chloroquine has been researched along with Ventricular Fibrillation in 6 studies
Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.
chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.
Ventricular Fibrillation: A potentially lethal cardiac arrhythmia that is characterized by uncoordinated extremely rapid firing of electrical impulses (400-600/min) in HEART VENTRICLES. Such asynchronous ventricular quivering or fibrillation prevents any effective cardiac output and results in unconsciousness (SYNCOPE). It is one of the major electrocardiographic patterns seen with CARDIAC ARREST.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Atrial and ventricular tachyarrhythmias can be perpetuated by up-regulation of inward rectifier potassium channels." | 1.36 | Specific residues of the cytoplasmic domains of cardiac inward rectifier potassium channels are effective antifibrillatory targets. ( Berenfeld, O; Calvo, CJ; Chapula, JA; Ferrer-Villada, T; Grzeda, KR; Jalife, J; López-Izquierdo, A; Noujaim, SF; Pandit, S; Ponce-Balbuena, D; Stuckey, JA, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (33.33) | 18.7374 |
| 1990's | 2 (33.33) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Aslanger, E | 1 |
| Altun, I | 1 |
| Noujaim, SF | 1 |
| Stuckey, JA | 1 |
| Ponce-Balbuena, D | 1 |
| Ferrer-Villada, T | 1 |
| López-Izquierdo, A | 1 |
| Pandit, S | 1 |
| Calvo, CJ | 1 |
| Grzeda, KR | 1 |
| Berenfeld, O | 1 |
| Chapula, JA | 1 |
| Jalife, J | 1 |
| McCann, WP | 1 |
| Permisohn, R | 1 |
| Palmisano, PA | 1 |
| Collee, GG | 1 |
| Samra, GS | 1 |
| Hanson, GC | 1 |
| Bauer, P | 1 |
| Maire, B | 1 |
| Weber, M | 1 |
| Bollaert, PE | 1 |
| Larcan, A | 1 |
| Lambert, H | 1 |
| Kubasta, M | 1 |
| Vykydal, M | 1 |
| Zmeskal, A | 1 |
| Gikalovová, I | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Chloroquine for Patients With Symptomatic Persistent Atrial Fibrillation: A Prospective Pilot Study[NCT02932007] | Phase 2 | 40 participants (Anticipated) | Interventional | 2017-03-28 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
6 other studies available for chloroquine and Ventricular Fibrillation
| Article | Year |
|---|---|
Sudden cardiac arrest in a patient taking chloroquine.
Topics: Antirheumatic Agents; Atrioventricular Block; Chloroquine; Heart Arrest; Humans; Male; Pacemaker, Ar | 2009 |
Specific residues of the cytoplasmic domains of cardiac inward rectifier potassium channels are effective antifibrillatory targets.
Topics: Animals; Anti-Arrhythmia Agents; Chloroquine; Cytoplasm; Heart; Mice; Models, Molecular; Potassium C | 2010 |
Fatal chloroquine poisoning in a child: experience with peritoneal dialysis.
Topics: Brain; Child, Preschool; Chloroquine; Heart Massage; Humans; Hypothermia; Intubation, Intratracheal; | 1975 |
Chloroquine poisoning: ventricular fibrillation following 'trivial' overdose in a child.
Topics: Adolescent; Cardiopulmonary Resuscitation; Chloroquine; Drug Overdose; Electrocardiography; Gastric | 1992 |
Full recovery after a chloroquine suicide attempt.
Topics: Adult; Chloroquine; Combined Modality Therapy; Diazepam; Dobutamine; Epinephrine; Female; Humans; Po | 1991 |
Cardiotoxicity of chloroquine in rabbits.
Topics: Animals; Cardiac Complexes, Premature; Chloroquine; Heart; Injections, Intramuscular; Injections, In | 1967 |