chloroquine has been researched along with Tuberous Sclerosis in 1 studies
Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.
chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.
Tuberous Sclerosis: Autosomal dominant neurocutaneous syndrome classically characterized by MENTAL RETARDATION; EPILEPSY; and skin lesions (e.g., adenoma sebaceum and hypomelanotic macules). There is, however, considerable heterogeneity in the neurologic manifestations. It is also associated with cortical tuber and HAMARTOMAS formation throughout the body, especially the heart, kidneys, and eyes. Mutations in two loci TSC1 and TSC2 that encode hamartin and tuberin, respectively, are associated with the disease.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (100.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kovalenko, A | 1 |
| Sanin, A | 1 |
| Kosmas, K | 1 |
| Zhang, L | 1 |
| Wang, J | 1 |
| Akl, EW | 1 |
| Giannikou, K | 1 |
| Probst, CK | 1 |
| Hougard, TR | 1 |
| Rue, RW | 1 |
| Krymskaya, VP | 1 |
| Asara, JM | 1 |
| Lam, HC | 1 |
| Kwiatkowski, DJ | 1 |
| Henske, EP | 1 |
| Filippakis, H | 1 |
1 other study available for chloroquine and Tuberous Sclerosis
| Article | Year |
|---|---|
Therapeutic Targeting of DGKA-Mediated Macropinocytosis Leads to Phospholipid Reprogramming in Tuberous Sclerosis Complex.
Topics: Angiolipoma; Animals; Autophagy; Cell Proliferation; Chloroquine; Diacylglycerol Kinase; Down-Regula | 2021 |