chloroquine has been researched along with Zika Virus Infection in 8 studies
Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.
chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.
Zika Virus Infection: A viral disease transmitted by the bite of AEDES mosquitoes infected with ZIKA VIRUS. Its mild DENGUE-like symptoms include fever, rash, headaches and ARTHRALGIA. The viral infection during pregnancy, in rare cases, is associated with congenital brain and ocular abnormalities, called Congenital Zika Syndrome, including MICROCEPHALY and may also lead to GUILLAIN-BARRE SYNDROME.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We applied pharmacokinetic modeling to develop a predictive model for CQ exposure to identify an optimal maternal/fetal dosing regimen to prevent ZIKV endocytosis in brain cells." | 5.51 | Dose Optimization of Chloroquine by Pharmacokinetic Modeling During Pregnancy for the Treatment of Zika Virus Infection. ( Badhan, RKS; Olafuyi, O, 2019) |
| " We applied pharmacokinetic modeling to develop a predictive model for CQ exposure to identify an optimal maternal/fetal dosing regimen to prevent ZIKV endocytosis in brain cells." | 1.51 | Dose Optimization of Chloroquine by Pharmacokinetic Modeling During Pregnancy for the Treatment of Zika Virus Infection. ( Badhan, RKS; Olafuyi, O, 2019) |
| "Chloroquine treatment significantly improved the survival of ZIKV-infected 1-day old suckling SCID Beige mice and reduced viremia in adult SCID Beige mice." | 1.51 | Chloroquine inhibits endosomal viral RNA release and autophagy-dependent viral replication and effectively prevents maternal to fetal transmission of Zika virus. ( Chen, L; Feng, L; Guo, W; Li, C; Li, P; Liu, X; Niu, X; Pan, W; Peng, J; Qu, L; Wang, Q; Wu, M; Yan, Q; Ye, X; Yi, C; Zhang, F; Zhang, S, 2019) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 6 (75.00) | 24.3611 |
| 2020's | 2 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bernatchez, JA | 1 |
| Tran, LT | 1 |
| Li, J | 1 |
| Luan, Y | 1 |
| Siqueira-Neto, JL | 1 |
| Li, R | 1 |
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 1 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Li, C | 2 |
| Zhu, X | 1 |
| Ji, X | 1 |
| Quanquin, N | 1 |
| Deng, YQ | 1 |
| Tian, M | 1 |
| Aliyari, R | 1 |
| Zuo, X | 1 |
| Yuan, L | 1 |
| Afridi, SK | 1 |
| Li, XF | 1 |
| Jung, JU | 1 |
| Nielsen-Saines, K | 1 |
| Qin, FX | 1 |
| Qin, CF | 1 |
| Xu, Z | 1 |
| Cheng, G | 1 |
| Shiryaev, SA | 1 |
| Mesci, P | 1 |
| Pinto, A | 1 |
| Fernandes, I | 1 |
| Sheets, N | 1 |
| Shresta, S | 1 |
| Farhy, C | 1 |
| Huang, CT | 1 |
| Strongin, AY | 1 |
| Muotri, AR | 1 |
| Terskikh, AV | 1 |
| Peng, H | 1 |
| Liu, B | 1 |
| Yves, TD | 1 |
| He, Y | 1 |
| Wang, S | 1 |
| Tang, H | 1 |
| Ren, H | 1 |
| Zhao, P | 1 |
| Qi, Z | 1 |
| Qin, Z | 1 |
| Olafuyi, O | 1 |
| Badhan, RKS | 1 |
| Zhang, S | 1 |
| Yi, C | 1 |
| Zhang, F | 1 |
| Peng, J | 1 |
| Wang, Q | 1 |
| Liu, X | 1 |
| Ye, X | 1 |
| Li, P | 1 |
| Wu, M | 1 |
| Yan, Q | 1 |
| Guo, W | 1 |
| Niu, X | 1 |
| Feng, L | 1 |
| Pan, W | 1 |
| Chen, L | 1 |
| Qu, L | 1 |
| Delvecchio, R | 1 |
| Higa, LM | 1 |
| Pezzuto, P | 1 |
| Valadão, AL | 1 |
| Garcez, PP | 1 |
| Monteiro, FL | 1 |
| Loiola, EC | 1 |
| Dias, AA | 1 |
| Silva, FJ | 1 |
| Aliota, MT | 1 |
| Caine, EA | 1 |
| Osorio, JE | 1 |
| Bellio, M | 1 |
| O'Connor, DH | 1 |
| Rehen, S | 1 |
| de Aguiar, RS | 1 |
| Savarino, A | 1 |
| Campanati, L | 1 |
| Tanuri, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Hydroxychloroquine Post-Exposure Prophylaxis for Coronavirus Disease (COVID-19) Among Health-Care Workers: A Randomized-Controlled Trial[NCT04438837] | 582 participants (Anticipated) | Interventional | 2020-07-31 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for chloroquine and Zika Virus Infection
| Article | Year |
|---|---|
Drugs for the Treatment of Zika Virus Infection.
Topics: Animals; Antiviral Agents; Drug Development; Drug Discovery; Humans; Viral Vaccines; Zika Virus; Zik | 2020 |
7 other studies available for chloroquine and Zika Virus Infection
| Article | Year |
|---|---|
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
Chloroquine, a FDA-approved Drug, Prevents Zika Virus Infection and its Associated Congenital Microcephaly in Mice.
Topics: Animals; Cell Line; Chlorocebus aethiops; Chloroquine; Disease Models, Animal; Drug Approval; Drug E | 2017 |
Repurposing of the anti-malaria drug chloroquine for Zika Virus treatment and prophylaxis.
Topics: Animals; Antimalarials; Chloroquine; Disease Models, Animal; Drug Repositioning; Humans; Mice; Neura | 2017 |
Zika Virus Induces Autophagy in Human Umbilical Vein Endothelial Cells.
Topics: Androstadienes; Animals; Autophagy; Chlorocebus aethiops; Chloroquine; Gene Knockout Techniques; Hum | 2018 |
Dose Optimization of Chloroquine by Pharmacokinetic Modeling During Pregnancy for the Treatment of Zika Virus Infection.
Topics: Antimalarials; Arthritis, Rheumatoid; Chloroquine; Female; Gestational Age; Humans; Lupus Erythemato | 2019 |
Chloroquine inhibits endosomal viral RNA release and autophagy-dependent viral replication and effectively prevents maternal to fetal transmission of Zika virus.
Topics: Animals; Antimalarials; Autophagy; Cell Line; Chlorocebus aethiops; Chloroquine; Disease Models, Ani | 2019 |
Chloroquine, an Endocytosis Blocking Agent, Inhibits Zika Virus Infection in Different Cell Models.
Topics: Animals; Antiviral Agents; Cell Line; Chlorocebus aethiops; Chloroquine; Endocytosis; Humans; Mice; | 2016 |