chlorothiazide has been researched along with Cardiac Failure in 157 studies
Chlorothiazide: A thiazide diuretic with actions and uses similar to those of HYDROCHLOROTHIAZIDE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p812)
thiazide : Heterocyclic compound with sulfur and nitrogen in the ring.
chlorothiazide : 4H-1,2,4-benzothiadiazine 1,1-dioxide in which the hydrogen at position is substituted by chlorine and that at position 7 is substituted by a sulfonamide group. A diuretic, it is used for treatment of oedema and hypertension.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Piretanide, a diuretic that acts on the loop of Henle, was used to treat patients with cardiac failure." | 9.05 | Comparison of piretanide and chlorothiazide in the treatment of cardiac failure. ( Gillies, A; Morgan, T; Myers, J, 1980) |
| "The efficacy of treatment with spironolactone for congestive heart failure secondary to congenital heart disease was studied in 21 infants under 1 year of age." | 9.05 | Spironolactone therapy in infants with congestive heart failure secondary to congenital heart disease. ( Fowler, RS; Hobbins, SM; Korey, AG; Rowe, RD, 1981) |
| "Metolazone and intravenous (IV) chlorothiazide are commonly used diuretics for sequential nephron blockade (SNB) in patients with acute decompensated heart failure (ADHF)." | 8.12 | Metolazone Versus Intravenous Chlorothiazide for Decompensated Heart Failure Sequential Nephron Blockade: A Retrospective Cohort Study. ( Biskupiak, J; Cisowska, T; Fang, JC; Jacobs, JA; Pan, IZ; Shah, KS, 2022) |
| "To assess the efficacy of intravenous chlorothiazide in patients with acute decompensated heart failure (ADHF) who were determined to be loop diuretic resistant and refractory to metolazone." | 7.83 | Efficacy of Intravenous Chlorothiazide for Refractory Acute Decompensated Heart Failure Unresponsive to Adjunct Metolazone. ( Altshuler, J; Cardinale, M; Testani, JM, 2016) |
| "To assess the efficacy and safety of intravenous (IV) chlorothiazide versus oral metolazone when added to loop diuretics in patients with acute decompensated heart failure (ADHF) and loop diuretic resistance." | 7.83 | Efficacy and Safety of Intravenous Chlorothiazide versus Oral Metolazone in Patients with Acute Decompensated Heart Failure and Loop Diuretic Resistance. ( Devabhakthuni, S; Ivaturi, V; Jiang, A; Liu, T; Reed, BN; Shulenberger, CE, 2016) |
| "To compare the effects of combination diuretic therapy with oral hydrochlorothiazide or intravenous chlorothiazide added to background intravenous loop diuretic therapy among patients hospitalized with heart failure." | 7.80 | Comparison of the effects of combination diuretic therapy with oral hydrochlorothiazide or intravenous chlorothiazide in patients receiving intravenous furosemide therapy for the treatment of heart failure. ( Kissling, KT; Pickworth, KK, 2014) |
| "The efficacy and side effects of the combination therapy of thiazide and furosemide administered to patients with refractory heart failure, for a prolonged period of time, were assessed." | 7.69 | Prolonged therapy by the combination of furosemide and thiazides in refractory heart failure and other fluid retaining conditions. ( Brif, I; Farfel, Z; Mayan, H; Mouallem, M, 1995) |
| "Metolazone was as effective as chlorothiazide to augment loop diuretic therapy in ADHF in most studies with no pooled difference in net or total urine output." | 6.66 | A Systematic Review and Meta-Analysis of Metolazone Compared to Chlorothiazide for Treatment of Acute Decompensated Heart Failure. ( Howard, ML; Janzen, KM; Steuber, TD, 2020) |
| "Piretanide, a diuretic that acts on the loop of Henle, was used to treat patients with cardiac failure." | 5.05 | Comparison of piretanide and chlorothiazide in the treatment of cardiac failure. ( Gillies, A; Morgan, T; Myers, J, 1980) |
| "The efficacy of treatment with spironolactone for congestive heart failure secondary to congenital heart disease was studied in 21 infants under 1 year of age." | 5.05 | Spironolactone therapy in infants with congestive heart failure secondary to congenital heart disease. ( Fowler, RS; Hobbins, SM; Korey, AG; Rowe, RD, 1981) |
| "Metolazone and intravenous (IV) chlorothiazide are commonly used diuretics for sequential nephron blockade (SNB) in patients with acute decompensated heart failure (ADHF)." | 4.12 | Metolazone Versus Intravenous Chlorothiazide for Decompensated Heart Failure Sequential Nephron Blockade: A Retrospective Cohort Study. ( Biskupiak, J; Cisowska, T; Fang, JC; Jacobs, JA; Pan, IZ; Shah, KS, 2022) |
| "To assess the efficacy of intravenous chlorothiazide in patients with acute decompensated heart failure (ADHF) who were determined to be loop diuretic resistant and refractory to metolazone." | 3.83 | Efficacy of Intravenous Chlorothiazide for Refractory Acute Decompensated Heart Failure Unresponsive to Adjunct Metolazone. ( Altshuler, J; Cardinale, M; Testani, JM, 2016) |
| "To assess the efficacy and safety of intravenous (IV) chlorothiazide versus oral metolazone when added to loop diuretics in patients with acute decompensated heart failure (ADHF) and loop diuretic resistance." | 3.83 | Efficacy and Safety of Intravenous Chlorothiazide versus Oral Metolazone in Patients with Acute Decompensated Heart Failure and Loop Diuretic Resistance. ( Devabhakthuni, S; Ivaturi, V; Jiang, A; Liu, T; Reed, BN; Shulenberger, CE, 2016) |
| "To compare the effects of combination diuretic therapy with oral hydrochlorothiazide or intravenous chlorothiazide added to background intravenous loop diuretic therapy among patients hospitalized with heart failure." | 3.80 | Comparison of the effects of combination diuretic therapy with oral hydrochlorothiazide or intravenous chlorothiazide in patients receiving intravenous furosemide therapy for the treatment of heart failure. ( Kissling, KT; Pickworth, KK, 2014) |
| "The efficacy and side effects of the combination therapy of thiazide and furosemide administered to patients with refractory heart failure, for a prolonged period of time, were assessed." | 3.69 | Prolonged therapy by the combination of furosemide and thiazides in refractory heart failure and other fluid retaining conditions. ( Brif, I; Farfel, Z; Mayan, H; Mouallem, M, 1995) |
| "Metolazone was as effective as chlorothiazide to augment loop diuretic therapy in ADHF in most studies with no pooled difference in net or total urine output." | 2.66 | A Systematic Review and Meta-Analysis of Metolazone Compared to Chlorothiazide for Treatment of Acute Decompensated Heart Failure. ( Howard, ML; Janzen, KM; Steuber, TD, 2020) |
| "This metolazone emulsion was capable of increasing urine volume output and demonstrated both natriuretic and kaliuretic properties." | 1.72 | Formulation, Characterization, and the Diuretic Effects of a New Intravenous Metolazone Emulsion. ( Ahlschwede, KM; Andey, T; Ofori, E; Osei, A; Somberg, JS, 2022) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 147 (93.63) | 18.7374 |
| 1990's | 1 (0.64) | 18.2507 |
| 2000's | 1 (0.64) | 29.6817 |
| 2010's | 4 (2.55) | 24.3611 |
| 2020's | 4 (2.55) | 2.80 |
| Authors | Studies |
|---|---|
| Ahlschwede, KM | 1 |
| Ofori, E | 1 |
| Andey, T | 1 |
| Osei, A | 1 |
| Somberg, JS | 1 |
| Cisowska, T | 1 |
| Pan, IZ | 1 |
| Biskupiak, J | 1 |
| Shah, KS | 1 |
| Fang, JC | 1 |
| Jacobs, JA | 1 |
| Cox, ZL | 1 |
| Hung, R | 1 |
| Lenihan, DJ | 1 |
| Testani, JM | 2 |
| Steuber, TD | 1 |
| Janzen, KM | 1 |
| Howard, ML | 1 |
| Kissling, KT | 1 |
| Pickworth, KK | 1 |
| Moranville, MP | 1 |
| Choi, S | 1 |
| Hogg, J | 1 |
| Anderson, AS | 1 |
| Rich, JD | 1 |
| Cardinale, M | 1 |
| Altshuler, J | 1 |
| Shulenberger, CE | 1 |
| Jiang, A | 1 |
| Devabhakthuni, S | 1 |
| Ivaturi, V | 1 |
| Liu, T | 1 |
| Reed, BN | 1 |
| SCHREINER, GE | 1 |
| BLOOMER, HA | 1 |
| LARAGH, JH | 3 |
| HEINEMANN, HO | 2 |
| DEMARTINI, FE | 1 |
| GOODKIND, MJ | 1 |
| HARVEY, RM | 1 |
| RICHARDS, DW | 1 |
| BAYLISS, RI | 1 |
| MARRACK, D | 1 |
| PIRKIS, J | 1 |
| REES, JR | 1 |
| ZILVA, JF | 1 |
| SLATER, JD | 1 |
| NABARRO, JD | 1 |
| DAVIES, DW | 1 |
| EVANS, B | 1 |
| WENER, J | 2 |
| FRIEDMAN, R | 2 |
| SCHUCHER, R | 2 |
| PECKENSCHNEIDER, LE | 1 |
| POKORNY, C | 1 |
| BECKER, MC | 2 |
| DI MASCOLO, R | 1 |
| DE NYSE, DL | 1 |
| ZUCKERMAN, AJ | 1 |
| CHAZAN, AA | 1 |
| NICROSINI, F | 1 |
| PICCINELLI, O | 1 |
| KEYES, JW | 4 |
| BERLACHER, FJ | 1 |
| VAN DER MEER, C | 1 |
| LINDEBOOM, GA | 1 |
| BEYER, T | 1 |
| ZONDAG, HA | 1 |
| VAN DER KOOI, MW | 1 |
| HARTOG, HA | 1 |
| BERRETA, JA | 1 |
| SALITA, S | 1 |
| ZUNDER, J | 1 |
| ROISINBLIT, R | 1 |
| ANUNZIATO, L | 1 |
| WARSHAW, LJ | 1 |
| FAIRWEATHER, MJ | 1 |
| LEWIS, JM | 1 |
| CHAPMAN, DW | 1 |
| FORD, RV | 1 |
| PLANCHEREL, P | 1 |
| HOFSTETTER, JR | 1 |
| KAINDL, F | 2 |
| KOHN, P | 2 |
| WATSCHINGER, B | 1 |
| DI PERRI, T | 1 |
| RAVENNI, G | 1 |
| HARVEY, SD | 1 |
| MANOR, B | 1 |
| DEGRAFF, AC | 1 |
| FITZPATRICK, DP | 1 |
| WYSO, EM | 2 |
| RICHARDSON, DW | 2 |
| SHAPIRA, A | 1 |
| CRAMER, G | 1 |
| BJORNTORP, P | 1 |
| GESSA, GL | 1 |
| VARGIU, L | 1 |
| ZANDA, CE | 1 |
| BREST, AN | 2 |
| BRENEMAN, GM | 3 |
| ALVAREZ, H | 2 |
| ARMAS CRUZ, R | 1 |
| HARNECKER, J | 1 |
| KUSMANIC, A | 1 |
| SAAVEDRA, J | 1 |
| MELFI, M | 1 |
| SCHIAFFINO, M | 1 |
| SUNNAH, E | 1 |
| VILLANUEVA, S | 1 |
| ACUNA, M | 1 |
| DONOSO, P | 1 |
| GUERRA, V | 1 |
| IBANEZ, E | 1 |
| GOFFARD, G | 1 |
| CONTI, E | 1 |
| FANCINI, P | 2 |
| DE BIASI, R | 1 |
| MANES, L | 1 |
| NOUAILLE, J | 2 |
| AUZEPY, P | 1 |
| OGDEN, DA | 1 |
| SCHERR, L | 1 |
| SPRITZ, N | 1 |
| RUBIN, AL | 1 |
| PORTER, GA | 2 |
| DAVID, NA | 1 |
| ROSENBLUM, MA | 1 |
| RUTISHAUSER, W | 1 |
| RHOMBERG, F | 1 |
| SACK, P | 1 |
| SETTEL, E | 2 |
| KOVACEVIC, M | 1 |
| BRCELJ, S | 1 |
| PERISIC, Z | 1 |
| LICHTIG, C | 1 |
| YOUNES, A | 1 |
| AJZEN, H | 1 |
| de MELLO, H | 1 |
| MAYER-BIRKHOF, K | 1 |
| TEODORESCU, P | 1 |
| LILIS, M | 1 |
| STEFAN, I | 1 |
| TINCU, S | 1 |
| SIRBULESCU, R | 1 |
| POMPILIAN, P | 1 |
| CUCU, N | 1 |
| STERIAN, I | 1 |
| CASTOLDI, P | 1 |
| CAVELL, GF | 1 |
| D'ALESANDRO, S | 1 |
| GURMINDO, BJ | 1 |
| ESEREQUIS, M | 1 |
| CERROTTI, MI | 1 |
| DATEY, KK | 1 |
| SHAH, PM | 1 |
| KURIEN, J | 1 |
| EILERSEN, P | 1 |
| BERTHELSEN, HC | 1 |
| FERRERO, C | 1 |
| LENEGRE, J | 1 |
| SCEBAT, L | 1 |
| DORET, JP | 1 |
| LOIZEAU, E | 1 |
| FUCHS, M | 1 |
| MALLIN, SR | 1 |
| IRIE, S | 1 |
| LIPPMANN, E | 1 |
| WEINER, AA | 1 |
| LEVINE, J | 1 |
| RUSSO, JL | 1 |
| ZAGALA, J | 1 |
| WEISSEL, W | 1 |
| MAYMAN, A | 1 |
| DJORDJEVIC, BS | 1 |
| LAMBIE, I | 1 |
| BUDIMIR, M | 1 |
| FORTIN, P | 1 |
| BERNARD-BRUNEL, J | 1 |
| GAY, A | 1 |
| SANTI, ML | 1 |
| PERASSO, F | 1 |
| GLAUBITT, D | 1 |
| RAUSCH-STROOMANN, JG | 1 |
| HARNAGEA, P | 2 |
| OLINESCU, R | 1 |
| SUTIANU, A | 1 |
| SHARAPOV, UB | 1 |
| SPRING, M | 1 |
| STEIN, I | 1 |
| KATABI, G | 1 |
| VERTES, V | 1 |
| KATZ, JB | 1 |
| ROBINOW, SH | 1 |
| VILLARREAL, H | 1 |
| LINTRUP, J | 2 |
| FRIIS, T | 2 |
| NISSEN, NI | 2 |
| BENATI, E | 1 |
| TOLVA, D | 1 |
| ADAMSKA-MARCINKOWSKA, H | 1 |
| KREIDBERG, MB | 1 |
| CHERNOFF, HL | 1 |
| LOPEZ, WL | 1 |
| JUNG, I | 1 |
| CSERNAY, L | 1 |
| VARRO, V | 1 |
| HAUCK, AJ | 1 |
| NADAS, AS | 1 |
| BARNETT, AJ | 1 |
| BAUMGARTEN, A | 1 |
| BRANDSTATER, M | 1 |
| DOBREANU-ENESCU, V | 1 |
| TEODORINI, S | 1 |
| VLADESCU, C | 1 |
| CHIAVERINI, R | 1 |
| BRETTELL, HR | 1 |
| SMITH, JG | 1 |
| AIKAWA, JK | 1 |
| EVANS, DW | 1 |
| FLEAR, CT | 1 |
| DOMENET, JG | 1 |
| JANUARY, LE | 1 |
| KIRKENDALL, WM | 2 |
| THEILEN, EO | 1 |
| ECKSTEIN, JW | 1 |
| SALVAGGIO, JE | 1 |
| KEITT, AS | 1 |
| LOWELL, FC | 1 |
| FRANKLIN, W | 1 |
| YOSHIDA, T | 1 |
| NIMURA, Y | 1 |
| SAKAKIBARA, H | 1 |
| MATSUTANI, K | 1 |
| NISHIZAKI, K | 1 |
| NAKATA, T | 1 |
| LEDINGHAM, JG | 1 |
| ARMASCRUZ, R | 1 |
| GOMEZ, R | 1 |
| MARDONES, J | 1 |
| PLAZADELOSREYES, M | 1 |
| POLIMENI, R | 1 |
| MARCHESE, G | 1 |
| BAGROS, P | 1 |
| PLATT, MA | 1 |
| NIELSEN, OE | 1 |
| WILLUMSEN, J | 1 |
| GARFUNKEL, JM | 1 |
| WELLS, CR | 1 |
| LIEBMAN, J | 1 |
| GADBOYS, HL | 1 |
| WISOFF, G | 1 |
| LITWAK, RS | 1 |
| MERZON, AK | 1 |
| KASIANOVA, TN | 1 |
| WALSH, AC | 1 |
| MOYES, A | 1 |
| KROPP, AD | 1 |
| LIUM, O | 1 |
| TVETER, KJ | 1 |
| BERLYNE, GM | 1 |
| TAVILL, AS | 1 |
| DE BAKER, SB | 1 |
| CANNON, PJ | 2 |
| STASON, WB | 1 |
| SILBERSTEIN, EB | 1 |
| HUTCHEON, DE | 1 |
| MEHTA, D | 1 |
| ROMANO, A | 1 |
| PELTOLA, P | 1 |
| JACONO, A | 1 |
| GUERRIERI, R | 1 |
| DE CIUTIIS, D | 1 |
| ARPINO, E | 1 |
| LOURENCO, RV | 1 |
| TELES, EM | 1 |
| MALTEZ, JS | 1 |
| PERRIN, A | 2 |
| FATH, A | 2 |
| DESCROIX, M | 2 |
| DUPORTET, B | 2 |
| PRINO, G | 1 |
| ROMANI, JD | 1 |
| KUTTNER, H | 1 |
| SABBAGA, E | 1 |
| SALDANHA, RV | 1 |
| de FARIA, C | 1 |
| NUSSENZVEIG, I | 1 |
| HUEDEPOHL, M | 1 |
| LEDERBOGEN, K | 1 |
| KARTUN, P | 1 |
| AZERAD, E | 1 |
| KHAJAVI, A | 1 |
| KRAVCHENKO, GT | 1 |
| OLESEN, K | 3 |
| SANDOE, E | 3 |
| PINTO, IJ | 1 |
| DIVEKAR, MV | 1 |
| RAGHAVAN, P | 1 |
| MEHTA, DJ | 1 |
| SHETH, UK | 1 |
| PUDDU, HS | 1 |
| Vorburger, C | 1 |
| Cottier, P | 1 |
| Pyle, RL | 1 |
| Gillies, A | 1 |
| Morgan, T | 1 |
| Myers, J | 1 |
| Hobbins, SM | 1 |
| Fowler, RS | 1 |
| Rowe, RD | 1 |
| Korey, AG | 1 |
| Mouallem, M | 1 |
| Brif, I | 1 |
| Mayan, H | 1 |
| Farfel, Z | 1 |
| Puschett, JB | 1 |
| Rosenquist, GC | 1 |
| Taylor, JF | 1 |
| Stark, J | 1 |
| Viles, PH | 1 |
| Manning, JA | 1 |
| Hastings, SG | 1 |
| Johnston, DJ | 1 |
| Blouin, LT | 1 |
| Sycheva, IM | 1 |
| Vinogradov, AV | 1 |
| Bennett, WM | 1 |
| Bagby, GC | 1 |
| Antonovic, JN | 1 |
| Lindy, S | 1 |
| Tarssanen, L | 1 |
| Kabakov, AI | 2 |
| Bucur, V | 1 |
| Bunghez, G | 1 |
| Bull, MB | 1 |
| Kumbhani, AP | 1 |
| Votchal, BE | 1 |
| Vagnucci, AH | 1 |
| Nash, HL | 1 |
| Fitz, AE | 1 |
| Wilson, WR | 1 |
| Kioschos, JM | 1 |
| Moyer, JH | 1 |
| Arnott, WM | 1 |
| Botticelli, JT | 1 |
| Schlueter, DP | 1 |
| Lange, RL | 1 |
| Hickie, JB | 1 |
| Lazarus, L | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Comparison of Oral Thiazides vs Intravenous Thiazides vs Tolvaptan in Combination With Loop Diuretics for Diuretic Resistant Decompensated Heart Failure[NCT02606253] | Phase 4 | 60 participants (Actual) | Interventional | 2016-02-29 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Change in estimated glomerular filtration rate (ml/min/m2) from baseline to 48 hours (NCT02606253)
Timeframe: 48 hours
| Intervention | ml/min/m2 (Mean) |
|---|---|
| Metolazone | -6 |
| Chlorothiazide | -9 |
| Tolvaptan | 2 |
"Participants will score their congestion on a 10cm scale ranging from Best (10cm) to Worst (0cm). Change in score (units in centimeters) from baseline to 48 hours." (NCT02606253)
Timeframe: 48 hours
| Intervention | cm of dyspena analog scale (Median) |
|---|---|
| Metolazone | 4.0 |
| Chlorothiazide | 3.0 |
| Tolvaptan | 3.0 |
Change in serum chloride (mEq/L) from baseline to 48 hrs (NCT02606253)
Timeframe: 48 hours
| Intervention | mEq/L (Mean) |
|---|---|
| Metolazone | -7 |
| Chlorothiazide | -7 |
| Tolvaptan | 2 |
Diuretic Efficiency is calculated as 48hr urine output/ 48hr Furosemide equivalents in milligrams (NCT02606253)
Timeframe: 48 hours
| Intervention | UOP / 40mg IV furosemide (Mean) |
|---|---|
| Metolazone | 217 |
| Chlorothiazide | 294 |
| Tolvaptan | 326 |
Mean change in glomerular filtration rate from enrollment to end of study at hospital discharge, an average of 5 days (NCT02606253)
Timeframe: hospital discharge an average of 5 days
| Intervention | ml/min/m2 (Mean) |
|---|---|
| Metolazone | -2 |
| Chlorothiazide | -2 |
| Tolvaptan | -6 |
Mean change in serum creatinine (mg/dl) from enrollment to end of study at 48 hours (NCT02606253)
Timeframe: 48 hours
| Intervention | mg/dl (Mean) |
|---|---|
| Metolazone | 0.3 |
| Chlorothiazide | 0.5 |
| Tolvaptan | 0.03 |
Mean change in serum potassium (mEq/L) from enrollment to end of study at 48 hours (NCT02606253)
Timeframe: 48 hours
| Intervention | mEq/L (Mean) |
|---|---|
| Metolazone | -0.1 |
| Chlorothiazide | -0.2 |
| Tolvaptan | 0.1 |
Mean change in serum sodium (mEq/L) from enrollment to end of study at 48 hours (NCT02606253)
Timeframe: 48 hours
| Intervention | mEq/L (Mean) |
|---|---|
| Metolazone | -1 |
| Chlorothiazide | -1 |
| Tolvaptan | 4 |
Net urine output from enrollment to the end of study at 48 hours measured in liters (NCT02606253)
Timeframe: 48 hours
| Intervention | liters (Median) |
|---|---|
| Metolazone | -7.8 |
| Chlorothiazide | -8.8 |
| Tolvaptan | -9.8 |
Incidence of new atrial or ventricular arrhythmias from enrollment to end of study at 48 hours (NCT02606253)
Timeframe: 48 hours
| Intervention | Participants (Count of Participants) |
|---|---|
| Metolazone | 0 |
| Chlorothiazide | 0 |
| Tolvaptan | 0 |
Provider escalation of loop diuretic dosage at 24 hours for urine output less than 3 L at 24 hours (NCT02606253)
Timeframe: 24 hours
| Intervention | Participants (Count of Participants) |
|---|---|
| Metolazone | 4 |
| Chlorothiazide | 4 |
| Tolvaptan | 2 |
Incidence of hypokalemia (serum potassium less than 3.5mEq/L ) from enrollment to end of study (NCT02606253)
Timeframe: 48 hours
| Intervention | Participants (Count of Participants) |
|---|---|
| Metolazone | 3 |
| Chlorothiazide | 2 |
| Tolvaptan | 2 |
Incidence of death from study enrollment to hospital discharge, an average of 5 days (NCT02606253)
Timeframe: Enrollment to hospital discharge an average of 5 days
| Intervention | Participants (Count of Participants) |
|---|---|
| Metolazone | 0 |
| Chlorothiazide | 0 |
| Tolvaptan | 0 |
Incidence of new initiation of dopamine, dobutamine, or milrinone from enrollment to end of study at 48 hours (NCT02606253)
Timeframe: 48 hours
| Intervention | Participants (Count of Participants) |
|---|---|
| Metolazone | 1 |
| Chlorothiazide | 0 |
| Tolvaptan | 2 |
Incidence of Renal replacement therapy utilization (hemodialysis, ultrafiltration) from enrollment to hospital discharge, an average of 5 days (NCT02606253)
Timeframe: enrollment to hospital discharge an average of 5 days
| Intervention | Participants (Count of Participants) |
|---|---|
| Metolazone | 0 |
| Chlorothiazide | 0 |
| Tolvaptan | 0 |
SBP < 85 mmHg plus medical intervention for symptomatic hypotension (NCT02606253)
Timeframe: 48 hours
| Intervention | Participants (Count of Participants) |
|---|---|
| Metolazone | 2 |
| Chlorothiazide | 0 |
| Tolvaptan | 2 |
Cumulative dose of potassium supplementation (mEq) administered from enrollment to end of study at 48 hours (NCT02606253)
Timeframe: 48 hours
| Intervention | mEq (Mean) |
|---|---|
| Metolazone | 103 |
| Chlorothiazide | 63 |
| Tolvaptan | 58 |
The primary outcome will be 48-hour standing scale weight change (kg) from enrollment among the metolazone, intravenous chlorothiazide, and tolvaptan arms, using metolazone group as the comparator group for all other groups. (NCT02606253)
Timeframe: 48 hours
| Intervention | kg (Mean) |
|---|---|
| Metolazone | -4.6 |
| Chlorothiazide | -5.8 |
| Tolvaptan | -4.1 |
7 reviews available for chlorothiazide and Cardiac Failure
| Article | Year |
|---|---|
A Systematic Review and Meta-Analysis of Metolazone Compared to Chlorothiazide for Treatment of Acute Decompensated Heart Failure.
Topics: Chlorothiazide; Diuretics; Heart Failure; Humans; Metolazone | 2020 |
HEART FAILURE IN INFANTS AND CHILDREN. SURVEY OF RECENT LITERATURE, ETIOLOGIC CONSIDERATIONS AND RECOMMENDATIONS FOR THERAPY.
Topics: Arrhythmias, Cardiac; Cardiac Surgical Procedures; Child; Chlorothiazide; Coxsackievirus Infections; | 1963 |
[THE WATER-ELECTROLYTE STATE IN EDEMA CAUSED BY CONGESTIVE CARDIO-CIRCULATORY INSUFFICIENCY. PHYSIOPATHOGENETIC CONSIDERATIONS AND THERAPEUTIC TRENDS].
Topics: Adrenal Cortex Hormones; Aldosterone; Chlorothiazide; Diet; Diet Therapy; Diuretics; Edema; Electrol | 1964 |
Diuretics and the therapy of hypertension.
Topics: Antihypertensive Agents; Blood Pressure; Chlorothiazide; Diuretics; Edema; Furosemide; Guidelines as | 2000 |
[Pathogenesis and therapy of Cardiac edema].
Topics: Capillary Permeability; Chlorothiazide; Diuretics; Glomerular Filtration Rate; Heart Failure; Heart | 1972 |
Diuretics in edema: how they work; how to pick the best one.
Topics: Carbonic Anhydrase Inhibitors; Chlorothiazide; Diuretics; Edema; Ethacrynic Acid; Furosemide; Heart | 1972 |
Recent advances in the treatment of congenital heart disease.
Topics: Age Factors; Arrhythmias, Cardiac; Child; Child, Preschool; Chlorothiazide; Diet, Sodium-Restricted; | 1974 |
3 trials available for chlorothiazide and Cardiac Failure
| Article | Year |
|---|---|
Diuretic Strategies for Loop Diuretic Resistance in Acute Heart Failure: The 3T Trial.
Topics: Administration, Oral; Aged; Chlorothiazide; Diuretics; Dose-Response Relationship, Drug; Double-Blin | 2020 |
Comparison of piretanide and chlorothiazide in the treatment of cardiac failure.
Topics: Adult; Aged; Body Weight; Chlorothiazide; Clinical Trials as Topic; Diuretics; Heart Failure; Humans | 1980 |
Spironolactone therapy in infants with congestive heart failure secondary to congenital heart disease.
Topics: Chlorothiazide; Clinical Trials as Topic; Digoxin; Drug Therapy, Combination; Female; Heart Defects, | 1981 |
147 other studies available for chlorothiazide and Cardiac Failure
| Article | Year |
|---|---|
Formulation, Characterization, and the Diuretic Effects of a New Intravenous Metolazone Emulsion.
Topics: Administration, Intravenous; Animals; Chlorothiazide; Diuretics; Emulsions; Heart Failure; Metolazon | 2022 |
Metolazone Versus Intravenous Chlorothiazide for Decompensated Heart Failure Sequential Nephron Blockade: A Retrospective Cohort Study.
Topics: Chlorothiazide; Diuretics; Furosemide; Heart Failure; Humans; Metolazone; Nephrons; Retrospective St | 2022 |
Comparison of the effects of combination diuretic therapy with oral hydrochlorothiazide or intravenous chlorothiazide in patients receiving intravenous furosemide therapy for the treatment of heart failure.
Topics: Administration, Intravenous; Administration, Oral; Aged; Chlorothiazide; Diuretics; Drug Therapy, Co | 2014 |
Comparison of metolazone versus chlorothiazide in acute decompensated heart failure with diuretic resistance.
Topics: Acute Disease; Administration, Intravenous; Administration, Oral; Aged; Chicago; Chlorothiazide; Dru | 2015 |
Efficacy of Intravenous Chlorothiazide for Refractory Acute Decompensated Heart Failure Unresponsive to Adjunct Metolazone.
Topics: Acute Disease; Administration, Intravenous; Adult; Aged; Chlorothiazide; Diuretics; Female; Heart Fa | 2016 |
Efficacy and Safety of Intravenous Chlorothiazide versus Oral Metolazone in Patients with Acute Decompensated Heart Failure and Loop Diuretic Resistance.
Topics: Acute Disease; Administration, Intravenous; Administration, Oral; Adult; Aged; Chlorothiazide; Cohor | 2016 |
Effect of chlorothiazide on the edema of cirrhosis, nephrosis, congestive heart failure and chronic renal insufficiency.
Topics: Chlorothiazide; Diuretics; Edema; Fibrosis; Heart Failure; Humans; Nephrosis; Renal Insufficiency, C | 1957 |
Effect of chlorothiazide on electrolyte transport in man; its use in the treatment of edema of congestive heart failure, nephrosis, and cirrhosis.
Topics: Acetazolamide; Chlorothiazide; Edema; Electrolytes; Heart Failure; Liver Cirrhosis; Nephrosis | 1958 |
Use of chlorothiazide in the treatment of edema.
Topics: Acetazolamide; Chlorothiazide; Edema; Heart Failure | 1958 |
Chlorothiazide: an oral diuretic.
Topics: Acetazolamide; Chlorothiazide; Diuretics; Edema; Heart Failure | 1958 |
Clinical experience with chlorothiazide.
Topics: Acetazolamide; Ascites; Chlorothiazide; Gastrointestinal Diseases; Heart Failure; Hypertension; Hype | 1958 |
Early observations on the diuretic effort of oral chlorothiazide.
Topics: Chlorothiazide; Diuretics; Heart Failure | 1958 |
Chlorothiazide in the management of cardiac oedema.
Topics: Acetazolamide; Chlorothiazide; Disease Management; Edema, Cardiac; Heart Failure | 1958 |
Oral diuril; its use in therapy of chronic heart failure.
Topics: Acetazolamide; Chlorothiazide; Chronic Disease; Heart Failure | 1958 |
Chlorothiazide as a diuretic and hypotensive agent.
Topics: Acetazolamide; Antihypertensive Agents; Chlorothiazide; Diuretics; Heart Failure; Hypertension | 1958 |
[Research on the diuretic effect of chlorothiazide in heart diseases].
Topics: Acetazolamide; Chlorothiazide; Diuretics; Heart Diseases; Heart Failure; Research | 1958 |
Clinical evaluation with serum concentration studies of chlorothiazide (diuril).
Topics: Acetazolamide; Chlorothiazide; Heart Failure; Hypertension; Research | 1958 |
Agranulocytosis with thrombocytopenia following chlorothiazide therapy.
Topics: Acetazolamide; Agranulocytosis; Blood Platelets; Chlorothiazide; Heart Failure; Thrombocytopenia | 1958 |
[First observations on the combined use of prednisone & chlorothiazide in the treatment of water retention states].
Topics: Acetazolamide; Chlorothiazide; Edema; Extremities; Heart Failure; Prednisone; Water-Electrolyte Bala | 1958 |
Chlorothiazide (diuril): a new, nonmercurial, orally given diuretic.
Topics: Acetazolamide; Chlorothiazide; Diuresis; Diuretics; Heart Failure | 1959 |
Chlorothiazide in congestive heart failure.
Topics: Acetazolamide; Chlorothiazide; Heart Failure | 1958 |
[Treatment of cardiac decompensation with chlorothiazide].
Topics: Acetazolamide; Chlorothiazide; Heart Failure | 1958 |
[Clinical evaluation of a new oral diuretic: chlorothiazide].
Topics: Acetazolamide; Chlorothiazide; Diuretics; Heart Failure | 1958 |
Evaluation of chlorothiazide in the diuretic therapy of congestive heart failure.
Topics: Acetazolamide; Chlorothiazide; Diuretics; Heart Failure; Humans | 1959 |
Comparison of the diuretic effects of oral administration of chlorothiazide and parenteral administration of mercaptomerin.
Topics: Acetazolamide; Administration, Oral; Chlorothiazide; Diuretics; Heart Failure; Humans; Liver Cirrhos | 1959 |
[Treatment of cardiac edema with chlorothiazide (chlotride)].
Topics: Acetazolamide; Chlorothiazide; Edema, Cardiac; Heart Failure | 1959 |
[Chlorothiazide (chlotride) treatment of cardiac and liver insufficiency with water retention].
Topics: Acetazolamide; Chlorothiazide; Heart Failure; Hepatic Insufficiency; Liver Diseases; Water-Electroly | 1959 |
[Effectiveness of chlorothiazide (chlotride) in cardiac decompensation].
Topics: Acetazolamide; Chlorothiazide; Heart Failure | 1958 |
[Chlorothiazide in depletive therapy of congestive heart failure].
Topics: Acetazolamide; Chlorothiazide; Heart Failure | 1959 |
Clinical experience with chlorothiazide in the treatment of congestive heart failure.
Topics: Acetazolamide; Chlorothiazide; Heart Failure | 1959 |
Chlorothiazide in the treatment of severe congestive heart failure.
Topics: Acetazolamide; Chlorothiazide; Heart Failure | 1959 |
[Chlorothiazide in the treatment of cardiac failure].
Topics: Acetazolamide; Chlorothiazide; Heart Failure | 1959 |
[Extraordinary diuresis induced by chlorothiazide in posthypertensive cardiac insufficiency].
Topics: Acetazolamide; Chlorothiazide; Diuresis; Heart Failure; Hypertension | 1959 |
[Chlorothiazide in cardiac insufficiency].
Topics: Acetazolamide; Chlorothiazide; Heart Failure | 1959 |
[Diuretic activity of chlorothiazide. I. Action of chlorothiazide on drug-induced water retention].
Topics: Acetazolamide; Chlorothiazide; Diuretics; Edema; Extremities; Heart Failure; Water-Electrolyte Balan | 1959 |
The use of chlorothiazide and hydrochlorothiazide in the treatment of congestive heart failure.
Topics: Acetazolamide; Chlorothiazide; Heart Failure; Hydrochlorothiazide | 1959 |
Chlorothiazide and hydrochlorothiazide in the treatment of congestive heart failure.
Topics: Acetazolamide; Chlorothiazide; Heart Failure; Hydrochlorothiazide | 1959 |
[Effect of chlorothiazide in the treatment of syndrome with water-salt retention & arterial hypertension].
Topics: Acetazolamide; Body Fluids; Chlorothiazide; Heart Failure; Hypertension; Sodium Chloride, Dietary; W | 1959 |
[Chlorothiazide: a new diuretic in the treatment of cardiac insufficiency].
Topics: Acetazolamide; Chlorothiazide; Diuretics; Heart Failure | 1959 |
Trichlormethiazide in the management of congestive heart failure.
Topics: Chlorothiazide; Disease Management; Heart Failure; Trichlormethiazide | 1961 |
[Clinical study on the diuretic effect of the combined administration of 1-beta-hydroxypropyl-theobromine and 6-chloro-7-sulfamyl-1,2,4-benzothiodiazine-1, 1-dioxido in heart patients with water retention].
Topics: Chlorothiazide; Combined Modality Therapy; Diuretics; Edema; Heart Failure; Theobromine; Water-Elect | 1961 |
[The clinical use of hydrochlorothiazide in the therapy of cardiocirculatory insufficiency].
Topics: Chlorothiazide; Heart Failure; Humans; Hydrochlorothiazide | 1960 |
[On the diuretic effect of dexamethasone and of the combination of chlorothiazide and dexamethasone].
Topics: Chlorothiazide; Dexamethasone; Diuretics; Glomerulonephritis; Heart Failure; Liver Cirrhosis; Organi | 1960 |
[Medical treatment of cardiac insufficiency in infants].
Topics: Child; Chlorothiazide; Digitalis; Heart Failure; Humans; Infant; Plant Extracts | 1961 |
A comparison of the properties of chlorothiazide, spironolactone and a combination of both as diuretic agents.
Topics: Aldosterone; Chlorothiazide; Diuretics; Heart Failure; Liver Cirrhosis; Mineralocorticoid Receptor A | 1961 |
Hydrochlorothiazide used alone in congestive heart failure and in combination with prednisone and other diuretics in cirrhosis and nephrosis.
Topics: Chlorothiazide; Diuretics; Heart Failure; Hydrochlorothiazide; Liver Cirrhosis; Nephrosis; Prednison | 1960 |
Some effects of diuresis with hydrochlorothiazide.
Topics: Chlorothiazide; Diuresis; Heart Failure; Hydrochlorothiazide; Liver Diseases; Organic Chemicals | 1960 |
[On changes in the blood circulation time during the treatment of hemodynamic cardiac insufficiency with diuretics and cardiac glycosides].
Topics: Aldosterone; Blood Circulation; Blood Circulation Time; Cardanolides; Cardiac Glycosides; Cardiotoni | 1960 |
Combined spironolactone-hydrochlorothiazide (Aldactazide) treatment in refractory congestive failure.
Topics: Chlorothiazide; Drug Combinations; Heart Failure; Hydrochlorothiazide; Lactones; Spironolactone | 1961 |
[Hydrochlorothiazide in the treatment of cardiac edema and of its effects on electrolyte metabolism].
Topics: Chlorothiazide; Edema, Cardiac; Electrolytes; Heart Failure; Hydrochlorothiazide | 1960 |
[Comparative study of the acute effects of hydrochlorothiazide in relation to chlorothiazide and other mercurial diuretics].
Topics: Chlorothiazide; Diuretics; Heart Failure; Hydrochlorothiazide | 1961 |
[On the treatment of edemas of various causes with Esmarin].
Topics: Chlorothiazide; Edema; Heart Failure | 1961 |
[Treatment with sulfonamide diuretics in refractory cardiac insufficiency].
Topics: Chlorothiazide; Diuretics; Heart Failure; Sulfanilamide; Sulfanilamides; Sulfonamides | 1961 |
Treatment of congestive heart failure with 3-benzyl dihydroflumethiazide: preliminary report.
Topics: Chlorothiazide; Heart Failure | 1959 |
[Chlorothiazide in decompensated hypertensive heart disease].
Topics: Chlorothiazide; Heart Diseases; Heart Failure; Humans; Hypertension | 1959 |
Hydrochlorothiazide in severe congestive heart failure. Clinical experience in the treatment.
Topics: Chlorothiazide; Heart Failure; Hydrochlorothiazide | 1959 |
[On a new orally-administered diuretic].
Topics: Chlorothiazide; Diuretics; Heart Failure | 1959 |
Hydrochlorothiazide as a diuretic agent. Preliminary report of our clinical trials.
Topics: Chlorothiazide; Diuretics; Heart Failure; Hydrochlorothiazide | 1960 |
[Long-term treatment of chronic cardiac decompensation with hydroflumethiazide (rontyl). 14-Months experience].
Topics: Chlorothiazide; Heart Failure; Humans; Hydroflumethiazide; Long-Term Care | 1960 |
[Study of the immediate hemodynamic effect of chlorothiazide on the cardiac patient].
Topics: Chlorothiazide; Heart Failure; Hemodynamics | 1960 |
Diuretic effects of flumethiazide, a benzothiadiazine derivative.
Topics: Benzothiadiazines; Chlorothiazide; Diuretics; Heart Failure; Humans | 1959 |
Treatment of congestive heart failure and hypertension: clinical experience with hydrochlorothiazide.
Topics: Chlorothiazide; Heart Failure; Hydrochlorothiazide; Hypertension | 1960 |
[Treatment of cardiac edema with chlorothiazide].
Topics: Chlorothiazide; Edema, Cardiac; Heart Failure | 1959 |
Hydrochlorothiazide (hydrodiuril) in the management of cardiac oedema.
Topics: Chlorothiazide; Disease Management; Edema, Cardiac; Heart Failure; Hydrochlorothiazide | 1959 |
[Our experience with hydrochlorothiazide in the treatment of cardiac insufficiency].
Topics: Chlorothiazide; Heart Failure; Hydrochlorothiazide | 1961 |
[Results obtained in cardiac insufficiency by the use of a new diuretic: S-3500].
Topics: Chlorothiazide; Diuretics; Heart Failure | 1961 |
[Clinical and laboratory observations on a new salidiuretic: polythiazide].
Topics: Chlorothiazide; Edetic Acid; Heart Failure; Humans; Polythiazide | 1962 |
[Magnesium, calcium and phosphorus balances in essential hypertension and heart insufficiency in the treatment with hydrochlorothiazide].
Topics: Calcium, Dietary; Chlorothiazide; Essential Hypertension; Heart Failure; Humans; Hydrochlorothiazide | 1962 |
[The diuretic effect of chlorothiazide in cardiac insufficiency and liver cirrhosis].
Topics: Chlorothiazide; Diuretics; Heart Failure; Liver Cirrhosis; Organic Chemicals | 1961 |
[Comparative evaluation of diuretic action of novurit, hypothiazide, diacarb in circulatory insufficiency].
Topics: Acetazolamide; Alkylmercury Compounds; Chlorothiazide; Diuretics; Drug Combinations; Heart Failure; | 1961 |
Cardiac failure treated with polythiazide.
Topics: Chlorothiazide; Heart Failure; Polythiazide | 1962 |
The use of a new diuretic (polythiazide) in congestive failure and hypertension.
Topics: Chlorothiazide; Diuretics; Edetic Acid; Heart Failure; Hypertension; Polythiazide | 1962 |
Comparison of short term metabolic effects of hydroflumethiazide and hydrochlorothiazide.
Topics: Chlorothiazide; Heart Failure; Humans; Hydrochlorothiazide; Hydroflumethiazide; Hypertension; Ions; | 1962 |
[Thiazides and mercurials in cardiac insufficiency].
Topics: Chlorothiazide; Diuretics; Heart Failure; Organomercury Compounds; Thiazides | 1962 |
[Diuretic action of chlorothiazide and spironolactone in edema of cardiac and hepatic origin].
Topics: Chlorothiazide; Diuretics; Edema; Heart Failure; Liver Diseases; Spironolactone | 1963 |
[Use of combined cardiotonic-diuretic-tranquilizing therapy in circulatory insufficiency].
Topics: Cardiotonic Agents; Chlorothiazide; Digitoxin; Diuretics; Heart Failure; Humans; Hypnotics and Sedat | 1962 |
[Comparative studies on the diuretic effect of diurazine and other commonly used diuretics].
Topics: Acetazolamide; Chlorothiazide; Diuretics; Heart Failure; Humans; Liver Cirrhosis; Organomercury Comp | 1963 |
Treatment of cardiac failure in infancy and childhood.
Topics: Child; Chlorothiazide; Digoxin; Diuretics; Heart Defects, Congenital; Heart Failure; Humans; Morphin | 1963 |
[The role of water retention in the pathogenesis of experimental phenylbutazone ulcer].
Topics: Acetazolamide; Chlorothiazide; Diuretics; Edema; Heart Failure; Organomercury Compounds; Peptic Ulce | 1963 |
OBSERVATIONS ON TRIAMTERENE--A NEW DIURETIC.
Topics: Chlorides; Chlorothiazide; Coronary Disease; Craniocerebral Trauma; Diuretics; Edema; Geriatrics; He | 1963 |
[CONSIDERATIONS ON TREATMENT WITH SALURETIC SULFONAMIDES IN CARDIAC INSUFFICIENCY].
Topics: Benzothiadiazines; Chlorothiazide; Diuretics; Heart Failure; Hydrochlorothiazide; Organomercury Comp | 1963 |
COMPARATIVE STUDIES ON THE DIURETIC EFFECT OF CHLOROTHIAZIDE AND SPIRONOLACTONE IN CARDIAC AND HEPATOGENIC OEDEMA.
Topics: Chlorothiazide; Diuretics; Edema; Heart Failure; Liver Cirrhosis; Prednisone; Spironolactone | 1963 |
[DIURETIC THERAPEUTICS].
Topics: Acetazolamide; Aminophylline; Chlorothiazide; Diuretics; Edema; Ethylenediamines; Heart Failure; Liv | 1963 |
S35-LABELED BENDROFLUMETHIAZIDE IN HUMAN BEINGS: CLINICAL STUDIES.
Topics: Adolescent; Bendroflumethiazide; Chlorothiazide; Geriatrics; Heart Failure; Humans; Hydrochlorothiaz | 1964 |
SPIRONOLACTONE AS AN ADJUVANT TO THE TREATMENT OF CONGESTIVE CARDIAC FAILURE.
Topics: Blood; Body Weight; Chlorothiazide; Heart Failure; Humans; Potassium; Sodium; Spironolactone; Urea; | 1964 |
CONCEPTS IN THE PATHOGENESIS AND TREATMENT OF CONGESTIVE HEART FAILURE.
Topics: Chlorothiazide; Digitalis Glycosides; Diuretics; Heart Failure; Heparin; Humans; Kidney Diseases; Po | 1964 |
ASPIRIN-INDUCED BRONCHIAL ASTHMA. A DIAGNOSTIC PROBLEM.
Topics: Aminophylline; Aspirin; Asthma; Chlorothiazide; Diagnosis, Differential; Diuretics; Epinephrine; Hea | 1964 |
A DIFFUSE ENDOCARDIAL FIBROELASTOSIS WITH MARKEDLY DILATED RIGHT ATRIUM OBSERVED IN AN ADULT.
Topics: Ascites; Cardiomegaly; Chlorothiazide; Digitoxin; Diuretics; Electrocardiography; Endocardial Fibroe | 1964 |
ETHACRYNIC ACID PARENTERALLY IN THE TREATMENT AND PREVENTION OF PULMONARY OEDEMA.
Topics: Adrenalectomy; Ascites; Blood Transfusion; Chlorothiazide; Digoxin; Diuretics; Edema; Ethacrynic Aci | 1964 |
[NATRIURETIC DRUGS].
Topics: Acetazolamide; Aldosterone; Ascites; Chlorothiazide; Dexamethasone; Diabetes Insipidus; Diuresis; Di | 1963 |
[THE TREATMENT OF EDEMA WITH SULFONAMIDE DIURETICS].
Topics: Acetazolamide; Acidosis; Benzothiadiazines; Chlorothiazide; Chlorthalidone; Dehydration; Diuretics; | 1964 |
CARDIAC AND METABOLIC DISEASE, AND INFECTIONS IN THE OBSTETRIC PATIENT.
Topics: Acetazolamide; Acid-Base Equilibrium; Blood Circulation; Chlorothiazide; Chlorthalidone; Diet, Sodiu | 1964 |
[TRIAMTERENE. CLINICAL INVESTIGATIONS ON THE DIURETIC AND POTASSIUM-RETAINING EFFECT DURING COMBINED TREATMENT WITH A CHLOROTHIAZIDE DERIVATIVE (TRICHLORMETHIAZIDE) AND ON THE EFFECT OF THE PREPARATION ON RENAL FILTRATION].
Topics: Blood Chemical Analysis; Chlorothiazide; Coenzymes; Creatine; Creatinine; Diuretics; Heart Failure; | 1964 |
[TRICHLORMETHIAZIDE (FLUITRAN) AS A DIURETIC].
Topics: Bicarbonates; Blood Chemical Analysis; Chlorides; Chlorothiazide; Creatine; Creatinine; Diuretics; E | 1964 |
SEVERE CONGENITAL HEART DISEASE IN INFANCY. DIAGNOSIS AND MANAGEMENT.
Topics: Cardiac Catheterization; Cardiac Surgical Procedures; Chlorothiazide; Digitalis Glycosides; Diuretic | 1963 |
ACLINICOPATHOLOGICAL CONFERENCE FROM THE OHIO STATE UNIVERSITY HOSPITAL, COLUMBUS, OHIO.
Topics: Angiography; Chlorothiazide; Contrast Media; Heart Failure; Hospitals, University; Humans; Hypertens | 1964 |
SURGICAL TREATMENT OF COMPLETE HEART BLOCK. AN ANALYSIS OF 36 CASES.
Topics: Atropine; Chlorothiazide; Diabetes Mellitus; Ephedrine; Geriatrics; Heart Block; Heart Failure; Huma | 1964 |
[CLINICAL AND BIOCHEMICAL EVALUATION OF THE DIURETIC ACTION OF HYPOTHIAZIDE].
Topics: Biomedical Research; Blood; Chlorine; Chlorothiazide; Diuretics; Drug Therapy; Edema; Heart Failure; | 1964 |
INTRACTABLE CONGESTIVE HEART FAILURE SUCCESSFULLY TREATED WITH SOUTHEY TUBES.
Topics: Body Fluids; Chlorothiazide; Diuretics; Drainage; Edema; Equipment and Supplies; Heart Failure; Leg; | 1964 |
HYPONATREMIA IN CONGESTIVE HEART FAILURE.
Topics: Chlorides; Chlorothiazide; Diuretics; Heart Failure; Hyponatremia; Lysine; Organomercury Compounds; | 1964 |
[URATIC ARTHRITIS AS A COMPLICATION OF DIURETIC THERAPY].
Topics: Arthritis; Chlorothiazide; Chlorthalidone; Diuretics; Gout; Heart Failure; Hypertension; Rheumatic H | 1964 |
RENAL ARTERY STENOSIS AND THE NEPHROTIC SYNDROME.
Topics: Aorta; Aorta, Abdominal; Arteriosclerosis; Child; Chlorothiazide; Glomerulonephritis; Heart Failure; | 1964 |
ETHACRYNIC ACID: EFFECTIVENESS AND MODE OF DIURETIC ACTION IN MAN.
Topics: Acetazolamide; Acidosis; Acidosis, Renal Tubular; Alkalosis; Ascites; Carbonic Anhydrase Inhibitors; | 1965 |
ERYSIPELOTHRIX ENDOCARDITIS: REPORT OF A CASE WITH CEREBRAL MANIFESTATIONS.
Topics: Brain Diseases; Chloramphenicol; Chlorothiazide; Digoxin; Diuretics; Drug Therapy; Endocarditis; End | 1965 |
DIURETIC ACTION OF FUROSEMIDE.
Topics: Acetazolamide; Bicarbonates; Biomedical Research; Blood Chemical Analysis; Carbonic Anhydrase Inhibi | 1965 |
FURTHER EXPERIENCE WITH SPIRONOLACTONE-HYDRO-CHLOROTHIAZIDE (ALDACTAZIDE-A) IN THE LONG-TERM TREATMENT OF REFRACTORY CARDIAC EDEMA.
Topics: Arteriosclerosis; Chlorothiazide; Coronary Disease; Drug Combinations; Drug Therapy; Edema; Edema, C | 1965 |
FUROSEMIDE (LASIX) AS A DIURETIC.
Topics: Chlorothiazide; Chlorthalidone; Diuretics; Drug Therapy; Furosemide; Heart Failure; Hydrochlorothiaz | 1965 |
[A new diuretic and saluretic of the benzothiodiazine series: benzhydroflumethiazide].
Topics: Chlorothiazide; Diuretics; Heart Failure; Liver Cirrhosis | 1960 |
Hydrochlorothiazide in the treatment of congestive heart failure.
Topics: Chlorothiazide; Heart Failure; Hydrochlorothiazide | 1959 |
[The value of chlorothiazide as a diuretic].
Topics: Chlorothiazide; Diuretics; Heart Failure; Pulmonary Heart Disease | 1959 |
[Treatment of cardiac edema by hydrochlorothiazide].
Topics: Chlorothiazide; Edema, Cardiac; Heart Failure; Hydrochlorothiazide | 1959 |
[A new diuretic: hydrochlorothiazide in the treatment of cardiac insufficiency].
Topics: Chlorothiazide; Diuretics; Heart Failure; Hydrochlorothiazide | 1959 |
[Hydrochlorothiazide. A new diuretic in the treatment of cardiac insufficiency].
Topics: Chlorothiazide; Diuretics; Heart Failure; Hydrochlorothiazide | 1959 |
[Reaction of chlorothiazide in fluid retention induced by pitressin and desoxycorticosterone acetate in rats].
Topics: Animals; Chlorothiazide; Desoxycorticosterone; Desoxycorticosterone Acetate; Heart Failure; Rats; Va | 1959 |
[Current status of diuretic therapeutics in edemas of cardiac insufficiency].
Topics: Adrenal Cortex Hormones; Chlorothiazide; Diuretics; Edema; Heart Failure; Organomercury Compounds | 1959 |
[Clinical study of the diuretic action of hydrochlorothiazide].
Topics: Biomedical Research; Chlorothiazide; Diuretics; Heart Failure; Hydrochlorothiazide; Nephrotic Syndro | 1959 |
[Treatment of hepatogenic fluid retentions with trichlormethiazide (Esmarin)].
Topics: Acid-Base Imbalance; Body Fluids; Chlorothiazide; Heart Failure; Trichlormethiazide; Water-Electroly | 1962 |
[Clinical experimentation on a new oral saldiuretic, the potassium salt of trichloromethyl hydrochlorothiazide (PS-207) in cardiac insufficiency].
Topics: Chlorothiazide; Empirical Research; Heart Failure; Hydrochlorothiazide; Potassium; Potassium Compoun | 1962 |
Hydrochlorothiazide in congestive heart failure and in toxemia of pregnancy.
Topics: Chlorothiazide; Female; Heart Failure; Hydrochlorothiazide; Pre-Eclampsia; Pregnancy | 1962 |
[On the diuretic action of hypothiazide].
Topics: Cardiovascular Diseases; Chlorothiazide; Diuretics; Heart Failure; Hydrochlorothiazide | 1962 |
[Hypokalemis, hypochloremia and alkalosis in the long-term treatment of edematous heart insufficiency with benzothiadiazine diuretics. III. Effects of spirolactone].
Topics: Aldosterone; Alkalosis; Chlorothiazide; Diuretics; Edema; Heart Failure; Mineralocorticoid Receptor | 1962 |
Clinical trials with hydrochlorothiazide.
Topics: Chlorothiazide; Heart Failure; Hydrochlorothiazide; Hypertension | 1962 |
[The chlorothiazides in medical practice].
Topics: Chlorothiazide; Edetic Acid; Heart Failure | 1961 |
[Hypokalemia, hypochloremia and alkalosis in the long-term treatment of edematous heart insufficiency with benzothiadiazine diuretics. I. Incidence and pathophysiology].
Topics: Alkalosis; Chlorothiazide; Edema; Heart Failure; Humans; Hypokalemia; Incidence; Potassium; Sodium C | 1962 |
[Hypokalemis, hypochloremia and alkalosis in the long-term treatment of edematous heart insufficiency with benzothiadiazine diuretics. II. The prophylactic value of potassium chloride].
Topics: Alkalosis; Chlorides; Chlorothiazide; Edema; Heart Failure; Humans; Potassium; Potassium Chloride; S | 1962 |
[Saluretics in the treatment of cardiac and renal edema].
Topics: Blood Circulation; Body Weight; Chlorothiazide; Diuretics; Edema; Ethacrynic Acid; Furosemide; Heart | 1966 |
Conversion of atrial fibrillation with quinidine sulfate in a dog.
Topics: Animals; Atrial Fibrillation; Chlorothiazide; Digoxin; Dirofilariasis; Dog Diseases; Dogs; Electroca | 1967 |
Prolonged therapy by the combination of furosemide and thiazides in refractory heart failure and other fluid retaining conditions.
Topics: Aged; Aged, 80 and over; Cardiomyopathy, Dilated; Chlorothiazide; Diuretics; Drug Administration Sch | 1995 |
[Medical treatment of heart failure in infants and young children].
Topics: Anti-Bacterial Agents; Anticoagulants; Aortic Coarctation; Bradycardia; Chlorothiazide; Diet, Sodium | 1969 |
Aortopulmonary fenestration and aortic atresia. Report of an infant with ventricular septal defect, persistent ductus arteriosus, and interrupted aortic arch.
Topics: Aorta; Aortic Arch Syndromes; Aortic Valve; Autopsy; Birth Weight; Chlorothiazide; Digoxin; Ductus A | 1974 |
Diuretic therapy in experimental right heart failure of the rhesus monkey.
Topics: Animals; Benzoates; Body Weight; Chlorothiazide; Diuretics; Edema; Furosemide; Haplorhini; Heart Fai | 1972 |
[A combination of diuretics from different classes in the treatment of cardiac insufficiency].
Topics: Adult; Aged; Chlorothiazide; Diuresis; Female; Heart Failure; Humans; Male; Middle Aged; Natriuresis | 1972 |
Influence of volume expansion on proximal tubular sodium reabsorption in congestive heart failure.
Topics: Aged; Aldosterone; Aminohippuric Acids; Chlorides; Chlorothiazide; Chromium Isotopes; Diuresis; Eryt | 1973 |
Serum calcium and phosphorus in patients treated with thiazides and furosemide.
Topics: Adult; Aged; Calcium; Chlorothiazide; Depression, Chemical; Female; Furosemide; Heart Failure; Human | 1973 |
[Effect of daily treatment with hypothiazide and novurit on the acid-base balance and mineral metabolism in patients with circulatory insufficiency].
Topics: Acid-Base Equilibrium; Adolescent; Adult; Aged; Chlorothiazide; Female; Heart Failure; Humans; Hyper | 1969 |
Report of the panels on cardiovascular drugs from the drug efficacy study.
Topics: Angina Pectoris; Cardiovascular Diseases; Chlorothiazide; Digitalis Glycosides; Drug Industry; Drug | 1970 |
Hypertension, hyperuricemia and iatrogenic disease.
Topics: Aged; Allopurinol; Aortic Diseases; Arteriosclerosis; Brain; Catheterization; Chlorothiazide; Diagno | 1970 |
[Furosemide in the treatment of cardiac insufficiency].
Topics: Adult; Aged; Chlorothiazide; Chlorthalidone; Diuresis; Electrolytes; Female; Furosemide; Heart Failu | 1967 |
Amiloride. A potassium-sparing natriuretic agent.
Topics: Acetazolamide; Aldosterone; Ammonia; Ascites; Bicarbonates; Blood Pressure; Chlorides; Chlorothiazid | 1968 |
Flapping tremors--hepatic failure from oral diuretics for cardiac failure.
Topics: Aged; Chlorothiazide; Extremities; Heart Failure; Humans; Liver; Male; Middle Aged; Tremor | 1968 |
[Resistance to diuretics].
Topics: Adolescent; Adult; Aged; Chlorothiazide; Female; Heart Failure; Humans; Male; Middle Aged; Organomer | 1968 |
Selective aldosterone deficiency.
Topics: 17-Ketosteroids; Adolescent; Adrenal Insufficiency; Aged; Aldosterone; Aminohippuric Acids; Carbon I | 1969 |
Cardiorenal hemodynamic effects of ethacrynic acid.
Topics: Chlorothiazide; Diabetes Insipidus; Edema; Electrolytes; Ethacrynic Acid; Heart; Heart Failure; Hear | 1966 |
Clinical pharmacology of diuretic drugs.
Topics: Acetazolamide; Aldosterone; Ammonium Chloride; Chlorothiazide; Diuretics; Heart Failure; Humans; Org | 1966 |
Heart failure.
Topics: Chlorothiazide; Digitalis Glycosides; Diuretics; Heart Failure; Humans; Morphine | 1966 |
Pulmonary venous and arterial hypertension due to chronic fibrous mediastinitis. Hemodynamics and pulmonary function.
Topics: Adult; Chlorothiazide; Heart Failure; Hemodynamics; Humans; Hypertension, Pulmonary; Lung; Male; Med | 1966 |
Aldosterone metabolism in cardiac failure.
Topics: Aldosterone; Chlorothiazide; Diet, Sodium-Restricted; Digitalis Glycosides; Heart Failure; Humans; H | 1966 |