chlorothiazide has been researched along with Cardiomegaly in 5 studies
Chlorothiazide: A thiazide diuretic with actions and uses similar to those of HYDROCHLOROTHIAZIDE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p812)
thiazide : Heterocyclic compound with sulfur and nitrogen in the ring.
chlorothiazide : 4H-1,2,4-benzothiadiazine 1,1-dioxide in which the hydrogen at position is substituted by chlorine and that at position 7 is substituted by a sulfonamide group. A diuretic, it is used for treatment of oedema and hypertension.
Cardiomegaly: Enlargement of the HEART, usually indicated by a cardiothoracic ratio above 0.50. Heart enlargement may involve the right, the left, or both HEART VENTRICLES or HEART ATRIA. Cardiomegaly is a nonspecific symptom seen in patients with chronic systolic heart failure (HEART FAILURE) or several forms of CARDIOMYOPATHIES.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The effects of prolonged chlorothiazide treatment of left ventricular failure on cardiac hypertrophy, circulating vasoactive hormones and exchangeable body sodium were examined in rats with chronic myocardial infarction induced by left coronary artery ligation." | 7.69 | Cardiomegaly and vasoactive hormones in rats with chronic myocardial infarction: long-term effects of chlorothiazide. ( Abe, K; Johnston, CI; Kanazawa, M; Kohzuki, M; Sato, T; Tsutsumi, E; Yasujima, M; Yoshida, K, 1996) |
| "The long-term effects of perindopril or chlorothiazide therapy were studied in rats after the induction of myocardial infarction by coronary artery ligation." | 7.68 | Comparative effects of angiotensin converting enzyme inhibition (perindopril) or diuretic therapy on cardiac hypertrophy and sympathetic activity following myocardial infarction in rats. ( Hodsman, GP; Howes, LG; Johnston, CI; Rowe, PR, 1991) |
| " The effects of prolonged chlorothiazide treatment of left ventricular failure on cardiac hypertrophy, circulating vasoactive hormones and exchangeable body sodium were examined in rats with chronic myocardial infarction induced by left coronary artery ligation." | 3.69 | Cardiomegaly and vasoactive hormones in rats with chronic myocardial infarction: long-term effects of chlorothiazide. ( Abe, K; Johnston, CI; Kanazawa, M; Kohzuki, M; Sato, T; Tsutsumi, E; Yasujima, M; Yoshida, K, 1996) |
| "The long-term effects of perindopril or chlorothiazide therapy were studied in rats after the induction of myocardial infarction by coronary artery ligation." | 3.68 | Comparative effects of angiotensin converting enzyme inhibition (perindopril) or diuretic therapy on cardiac hypertrophy and sympathetic activity following myocardial infarction in rats. ( Hodsman, GP; Howes, LG; Johnston, CI; Rowe, PR, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (40.00) | 18.7374 |
| 1990's | 2 (40.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Andrukhova, O | 1 |
| Slavic, S | 1 |
| Smorodchenko, A | 1 |
| Zeitz, U | 1 |
| Shalhoub, V | 1 |
| Lanske, B | 1 |
| Pohl, EE | 1 |
| Erben, RG | 1 |
| YOSHIDA, T | 1 |
| NIMURA, Y | 1 |
| SAKAKIBARA, H | 1 |
| MATSUTANI, K | 1 |
| NISHIZAKI, K | 1 |
| NAKATA, T | 1 |
| Kohzuki, M | 1 |
| Kanazawa, M | 1 |
| Yoshida, K | 1 |
| Tsutsumi, E | 1 |
| Yasujima, M | 1 |
| Abe, K | 1 |
| Johnston, CI | 2 |
| Sato, T | 1 |
| Smith, WM | 1 |
| Howes, LG | 1 |
| Hodsman, GP | 1 |
| Rowe, PR | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Hypertension in High School Students: Genetic and Environmental Factors[NCT06049641] | 2,638 participants (Actual) | Observational | 2014-10-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for chlorothiazide and Cardiomegaly
| Article | Year |
|---|---|
Treatment of mild hypertension: results of a ten-year intervention trial.
Topics: Adult; Blood Pressure; Cardiomegaly; Cerebrovascular Disorders; Chlorothiazide; Clinical Trials as T | 1977 |
4 other studies available for chlorothiazide and Cardiomegaly
| Article | Year |
|---|---|
FGF23 regulates renal sodium handling and blood pressure.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Cardiomegaly; Chlorothiazide; Fibroblast Growth Fa | 2014 |
A DIFFUSE ENDOCARDIAL FIBROELASTOSIS WITH MARKEDLY DILATED RIGHT ATRIUM OBSERVED IN AN ADULT.
Topics: Ascites; Cardiomegaly; Chlorothiazide; Digitoxin; Diuretics; Electrocardiography; Endocardial Fibroe | 1964 |
Cardiomegaly and vasoactive hormones in rats with chronic myocardial infarction: long-term effects of chlorothiazide.
Topics: Animals; Arginine Vasopressin; Atrial Natriuretic Factor; Cardiomegaly; Chlorothiazide; Chronic Dise | 1996 |
Comparative effects of angiotensin converting enzyme inhibition (perindopril) or diuretic therapy on cardiac hypertrophy and sympathetic activity following myocardial infarction in rats.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Cardiomegaly; Chlorothiazide; Female; Indoles; Me | 1991 |