Topics: Acetazolamide; Chlorothiazide; Heart Failure; Hydrochlorothiazide | 1959 |
Chlorothiazide and hydrochlorothiazide in the treatment of congestive heart failure.
Topics: Acetazolamide; Chlorothiazide; Heart Failure; Hydrochlorothiazide | 1959 |
[Effect of chlorothiazide in the treatment of syndrome with water-salt retention & arterial hypertension].
Topics: Acetazolamide; Body Fluids; Chlorothiazide; Heart Failure; Hypertension; Sodium Chloride, Dietary; W | 1959 |
[Chlorothiazide: a new diuretic in the treatment of cardiac insufficiency].
Topics: Acetazolamide; Chlorothiazide; Diuretics; Heart Failure | 1959 |
Trichlormethiazide in the management of congestive heart failure.
Topics: Chlorothiazide; Disease Management; Heart Failure; Trichlormethiazide | 1961 |
[Clinical study on the diuretic effect of the combined administration of 1-beta-hydroxypropyl-theobromine and 6-chloro-7-sulfamyl-1,2,4-benzothiodiazine-1, 1-dioxido in heart patients with water retention].
Topics: Chlorothiazide; Combined Modality Therapy; Diuretics; Edema; Heart Failure; Theobromine; Water-Elect | 1961 |
[The clinical use of hydrochlorothiazide in the therapy of cardiocirculatory insufficiency].
Topics: Chlorothiazide; Heart Failure; Humans; Hydrochlorothiazide | 1960 |
[On the diuretic effect of dexamethasone and of the combination of chlorothiazide and dexamethasone].
Topics: Chlorothiazide; Dexamethasone; Diuretics; Glomerulonephritis; Heart Failure; Liver Cirrhosis; Organi | 1960 |
[Medical treatment of cardiac insufficiency in infants].
Topics: Child; Chlorothiazide; Digitalis; Heart Failure; Humans; Infant; Plant Extracts | 1961 |
A comparison of the properties of chlorothiazide, spironolactone and a combination of both as diuretic agents.
Topics: Aldosterone; Chlorothiazide; Diuretics; Heart Failure; Liver Cirrhosis; Mineralocorticoid Receptor A | 1961 |
Hydrochlorothiazide used alone in congestive heart failure and in combination with prednisone and other diuretics in cirrhosis and nephrosis.
Topics: Chlorothiazide; Diuretics; Heart Failure; Hydrochlorothiazide; Liver Cirrhosis; Nephrosis; Prednison | 1960 |
Some effects of diuresis with hydrochlorothiazide.
Topics: Chlorothiazide; Diuresis; Heart Failure; Hydrochlorothiazide; Liver Diseases; Organic Chemicals | 1960 |
[On changes in the blood circulation time during the treatment of hemodynamic cardiac insufficiency with diuretics and cardiac glycosides].
Topics: Aldosterone; Blood Circulation; Blood Circulation Time; Cardanolides; Cardiac Glycosides; Cardiotoni | 1960 |
Combined spironolactone-hydrochlorothiazide (Aldactazide) treatment in refractory congestive failure.
Topics: Chlorothiazide; Drug Combinations; Heart Failure; Hydrochlorothiazide; Lactones; Spironolactone | 1961 |
[Hydrochlorothiazide in the treatment of cardiac edema and of its effects on electrolyte metabolism].
Topics: Chlorothiazide; Edema, Cardiac; Electrolytes; Heart Failure; Hydrochlorothiazide | 1960 |
[Comparative study of the acute effects of hydrochlorothiazide in relation to chlorothiazide and other mercurial diuretics].
Topics: Chlorothiazide; Diuretics; Heart Failure; Hydrochlorothiazide | 1961 |
[On the treatment of edemas of various causes with Esmarin].
Topics: Chlorothiazide; Edema; Heart Failure | 1961 |
[Treatment with sulfonamide diuretics in refractory cardiac insufficiency].
Topics: Chlorothiazide; Diuretics; Heart Failure; Sulfanilamide; Sulfanilamides; Sulfonamides | 1961 |
Treatment of congestive heart failure with 3-benzyl dihydroflumethiazide: preliminary report.
Topics: Chlorothiazide; Heart Failure | 1959 |
[Chlorothiazide in decompensated hypertensive heart disease].
Topics: Chlorothiazide; Heart Diseases; Heart Failure; Humans; Hypertension | 1959 |
Hydrochlorothiazide in severe congestive heart failure. Clinical experience in the treatment.
Topics: Chlorothiazide; Heart Failure; Hydrochlorothiazide | 1959 |
[On a new orally-administered diuretic].
Topics: Chlorothiazide; Diuretics; Heart Failure | 1959 |
Hydrochlorothiazide as a diuretic agent. Preliminary report of our clinical trials.
Topics: Chlorothiazide; Diuretics; Heart Failure; Hydrochlorothiazide | 1960 |
[Long-term treatment of chronic cardiac decompensation with hydroflumethiazide (rontyl). 14-Months experience].
Topics: Chlorothiazide; Heart Failure; Humans; Hydroflumethiazide; Long-Term Care | 1960 |
[Study of the immediate hemodynamic effect of chlorothiazide on the cardiac patient].
Topics: Chlorothiazide; Heart Failure; Hemodynamics | 1960 |
Diuretic effects of flumethiazide, a benzothiadiazine derivative.
Topics: Benzothiadiazines; Chlorothiazide; Diuretics; Heart Failure; Humans | 1959 |
Treatment of congestive heart failure and hypertension: clinical experience with hydrochlorothiazide.
Topics: Chlorothiazide; Heart Failure; Hydrochlorothiazide; Hypertension | 1960 |
[Treatment of cardiac edema with chlorothiazide].
Topics: Chlorothiazide; Edema, Cardiac; Heart Failure | 1959 |
Hydrochlorothiazide (hydrodiuril) in the management of cardiac oedema.
Topics: Chlorothiazide; Disease Management; Edema, Cardiac; Heart Failure; Hydrochlorothiazide | 1959 |
[Our experience with hydrochlorothiazide in the treatment of cardiac insufficiency].
Topics: Chlorothiazide; Heart Failure; Hydrochlorothiazide | 1961 |
[Results obtained in cardiac insufficiency by the use of a new diuretic: S-3500].
Topics: Chlorothiazide; Diuretics; Heart Failure | 1961 |
[Clinical and laboratory observations on a new salidiuretic: polythiazide].
Topics: Chlorothiazide; Edetic Acid; Heart Failure; Humans; Polythiazide | 1962 |
[Magnesium, calcium and phosphorus balances in essential hypertension and heart insufficiency in the treatment with hydrochlorothiazide].
Topics: Calcium, Dietary; Chlorothiazide; Essential Hypertension; Heart Failure; Humans; Hydrochlorothiazide | 1962 |
[The diuretic effect of chlorothiazide in cardiac insufficiency and liver cirrhosis].
Topics: Chlorothiazide; Diuretics; Heart Failure; Liver Cirrhosis; Organic Chemicals | 1961 |
[Comparative evaluation of diuretic action of novurit, hypothiazide, diacarb in circulatory insufficiency].
Topics: Acetazolamide; Alkylmercury Compounds; Chlorothiazide; Diuretics; Drug Combinations; Heart Failure; | 1961 |
Cardiac failure treated with polythiazide.
Topics: Chlorothiazide; Heart Failure; Polythiazide | 1962 |
The use of a new diuretic (polythiazide) in congestive failure and hypertension.
Topics: Chlorothiazide; Diuretics; Edetic Acid; Heart Failure; Hypertension; Polythiazide | 1962 |
Comparison of short term metabolic effects of hydroflumethiazide and hydrochlorothiazide.
Topics: Chlorothiazide; Heart Failure; Humans; Hydrochlorothiazide; Hydroflumethiazide; Hypertension; Ions; | 1962 |
[Thiazides and mercurials in cardiac insufficiency].
Topics: Chlorothiazide; Diuretics; Heart Failure; Organomercury Compounds; Thiazides | 1962 |
[Diuretic action of chlorothiazide and spironolactone in edema of cardiac and hepatic origin].
Topics: Chlorothiazide; Diuretics; Edema; Heart Failure; Liver Diseases; Spironolactone | 1963 |
[Use of combined cardiotonic-diuretic-tranquilizing therapy in circulatory insufficiency].
Topics: Cardiotonic Agents; Chlorothiazide; Digitoxin; Diuretics; Heart Failure; Humans; Hypnotics and Sedat | 1962 |
[Comparative studies on the diuretic effect of diurazine and other commonly used diuretics].
Topics: Acetazolamide; Chlorothiazide; Diuretics; Heart Failure; Humans; Liver Cirrhosis; Organomercury Comp | 1963 |
Treatment of cardiac failure in infancy and childhood.
Topics: Child; Chlorothiazide; Digoxin; Diuretics; Heart Defects, Congenital; Heart Failure; Humans; Morphin | 1963 |
[The role of water retention in the pathogenesis of experimental phenylbutazone ulcer].
Topics: Acetazolamide; Chlorothiazide; Diuretics; Edema; Heart Failure; Organomercury Compounds; Peptic Ulce | 1963 |
OBSERVATIONS ON TRIAMTERENE--A NEW DIURETIC.
Topics: Chlorides; Chlorothiazide; Coronary Disease; Craniocerebral Trauma; Diuretics; Edema; Geriatrics; He | 1963 |
[CONSIDERATIONS ON TREATMENT WITH SALURETIC SULFONAMIDES IN CARDIAC INSUFFICIENCY].
Topics: Benzothiadiazines; Chlorothiazide; Diuretics; Heart Failure; Hydrochlorothiazide; Organomercury Comp | 1963 |
COMPARATIVE STUDIES ON THE DIURETIC EFFECT OF CHLOROTHIAZIDE AND SPIRONOLACTONE IN CARDIAC AND HEPATOGENIC OEDEMA.
Topics: Chlorothiazide; Diuretics; Edema; Heart Failure; Liver Cirrhosis; Prednisone; Spironolactone | 1963 |
[DIURETIC THERAPEUTICS].
Topics: Acetazolamide; Aminophylline; Chlorothiazide; Diuretics; Edema; Ethylenediamines; Heart Failure; Liv | 1963 |
S35-LABELED BENDROFLUMETHIAZIDE IN HUMAN BEINGS: CLINICAL STUDIES.
Topics: Adolescent; Bendroflumethiazide; Chlorothiazide; Geriatrics; Heart Failure; Humans; Hydrochlorothiaz | 1964 |
SPIRONOLACTONE AS AN ADJUVANT TO THE TREATMENT OF CONGESTIVE CARDIAC FAILURE.
Topics: Blood; Body Weight; Chlorothiazide; Heart Failure; Humans; Potassium; Sodium; Spironolactone; Urea; | 1964 |
CONCEPTS IN THE PATHOGENESIS AND TREATMENT OF CONGESTIVE HEART FAILURE.
Topics: Chlorothiazide; Digitalis Glycosides; Diuretics; Heart Failure; Heparin; Humans; Kidney Diseases; Po | 1964 |
ASPIRIN-INDUCED BRONCHIAL ASTHMA. A DIAGNOSTIC PROBLEM.
Topics: Aminophylline; Aspirin; Asthma; Chlorothiazide; Diagnosis, Differential; Diuretics; Epinephrine; Hea | 1964 |
A DIFFUSE ENDOCARDIAL FIBROELASTOSIS WITH MARKEDLY DILATED RIGHT ATRIUM OBSERVED IN AN ADULT.
Topics: Ascites; Cardiomegaly; Chlorothiazide; Digitoxin; Diuretics; Electrocardiography; Endocardial Fibroe | 1964 |
ETHACRYNIC ACID PARENTERALLY IN THE TREATMENT AND PREVENTION OF PULMONARY OEDEMA.
Topics: Adrenalectomy; Ascites; Blood Transfusion; Chlorothiazide; Digoxin; Diuretics; Edema; Ethacrynic Aci | 1964 |
[NATRIURETIC DRUGS].
Topics: Acetazolamide; Aldosterone; Ascites; Chlorothiazide; Dexamethasone; Diabetes Insipidus; Diuresis; Di | 1963 |
[THE TREATMENT OF EDEMA WITH SULFONAMIDE DIURETICS].
Topics: Acetazolamide; Acidosis; Benzothiadiazines; Chlorothiazide; Chlorthalidone; Dehydration; Diuretics; | 1964 |
CARDIAC AND METABOLIC DISEASE, AND INFECTIONS IN THE OBSTETRIC PATIENT.
Topics: Acetazolamide; Acid-Base Equilibrium; Blood Circulation; Chlorothiazide; Chlorthalidone; Diet, Sodiu | 1964 |
[TRIAMTERENE. CLINICAL INVESTIGATIONS ON THE DIURETIC AND POTASSIUM-RETAINING EFFECT DURING COMBINED TREATMENT WITH A CHLOROTHIAZIDE DERIVATIVE (TRICHLORMETHIAZIDE) AND ON THE EFFECT OF THE PREPARATION ON RENAL FILTRATION].
Topics: Blood Chemical Analysis; Chlorothiazide; Coenzymes; Creatine; Creatinine; Diuretics; Heart Failure; | 1964 |
[TRICHLORMETHIAZIDE (FLUITRAN) AS A DIURETIC].
Topics: Bicarbonates; Blood Chemical Analysis; Chlorides; Chlorothiazide; Creatine; Creatinine; Diuretics; E | 1964 |
SEVERE CONGENITAL HEART DISEASE IN INFANCY. DIAGNOSIS AND MANAGEMENT.
Topics: Cardiac Catheterization; Cardiac Surgical Procedures; Chlorothiazide; Digitalis Glycosides; Diuretic | 1963 |
ACLINICOPATHOLOGICAL CONFERENCE FROM THE OHIO STATE UNIVERSITY HOSPITAL, COLUMBUS, OHIO.
Topics: Angiography; Chlorothiazide; Contrast Media; Heart Failure; Hospitals, University; Humans; Hypertens | 1964 |
SURGICAL TREATMENT OF COMPLETE HEART BLOCK. AN ANALYSIS OF 36 CASES.
Topics: Atropine; Chlorothiazide; Diabetes Mellitus; Ephedrine; Geriatrics; Heart Block; Heart Failure; Huma | 1964 |
[CLINICAL AND BIOCHEMICAL EVALUATION OF THE DIURETIC ACTION OF HYPOTHIAZIDE].
Topics: Biomedical Research; Blood; Chlorine; Chlorothiazide; Diuretics; Drug Therapy; Edema; Heart Failure; | 1964 |
INTRACTABLE CONGESTIVE HEART FAILURE SUCCESSFULLY TREATED WITH SOUTHEY TUBES.
Topics: Body Fluids; Chlorothiazide; Diuretics; Drainage; Edema; Equipment and Supplies; Heart Failure; Leg; | 1964 |
HYPONATREMIA IN CONGESTIVE HEART FAILURE.
Topics: Chlorides; Chlorothiazide; Diuretics; Heart Failure; Hyponatremia; Lysine; Organomercury Compounds; | 1964 |
[URATIC ARTHRITIS AS A COMPLICATION OF DIURETIC THERAPY].
Topics: Arthritis; Chlorothiazide; Chlorthalidone; Diuretics; Gout; Heart Failure; Hypertension; Rheumatic H | 1964 |
RENAL ARTERY STENOSIS AND THE NEPHROTIC SYNDROME.
Topics: Aorta; Aorta, Abdominal; Arteriosclerosis; Child; Chlorothiazide; Glomerulonephritis; Heart Failure; | 1964 |
ETHACRYNIC ACID: EFFECTIVENESS AND MODE OF DIURETIC ACTION IN MAN.
Topics: Acetazolamide; Acidosis; Acidosis, Renal Tubular; Alkalosis; Ascites; Carbonic Anhydrase Inhibitors; | 1965 |
ERYSIPELOTHRIX ENDOCARDITIS: REPORT OF A CASE WITH CEREBRAL MANIFESTATIONS.
Topics: Brain Diseases; Chloramphenicol; Chlorothiazide; Digoxin; Diuretics; Drug Therapy; Endocarditis; End | 1965 |
DIURETIC ACTION OF FUROSEMIDE.
Topics: Acetazolamide; Bicarbonates; Biomedical Research; Blood Chemical Analysis; Carbonic Anhydrase Inhibi | 1965 |
FURTHER EXPERIENCE WITH SPIRONOLACTONE-HYDRO-CHLOROTHIAZIDE (ALDACTAZIDE-A) IN THE LONG-TERM TREATMENT OF REFRACTORY CARDIAC EDEMA.
Topics: Arteriosclerosis; Chlorothiazide; Coronary Disease; Drug Combinations; Drug Therapy; Edema; Edema, C | 1965 |
FUROSEMIDE (LASIX) AS A DIURETIC.
Topics: Chlorothiazide; Chlorthalidone; Diuretics; Drug Therapy; Furosemide; Heart Failure; Hydrochlorothiaz | 1965 |
[A new diuretic and saluretic of the benzothiodiazine series: benzhydroflumethiazide].
Topics: Chlorothiazide; Diuretics; Heart Failure; Liver Cirrhosis | 1960 |
Hydrochlorothiazide in the treatment of congestive heart failure.
Topics: Chlorothiazide; Heart Failure; Hydrochlorothiazide | 1959 |
[The value of chlorothiazide as a diuretic].
Topics: Chlorothiazide; Diuretics; Heart Failure; Pulmonary Heart Disease | 1959 |
[Treatment of cardiac edema by hydrochlorothiazide].
Topics: Chlorothiazide; Edema, Cardiac; Heart Failure; Hydrochlorothiazide | 1959 |
[A new diuretic: hydrochlorothiazide in the treatment of cardiac insufficiency].
Topics: Chlorothiazide; Diuretics; Heart Failure; Hydrochlorothiazide | 1959 |
[Hydrochlorothiazide. A new diuretic in the treatment of cardiac insufficiency].
Topics: Chlorothiazide; Diuretics; Heart Failure; Hydrochlorothiazide | 1959 |
[Reaction of chlorothiazide in fluid retention induced by pitressin and desoxycorticosterone acetate in rats].
Topics: Animals; Chlorothiazide; Desoxycorticosterone; Desoxycorticosterone Acetate; Heart Failure; Rats; Va | 1959 |
[Current status of diuretic therapeutics in edemas of cardiac insufficiency].
Topics: Adrenal Cortex Hormones; Chlorothiazide; Diuretics; Edema; Heart Failure; Organomercury Compounds | 1959 |
[Clinical study of the diuretic action of hydrochlorothiazide].
Topics: Biomedical Research; Chlorothiazide; Diuretics; Heart Failure; Hydrochlorothiazide; Nephrotic Syndro | 1959 |
[Treatment of hepatogenic fluid retentions with trichlormethiazide (Esmarin)].
Topics: Acid-Base Imbalance; Body Fluids; Chlorothiazide; Heart Failure; Trichlormethiazide; Water-Electroly | 1962 |
[Clinical experimentation on a new oral saldiuretic, the potassium salt of trichloromethyl hydrochlorothiazide (PS-207) in cardiac insufficiency].
Topics: Chlorothiazide; Empirical Research; Heart Failure; Hydrochlorothiazide; Potassium; Potassium Compoun | 1962 |
Hydrochlorothiazide in congestive heart failure and in toxemia of pregnancy.
Topics: Chlorothiazide; Female; Heart Failure; Hydrochlorothiazide; Pre-Eclampsia; Pregnancy | 1962 |
[On the diuretic action of hypothiazide].
Topics: Cardiovascular Diseases; Chlorothiazide; Diuretics; Heart Failure; Hydrochlorothiazide | 1962 |
[Hypokalemis, hypochloremia and alkalosis in the long-term treatment of edematous heart insufficiency with benzothiadiazine diuretics. III. Effects of spirolactone].
Topics: Aldosterone; Alkalosis; Chlorothiazide; Diuretics; Edema; Heart Failure; Mineralocorticoid Receptor | 1962 |
Clinical trials with hydrochlorothiazide.
Topics: Chlorothiazide; Heart Failure; Hydrochlorothiazide; Hypertension | 1962 |
[The chlorothiazides in medical practice].
Topics: Chlorothiazide; Edetic Acid; Heart Failure | 1961 |
[Hypokalemia, hypochloremia and alkalosis in the long-term treatment of edematous heart insufficiency with benzothiadiazine diuretics. I. Incidence and pathophysiology].
Topics: Alkalosis; Chlorothiazide; Edema; Heart Failure; Humans; Hypokalemia; Incidence; Potassium; Sodium C | 1962 |
[Hypokalemis, hypochloremia and alkalosis in the long-term treatment of edematous heart insufficiency with benzothiadiazine diuretics. II. The prophylactic value of potassium chloride].
Topics: Alkalosis; Chlorides; Chlorothiazide; Edema; Heart Failure; Humans; Potassium; Potassium Chloride; S | 1962 |
[Saluretics in the treatment of cardiac and renal edema].
Topics: Blood Circulation; Body Weight; Chlorothiazide; Diuretics; Edema; Ethacrynic Acid; Furosemide; Heart | 1966 |
Conversion of atrial fibrillation with quinidine sulfate in a dog.
Topics: Animals; Atrial Fibrillation; Chlorothiazide; Digoxin; Dirofilariasis; Dog Diseases; Dogs; Electroca | 1967 |
Prolonged therapy by the combination of furosemide and thiazides in refractory heart failure and other fluid retaining conditions.
Topics: Aged; Aged, 80 and over; Cardiomyopathy, Dilated; Chlorothiazide; Diuretics; Drug Administration Sch | 1995 |
[Medical treatment of heart failure in infants and young children].
Topics: Anti-Bacterial Agents; Anticoagulants; Aortic Coarctation; Bradycardia; Chlorothiazide; Diet, Sodium | 1969 |
Aortopulmonary fenestration and aortic atresia. Report of an infant with ventricular septal defect, persistent ductus arteriosus, and interrupted aortic arch.
Topics: Aorta; Aortic Arch Syndromes; Aortic Valve; Autopsy; Birth Weight; Chlorothiazide; Digoxin; Ductus A | 1974 |
Diuretic therapy in experimental right heart failure of the rhesus monkey.
Topics: Animals; Benzoates; Body Weight; Chlorothiazide; Diuretics; Edema; Furosemide; Haplorhini; Heart Fai | 1972 |
[A combination of diuretics from different classes in the treatment of cardiac insufficiency].
Topics: Adult; Aged; Chlorothiazide; Diuresis; Female; Heart Failure; Humans; Male; Middle Aged; Natriuresis | 1972 |
Influence of volume expansion on proximal tubular sodium reabsorption in congestive heart failure.
Topics: Aged; Aldosterone; Aminohippuric Acids; Chlorides; Chlorothiazide; Chromium Isotopes; Diuresis; Eryt | 1973 |
Serum calcium and phosphorus in patients treated with thiazides and furosemide.
Topics: Adult; Aged; Calcium; Chlorothiazide; Depression, Chemical; Female; Furosemide; Heart Failure; Human | 1973 |
[Effect of daily treatment with hypothiazide and novurit on the acid-base balance and mineral metabolism in patients with circulatory insufficiency].
Topics: Acid-Base Equilibrium; Adolescent; Adult; Aged; Chlorothiazide; Female; Heart Failure; Humans; Hyper | 1969 |
Report of the panels on cardiovascular drugs from the drug efficacy study.
Topics: Angina Pectoris; Cardiovascular Diseases; Chlorothiazide; Digitalis Glycosides; Drug Industry; Drug | 1970 |
Hypertension, hyperuricemia and iatrogenic disease.
Topics: Aged; Allopurinol; Aortic Diseases; Arteriosclerosis; Brain; Catheterization; Chlorothiazide; Diagno | 1970 |
[Furosemide in the treatment of cardiac insufficiency].
Topics: Adult; Aged; Chlorothiazide; Chlorthalidone; Diuresis; Electrolytes; Female; Furosemide; Heart Failu | 1967 |
Amiloride. A potassium-sparing natriuretic agent.
Topics: Acetazolamide; Aldosterone; Ammonia; Ascites; Bicarbonates; Blood Pressure; Chlorides; Chlorothiazid | 1968 |
Flapping tremors--hepatic failure from oral diuretics for cardiac failure.
Topics: Aged; Chlorothiazide; Extremities; Heart Failure; Humans; Liver; Male; Middle Aged; Tremor | 1968 |
[Resistance to diuretics].
Topics: Adolescent; Adult; Aged; Chlorothiazide; Female; Heart Failure; Humans; Male; Middle Aged; Organomer | 1968 |
Selective aldosterone deficiency.
Topics: 17-Ketosteroids; Adolescent; Adrenal Insufficiency; Aged; Aldosterone; Aminohippuric Acids; Carbon I | 1969 |
Cardiorenal hemodynamic effects of ethacrynic acid.
Topics: Chlorothiazide; Diabetes Insipidus; Edema; Electrolytes; Ethacrynic Acid; Heart; Heart Failure; Hear | 1966 |
Clinical pharmacology of diuretic drugs.
Topics: Acetazolamide; Aldosterone; Ammonium Chloride; Chlorothiazide; Diuretics; Heart Failure; Humans; Org | 1966 |
Heart failure.
Topics: Chlorothiazide; Digitalis Glycosides; Diuretics; Heart Failure; Humans; Morphine | 1966 |
Pulmonary venous and arterial hypertension due to chronic fibrous mediastinitis. Hemodynamics and pulmonary function.
Topics: Adult; Chlorothiazide; Heart Failure; Hemodynamics; Humans; Hypertension, Pulmonary; Lung; Male; Med | 1966 |
Aldosterone metabolism in cardiac failure.
Topics: Aldosterone; Chlorothiazide; Diet, Sodium-Restricted; Digitalis Glycosides; Heart Failure; Humans; H | 1966 |